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2. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial

Author

Wald, Ron, Gaudry, Stephane, da Costa, Bruno R., Adhikari, Neill K. J., Bellomo, Rinaldo, Du, Bin, Gallagher, Martin P., Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Dreyfuss, Didier, and Bagshaw, Sean M.

Published
2023
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5. Hemoadsorption

Author

Bellomo, Rinaldo, Mehta, Ravindra L., Forni, Lui G., Zarbock, Alexander, Ostermann, Marlies, Ronco, Claudio, Ankawi, Ghada, Bagshaw, Sean M., Baldwin, Ian, Basu, Rajit, Bottari, Gabriella, Cantaluppi, Vincenzo, Clark, William, De Rosa, Silvia, Forni, Lui G., Fuhrman, Dana, Gomez, Hernando, Husain-Syed, Faeq, Joannidis, Michael, Kashani, Kianoush, Lorenzin, Anna, Mehta, Ravindra, Murray, Patrick T., Murugan, Ragi, Ostermann, Marlies, Pannu, Neesh, Premuzic, Vedran, Prowle, John, Reis, Thiago, Rimmelé, Thomas, Rosner, Mitch, Schneider, Antoine, See, Emily, Soranno, Danielle, Villa, Gianluca, Whaley-Connell, Adam, and Zarbock, Alexander

Published
2024
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6. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis

Author

Vaara, Suvi T., Serpa Neto, Ary, Bellomo, Rinaldo, Adhikari, Neill K. J., Dreyfuss, Didier, Gallagher, Martin, Gaudry, Stephane, Hoste, Eric, Joannidis, Michael, Pettilä, Ville, Wang, Amanda Y., Kashani, Kianoush, Wald, Ron, Bagshaw, Sean M., Ostermann, Marlies, Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K.J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Bellomo, Rinaldo, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Gallagher, Martin P., Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Joannidis, Michael, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric A., Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Maisonneuve-Rosemont, Lafrance, Jean-Philippe, Lamontagne, François, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Langis Francoeur, Charles, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Tung Sia, Ying, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Rochwerg, Bram, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, Bagshaw, Sean M., van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Stelfox, Henry T., Ruddell, Stacey, Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Wald, Ron, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Adhikari, Neill K.J., Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Bagshaw, Sean M., Noel Gibney, R.T., Romanovsky, Adam S., Rewa, Oleksa, McCoshen, Lorena, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Du, Bin, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qiu, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Pettilä, Ville, Vaara, Suvi T., Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J, Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Dreyfuss, Didier, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Claude Lacherade, Jean, Colin, Gwenhaël, Lebert, Christine, Azais, Marie-Ange, Yehia, Aihem, Pouplet, Caroline, Henry- Lagarrigue, Matthieu, Seguin, Amélie, Crosby, Laura, Maizel, Julien, Titeca-Beauport, Dimitri, Combes, Alain, Nieszkowska, Ania, Masi, Paul, Demoule, Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Amélie Ordon, Marie, Morizot, Laura, Cantien, Marie, Pousset, François, Gaudry, Stéphane, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Christophe Callahan, Jean, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Didier Thevenin, Lens, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Mekontso Dessap, Armand, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Dang Van, Hoa, Boulet, Éric, Dubos, René, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Nichol, Alistair D., Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, McGuinness, Shay, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Schneider, Antoine G., Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Abed Mallaird, Samia, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Michelle Davies, Tracy, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Ostermann, Marlies, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Grau Novellas, Neus, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Castro Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Oliver Rose, Bernd, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Carlos Aycinena, Juan, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, and Dorfman, Robert

Published
2024
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7. Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial

Author

Wempe, Carola, Storck, Michael, Brix, Tobias, Strauss, Christian, Sadjadi, Mahan, Weiss, Raphael, Booke, Hendrik, Loomann, Lisa, Amini, Wida, Meschede, Dana, Göbel, Ulrich, Haaker, Jan Gerrit, Brenner, Thorsten, Espeter, Florian, Rahmel, Tim, Adamzik, Michael, Brandenburger, Timo, Putensen, Christian, Bode, Christian, Kruse, Philippe, Wild, Lennart, Rosenberger, Peter, Bernard, Alice, Jung-König, Mona, Larmann, Jan, Reutershan, Jörg, Arndt, Christian, Vojnar, Benjamin, Spieth, Peter M., Schneider, Antoine, Monard, Céline, Mura, Benedetta, Villa, Gianluca, Laici, Cristiana, Siniscalchi, Antonio, Capozzi, Chiara, Sita, Marco, Cattin, Lucia, de Rosa, Silvia, Spadaro, Savino, Franco, D'Arcangelo Benito, Ostermann, Marlies, Gossage, James, Verzelloni, Alessandra, Scaramuzzi, Marco, Glass, Adam, Silversides, Jon, Lonsdale, Elliot, Forni, Lui G., Haider, Syeda, Rossiter, Adam, Welters, Ingeborg, Hoste, Eric, Hollmann, Markus W., Ripollés-Melchor, Javier, Fernández-Valdes-Bango, Paula, Parise-Roux, Diego, Martin González, Maria Carmen, Bathal, Irene Romero, Jáuregui, Maider Puyada, Navarro-Perez, Rosalía, De Soto, Inés, García-Álvarez, Raquel, Sánchez, Elena Murcia, Suarez-de-la-Rica, Alejandro, Lalande, Robin, von Groote, Thilo, Danzer, Moritz Fabian, Meersch, Melanie, Zarbock, Alexander, and Gerß, Joachim

Published
2024
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10. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup

Author

Zarbock, Alexander, Nadim, Mitra K., Pickkers, Peter, Gomez, Hernando, Bell, Samira, Joannidis, Michael, Kashani, Kianoush, Koyner, Jay L., Pannu, Neesh, Meersch, Melanie, Reis, Thiago, Rimmelé, Thomas, Bagshaw, Sean M., Bellomo, Rinaldo, Cantaluppi, Vicenzo, Deep, Akash, De Rosa, Silvia, Perez-Fernandez, Xose, Husain-Syed, Faeq, Kane-Gill, Sandra L., Kelly, Yvelynne, Mehta, Ravindra L., Murray, Patrick T., Ostermann, Marlies, Prowle, John, Ricci, Zaccaria, See, Emily J., Schneider, Antoine, Soranno, Danielle E., Tolwani, Ashita, Villa, Gianluca, Ronco, Claudio, and Forni, Lui G.

Published
2023
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12. Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial

Author

Wald, Ron, Kirkham, Brian, daCosta, Bruno R, Ghamarian, Ehsan, Adhikari, Neill KJ, Beaubien-Souligny, William, Bellomo, Rinaldo, Gallagher, Martin P, Goldstein, Stuart, Hoste, Eric AJ, Liu, Kathleen D, Neyra, Javier A, Ostermann, Marlies, Palevsky, Paul M, Schneider, Antoine, Vaara, Suvi T, and Bagshaw, Sean M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Renal and urogenital, Good Health and Well Being, Humans, Acute Kidney Injury, Critical Illness, Renal Replacement Therapy, Water-Electrolyte Balance, Water-Electrolyte Imbalance, Acute kidney injury, Renal replacement therapy, Randomized controlled trial, Fluid balance, Clinical outcomes, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundAmong critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater fluid overload at randomization.MethodsWe conducted a pre-planned post hoc analysis of the STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. We evaluated the effect of accelerated RRT initiation on cumulative fluid balance over the course of 14 days following randomization using mixed models after censoring for death and ICU discharge. We assessed the modifying effect of baseline fluid balance on the impact of RRT initiation strategy on key clinical outcomes. Patients were categorized in quartiles of baseline fluid balance, and the effect of accelerated versus standard RRT initiation on clinical outcomes was assessed in each quartile using risk ratios (95% CI) for categorical variables and mean differences (95% CI) for continuous variables.ResultsAmong 2927 patients in the modified intention-to-treat analysis, 2738 had available data on baseline fluid balance and 2716 (92.8%) had at least one day of fluid balance data following randomization. Over the subsequent 14 days, participants allocated to the accelerated strategy had a lower cumulative fluid balance compared to those in the standard strategy (4509 (- 728 to 11,698) versus 5646 (0 to 13,151) mL, p = 0.03). Accelerated RRT initiation did not confer greater 90-day survival in any of the baseline fluid balance quartiles (quartile 1: RR 1.11 (95% CI 0.92 to 1.34), quartile 2: RR 1.03 (0.87 to 1.21); quartile 3: RR 1.08 (95% CI 0.91 to 1.27) and quartile 4: RR 0.87 (95% CI 0.73 to 1.03), p value for trend 0.08).ConclusionsEarlier RRT initiation in critically ill patients with AKI conferred a modest attenuation of cumulative fluid balance. Nonetheless, among patients with greater fluid accumulation at randomization, accelerated RRT initiation did not have an impact on all-cause mortality.Trial registrationClinicalTrials.gov number, https://clinicaltrials.gov/ct2/show/NCT02568722 , registered October 6, 2015.

Published
2022

17. Hemoperfusion in Burns

Author

Abraham, Paul, primary, Monard, Céline, additional, Lamblin, Antoine, additional, Schneider, Antoine, additional, and Rimmelé, Thomas, additional

Published
2023
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22. Hemoadsorption: Consensus report of the 30th Acute Disease Quality Initiative workgroup

Author

Ankawi, Ghada, primary, Bagshaw, Sean M, additional, Bellomo, Rinaldo, additional, Baldwin, Ian, additional, Basu, Rajit, additional, Bottari, Gabriella, additional, Cantaluppi, Vincenzo, additional, Clark, William, additional, De Rosa, Silvia, additional, Forni, Lui G, additional, Fuhrman, Dana, additional, Goldstein, Stuart, additional, Gomez, Hernando, additional, Husain-Syed, Faeq, additional, Joannidis, Michael, additional, Kashani, Kianoush, additional, Lorenzin, Anna, additional, Mehta, Ravindra, additional, Murray, Patrick T, additional, Murugan, Ragi, additional, Ostermann, Marlies, additional, Pannu, Neesh, additional, Premuzic, Vedran, additional, Prowle, John, additional, Reis, Thiago, additional, Rimmelé, Thomas, additional, Ronco, Claudio, additional, Rosner, Mitch, additional, Schneider, Antoine, additional, See, Emily, additional, Soranno, Danielle, additional, Villa, Gianluca, additional, Whaley-Connell, Adam, additional, and Zarbock, Alexander, additional

Published
2024
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28. Comments on: Reducing the Risks of Nuclear War—The Role of Health Professionals

Author

Lefrant, Jean-Yves, primary, Benhamou, Dan, additional, Fischer, Marc-Olivier, additional, Pirracchio, Romain, additional, Allaouchiche, Bernard, additional, Bastide, Sophie, additional, Biais, Matthieu, additional, Blet, Alice, additional, Bouvet, Lionel, additional, Brissaud, Olivier, additional, Brull, Sorin J, additional, Capdevila, Xavier, additional, Clausen, Nicola, additional, Cuvillon, Philippe, additional, Dadure, Christophe, additional, David, Jean-Stéphane, additional, Eley, Victoria, additional, Forget, Patrice, additional, Fujii, Tomoko, additional, Godier, Anne, additional, Gopalan, Dean, additional, Guinot, Pierre-Grégoire, additional, Hasanin, Ahmed, additional, Joannes-Boyau, Olivier, additional, Kerever, Sébastien, additional, Kipnis, Éric, additional, Landau, Ruth, additional, Le Guen, Morgan, additional, Legrand, Matthieu, additional, Lorne, Emmanuel, additional, Mercier, Frédéric, additional, Mongardon, Nicolas, additional, Myatra, Sheila Nainan, additional, Nicolas-Robin, Armelle, additional, Peters, Mark John, additional, Quintard, Hervé, additional, Rello, Jordi, additional, G Richebe, Philippe, additional, Roberts, Jason Alexander, additional, Sanfilippo, Filippo, additional, Schneider, Antoine, additional, T Sofonea, Mircea, additional, Treggiari, Miriam, additional, Veyckemans, Francis, additional, Von Ungern-Sternberg, Britta Regli, additional, Zeidan, Ahed, additional, Zieleskiewicz, Laurent, additional, Zielinska, Marzena, additional, Milman, Alexandre, additional, and Roquilly, Antoine, additional

Published
2023
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30. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Author

von Groote, Thilo, primary, Meersch, Melanie, additional, Romagnoli, Stefano, additional, Ostermann, Marlies, additional, Ripollés-Melchor, Javier, additional, Schneider, Antoine Guillaume, additional, Vandenberghe, Wim, additional, Monard, Céline, additional, De Rosa, Silvia, additional, Cattin, Lucia, additional, Rahmel, Tim, additional, Adamzik, Michael, additional, Parise, Diego, additional, Candela-Toha, Angel, additional, Haaker, Jan Gerrit, additional, Göbel, Ulrich, additional, Bernard, Alice, additional, Lumlertgul, Nuttha, additional, Fernández-Valdes-Bango, Paula, additional, Romero Bhathal, Irene, additional, Suarez-de-la-Rica, A, additional, Larmann, Jan, additional, Villa, Gianluca, additional, Spadaro, Savino, additional, Wulf, Hinnerk, additional, Arndt, Christian, additional, Putensen, Christian, additional, García-Álvarez, Raquel, additional, Brandenburger, Timo, additional, Siniscalchi, Antonio, additional, Ellerkmann, Richard, additional, Espeter, Florian, additional, Porschen, Christian, additional, Sadjadi, Mahan, additional, Saadat-Gilani, Khaschayar, additional, Weiss, Raphael, additional, Gerss, Joachim, additional, Kellum, John, additional, and Zarbock, Alexander, additional

Published
2023
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31. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Author

von Groote, Thilo; https://orcid.org/0000-0002-5287-1137, Meersch, Melanie; https://orcid.org/0000-0002-6011-8049, Romagnoli, Stefano, Ostermann, Marlies, Ripollés-Melchor, Javier, Schneider, Antoine Guillaume; https://orcid.org/0000-0003-0576-7094, Vandenberghe, Wim; https://orcid.org/0000-0001-5464-7940, Monard, Céline, De Rosa, Silvia; https://orcid.org/0000-0001-8987-4596, Cattin, Lucia, Rahmel, Tim, Adamzik, Michael, Parise, Diego, Candela-Toha, Angel, Haaker, Jan Gerrit, Göbel, Ulrich, Bernard, Alice, Lumlertgul, Nuttha; https://orcid.org/0000-0003-1506-4253, Fernández-Valdes-Bango, Paula, Romero Bhathal, Irene, Suarez-de-la-Rica, A, Larmann, Jan; https://orcid.org/0000-0003-3365-4572, Villa, Gianluca, Spadaro, Savino, Wulf, Hinnerk, Arndt, Christian, Putensen, Christian, García-Álvarez, Raquel, Brandenburger, Timo, Siniscalchi, Antonio, et al, BigpAK-2 Investigators, Hilty, Matthias; https://orcid.org/0000-0002-2765-881X, Spanaus, Katharina; https://orcid.org/0000-0003-1903-0122, von Groote, Thilo; https://orcid.org/0000-0002-5287-1137, Meersch, Melanie; https://orcid.org/0000-0002-6011-8049, Romagnoli, Stefano, Ostermann, Marlies, Ripollés-Melchor, Javier, Schneider, Antoine Guillaume; https://orcid.org/0000-0003-0576-7094, Vandenberghe, Wim; https://orcid.org/0000-0001-5464-7940, Monard, Céline, De Rosa, Silvia; https://orcid.org/0000-0001-8987-4596, Cattin, Lucia, Rahmel, Tim, Adamzik, Michael, Parise, Diego, Candela-Toha, Angel, Haaker, Jan Gerrit, Göbel, Ulrich, Bernard, Alice, Lumlertgul, Nuttha; https://orcid.org/0000-0003-1506-4253, Fernández-Valdes-Bango, Paula, Romero Bhathal, Irene, Suarez-de-la-Rica, A, Larmann, Jan; https://orcid.org/0000-0003-3365-4572, Villa, Gianluca, Spadaro, Savino, Wulf, Hinnerk, Arndt, Christian, Putensen, Christian, García-Álvarez, Raquel, Brandenburger, Timo, Siniscalchi, Antonio, et al, BigpAK-2 Investigators, Hilty, Matthias; https://orcid.org/0000-0002-2765-881X, and Spanaus, Katharina; https://orcid.org/0000-0003-1903-0122

Abstract

IntroductionPrevious studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation.Methods and analysisThe BigpAK-2 trial is an international, randomised, controlled, multicentre trial. The trial aims to enrol 1302 patients undergoing major surgery who are subsequently admitted to the intensive care or high dependency unit and are at high-risk for postoperative AKI as identified by urinary biomarkers (tissue inhibitor of metalloproteinases 2*insulin like growth factor binding protein 7 (TIMP-2)*IGFBP7)). Eligible patients will be randomised to receive either standard of care (control) or a KDIGO-based AKI care bundle (intervention). The primary endpoint is the incidence of moderate or severe AKI (stage 2 or 3) within 72 hours after surgery, according to the KDIGO 2012 criteria. Secondary endpoints include adherence to the KDIGO care bundle, occurrence and severity of any stage of AKI, change in biomarker values during 12 hours after initial measurement of (TIMP-2)*(IGFBP7), number of free days of mechanical ventilation and vasopressors, need for renal replacement therapy (RRT), duration of RRT, renal recovery, 30-day and 60-day mortality, intensive care unit length-of-stay and hospital length-of-stay and major adverse kidney events. An add-on study will investigate blood and urine samples from recruited patients for immunological functions and kidney damage.Ethics and disseminationThe BigpAK-2 trial was approved by the Ethics Committee of the Medical Faculty of the University of Münster and subsequently by the corresponding Ethics Committee of the participating sites. A study amendment was approved subsequently. In the UK, the trial was adopt

Published
2023

32. Role of post-transplant graft scintigraphy in kidney donation after circulatory death

Author

Belhoste, Manon, primary, Allenbach, Gilles, additional, Agius, Thomas, additional, Meier, Raphael P. H., additional, Venetz, Jean-Pierre, additional, Corpataux, Jean-Marc, additional, Schneider, Antoine, additional, Golshayan, Déla, additional, Prior, John O., additional, Déglise, Sébastien, additional, Nicod-Lalonde, Marie, additional, and Longchamp, Alban, additional

Published
2022
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37. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk

Author

Angriman, Federico, primary, Ferreyro, Bruno L., additional, Angeloni, Natalia, additional, da Costa, Bruno R., additional, Wald, Ron, additional, Bagshaw, Sean M., additional, Adhikari, Neill K.J., additional, Bellomo, Rinaldo, additional, Dreyfuss, Didier, additional, Du, Bin, additional, Gallagher, Martin P., additional, Gaudry, Stéphane, additional, Lamontagne, François, additional, Joannidis, Michael, additional, Liu, Kathleen D., additional, McAuley, Daniel F., additional, McGuinness, Shay P., additional, Nichol, Alistair D., additional, Ostermann, Marlies, additional, Palevsky, Paul M., additional, Qiu, Haibo, additional, Pettilä, Ville, additional, Schneider, Antoine G., additional, Smith, Orla M., additional, Vaara, Suvi T., additional, Weir, Matthew, additional, Eastwood, Glenn M., additional, Peck, Leah, additional, Young, Helen, additional, Kruger, Peter, additional, Laurie, Gordon, additional, Saylor, Emma, additional, Meyer, Jason, additional, Venz, Ellen, additional, Wetzig, Krista, additional, French, Craig, additional, McGain, Forbes, additional, Mulder, John, additional, Fennessy, Gerard, additional, Koottayi, Sathyajith, additional, Bates, Samantha, additional, Towns, Miriam, additional, Morgan, Rebecca, additional, Tippett, Anna, additional, Udy, Andrew, additional, Mason, Chris, additional, Licari, Elisa, additional, Gantner, Dashiell, additional, McClure, Jason, additional, Nichol, Alistair, additional, McCracken, Phoebe, additional, Board, Jasmin, additional, Martin, Emma, additional, Vallance, Shirley, additional, Young, Meredith, additional, Vladic, Chelsey, additional, McGloughlin, Steve, additional, Gattas, David, additional, Buhr, Heidi, additional, Coles, Jennifer, additional, Hutch, Debra, additional, Wun, James, additional, Cole, Louise, additional, Whitehead, Christina, additional, Lowrey, Julie, additional, Masters, Kristy, additional, Gresham, Rebecca, additional, Campbell, Victoria, additional, Gutierrez, David, additional, Brailsford, Jane, additional, Forbes, Loretta, additional, Murray, Lauren, additional, Maguire, Teena, additional, NiChonghaile, Martina, additional, Orford, Neil, additional, Bone, Allison, additional, Elderkin, Tania, additional, Salerno, Tania, additional, Chimunda, Tim, additional, Fletcher, Jason, additional, Broadfield, Emma, additional, Porwal, Sanjay, additional, Knott, Cameron, additional, Boschert, Catherine, additional, Smith, Julie, additional, Richardson, Angus, additional, Hill, Dianne, additional, Duke, Graeme, additional, Oziemski, Peter, additional, Cegarra, Santiago, additional, Chan, Peter, additional, Welsh, Deborah, additional, Hunter, Stephanie, additional, Roodenburg, Owen, additional, Dyett, John, additional, Kokotsis, Nicos, additional, Moser, Max, additional, Yang, Yang, additional, Padayachee, Laven, additional, Vetro, Joseph, additional, Gangopadhyay, Himangsu, additional, Kaufman, Melissa, additional, Ghosh, Angaj, additional, Said, Simone, additional, Patel, Alpesh, additional, Bihari, Shailesh, additional, Matheson, Elisha, additional, Jin, Xia, additional, Shrestha, Tapaswi, additional, Schwartz, Kate, additional, Cross, Rosalba, additional, Cheung, Winston, additional, Wong, Helen, additional, Kol, Mark, additional, Shah, Asim, additional, Wang, Amanda Y., additional, Endre, Zoltan, additional, Bradford, Celia, additional, Janin, Pierre, additional, Finfer, Simon, additional, Diel, Naomi, additional, Gatward, Jonathan, additional, Hammond, Naomi, additional, Delaney, Anthony, additional, Bass, Frances, additional, Yarad, Elizabeth, additional, Buscher, Hergen, additional, Reynolds, Claire, additional, Baker, Nerilee, additional, Bellmann, Romuald, additional, Peer, Andreas, additional, Hasslacher, Julia, additional, Koglberger, Paul, additional, Klein, Sebastian, additional, Zotter, Klemens, additional, Brandtner, Anna, additional, Finkenstedt, Armin, additional, Ditlbacher, Adelheid, additional, Hartig, Frank, additional, Fries, Dietmar, additional, Bachler, Mirjam, additional, Schenk, Bettina, additional, Wagner, Martin, additional, Eller, Philipp, additional, Staudinger, Thomas, additional, Tiller, Esther, additional, Schellongowski, Peter, additional, Bojic, Andja, additional, Hoste, Eric A., additional, Bracke, Stephanie, additional, Crop, Luc De, additional, Vermeiren, Daisy, additional, Thome, Fernando, additional, Chiella, Bianca, additional, Fendt, Lucia, additional, Antunes, Veronica, additional, D'Aragon, Frédérick, additional, St-Arnaud, Charles, additional, Mayette, Michael, additional, Carbonnaeu, Élaine, additional, Marchand, Joannie, additional, Masse, Marie-Hélène, additional, Ladouceur, Marilène, additional, Turgeon, Alexis F., additional, Lauzier, François, additional, Bellemare, David, additional, Francoeur, Charles Langis, additional, LeBlanc, Guillaume, additional, Guilbault, Gabrielle, additional, Grenier, Stéphanie, additional, Cloutier, Eve, additional, Boivin, Annick, additional, Delisle-Thibault, Charles, additional, Giannakouros, Panagiota, additional, Costerousse, Olivier, additional, Cailhier, Jean-François, additional, Carrier, François-Martin, additional, Ghamraoui, Ali, additional, Lebrasseur, Martine, additional, Benettaib, Fatna, additional, Salamé, Maya, additional, Boumahni, Dounia, additional, Sia, Ying Tung, additional, Naud, Jean-François, additional, Roy, Isabelle, additional, Stelfox, Henry T., additional, Ruddell, Stacey, additional, Manns, Braden J., additional, Duggan, Shelley, additional, Carney, Dominic, additional, Barchard, Jennifer, additional, Whitlock, Richard P., additional, Belley-Cote, Emilie, additional, Savija, Nevena, additional, Sabev, Alexandra, additional, Campbell, Troy, additional, Creary, Thais, additional, Devereaux, Kelson, additional, Brodutch, Shira, additional, Rigatto, Claudio, additional, Paunovic, Bojan, additional, Mooney, Owen, additional, Glybina, Anna, additional, Harasemiw, Oksana, additional, Di Nella, Michelle, additional, Harmon, John, additional, Mehta, Navdeep, additional, Lakatos, Louis, additional, Haslam, Nicole, additional, Lellouche, Francois, additional, Simon, Mathieu, additional, Tung, Ying, additional, Lizotte, Patricia, additional, Bourchard, Pierre-Alexandre, additional, Rochwerg, Bram, additional, Karachi, Tim, additional, Millen, Tina, additional, Muscedere, John, additional, Maslove, David, additional, Boyd, J. Gordon, additional, Sibley, Stephanie, additional, Drover, John, additional, Hunt, Miranda, additional, Georgescu, Ilinca, additional, Wax, Randy, additional, Lenga, Ilan, additional, Sridhar, Kavita, additional, Steele, Andrew, additional, Fusco, Kelly, additional, Ghate, Taneera, additional, Tolibas, Michael, additional, Robinson, Holly, additional, Weir, Matthew A., additional, Taneja, Ravi, additional, Ball, Ian M., additional, Garg, Amit, additional, Campbell, Eileen, additional, Ovsenek, Athena, additional, Diepen, Sean van, additional, Baig, Nadia, additional, Magder, Sheldon, additional, Yao, Han, additional, Alam, Ahsan, additional, Campisi, Josie, additional, MacIntyre, Erika, additional, Rokosh, Ella, additional, Scherr, Kimberly, additional, Lapinsky, Stephen, additional, Mehta, Sangeeta, additional, Shah, Sumesh, additional, Niven, Daniel J., additional, Russell, Michael, additional, Jim, Kym, additional, Brown, Gillian, additional, Oxtoby, Kerry, additional, Hall, Adam, additional, Benoit, Luc, additional, Sokolowski, Colleen, additional, Prasad, Bhanu, additional, Rao, Jag, additional, Giebel, Shelley, additional, Kutsogiannis, Demetrios J., additional, Thompson, Patricia, additional, Thompson, Tayne, additional, Cirone, Robert, additional, Kavikondala, Kanthi, additional, Soth, Mark, additional, Clarke, France, additional, Takaoka, Alyson, additional, Mazer, David, additional, Burns, Karen, additional, Friedrich, Jan, additional, Klein, David, additional, Sandhu, Gyan, additional, Santos, Marlene, additional, Khalid, Imrana, additional, Hodder, Jennifer, additional, Dodek, Peter, additional, Ayas, Najib, additional, Alcuaz, Victoria, additional, Suen, Gabriel, additional, Rewa, Oleksa, additional, Singh, Gurmeet, additional, Norris, Sean, additional, Gibson, Neil, additional, Arias, Castro, additional, Shami, Aysha, additional, Pelletier, Celine, additional, Zahirieh, Alireza, additional, Amaral, Andre, additional, Marinoff, Nicole, additional, Kaur, Navjot, additional, Perez, Adic, additional, Wang, Jane, additional, Haljan, Gregory, additional, Condin, Christopher, additional, McIntyre, Lauralyn, additional, Gomes, Brigette, additional, Porteous, Rebecca, additional, Watpool, Irene, additional, Hiremath, Swapnil, additional, Clark, Edward, additional, Herridge, Margaret S., additional, Backhouse, Felicity, additional, Wilcox, M. Elizabeth, additional, Walczak, Karolina, additional, Ki, Vincent, additional, Sharman, Asheer, additional, Romano, Martin, additional, Gibney, R.T. Noel, additional, Romanovsky, Adam S., additional, McCoshen, Lorena, additional, Wood, Gordon, additional, Ovakim, Daniel, additional, Auld, Fiona, additional, Carney, Gayle, additional, Duan, Meili, additional, Ji, Xiaojun, additional, Guo, Dongchen, additional, Qi, Zhili, additional, Lin, Jin, additional, Zhang, Meng, additional, Dong, Lei, additional, Liu, Jingfeng, additional, Liu, Pei, additional, Zhi, Deyuan, additional, Bai, Guoqiang, additional, Qiu, Yu, additional, Yang, Ziqi, additional, Bai, Jing, additional, Liu, Zhuang, additional, Zhuang, Haizhou, additional, Wang, Haiman, additional, Li, Jian, additional, Zhao, Mengya, additional, Zhou, Xiao, additional, Shi, Xianqing, additional, Ye, Baning, additional, Liu, Manli, additional, Wu, Jing, additional, Fu, Yongjian, additional, Long, Dali, additional, Pan, Yu, additional, Wang, Jinlong, additional, Mei, Huaxian, additional, Zhang, Songsong, additional, Wen, Mingxiang, additional, Yang, Enyu, additional, Mu, Sijie, additional, Li, Jianquan, additional, Hu, Tingting, additional, Qin, Bingyu, additional, Li, Min, additional, Wang, Cunzhen, additional, Dong, Xin, additional, Wang, Kaiwu, additional, Wang, Haibo, additional, Yang, Jianxu, additional, Wang, Chuanyao, additional, Wang, Dongxin, additional, Li, Nan, additional, Yu, Zhui, additional, Xu, Song, additional, Yao, Lan, additional, Hou, Guo, additional, Liu, Zhou, additional, Lu, Liping, additional, Lian, Yingtao, additional, Wang, Chunting, additional, Zhang, Jichen, additional, Ding, Ruiqi, additional, Qi, Guoqing, additional, Wang, Qizhi, additional, Wang, Peng, additional, Meng, Zhaoli, additional, Chen, Man, additional, Hu, Xiaobo, additional, He, Xiandi, additional, Zhao, Shibing, additional, Hang, Lele, additional, Li, Rui, additional, Qin, Suhui, additional, Lu, Kun, additional, Dun, Shijuan, additional, Liu, Cheng, additional, Zhou, Qi, additional, Chen, Zhenzhen, additional, Mei, Jing, additional, Zhang, Minwei, additional, Xu, Hao, additional, Lin, Jincan, additional, Shi, Qindong, additional, Fu, Lijuan, additional, Zeng, Qinjing, additional, Ma, Hongye, additional, Yan, Jinqi, additional, Gao, Lan, additional, Liu, Hongjuan, additional, Zhang, Lei, additional, Li, Hao, additional, He, Xiaona, additional, Fan, Jingqun, additional, Guo, Litao, additional, Liu, Yu, additional, Wang, Xue, additional, Sun, Jingjing, additional, Liu, Zhongmin, additional, Yang, Juan, additional, Ding, Lili, additional, Sheng, Lulu, additional, Liu, Xingang, additional, Yan, Jie, additional, Wang, Quihui, additional, Wang, Yifeng, additional, Zhao, Dan, additional, Zhao, Shuangping, additional, Hu, Chenghuan, additional, Li, Jing, additional, Deng, Fuxing, additional, Qui, Haibo, additional, Yang, Yi, additional, Mo, Min, additional, Pan, Chun, additional, Wu, Changde, additional, Huang, Yingzi, additional, Huang, Lili, additional, Liu, Airan, additional, Korhonen, Anna-Maija, additional, Törnblom, Sanna, additional, Sutinen, Sari, additional, Pettilä, Leena, additional, Heinonen, Jonna, additional, Lappi, Eliria, additional, Suhonen, Taria, additional, Karlsson, Sari, additional, Hoppu, Sanna, additional, Jalkanen, Ville, additional, Kuitunen, Anne, additional, Levoranta, Markus, additional, Långsjö, Jaakko, additional, Ristimäki, Sanna, additional, Malila, Kaisa, additional, Wootten, Anna, additional, Varila, Simo, additional, Järvisalo, Mikko J, additional, Inkinen, Outi, additional, Kentala, Satu, additional, Leivo, Keijo, additional, Haltia, Paivi, additional, Ricard, Jean-Damien, additional, Messika, Jonathan, additional, Tiagarajah, Abirami, additional, Emery, Malo, additional, Dechanet, Aline, additional, Gernez, Coralie, additional, Roux, Damien, additional, Martin-Lefevre, Laurent, additional, Fiancette, Maud, additional, Vinatier, Isabelle, additional, Claude Lacherade, Jean, additional, Colin, Gwenhaël, additional, Lebert, Christine, additional, Azais, Marie-Ange, additional, Yehia, Aihem, additional, Pouplet, Caroline, additional, Henry- Lagarrigue, Matthieu, additional, Seguin, Amélie, additional, Crosby, Laura, additional, Maizel, Julien, additional, Titeca-Beauport, Dimitri, additional, Combes, Alain, additional, Nieszkowska, Ania, additional, Masi, Paul, additional, Demoule, Alexandre, additional, Mayaux, Julien, additional, Dres, Martin, additional, Morawiec, Elise, additional, Decalvele, Maxens, additional, Demiri, Suela, additional, Faure, Morgane, additional, Marios, Clémence, additional, Mallet, Maxime, additional, Ordon, Marie Amélie, additional, Morizot, Laura, additional, Cantien, Marie, additional, Pousset, François, additional, Poirson, Florent, additional, Cohen, Yves, additional, Argaud, Laurent, additional, Cour, Martin, additional, Bitker, Laurent, additional, Simon, Marie, additional, Hernu, Romain, additional, Baudry, Thomas, additional, De La Salle, Sylvie, additional, Robine, Adrien, additional, Sedillot, Nicholas, additional, Tchenio, Xavier, additional, Bouisse, Camille, additional, Roux, Sylvie, additional, Tamion, Fabienne, additional, Grangé, Steven, additional, Carpentier, Dorothée, additional, Chevrel, Guillaume, additional, Ensenyat-Martin, Luis, additional, Marque, Sophie, additional, Quenot, Jean-Pierre, additional, Andreu, Pascal, additional, Dargent, Auguste, additional, Large, Audrey, additional, Chudeau, Nicolas, additional, Landais, Mickael, additional, Derrien, Benoit, additional, Callahan, Jean Christophe, additional, Guitton, Christophe, additional, Le Moal, Charlène, additional, Robert, Alain, additional, Asehnoune, Karim, additional, Cinotti, Raphaël, additional, Grillot, Nicolas, additional, Demeure, Dominique, additional, Vinsonneau, Christophe, additional, Rahmani, Imen, additional, Marzouk, Mehdi, additional, Dekeyser, Thibault, additional, Sejourne, Caroline, additional, Verlay, Mélanie, additional, Thevenin, Fabienne, additional, Delecolle, Lucie, additional, Thevenin, Didier, additional, Souweine, Bertrand, additional, Coupez, Elisabeth, additional, Adda, Mireille, additional, Eraldi, Jean-Pierre, additional, Marchalot, Antoine, additional, Prost, Nicolas De, additional, Dessap, Armand Mekontso, additional, Razazi, Keyvan, additional, Meziani, Ferhat, additional, Boisrame-Helms, Julie, additional, Clere-Jehl, Raphael, additional, Delabranche, Xavier, additional, Kummerlen, Christine, additional, Merdji, Hamid, additional, Monnier, Alexandra, additional, Rabouel, Yannick, additional, Rahmani, Hassene, additional, Allam, Hayat, additional, Chenaf, Samir, additional, Franja, Vincenta, additional, Pons, Bertrand, additional, Carles, Michel, additional, Martino, Frédéric, additional, Richard, Régine, additional, Zuber, Benjamin, additional, Lacave, Guillaume, additional, Lakhal, Karim, additional, Rozec, Bertrand, additional, Van, Hoa Dang, additional, Boulet, Éric, additional, Fadel, Fouad, additional, Cleophax, Cedric, additional, Dufour, Nicolas, additional, Grant, Caroline, additional, Thuong, Marie, additional, Reignier, Jean, additional, Canet, Emmanuel, additional, Nicolet, Laurent, additional, Boulain, Thierry, additional, Nay, Mai-Anh, additional, Benzekri, Dalila, additional, Barbier, François, additional, Bretagnol, Anne, additional, Kamel, Toufik, additional, Mathonnet, Armelle, additional, Muller, Grégoire, additional, Skarzynski, Marie, additional, Rossi, Julie, additional, Pradet, Amandine, additional, Santos, Sandra Dos, additional, Guery, Aurore, additional, Muller, Lucie, additional, Felix, Luis, additional, Bohé, Julien, additional, Thiéry, Guillaume, additional, Aissaoui, Nadia, additional, Vimpere, Damien, additional, Commeureuc, Morgane, additional, Diehl, Jean-Luc, additional, Guerot, Emmanuel, additional, Liangos, Orfeas, additional, Wittig, Monika, additional, Zarbock, Alexander, additional, Küllmar, Mira, additional, van Waegeningh, Thomas, additional, Rosenow, Nadine, additional, Brickell, Kathy, additional, Doran, Peter, additional, Murray, Patrick T., additional, Landoni, Giovanni, additional, Lembo, Rosalba, additional, Zangrillo, Alberto, additional, Monti, Giacomo, additional, Tozzi, Margherita, additional, Marzaroli, Matteo, additional, Lombardi, Gaetano, additional, Paternoster, Gianluca, additional, Vitiello, Michelangelo, additional, McGuinness, Shay, additional, Parke, Rachael, additional, Butler, Magdalena, additional, Gilder, Eileen, additional, Cowdrey, Keri-Anne, additional, Wallace, Samantha, additional, Hallion, Jane, additional, Woolett, Melissa, additional, Neal, Philippa, additional, Duffy, Karina, additional, Long, Stephanie, additional, McArthur, Colin, additional, Simmonds, Catherine, additional, Chen, Yan, additional, McConnochie, Rachael, additional, Newby, Lynette, additional, Knight, David, additional, Henderson, Seton, additional, Mehrtens, Jan, additional, Morgan, Stacey, additional, Morris, Anna, additional, Hayden, Kymbalee Vander, additional, Burke, Tara, additional, Bailey, Matthew, additional, Freebairn, Ross, additional, Chadwick, Lesley, additional, Park, Penelope, additional, Rolls, Christine, additional, Thomas, Liz, additional, Buehner, Ulrike, additional, Williams, Erin, additional, Albrett, Jonathan, additional, Kirkham, Simon, additional, Jackson, Carolyn, additional, Browne, Troy, additional, Goodson, Jennifer, additional, Jackson, David, additional, Houghton, James, additional, Callender, Owen, additional, Higson, Vicki, additional, Keet, Owen, additional, Dominy, Clive, additional, Young, Paul, additional, Hunt, Anna, additional, Judd, Harriet, additional, Lawrence, Cassie, additional, Olatunji, Shaanti, additional, Robertson, Yvonne, additional, Latimer-Bell, Charlotte, additional, Hendry, Deborah, additional, Mckay-Vucago, Agnes, additional, Beehre, Nina, additional, Lesona, Eden, additional, Navarra, Leanlove, additional, Robinson, Chelsea, additional, Jang, Ryan, additional, Junge, Andrea, additional, Lambert, Bridget, additional, Thibault, Michel, additional, Eckert, Philippe, additional, Kissling, Sébastien, additional, Polychronopoulos, Erietta, additional, Poli, Elettra, additional, Altarelli, Marco, additional, Schnorf, Madeleine, additional, Mallaird, Samia Abed, additional, Heidegger, Claudia, additional, Perret, Aurelie, additional, Montillier, Philippe, additional, Sangla, Frederic, additional, Neils, Seigenthaller, additional, Watteville, Aude De, additional, Phull, Mandeep-Kaur, additional, George, Aparna, additional, Hussain, Nauman, additional, Pogreban, Tatiana, additional, Lobaz, Steve, additional, Daniels, Alison, additional, Cunningham, Mishell, additional, Kerr, Deborah, additional, Nicholson, Alice, additional, Shanmugasundaram, Pradeep, additional, Abrams, Judith, additional, Manso, Katarina, additional, Hambrook, Geraldine, additional, McKerrow, Elizabeth, additional, Salva, Juvy, additional, Foulkes, Stephen, additional, Wise, Matthew, additional, Morgan, Matt, additional, Brooks, Jenny, additional, Cole, Jade, additional, Davies, Tracy Michelle, additional, Hill, Helen, additional, Thomas, Emma, additional, Vizcaychipi, Marcela, additional, Baharlo, Behrad, additional, Carungcong, Jaime, additional, Costa, Patricia, additional, Martins, Laura, additional, Kapoor, Ritoo, additional, Hazelton, Tracy, additional, Moon, Angela, additional, Musselwhite, Janine, additional, Shelley, Ben, additional, McCall, Philip, additional, Arbane, Gill, additional, Bociek, Aneta, additional, Marotti, Martina, additional, Lim, Rosario, additional, Campos, Sara, additional, Novellas, Neus Grau, additional, Cennamo, Armando, additional, Slack, Andrew, additional, Wyncoll, Duncan, additional, Camporota, Luigi, additional, Sparkes, Simon, additional, Tilley, Rosalinde, additional, Rattray, Austin, additional, Moreland, Gayle, additional, Duffy, Jane, additional, McGonigal, Elizabeth, additional, Hopkins, Philip, additional, Finney, Clare, additional, Smith, John, additional, Noble, Harriet, additional, Watson, Hayley, additional, Harris, Claire-Louise, additional, Clarey, Emma, additional, Corcoran, Eleanor, additional, Beck, James, additional, Howcroft, Clare, additional, Youngs, Nora, additional, Wilby, Elizabeth, additional, Ogg, Bethan, additional, Wolverson, Adam, additional, Lee, Sandra, additional, Butler, Susie, additional, Okubanjo, Maryanne, additional, Hindle, Julia, additional, Welters, Ingeborg, additional, Williams, Karen, additional, Johnson, Emily, additional, Patrick-Heselton, Julie, additional, Shaw, David, additional, Waugh, Victoria, additional, Stewart, Richard, additional, Mwaura, Esther, additional, Wren, Lynn, additional, Mew, Louise, additional, Sutherland, Sara-Beth, additional, Adderley, Jane, additional, Ruddy, Jim, additional, Harkins, Margaret, additional, Kaye, Callum, additional, Scott, Teresa, additional, Mitchell, Wendy, additional, Anderson, Felicity, additional, Willox, Fiona, additional, Jagannathan, Vijay, additional, Clark, Michele, additional, Purv, Sarah, additional, Sharman, Andrew, additional, Meredith, Megan, additional, Ryan, Lucy, additional, Conner, Louise, additional, Peters, Cecilia, additional, Harvey, Dan, additional, Roshdy, Ashraf, additional, Collins, Amy, additional, Sim, Malcolm, additional, Henderson, Steven, additional, Chee, Nigel, additional, Pitts, Sally, additional, Bowman, Katie, additional, Dilawershah, Maria, additional, Vamplew, Luke, additional, Howe, Elizabeth, additional, Rogers, Paula, additional, Hernandez, Clara, additional, Prendergast, Clara, additional, Benton, Jane, additional, Rosenberg, Alex, additional, Forni, Lui G., additional, Grant, Alice, additional, Carvelli, Paula, additional, Raithatha, Ajay, additional, Bird, Sarah, additional, Richardson, Max, additional, Needham, Matthew, additional, Hirst, Claire, additional, Ball, Jonathan, additional, Leaver, Susannah, additional, Howlett, Luisa, additional, Delgado, Carlos Castro, additional, Farnell-Ward, Sarah, additional, Farrah, Helen, additional, Gray, Geraldine, additional, Joseph, Gipsy, additional, Robinson, Francesca, additional, Tridente, Ascanio, additional, Harrop, Clare, additional, Shuker, Karen, additional, McLaughlan, Derek, additional, Ramsey, Judith, additional, Meehan, Sharon, additional, Rose, Bernd Oliver, additional, Reece-Anthony, Rosie, additional, Gurung, Babita, additional, Whitehouse, Tony, additional, Snelson, Catherine, additional, Veenith, Tonny, additional, Johnston, Andy, additional, Cooper, Lauren, additional, Carrera, Ron, additional, Ellis, Karen, additional, Fellows, Emma, additional, Harkett, Samanth, additional, Bergin, Colin, additional, Spruce, Elaine, additional, Despy, Liesl, additional, Goundry, Stephanie, additional, Dooley, Natalie, additional, Mason, Tracy, additional, Clark, Amy, additional, Dignam, Gemma, additional, Ward, Geraldine, additional, Attwood, Ben, additional, Parsons, Penny, additional, Mason, Sophie, additional, Margarson, Michael, additional, Lord, Jenny, additional, McGlone, Philip, additional, Hodgson, Luke E., additional, Chadbourn, Indra, additional, Gomez, Raquel, additional, Margalef, Jordi, additional, Pretorius, Rinus, additional, Hamshere, Alexandra, additional, Carter, Joseph, additional, Cahill, Hazel, additional, Grainger, Lia, additional, Howard, Kate, additional, Forshaw, Greg, additional, Guy, Zoe, additional, Kashani, Kianoush B., additional, Albright, Robert C., additional, Amsbaugh, Amy, additional, Stoltenberg, Anita, additional, Niven, Alexander S., additional, Lynch, Matthew, additional, O'Mara, AnnMarie, additional, Naeem, Syed, additional, Sharif, Sairah, additional, Goulart, Joyce McKenney, additional, Tolwani, Ashita, additional, Lyas, Claretha, additional, Latta, Laura, additional, Bihorac, Azra, additional, Hashemighouchani, Haleh, additional, Efron, Philip, additional, Ruppert, Matthew, additional, Cupka, Julie, additional, Kiley, Sean, additional, Carson, Joshua, additional, White, Peggy, additional, Omalay, George, additional, Brown, Sherry, additional, Velez, Laura, additional, Marceron, Alina, additional, Neyra, Javier A., additional, Aycinena, Juan Carlos, additional, Elias, Madona, additional, Ortiz-Soriano, Victor M., additional, Hauschild, Caroline, additional, and Dorfman, Robert, additional

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2022
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38. Sarcopenia assessed via computed tomography is associated with short-term outcomes and improves prognostic scores’ performance in critically ill patients with acute on chronic liver failure

Author

Del Rio, Thomas Mangana, primary, Becce, Fabio, additional, Vionnet, Julien, additional, Denys, Alban, additional, Schneider, Antoine, additional, Wetzel, Alexandre, additional, Moradpour, Darius, additional, Chiche, Jean-Daniel, additional, and Artru, Florent, additional

Published
2022
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41. Peace, not war in Ukraine or anywhere else, please

Author

Lefrant, Jean-Yves, primary, Pirracchio, Romain, additional, Benhamou, Dan, additional, Fischer, Marc-Olivier, additional, Njeim, Rosanna, additional, Allaouchiche, Bernard, additional, Bastide, Sophie, additional, Biais, Matthieu, additional, Bouvet, Lionel, additional, Brissaud, Olivier, additional, Brull, Sorin J., additional, Capdevila, Xavier, additional, Clausen, Nicola, additional, Cuvillon, Philippe, additional, Dadure, Christophe, additional, David, Jean-Stéphane, additional, Du, Bin, additional, Einav, Sharon, additional, Eley, Victoria, additional, Forget, Patrice, additional, Fujii, Tomoko, additional, Godier, Anne, additional, Gopalan, Dean P., additional, Hamada, Sophie, additional, Hasanin, Ahmed, additional, Joannes-boyau, Olivier, additional, Kerever, Sébastien, additional, Kipnis, Éric, additional, Kolodzie, Kerstin, additional, Landau, Ruth, additional, Le Gall, Arthur, additional, Le Guen, Morgan, additional, Legrand, Matthieu, additional, Lorne, Emmanuel, additional, Mercier, Frédéric J., additional, Mongardon, Nicolas, additional, Myatra, Sheila, additional, Nicolas-Robin, Armelle, additional, John Peters, Mark, additional, Quintard, Hervé, additional, Rello, Jordi, additional, Richebé, Philippe, additional, Roberts, Jason Alexander, additional, Rocquilly, Antoine, additional, Sanfilippo, Filippo, additional, Schneider, Antoine, additional, Sofonea, Mircea T., additional, Veyckemans, Francis, additional, Zetlaoui, Paul, additional, Zeidan, Ahed, additional, Zieleskiewicz, Laurent, additional, Zielinska, Marzena, additional, Von Ungern-Sternberg, Britta, additional, Abou Arab, Osama, additional, Blet, Alice, additional, Bounes, Fanny, additional, Boisson, Matthieu, additional, Caillard, Anaïs, additional, Carillion, Aude, additional, Clavier, Thomas, additional, Frasca, Denis, additional, James, Arthur, additional, Sigaut, Stéphanie, additional, Rozencwajg, Sacha, additional, Albaladejo, Pierre, additional, and Bouaziz, Hervé, additional

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2022
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42. Early sedation in traumatic brain injury:a multicentre international observational study

Author

Russo, Giovanni, Harrois, Anatole, Anstey, James, Van Der Jagt, Mathieu, Taccone, Fabio, Udy, Andrew, Citerio, Giuseppe, Duranteau, Jacques, Ichai, Carole, Badenes, Rafael, Prowle, John, Ercole, Ari, Oddo, Mauro, Schneider, Antoine, Wolf, Stefan, Helbok, Raimund, Nelson, David, Cooper, Jamie, Russo, Giovanni, Harrois, Anatole, Anstey, James, Van Der Jagt, Mathieu, Taccone, Fabio, Udy, Andrew, Citerio, Giuseppe, Duranteau, Jacques, Ichai, Carole, Badenes, Rafael, Prowle, John, Ercole, Ari, Oddo, Mauro, Schneider, Antoine, Wolf, Stefan, Helbok, Raimund, Nelson, David, and Cooper, Jamie

Abstract

Objectives: We aimed to investigate the use of sedation in patients with severe traumatic brain injury (TBI), focusing on the choice of sedative agent, dose, duration, and their association with clinical outcomes. Design: Multinational, multicentre, retrospective observational study. Settings: 14 trauma centres in Europe, Australi a and the United Kingdom. Participants: A total of 262 adult patients with severe TBI and intracranial pressure monitoring. Main outcome measures: We described how sedative agents were used in this population. The primary outcome was 60-day mortality according to the use of different sedative agents. Secondary outcomes included intensive care unit and hospital length of stay, and the Extended Glasgow Outcome Scale at hospital discharge. Results: Propofol and midazolam were the most commonly used sedatives. Propofol was more common than midazolam as first line therapy (35.4% v 25.6% respectively). Patients treated with propofol had similar Acute Physiology and Chronic Health Evaluation (APACHE) II and International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) scores to patients treated with midazolam, but lower Injury Severity Score (ISS) (median, 26 [IQR, 22–38] v 34 [IQR, 26–44]; P = 0.001). The use of propofol was more common in heavier patients, and midazolam use was strongly associated with opioid co-administration (OR, 12.9; 95% CI, 3.47–47.95; P < 0.001). Sixty-day mortality and hospital mortality were predicted by a higher IMPACT score (P < 0.001) and a higher ISS (P < 0.001), but, after adjustment, were not related to the choice of sedative agent. Conclusions: Propofol was used more often than midazolam, and large doses were common for both sedatives. The first choice was highly variable, was affected by injury severity, and was not independently associated with 60-day mortality.

Published
2022

43. Early sedation in traumatic brain injury: a multicentre international observational study

Author

Russo, G, Harrois, A, Anstey, J, Van Der Jagt, M, Taccone, F, Udy, A, Citerio, G, Duranteau, J, Chai, C, Badenes, R, Prowle, J, Ercole, A, Oddo, M, Schneider, A, Wolf, S, Helbok, R, Nelson, D, Cooper, J, Russo, Giovanni, Harrois, Anatole, Anstey, James, Van Der Jagt, Mathieu, Taccone, Fabio, Udy, Andrew, Citerio, Giuseppe, Duranteau, Jacques, chai, Carole I, Badenes, Rafael, Prowle, John, Ercole, Ari, Oddo, Mauro, Schneider, Antoine, Wolf, Stefan, Helbok, Raimund, Nelson, David, Cooper, Jamie, Russo, G, Harrois, A, Anstey, J, Van Der Jagt, M, Taccone, F, Udy, A, Citerio, G, Duranteau, J, Chai, C, Badenes, R, Prowle, J, Ercole, A, Oddo, M, Schneider, A, Wolf, S, Helbok, R, Nelson, D, Cooper, J, Russo, Giovanni, Harrois, Anatole, Anstey, James, Van Der Jagt, Mathieu, Taccone, Fabio, Udy, Andrew, Citerio, Giuseppe, Duranteau, Jacques, chai, Carole I, Badenes, Rafael, Prowle, John, Ercole, Ari, Oddo, Mauro, Schneider, Antoine, Wolf, Stefan, Helbok, Raimund, Nelson, David, and Cooper, Jamie

Abstract

Objectives: We aimed to investigate the use of sedation in patients with severe traumatic brain injury (TBI), focusing on the choice of sedative agent, dose, duration, and their association with clinical outcomes. Design: Multinational, multicentre, retrospective observational study. Settings: 14 trauma centres in Europe, Australi a and the United Kingdom. Participants: A total of 262 adult patients with severe TBI and intracranial pressure monitoring. Main outcome measures: We described how sedative agents were used in this population. The primary outcome was 60-day mortality according to the use of different sedative agents. Secondary outcomes included intensive care unit and hospital length of stay, and the Extended Glasgow Outcome Scale at hospital discharge. Results: Propofol and midazolam were the most commonly used sedatives. Propofol was more common than midazolam as first line therapy (35.4% v 25.6% respectively). Patients treated with propofol had similar Acute Physiology and Chronic Health Evaluation (APACHE) II and International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) scores to patients treated with midazolam, but lower Injury Severity Score (ISS) (median, 26 [IQR, 22–38] v 34 [IQR, 26–44]; P = 0.001). The use of propofol was more common in heavier patients, and midazolam use was strongly associated with opioid co-administration (OR, 12.9; 95% CI, 3.47–47.95; P < 0.001). Sixty-day mortality and hospital mortality were predicted by a higher IMPACT score (P < 0.001) and a higher ISS (P < 0.001), but, after adjustment, were not related to the choice of sedative agent. Conclusions: Propofol was used more often than midazolam, and large doses were common for both sedatives. The first choice was highly variable, was affected by injury severity, and was not independently associated with 60-day mortality.

Published
2022

47. Additional file 1 of Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study

Author

Boffi, Andrea, Ravenel, Maximilien, Lupieri, Ermes, Schneider, Antoine, Liaudet, Lucas, Gonzalez, Michel, Chiche, Jean-Daniel, and Piquilloud, Lise

Abstract

Additional file 1: Table S1. Physiological, ventilatory and hemodynamic data for all the sessions considered together (n=191) and for the first (n=42), the second (n=37), the third (n=31), the fourth (n=18) and the fifth (n=14) proning sessions). Table S2. Variations in physiological and ventilatory parameters during the fourth (n=18), the fifth (n=14) proning sessions. Comparisons between the success and failure group.

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2022
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48. Additional file 1 of Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial

Author

Wald, Ron, Kirkham, Brian, daCosta, Bruno R., Ghamarian, Ehsan, Adhikari, Neill K. J., Beaubien-Souligny, William, Bellomo, Rinaldo, Gallagher, Martin P., Goldstein, Stuart, Hoste, Eric A. J., Liu, Kathleen D., Neyra, Javier A., Ostermann, Marlies, Palevsky, Paul M., Schneider, Antoine, Vaara, Suvi T., and Bagshaw, Sean M.

Abstract

Additional file 1. Table S1: Median fluid accumulation through Day 14, in the modified intention to treat population, stratified by subgroups. Table S2: The effect of accelerated vs standard RRT strategy on outcomes across deciles of baseline fluid balance. Table S3: The effect of accelerated vs standard RRT strategy on outcomes in patients with ≤ or > 10% fluid overload at baseline.

Published
2022
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49. A Bayesian reanalysis of the standard versus accelerated initiation of renal-replacement therapy in acute kidney injury (STARRT-AKI) trial

Author

Zampieri, Fernando G., da Costa, Bruno R., Vaara, Suvi T., Lamontagne, François, Rochwerg, Bram, Nichol, Alistair D., McGuinness, Shay, McAuley, Danny F., Ostermann, Marlies, Wald, Ron, Bagshaw, Sean M., Adhikari, Neill K. J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi, Weir, Matthew, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Eller, Philipp, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric, Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Lafrance, Jean-Philippe, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Francoeur, Charles Langis, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Sia, Ying Tung, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Noel Gibney, R. T., Romanovsky, Adam S., McCoshen, Lorena, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qui, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J., Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, 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Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Mallaird, Samia Abed, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, 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Subjects
Kidney-replacement therapy, Critical Illness, Acute Kidney Injury/therapy, Randomized, Bayes Theorem, Acute Kidney Injury, Critical Care and Intensive Care Medicine, Bayesian, Trial, Acute kidney injury, Renal Replacement Therapy, Renal Replacement Therapy/methods, Critical Illness/therapy, Medicine and Health Sciences, Humans, Mortality, Dialysis, Probability
Abstract

Background Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework. Methods We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression. Results The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66. Conclusions In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation.

Published
2022

50. Comments on: Reducing the Risks of Nuclear War—The Role of Health Professionals

Author

Lefrant, Jean-Yves, Benhamou, Dan, Fischer, Marc-Olivier, Pirracchio, Romain, Allaouchiche, Bernard, Bastide, Sophie, Biais, Matthieu, Blet, Alice, Bouvet, Lionel, Brissaud, Olivier, Brull, Sorin J, Capdevila, Xavier, Clausen, Nicola, Cuvillon, Philippe, Dadure, Christophe, David, Jean-Stéphane, Eley, Victoria, Forget, Patrice, Fujii, Tomoko, Godier, Anne, Gopalan, Dean, Guinot, Pierre-Grégoire, Hasanin, Ahmed, Joannes-Boyau, Olivier, Kerever, Sébastien, Kipnis, Éric, Landau, Ruth, Le Guen, Morgan, Legrand, Matthieu, Lorne, Emmanuel, Mercier, Frédéric, Mongardon, Nicolas, Myatra, Sheila Nainan, Nicolas-Robin, Armelle, Peters, Mark John, Quintard, Hervé, Rello, Jordi, G Richebe, Philippe, Roberts, Jason Alexander, Sanfilippo, Filippo, Schneider, Antoine, T Sofonea, Mircea, Treggiari, Miriam, Veyckemans, Francis, Von Ungern-Sternberg, Britta Regli, Zeidan, Ahed, Zieleskiewicz, Laurent, Zielinska, Marzena, Milman, Alexandre, and Roquilly, Antoine

Published
2024
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