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Your search keyword '"Shamsan, Ghaidan A."' showing total 9 results
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2. Directed cell migration towards softer environments

Author

Isomursu, Aleksi, Park, Keun-Young, Hou, Jay, Cheng, Bo, Mathieu, Mathilde, Shamsan, Ghaidan A., Fuller, Benjamin, Kasim, Jesse, Mahmoodi, M. Mohsen, Lu, Tian Jian, Genin, Guy M., Xu, Feng, Lin, Min, Distefano, Mark D., Ivaska, Johanna, and Odde, David J.

Published
2022
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3. Mutual antagonism between CD44 and integrins in glioblastoma cell traction and migration.

Author

Kelly, Marcus D., Pawlak, Matthew R., Zhan, Kevin H., Shamsan, Ghaidan A., Gordon, Wendy R., and Odde, David J.

Subjects
CELL migration, CD44 antigen, EXTRACELLULAR matrix, HYALURONIC acid, CANCER invasiveness
Abstract

Cell migration is the major driver of invasion and metastasis during cancer progression. For cells to migrate, they utilize the actin–myosin cytoskeleton and adhesion molecules, such as integrins and CD44, to generate traction forces in their environment. CD44 primarily binds to hyaluronic acid (HA) and integrins primarily bind to extracellular matrix (ECM) proteins such as collagen. However, the role of CD44 under integrin-mediated conditions and vice versa is not well known. Here, we performed traction force microscopy (TFM) on U251 cells seeded on collagen I-coated polyacrylamide gels to assess the functional mechanical relationship between integrins and CD44. Performing TFM on integrin-mediated adhesion conditions, i.e., collagen, we found that CD44KO U251 cells exerted more traction force than wild-type (WT) U251 cells. Furthermore, untreated WT and CD44-blocked WT exhibited comparable results. Conversely, in CD44-mediated adhesive conditions, integrin-blocked WT cells exerted a higher traction force than untreated WT cells. Our data suggest that CD44 and integrins have a mutually antagonistic relationship where one receptor represses the other's ability to generate traction force on its cognate substrate. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Supplementary Figures 4-7 from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Author

Beckmann, Pauline J., primary, Larson, Jon D., primary, Larsson, Alex T., primary, Ostergaard, Jason P., primary, Wagner, Sandra, primary, Rahrmann, Eric P., primary, Shamsan, Ghaidan A., primary, Otto, George M., primary, Williams, Rory L., primary, Wang, Jun, primary, Lee, Catherine, primary, Tschida, Barbara R., primary, Das, Paramita, primary, Dubuc, Adrian M., primary, Moriarity, Branden S., primary, Picard, Daniel, primary, Wu, Xiaochong, primary, Rodriguez, Fausto J., primary, Rosemarie, Quincy, primary, Krebs, Ryan D., primary, Molan, Amy M., primary, Demer, Addison M., primary, Frees, Michelle M., primary, Rizzardi, Anthony E., primary, Schmechel, Stephen C., primary, Eberhart, Charles G., primary, Jenkins, Robert B., primary, Wechsler-Reya, Robert J., primary, Odde, David J., primary, Huang, Annie, primary, Taylor, Michael D., primary, Sarver, Aaron L., primary, and Largaespada, David A., primary

Published
2023
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5. Data from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Author

Beckmann, Pauline J., primary, Larson, Jon D., primary, Larsson, Alex T., primary, Ostergaard, Jason P., primary, Wagner, Sandra, primary, Rahrmann, Eric P., primary, Shamsan, Ghaidan A., primary, Otto, George M., primary, Williams, Rory L., primary, Wang, Jun, primary, Lee, Catherine, primary, Tschida, Barbara R., primary, Das, Paramita, primary, Dubuc, Adrian M., primary, Moriarity, Branden S., primary, Picard, Daniel, primary, Wu, Xiaochong, primary, Rodriguez, Fausto J., primary, Rosemarie, Quincy, primary, Krebs, Ryan D., primary, Molan, Amy M., primary, Demer, Addison M., primary, Frees, Michelle M., primary, Rizzardi, Anthony E., primary, Schmechel, Stephen C., primary, Eberhart, Charles G., primary, Jenkins, Robert B., primary, Wechsler-Reya, Robert J., primary, Odde, David J., primary, Huang, Annie, primary, Taylor, Michael D., primary, Sarver, Aaron L., primary, and Largaespada, David A., primary

Published
2023
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6. Supplementary Tables 1-9 from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Author

Beckmann, Pauline J., primary, Larson, Jon D., primary, Larsson, Alex T., primary, Ostergaard, Jason P., primary, Wagner, Sandra, primary, Rahrmann, Eric P., primary, Shamsan, Ghaidan A., primary, Otto, George M., primary, Williams, Rory L., primary, Wang, Jun, primary, Lee, Catherine, primary, Tschida, Barbara R., primary, Das, Paramita, primary, Dubuc, Adrian M., primary, Moriarity, Branden S., primary, Picard, Daniel, primary, Wu, Xiaochong, primary, Rodriguez, Fausto J., primary, Rosemarie, Quincy, primary, Krebs, Ryan D., primary, Molan, Amy M., primary, Demer, Addison M., primary, Frees, Michelle M., primary, Rizzardi, Anthony E., primary, Schmechel, Stephen C., primary, Eberhart, Charles G., primary, Jenkins, Robert B., primary, Wechsler-Reya, Robert J., primary, Odde, David J., primary, Huang, Annie, primary, Taylor, Michael D., primary, Sarver, Aaron L., primary, and Largaespada, David A., primary

Published
2023
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7. Supplementary Figures 1-3 from Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Author

Beckmann, Pauline J., primary, Larson, Jon D., primary, Larsson, Alex T., primary, Ostergaard, Jason P., primary, Wagner, Sandra, primary, Rahrmann, Eric P., primary, Shamsan, Ghaidan A., primary, Otto, George M., primary, Williams, Rory L., primary, Wang, Jun, primary, Lee, Catherine, primary, Tschida, Barbara R., primary, Das, Paramita, primary, Dubuc, Adrian M., primary, Moriarity, Branden S., primary, Picard, Daniel, primary, Wu, Xiaochong, primary, Rodriguez, Fausto J., primary, Rosemarie, Quincy, primary, Krebs, Ryan D., primary, Molan, Amy M., primary, Demer, Addison M., primary, Frees, Michelle M., primary, Rizzardi, Anthony E., primary, Schmechel, Stephen C., primary, Eberhart, Charles G., primary, Jenkins, Robert B., primary, Wechsler-Reya, Robert J., primary, Odde, David J., primary, Huang, Annie, primary, Taylor, Michael D., primary, Sarver, Aaron L., primary, and Largaespada, David A., primary

Published
2023
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9. Differential migration mechanics and immune responses of glioblastoma subtypes

Author

Shamsan, Ghaidan A., primary, Liu, Chao J., additional, Braman, Brooke C., additional, Rathe, Susan K., additional, Sarver, Aaron L., additional, Ghaderi, Nima, additional, McMahon, Mariah M., additional, Klank, Rebecca L., additional, Tschida, Barbara R., additional, McFarren, S. Joey, additional, Rosato, Pamela C., additional, Masopust, David, additional, Sarkaria, Jann N., additional, Clark, H. Brent, additional, Rosenfeld, Steven S., additional, Largaespada, David A., additional, and Odde, David J., additional

Published
2022
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