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Abstract We study infinite-distance limits in the complex structure moduli space of elliptic Calabi-Yau threefolds. In F-theory compactifications to six dimensions, such limits include infinite-distance trajectories in the non-perturbative open string moduli space. The limits are described as degenerations of elliptic threefolds whose central elements exhibit non-minimal elliptic fibers, in the Kodaira sense, over curves on the base. We show how these non-crepant singularities can be removed by a systematic sequence of blow-ups of the base, leading to a union of log Calabi-Yau spaces glued together along their boundaries. We identify criteria for the blow-ups to give rise to open chains or more complicated trees of components and analyse the blow-up geometry. While our results are general and applicable to all non-minimal degenerations of Calabi-Yau threefolds in codimension one, we exemplify them in particular for elliptic threefolds over Hirzebruch surface base spaces. We also explain how to extract the gauge algebra for F-theory probing such reducible asymptotic geometries. This analysis is the basis for a detailed F-theory interpretation of the associated infinite-distance limits that will be provided in a companion paper [1].

Background: We compared the prognostic value of the C-reactive protein (CRP)-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and modified Glasgow prognostic score (mGPS) with the Sequential Organ Failure Assessment (SOFA) score in an intensive care unit (ICUs). Methods: This study used the data of 53,877 adult patients admitted to an ICU between June 2013 and May 2022. Using the CAR, NLR, and mGPS values, as well as the SOFA score from the ICU, we conducted multivariable logistic regression analysis and used the receiver operating characteristic (ROC) curve to compare the predictive value for 28-day and 1-year mortality. Results: A total of 2419 patients (4.5%) died within 28 days, and 6209 (11.5%) patients died within 1 year. After an adjustment, all predictors were found to be independent risk factors for 28-day mortality (odds ratio [OR] 1.31, 95% confidence interval [CI] 1.29–1.33, p < 0.001 for the SOFA score; OR 1.05, 95% CI 1.03–1.07, p < 0.001 for CAR; OR 1.01, 95% CI 1.00–1.02, p < 0.001 for the NLR; and OR 1.19, 95% CI 1.08–1.30, p < 0.001 for the mGPS). This trend persisted for the 1-year mortality. In ROC curve analysis, the CAR showed better predictability than the NLR and mGPS. Furthermore, the predictive power of the CAR was significantly higher than that of the SOFA score for 1-year mortality. Conclusions: The CAR, NLR, and mGPS values at ICU admission were independent risk factors of mortality after ICU admission. The predictive value of CAR was higher than that of the SOFA score for 1-year mortality. CAR assessment at ICU admission may be a feasible predictor of long-term mortality.

Abstract Motivated by the Swampland Distance and the Emergent String Conjecture of Quantum Gravity, we analyse the infinite distance degenerations in the complex structure moduli space of elliptic K3 surfaces. All complex degenerations of K3 surfaces are known to be classified according to their associated Kulikov models of Type I (finite distance), Type II or Type III (infinite distance). For elliptic K3 surfaces, we characterise the underlying Weierstrass models in detail. Similarly to the known two classes of Type II Kulikov models for elliptic K3 surfaces we find that the Weierstrass models of the more elusive Type III Kulikov models can be brought into two canonical forms. We furthermore show that all infinite distance limits are related to degenerations of Weierstrass models with non-minimal singularities in codimension one or to models with degenerating generic fibers as in the Sen limit. We explicitly work out the general structure of blowups and base changes required to remove the non-minimal singularities. These results form the basis for a classification of the infinite distance limits of elliptic K3 surfaces as probed by F-theory in the companion paper [1]. The Type III limits, in particular, are (partial) decompactification limits as signalled by an emergent affine enhancement of the symmetry algebra.

Abstract We investigate infinite distance limits in the complex structure moduli space of F-theory compactified on K3 to eight dimensions. While this is among the simplest possible arenas to test ideas about the Swampland Distance Conjecture, it is nevertheless non-trivial enough to improve our understanding of the physics for these limiting geometries, including phenomena of emergence. It also provides a perspective on infinite distance limits from the viewpoint of open strings. The paper has two quite independent themes. In the main part we show that all degenerations of elliptic K3 surfaces at infinite distance as analysed in the companion paper [1] can be interpreted as (partial) decompactification or emergent string limits in F-theory, in agreement with the Emergent String Conjecture. We present a unified geometric picture of the possible towers of states that can become light and illustrate our general claims via the connection between Kulikov models of degenerating K3 surfaces and the dual heterotic string. As an application we classify the possible maximal non-abelian Lie algebras and their Kac-Moody and loop extensions that can arise in the infinite distance limits. In the second part we discuss the infinite distance behaviour of certain exact quartic gauge couplings. We encounter a tension with the hypothesis that effective couplings should be fully generated by integrating out massive states. We show that by appropriately renormalizing the string coupling, at least partial emergence can be achieved.

Abstract We investigate holomorphic anomalies of partition functions underlying string compactifications on Calabi-Yau fourfolds with background fluxes. For elliptic fourfolds the partition functions have an alternative interpretation as elliptic genera of N = 1 supersymmetric string theories in four dimensions, or as generating functions for relative, genus zero Gromov-Witten invariants of fourfolds with fluxes. We derive the holomorphic anomaly equations by starting from the BCOV formalism of topological strings, and translating them into geometrical terms. The result can be recast into modular and elliptic anomaly equations. As a new feature, as compared to threefolds, we find an extra contribution which is given by a gravitational descendant invariant. This leads to linear terms in the anomaly equations, which support an algebra of derivatives mapping between partition functions of the various flux sectors. These geometric features are mirrored by certain properties of quasi-Jacobi forms. We also offer an interpretation of the physics from the viewpoint of the worldsheet theory, and comment on holomorphic anomalies at genus one.

Abstract We systematically analyse weak coupling limits for 2-form tensor fields in the presence of gravity. Such limits are significant for testing various versions of the Weak Gravity and Swampland Distance Conjectures, and more broadly, the phenomenon of emergence. The weak coupling limits for 2-forms correspond to certain infinite-distance limits in the moduli space of string compactifications, where asymptotically tensionless, solitonic strings arise. These strings are identified as weakly coupled fundamental strings in a dual frame, which makes the idea of emergence manifest. Concretely we first consider weakly coupled tensor fields in six-dimensional compactifications of F-theory, where the arising tensionless strings play the role of dual weakly coupled heterotic strings. As the main part of this work, we consider certain infinite distance limits of Type IIB strings on K3 surfaces, for which we show that the asymptotically tensionless strings describe dual fundamental Type IIB strings, again on K3 surfaces. By contrast the analogous weak coupling limits of M-theory compactifications are found to correspond to an F-theory limit where an extra dimension emerges rather than tensionless strings. We comment on extensions of our findings to four-dimensional compactifications.

Abstract As a refinement of the Swampland Distance Conjecture, we propose that a quantum gravitational theory in an infinite distance limit of its moduli space either decompactifies, or reduces to an asymptotically tensionless, weakly coupled string theory. We support our claim by classifying, as special cases, the behaviour of M-Theory and Type IIA string theory compactifications on Calabi-Yau three-folds at infinite distances in Kähler moduli space. The analysis comprises three parts: we first classify the possible infinite distance limits in the classical Kähler moduli space of a Calabi-Yau three-fold. Each such limit at finite volume is characterized by a universal fibration structure, for which the generic fiber shrinking in the limit is either an elliptic curve, a K3 surface, or an Abelian surface. In the second part we focus on M-Theory and investigate the nature of the towers of asymptotically massless states that arise from branes wrapped on the shrinking fibers. Depending on which of the three classes of fibrations are considered, we obtain decompactification to F-Theory, or a theory with a unique asymptotically tensionless, weakly coupled heterotic or Type II string, respectively. The latter probes a dual D-manifold which is in general non-geometric. In addition to the intrinsic string excitations, towers of states from M2-branes along non-contractible curves become light and correspond to further wrapping and winding modes of the tensionless heterotic or Type II string. In the third part of the analysis, we consider Type IIA string theory on Calabi-Yau three-folds and show that quantum effects obstruct taking finite volume infinite distance limits in the Kähler moduli space. The only possible infinite distance limit which is not a decompactification limit involves K3-fibrations with string scale fiber volume and gives rise to an emergent tensionless heterotic string.

Purpose There are many studies on sentinel lymph node (SLN) biopsy in thyroid carcinoma but SLN biopsy (SLNB) in papillary thyroid carcinoma (PTC) remains open to debate. Therefore in this retrospective study, the usefulness of SLNB in thyroid carcinoma patients who had micro-PTC without cervical lymphadenopathy was assessed. Methods SLNB was performed in 114 patients who were diagnosed with micro-PTC in a single lobe without palpable or ultrasound-detected lymph node at the tertiary center between January 2012 and December 2013. After SLNB, all patients underwent total thyroidectomy and central neck dissection or thyroid lobectomy and central neck dissection of the single side. Results SLNs were identified in 112 of 114 patients with 41 positive SLNs and 71 negative SLNs on intraoperative frozen sections. However, eight negative patients were found to be positive in the final pathology. Sentinel node identification rate and false negative value of SLNB were 98.2% and 11.3%, respectively. In the univariate analysis, higher lymph node metastasis was detected in men than in women. Higher detection number of SLN showed higher probability of lymph node metastasis. Conclusion SLNB may be helpful in papillary thyroid cancer, especially in male patients. Also, it is useful for the staging of nodal status and clearance of persistent disease.

The volatile compounds and sensory profiles of 18 different types of distilled soju, chosen with regard to various raw materials and distillation methods (atmospheric vs. vacuum), were explored using headspace solid-phase microextraction (HS-SPME) with gas chromatography-mass spectrometry (GC-MS) and descriptive analysis. General chemical properties such as pH, total acidity (TA), total soluble solids (°Brix), and lactic acid concentration were also determined. A total of 56 volatile compounds, comprising 31 esters, 11 alcohols, 1 acid, 4 aldehydes, 3 ketones, and 6 miscellaneous compounds, were identified. From the principal component analysis (PCA) of the volatile data, samples made using atmospheric distillation such as MSO and PJU showed a clear difference from decompressed distillation samples. Based on the PCA of the sensory data, there was also a clear distinction between samples by their distillation method. To explore relationships among chemical, volatile, and sensory data sets, multiple factor analysis (MFA) was applied. Yeasty and earthy flavors showed a close relationship with 1-nonanol, octatonic acid, and longer-chain esters such as ethyl phenylacetate and ethyl tetradecanoate, and with chemical parameters such as TA, °Brix, and lactic acid.

Ammonium toxicity is a significant source of pollution from industrial civilization that is disrupting the balance of natural systems, adversely affecting soil and water quality, and causing several environmental problems that affect aquatic and human life, including the strong promotion of eutrophication and increased dissolved oxygen consumption. Thus, a cheap catalyst is required for power generation and detoxification. Herein, compost soil is employed as a novel electrocatalyst for ammonium degradation and high-power generation. Moreover, its effect on catalytic activity and material performances is systematically optimized and compared by treating it with various reducing agents, including potassium ferricyanide, ferrocyanide, and manganese dioxide. Ammonium fuel was supplied to the compost soil ammonium fuel cell (CS-AFC) at concentrations of 0.1, 0.2, and 0.3 g/mL. The overall results show that ferricyanide affords a maximum power density of 1785.20 mW/m2 at 0.2 g/mL fuel concentration. This study focuses on high-power generation for CS-AFC. CS-AFCs are sustainable for many hours without any catalyst deactivation; however, they need to be refueled at regular intervals (every 12 h). Moreover, CS-AFCs afford the best performance when ferricyanide is used as the electron acceptor at the cathode. This study proposes a cheap electrocatalyst and possible solutions to the more serious energy generation problems. This study will help in recycling ammonium-rich wastewaters as free fuel for running CS-AFC devices to yield high-power generation with reducing agents for ammonium fuel cell power applications.

Conventional categorical data imputation techniques, such as mode imputation, often encounter issues related to overestimation. If the variable has too many categories, multinomial logistic regression imputation method may be impossible due to computational limitations. To rectify these limitations, we propose a two-stage imputation method. During the first stage, we utilize the Boruta variable selection method on the complete dataset to identify significant variables for the target categorical variable. Then, in the second stage, we use the important variables for the target categorical variable for logistic regression to impute missing data in binary variables, polytomous regression to impute missing data in categorical variables, and predictive mean matching to impute missing data in quantitative variables. Through analysis of both asymmetric and non-normal simulated and real data, we demonstrate that the two-stage imputation method outperforms imputation methods lacking variable selection, as evidenced by accuracy measures. During the analysis of real survey data, we also demonstrate that our suggested two-stage imputation method surpasses the current imputation approach in terms of accuracy. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate the efficacy of intraoperative indocyanine green videoangiography (ICG-VA) and intraoperative neuromonitoring (IONM) to prevent postoperative ischemic complications during microsurgical clipping of unruptured anterior choroidal artery (AChA) aneurysms. Methods: We retrospectively reviewed the clinical and radiological records of all patients who had undergone microsurgical clipping for unruptured AChA aneurysms at our institution between April 2001 and December 2019. We compared the postoperative complication rate of the group for which intraoperative ICG-VA and IONM were utilized (group B; n=324) with that of the group for which intraoperative ICG-VA and IONM were not utilized (group A; n=72). Results: There were no statistically significant differences in demographic data between the two groups. Statistically significant differences were observed in the rate of overall complications (p=0.014) and postoperative ischemic complications related to AChA territory (p=0.039). All the cases (n=4) in group B who had postoperative infarctions related to AChA territory showed false-negative results of intraoperative ICG-VA and IONM. Conclusions: Preserving the patency of the AChA is essential to minimize postoperative complications. Intraoperative monitoring tools including ICG-VA and IONM can greatly contribute to lowering complication rates. However, their pitfalls and false-negative results should always be considered. [ABSTRACT FROM AUTHOR]