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Your search keyword '"Shao, Lulu"' showing total 16 results
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16 results on '"Shao, Lulu"'

11. Supplementary Figure legends from IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Author

Shao, Lulu, primary, Hou, Weizhou, primary, Scharping, Nicole E., primary, Vendetti, Frank P., primary, Srivastava, Rashmi, primary, Roy, Chandra Nath, primary, Menk, Ashley V., primary, Wang, Yiyang, primary, Chauvin, Joe-Marc, primary, Karukonda, Pooja, primary, Thorne, Stephen H., primary, Hornung, Veit, primary, Zarour, Hassane M., primary, Bakkenist, Christopher J., primary, Delgoffe, Greg M., primary, and Sarkar, Saumendra N., primary

Published
2023
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12. Figure S1 from IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Author

Shao, Lulu, primary, Hou, Weizhou, primary, Scharping, Nicole E., primary, Vendetti, Frank P., primary, Srivastava, Rashmi, primary, Roy, Chandra Nath, primary, Menk, Ashley V., primary, Wang, Yiyang, primary, Chauvin, Joe-Marc, primary, Karukonda, Pooja, primary, Thorne, Stephen H., primary, Hornung, Veit, primary, Zarour, Hassane M., primary, Bakkenist, Christopher J., primary, Delgoffe, Greg M., primary, and Sarkar, Saumendra N., primary

Published
2023
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13. Data from IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Author

Shao, Lulu, primary, Hou, Weizhou, primary, Scharping, Nicole E., primary, Vendetti, Frank P., primary, Srivastava, Rashmi, primary, Roy, Chandra Nath, primary, Menk, Ashley V., primary, Wang, Yiyang, primary, Chauvin, Joe-Marc, primary, Karukonda, Pooja, primary, Thorne, Stephen H., primary, Hornung, Veit, primary, Zarour, Hassane M., primary, Bakkenist, Christopher J., primary, Delgoffe, Greg M., primary, and Sarkar, Saumendra N., primary

Published
2023
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15. Cytochalasans produced by Xylaria karyophthoraand their biological activities

Author

Lambert, Christopher, Shao, Lulu, Zeng, Haoxuan, Surup, Frank, Saetang, Praphatsorn, Aime, Mary Catherine, Husbands, Dillon R., Rottner, Klemens, Stradal, Theresia E. B., and Stadler, Marc

Abstract

ABSTRACTThe recent description of the putative fungal pathogen of greenheart trees, Xylaria karyophthora(Xylariaceae, Ascomycota), prompted a study of its secondary metabolism to access its ability to produce cytochalasans in culture. Solid-state fermentation of the ex-type strain on rice medium resulted in the isolation of a series of 19,20-epoxidated cytochalasins by means of preparative high-performance liquid chromatography (HPLC). Nine out of 10 compounds could be assigned to previously described structures, with one compound being new to science after structural assignment via nuclear magnetic resonance (NMR) assisted by high-resolution mass spectrometry (HRMS). We propose the trivial name “karyochalasin” for the unprecedented metabolite. The compounds were used in our ongoing screening campaign to study the structure-activity relationship of this family of compounds. This was done by examining their cytotoxicity against eukaryotic cells and impact on the organization of networks built by their main target, actin—a protein indispensable for processes mediating cellular shape changes and movement. Moreover, the cytochalasins’ ability to inhibit the biofilm formation of Candida albicansand Staphylococcus aureuswas examined.

Published
2023
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16. An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T Cells and Promotes Tumor Clearance.

Author

Shao L, Srivastava R, Delgoffe GM, Thorne SH, and Sarkar SN

Subjects
Animals, Female, Humans, Mice, Cell Line, Tumor, Disease Models, Animal, Interferon Regulatory Factor-1 metabolism, Interferon Regulatory Factor-1 genetics, Melanoma, Experimental immunology, Melanoma, Experimental therapy, Mice, Inbred C57BL, T-Lymphocytes immunology, Vaccinia virus genetics, Vaccinia virus immunology, Interferon Regulatory Factor-2 metabolism, Interferon Regulatory Factor-2 genetics, Oncolytic Virotherapy methods, Oncolytic Viruses genetics, Oncolytic Viruses immunology
Abstract

IFN regulatory factor 1 (IRF1) can promote antitumor immunity. However, we have shown previously that in the tumor cell, IRF1 can promote tumor growth, and IRF1-deficient tumor cells exhibit severely restricted tumor growth in several syngeneic mouse tumor models. Here, we investigate the potential of functionally modulating IRF1 to reduce tumor progression and prolong survival. Using inducible IRF1 expression, we established that it is possible to regulate IRF1 expression to modulate tumor progression in established B16-F10 tumors. Expression of IRF2, which is a functional antagonist of IRF1, downregulated IFNγ-induced expression of inhibitory ligands, upregulated MHC-related molecules, and slowed tumor growth and extended survival. We characterized the functional domain(s) of IRF2 needed for this antitumor activity, showing that a full-length IRF2 was required for its antitumor functions. Finally, using an oncolytic vaccinia virus as a delivery platform, we showed that IRF2-expressing vaccinia virus suppressed tumor progression and prolonged survival in multiple tumor models. These results suggest the potency of targeting IRF1 and using IRF2 to modulate immunotherapy., (©2024 American Association for Cancer Research.)

Published
2024
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