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154 results on '"Schrauwen, Patrick"'

2. A conserved complex lipid signature marks human muscle aging and responds to short-term exercise

Author

Janssens, Georges E., Molenaars, Marte, Herzog, Katharina, Grevendonk, Lotte, Remie, Carlijn M. E., Vervaart, Martin A. T., Elfrink, Hyung L., Wever, Eric J. M., Schomakers, Bauke V., Denis, Simone W., Waterham, Hans R., Pras-Raves, Mia L., van Weeghel, Michel, van Kampen, Antoine H. C., Tammaro, Alessandra, Butter, Loes M., van der Rijt, Sanne, Florquin, Sandrine, Jongejan, Aldo, Moerland, Perry D., Hoeks, Joris, Schrauwen, Patrick, Vaz, Frédéric M., and Houtkooper, Riekelt H.

Published
2024
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4. Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes

Author

Parker, Victoria E. R., Robertson, Darren, Erazo-Tapia, Edmundo, Havekes, Bas, Phielix, Esther, de Ligt, Marlies, Roumans, Kay H. M., Mevenkamp, Julian, Sjoberg, Folke, Schrauwen-Hinderling, Vera B., Johansson, Edvin, Chang, Yi-Ting, Esterline, Russell, Smith, Kenneth, Wilkinson, Daniel J., Hansen, Lars, Johansson, Lars, Ambery, Philip, Jermutus, Lutz, and Schrauwen, Patrick

Published
2023
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9. Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial

Author

van Beek, Sten M. M., Bruls, Yvonne M. H., Vanweert, Froukje, Fealy, Ciarán E., Connell, Niels J., Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna A., Vaz, Frédéric M., Smeets, Ellen T. H. C., Joris, Peter J., Gemmink, Anne, Houtkooper, Riekelt H., Hesselink, Matthijs K. C., Bengtsson, Tore, Havekes, Bas, Schrauwen, Patrick, and Hoeks, Joris

Published
2023
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14. Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial

Author

Veelen, Anna, Andriessen, Charlotte, Op den Kamp, Yvo, Erazo-Tapia, Edmundo, de Ligt, Marlies, Mevenkamp, Julian, Jörgensen, Johanna A., Moonen-Kornips, Esther, Schaart, Gert, Esterline, Russell, Havekes, Bas, Oscarsson, Jan, Schrauwen-Hinderling, Vera B., Phielix, Esther, and Schrauwen, Patrick

Published
2023
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17. Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

Author

op den Kamp, Yvo J.M., Gemmink, Anne, de Ligt, Marlies, Dautzenberg, Bas, Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Esterline, Russell, Pava, Diego A., Hoeks, Joris, Schrauwen-Hinderling, Vera B., Kersten, Sander, Havekes, Bas, Koves, Timothy R., Muoio, Deborah M., Hesselink, Matthijs K.C., Oscarsson, Jan, Phielix, Esther, and Schrauwen, Patrick

Published
2022
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23. De effecten van een PPAR-α-agonist (ciprofibraat) op de weefselspecifieke glucoseopname in insulineresistentie; resultaten van een gerandomiseerde dubbelblinde placebogecontroleerde cross-overstudie.

Author

de Wit-Verheggen, Vera, Vanweert, Froukje, Raiko, Juho, Liénard, Viktor, Schaart, Gert, Gemmink, Anne, Nascimento, Emmani, Hesselink, Matthijs, Wildberger, Joachim, Wierts, Roel, Joris, Peter, Haas, Joel, Montaigne, David, Staels, Bart, Phielix, Esther, Schrauwen, Patrick, Schrauwen-Hinderling, Vera, and van de Weijer, Tineke

Published
2024
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26. Exercise training modifies skeletal muscle clock gene expression but not 24‐hour rhythmicity in substrate metabolism of men with insulin resistance

Author

Harmsen, Jan‐Frieder, primary, Kotte, Marit, additional, Habets, Ivo, additional, Bosschee, Frederieke, additional, Frenken, Koen, additional, Jorgensen, Johanna A., additional, de Kam, Soraya, additional, Moonen‐Kornips, Esther, additional, Cissen, Jochem, additional, Doligkeit, Daniel, additional, van de Weijer, Tineke, additional, Erazo‐Tapia, Edmundo, additional, Buitinga, Mijke, additional, Hoeks, Joris, additional, and Schrauwen, Patrick, additional

Published
2023
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28. Metabolic responses to mild cold acclimation in type 2 diabetes patients

Author

Remie, Carlijn M. E., Moonen, Michiel P. B., Roumans, Kay H. M., Nascimento, Emmani B. M., Gemmink, Anne, Havekes, Bas, Schaart, Gert, Kornips, Esther, Joris, Peter J., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Kersten, Sander, Hesselink, Matthijs K. C., Phielix, Esther, Lichtenbelt, Wouter D. van Marken, and Schrauwen, Patrick

Published
2021
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30. The tissue‐specific metabolic effects of the PPARα agonist ciprofibrate in insulin‐resistant male individuals: a double‐blind, randomized, placebo‐controlled crossover study

Author

de Wit‐Verheggen, Vera H. W., primary, Vanweert, Froukje, additional, Raiko, Juho, additional, Liénard, Viktor, additional, Schaart, Gert, additional, Gemmink, Anne, additional, Nascimento, Emmani B. M., additional, Hesselink, Matthijs K. C., additional, Wildberger, Joachim E., additional, Wierts, Roel, additional, Joris, Peter J., additional, Haas, Joel, additional, Montaigne, David, additional, Staels, Bart, additional, Phielix, Esther, additional, Schrauwen, Patrick, additional, Schrauwen‐Hinderling, Vera B., additional, and van de Weijer, Tineke, additional

Published
2023
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32. Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release.

Author

Jiménez-Sánchez, Cecilia, Sinturel, Flore, Mezza, Teresa, Loizides-Mangold, Ursula, Montoya, Jonathan Paz, Li, Lingzi, Di Giuseppe, Gianfranco, Quero, Giuseppe, Guessous, Idris, Jornayvaz, François, Schrauwen, Patrick, Stenvers, Dirk Jan, Alfieri, Sergio, Giaccari, Andrea, Berishvili, Ekaterine, Compagnon, Philippe, Bosco, Domenico, Riezman, Howard, Dibner, Charna, and Maechler, Pierre

Subjects
INSULIN, BLOOD lipids, TYPE 2 diabetes, GLYCEMIC control, BIOLOGICAL extinction
Abstract

In this study, we identified new lipid species associated with the loss of pancreatic β-cells triggering diabetes. We performed lipidomics measurements on serum from prediabetic mice lacking β-cell prohibitin-2 (a model of monogenic diabetes) patients without previous history of diabetes but scheduled for pancreaticoduodenectomy resulting in the acute reduction of their β-cell mass (∼50%), and patients with type 2 diabetes (T2D). We found lysophosphatidylinositols (lysoPIs) were the main circulating lipid species altered in prediabetic mice. The changes were confirmed in the patients with acute reduction of their β-cell mass and in those with T2D. Increased lysoPIs significantly correlated with HbA1c (reflecting glycemic control), fasting glycemia, and disposition index, and did not correlate with insulin resistance or obesity in human patients with T2D. INS-1E β-cells as well as pancreatic islets isolated from nondiabetic mice and human donors exposed to exogenous lysoPIs showed potentiated glucose-stimulated and basal insulin secretion. Finally, addition of exogenous lysoPIs partially rescued impaired glucose-stimulated insulin secretion in islets from mice and humans in the diabetic state. Overall, lysoPIs appear to be lipid species upregulated in the prediabetic stage associated with the loss of β-cells and that support the secretory function of the remaining β-cells. Article Highlights: Circulating lysophosphatidylinositols (lysoPIs) are increased in situations associated with β-cell loss in mice and humans such as (pre-)diabetes, and hemipancreatectomy. Pancreatic islets isolated from nondiabetic mice and human donors, as well as INS-1E β-cells, exposed to exogenous lysoPIs exhibited potentiated glucose-stimulated and basal insulin secretion. Addition of exogenous lysoPIs partially rescued impaired glucose-stimulated insulin secretion in islets from mice and humans in the diabetic state. LysoPIs appear as lipid species being upregulated already in the prediabetic stage associated with the loss of β-cells and supporting the function of the remaining β-cells. [ABSTRACT FROM AUTHOR]

Published
2024
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33. A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial

Author

Roumans, Kay H. M., primary, Veelen, Anna, additional, Andriessen, Charlotte, additional, Mevenkamp, Julian, additional, Kornips, Esther, additional, Veeraiah, Pandichelvam, additional, Havekes, Bas, additional, Peters, Harry P. F., additional, Lindeboom, Lucas, additional, Schrauwen, Patrick, additional, and Schrauwen‐Hinderling, Vera B., additional

Published
2023
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34. Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions

Author

Basset-Sagarminaga, Jeremy, primary, Roumans, Kay H. M., additional, Havekes, Bas, additional, Mensink, Ronald P., additional, Peters, Harry P. F., additional, Zock, Peter L., additional, Mutsert, Renée de, additional, Borén, Jan, additional, Lindeboom, Lucas, additional, Schrauwen, Patrick, additional, and Schrauwen-Hinderling, Vera B., additional

Published
2023
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35. SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance

Author

Osborne, Brenna, Wright, Lauren E., Brandon, Amanda E., Stuart, Ella, Small, Lewin, Hoeks, Joris, Schrauwen, Patrick, Sinclair, David A, Montgomery, Magdalene K, Cooney, Gregory J, Turner, Nigel, Osborne, Brenna, Wright, Lauren E., Brandon, Amanda E., Stuart, Ella, Small, Lewin, Hoeks, Joris, Schrauwen, Patrick, Sinclair, David A, Montgomery, Magdalene K, Cooney, Gregory J, and Turner, Nigel

Abstract

Reduced expression of the NAD+-dependent deacetylase, SIRT3, has been associated with insulin resistance and metabolic dysfunction in humans and rodents. In this study, we investigated whether specific overexpression of SIRT3 in vivo in skeletal muscle could prevent high-fat diet (HFD)-induced muscle insulin resistance. To address this, we used a muscle-specific adeno-associated virus (AAV) to overexpress SIRT3 in rat tibialis and extensor digitorum longus (EDL) muscles. Mitochondrial substrate oxidation, substrate switching and oxidative enzyme activity were assessed in skeletal muscles with and without SIRT3 overexpression. Muscle-specific insulin action was also assessed by hyperinsulinaemic–euglycaemic clamps in rats that underwent a 4-week HFD-feeding protocol. Ex vivo functional assays revealed elevated activity of selected SIRT3-target enzymes including hexokinase, isocitrate dehydrogenase and pyruvate dehydrogenase that was associated with an increase in the ability to switch between fatty acid- and glucose-derived substrates in muscles with SIRT3 overexpression. However, during the clamp, muscles from rats fed an HFD with increased SIRT3 expression displayed equally impaired glucose uptake and insulin-stimulated glycogen synthesis as the contralateral control muscle. Intramuscular triglyceride content was similarly increased in the muscle of high-fat-fed rats, regardless of SIRT3 status. Thus, despite SIRT3 knockout (KO) mouse models indicating many beneficial metabolic roles for SIRT3, our findings show that muscle-specific overexpression of SIRT3 has only minor effects on the acute development of skeletal muscle insulin resistance in high-fat-fed rats., Reduced expression of the NAD+-dependent deacetylase, SIRT3, has been associated with insulin resistance and metabolic dysfunction in humans and rodents. In this study we investigated whether specific overexpression of SIRT3 in vivo in skeletal muscle could prevent HFD-induced muscle insulin resistance. To address this we used a muscle-specific adeno-associated virus (AAV) to overexpress SIRT3 in rat tibialis and EDL muscles. Mitochondrial substrate oxidation, substrate switching and oxidative enzyme activity were assessed in skeletal muscle with and without SIRT3 overexpression. Muscle-specific insulin action was also assessed by hyperinsulinaemic-euglycaemic clamps in rats that underwent a 4-week HFD-feeding protocol. Ex vivo functional assays revealed elevated activity of selected SIRT3-target enzymes including hexokinase, isocitrate dehydrogenase and pyruvate dehydrogenase that was associated with an increase in the ability to switch between fatty acid and glucose-derived substrates in muscle with SIRT3 overexpression. However, during the clamp, muscle from rats fed a HFD with increased SIRT3 expression displayed equally impaired glucose uptake and insulin-stimulated glycogen synthesis as the contralateral control muscle. Intramuscular triglyceride content was similarly increased in muscle of high fat fed rats, regardless of SIRT3 status. Thus, despite SIRT3 KO mouse models indicating many beneficial metabolic roles for SIRT3, our findings show that muscle-specific overexpression of SIRT3 has only minor effects on the acute development of skeletal muscle insulin resistance in high fat fed rats.

Published
2023

36. The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Author

Vanweert, Froukje, Boone, Sebastiaan C., Brouwers, Bram, Mook-Kanamori, Dennis O., de Mutsert, Renée, Rosendaal, Frits R., Lamb, Hildo J., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick, Hesselink, Matthijs K. C., and Phielix, Esther

Abstract

Aims: To evaluate whether the association between plasma branched-chain amino acids (BCAA) and intrahepatic lipid (IHL) was affected by physical activity level. Furthermore, to investigate if a conventional exercise training program, a subcategory of physical activity, could lower plasma BCAA along with alterations in IHL content in patients with type 2 diabetes (T2DM) and people with nonalcoholic fatty liver (NAFL). Methods: To investigate the effect of physical activity on the association between plasma BCAA and IHL content, linear regression analyses were performed in 1983 individuals from the Netherlands Epidemiology of Obesity (NEO) stratified by physical activity frequency. Furthermore, the effect of a 12-week supervised combined aerobic resistance-exercise program on plasma BCAA, insulin sensitivity (hyperinsulinemic–euglycemic clamp), and IHL (proton-magnetic resonance spectroscopy (1H-MRS)) was investigated in seven patients with T2DM, seven individuals with NAFL and seven BMI-matched control participants (CON). Results: We observed positive associations between plasma valine, isoleucine and leucine level, and IHL content (1.29 (95% CI: 1.21, 1.38), 1.52 (95% CI: 1.43, 1.61), and 1.54 (95% CI: 1.44, 1.64) times IHL, respectively, per standard deviation of plasma amino acid level). Similar associations were observed in less active versus more active individuals. Exercise training did not change plasma BCAA levels among groups, but reduced IHL content in NAFL (from 11.6 ± 3.0% pre-exercise to 8.1 ± 2.0% post exercise, p< 0.05) and CON (from 2.4 ± 0.6% pre-exercise to 1.6 ± 1.4% post exercise, p< 0.05), and improved peripheral insulin sensitivity in NAFL as well by ~23% (p< 0.05). Conclusions: The association between plasma BCAA levels and IHL is not affected by physical activity level. Exercise training reduced IHL without affecting plasma BCAA levels in individuals with NAFL and CON. We conclude that exercise training-induced reduction in IHL content is not related to changes in plasma BCAA levels. Trial registration: Trial registry number: NCT01317576.

Published
2024
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40. Circulating 1,5-Anhydroglucitol as a Biomarker of ß-cell Mass Independent of a Diabetes Phenotype in Human Subjects

Author

Jiménez-Sánchez, Cecilia, primary, Mezza, Teresa, additional, Sinturel, Flore, additional, Li, Lingzi, additional, Di Giuseppe, Gianfranco, additional, Quero, Giuseppe, additional, Jornayvaz, François R, additional, Guessous, Idris, additional, Dibner, Charna, additional, Schrauwen, Patrick, additional, Alfieri, Sergio, additional, Giaccari, Andrea, additional, and Maechler, Pierre, additional

Published
2022
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42. Novel insights in intestinal and hepatic fructose metabolism: from mice to men

Author

Koene, Evi, Schrauwen-Hinderling, Vera B, Schrauwen, Patrick, Brouwers, Martijn C G J, Koene, Evi, Schrauwen-Hinderling, Vera B, Schrauwen, Patrick, and Brouwers, Martijn C G J

Abstract

PURPOSE OF REVIEW: The rise in fructose consumption in parallel with the current epidemic of obesity and related cardiometabolic disease requires a better understanding of the pathophysiological pathways that are involved.RECENT FINDINGS: Animal studies have shown that fructose has various effects on the intestines that subsequently affect intrahepatic lipid accumulation and inflammation. Fructose adversely affects the gut microbiome - as a producer of endotoxins and intermediates of de novo lipogenesis - and intestinal barrier function. Furthermore, intestinal fructose metabolism shields fructose away from the liver. Finally, fructose 1-phosphate (F1-P) serves as a signal molecule that promotes intestinal cell survival and, consequently, intestinal absorption capacity. Intervention and epidemiological studies have convincingly shown that fructose, particularly derived from sugar-sweetened beverages, stimulates de novo lipogenesis and intrahepatic lipid accumulation in humans. Of interest, individuals with aldolase B deficiency, who accumulate F1-P, are characterized by a greater intrahepatic lipid content. First phase II clinical trials have recently shown that reduction of F1-P, by inhibition of ketohexokinase, reduces intrahepatic lipid content.SUMMARY: Experimental evidence supports current measures to reduce fructose intake, for example by the implementation of a tax on sugar-sweetened beverages, and pharmacological inhibition of fructose metabolism to reduce the global burden of cardiometabolic disease.

Published
2022

43. Circulating 1,5-anhydroglucitol as a biomarker of ß-cell mass independent of a diabetes phenotype in human subjects

Author

Jiménez-Sánchez, Cecilia, Mezza, Teresa, Sinturel, Flore, Li, Lingzi, Di Giuseppe, Gianfranco, Quero, Giuseppe, Jornayvaz, François R, Guessous, Idris, Dibner, Charna, Schrauwen, Patrick, Alfieri, Sergio, Giaccari, Andrea, Maechler, Pierre, Jiménez-Sánchez, Cecilia, Mezza, Teresa, Sinturel, Flore, Li, Lingzi, Di Giuseppe, Gianfranco, Quero, Giuseppe, Jornayvaz, François R, Guessous, Idris, Dibner, Charna, Schrauwen, Patrick, Alfieri, Sergio, Giaccari, Andrea, and Maechler, Pierre

Abstract

CONTEXT: During an asymptomatic pre-diabetic state, the functional ß-cell mass decreases up to a critical threshold triggering diabetes and related symptoms. To date, there are no reliable readouts able to capture in vivo a potential drop of the ß-cell mass.OBJECTIVE: Beside its use as a short-term marker of glycemic control, the deoxyhexose 1,5-anhydroglucitol was identified in rodents as a circulating biomarker of the functional ß-cell mass already in the asymptomatic prediabetic stage. The present study investigated the putative corresponding relevance of circulating 1,5-anhydroglucitol in different human cohorts.METHODS: We analyzed clinical and blood parameters in patients with established type 2 diabetes and subjects considered at high risk of developing diabetes, as well as patients with no history of diabetes scheduled for pancreaticoduodenectomy.RESULTS: Circulating 1,5-anhydroglucitol was reduced in type 2 diabetic patients, negatively correlating with fasting plasma glucose (p<0.0001) and HbA1c (p<0.0001). In healthy subjects, 1,5-AG levels positively correlated with body mass index (p=0.004) and HOMA%S (p<0.03) and was particularly high in nondiabetic obese individuals, potential accounting for compensatory ß-cell expansion. Patients with no history of diabetes undergoing pancreaticoduodenectomy exhibited a 50% reduction of circulating 1,5-anhydroglucitol levels following surgery leading to an acute loss of their ß-cell mass (p=0.002), regardless their glucose tolerance status.CONCLUSION: In summary, plasma concentration of 1,5-anhydroglucitol follows the ß-cell mass and its non-invasive monitoring may alert about the loss of ß-cells in subjects at risk for diabetes, an event that cannot be captured by other clinical parameters of glycemic control.

Published
2022

44. Erratum. Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial. Diabetes Care 2021;44:1334–1343

Author

Kamp, Yvo J.M. Op den, primary, Ligt, Marlies de, additional, Dautzenberg, Bas, additional, Kornips, Esther, additional, Esterline, Russell, additional, Hesselink, Matthijs K.C., additional, Hoeks, Joris, additional, Schrauwen-Hinderling, Vera B., additional, Havekes, Bas, additional, Oscarsson, Jan, additional, Phielix, Esther, additional, and Schrauwen, Patrick, additional

Published
2022
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47. Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids.

Author

Daemen, Sabine, van Polanen, Nynke, Bilet, Lena, Phielix, Esther, Moonen-Kornips, Esther, Schrauwen-Hinderling, Vera B., Schrauwen, Patrick, and Hesselink, Matthijs K. C.

Subjects
FREE fatty acids, ACTIVE recovery, LIPIDS, SURFACE coatings, CONFOCAL microscopy
Abstract

Intramyocellular lipid (IMCL) content is an energy source during acute exercise. Nonesterified fatty acid (NEFA) levels can compete with IMCL utilization during exercise. IMCL content is stored as lipid droplets (LDs) that vary in size, number, subcellular distribution, and in coating with LD protein PLIN5. Little is known about how these factors are affected during exercise and recovery. Here, we aimed to investigate the effects of acute exercise with and without elevated NEFA levels on intramyocellular LD size and number, intracellular distribution and PLIN5 coating, using high-resolution confocal microscopy. In a crossover study, 9 healthy lean young men performed a 2-h moderate intensity cycling protocol in the fasted (high NEFA levels) and glucose-fed state (low NEFA levels). IMCL and LD parameters were measured at baseline, directly after exercise and 4 h postexercise. We found that total IMCL content was not changed directly after exercise (irrespectively of condition), but IMCL increased 4 h postexercise in the fasting condition, which was due to an increased number of LDs rather than changes in size. The effects were predominantly detected in type I muscle fibers and in LDs coated with PLIN5. Interestingly, subsarcolemmal, but not intermyofibrillar IMCL content, was decreased directly after exercise in the fasting condition and was replenished during the 4 h recovery period. In conclusion, acute exercise affects IMCL storage during exercise and recovery, particularly in type I muscle fibers, in the subsarcolemmal region and in the presence of PLIN5. Moreover, the effects of exercise on IMCL content are affected by plasma NEFA levels. [ABSTRACT FROM AUTHOR]

Published
2021
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50. A metabolically healthy lifestyle

Author

Andriessen, Charlotte, Schrauwen, Patrick, Hoeks, Joris, Schrauwen - Hinderling, Vera, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Nutrition and Movement Sciences

Published
2023

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