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318 results on '"Schmidt, U."'

2. Reanalysis of the $\beta - \bar{\nu_e}$ Angular Correlation Measurement from the aSPECT Experiment with New Constraints on Fierz Interference

Author

Beck, M., Heil, W., Schmidt, C., Baeßler, S., Glück, F., Konrad, G., and Schmidt, U.

Subjects
Nuclear Experiment
Abstract

On the basis of revisions of some of the systematic errors, we reanalyzed the electron-antineutrino angular correlation ($a$ coefficient) in free neutron decay inferred from the recoil energy spectrum of the protons which are detected in 4$\pi$ by the aSPECT spectrometer. With $a = -0.10402(82)$ the new value differs only marginally from the one published in 2020. The experiment also has sensitivity to $b$, the Fierz interference term. From a correlated $(b,a)$ fit to the proton recoil spectrum, we derive a limit of $b = -0.0098(193)$ which translates into a somewhat improved 90 \% CL region of $-0.041 \leq b \leq 0.022$ on this hypothetical term. Tighter constraints on $b$ can be set from a combined$^{(c)}$ analysis of the PERKEO~III ($\beta$ asymmetry) and aSPECT measurement which suggests a finite value of $b$ with $b^{(c)}$ = -0.0181 $\pm$ 0.0065 deviating by 2.82$\sigma$ from the standard model., Comment: 8 pages, 5 figures. arXiv admin note: text overlap with arXiv:1908.04785

Published
2023

3. Particle Physics at the European Spallation Source

Author

Abele, H., Alekou, A., Algora, A., Andersen, K., Baessler, S., Barron-Palos, L., Barrow, J., Baussan, E., Bentley, P., Berezhiani, Z., Bessler, Y., Bhattacharyya, A. K., Bianchi, A., Bijnens, J., Blanco, C., Kraljevic, N. Blaskovic, Blennow, M., Bodek, K., Bogomilov, M., Bohm, C., Bolling, B., Bouquerel, E., Brooijmans, G., Broussard, L. J., Buchan, O., Burgman, A., Calen, H., Carlile, C. J., Cederkall, J., Chanel, E., Christiansen, P., Cirigliano, V., Collar, J. I., Collins, M., Crawford, C. B., Morales, E. Cristaldo, Cupial, P., D'Alessi, L., Damian, J. I. M., Danared, H., Dancila, D., de Andre, J. P. A. M., Delahaye, J. P., Degenkolb, S., Di Julio, D. D., Dracos, M., Dunne, K., Efthymiopoulos, I., Ekelof, T., Eklund, L., Eshraqi, M., Esteban, I., Fanourakis, G., Farricker, A., Fernandez-Martinez, E., Ferreira, M. J., Fertl, M., Fierlinger, P., Folsom, B., Frank, A., Fratangelo, A., Friman-Gayer, U., Fukuda, T., Fynbo, H . O . U., Sosa, A. Garcia, Gazis, N., Galnander, B., Geralis, Th., Ghosh, M., Gokbulut, G., Gomez-Cadenas, J . J., Gonzalez-Alonso, M., Gonzalez, F., Halic, L., Happe, C., Heil, P., Heinz, A., Herde, H., Holl, M., Jenke, T., Jenssen, M., Jericha, E., Johansson, H. T., Johansson, R., Johansson, T., Kamyshkov, Y., Topaksu, A. Kayis, Kildetoft, B., Kirch, K., Klicek, B., Klinkby, E., Kolevatov, R., Konrad, G., Koziol, M., Krhac, K., Kupsc, A., Lacny, L., Larizgoitia, L., Lewis, C. M., Lindroos, M., Lychagin, E., Lytken, E., Maiano, C., Marciniewski, P., Markaj, G., Markisch, B., Marrelli, C., Martins, C., Meirose, B., Mezzetto, M., Milas, N., Milstead, D., Monrabal, F., Muhrer, G., Nepomuceno, A., Nesvizhevsky, V., Nilsson, T., Novella, P., Oglakci, M., Ohlsson, T., Olvegard, M., Oskarsson, A., Ota, T., Park, J., Patrzalek, D., Perrey, H., Persoz, M., Petkov, G., Piegsa, F. M., Pistillo, C., Poussot, P., Privitera, P., Rataj, B., Ries, D., Rizzi, N., Rosauro-Alcaraz, S., Rozpedzik, D., Saiang, D., Santoro, V., Schmidt, U., Schober, H., Schulthess, I., Silverstein, S., Simon, A., Sina, H., Snamina, J., Snow, W. M., Soldner, T., Stavropoulos, G., Stipcevic, M., Szybinski, B., Takibayev, A., Tang, Z., Tarkeshian, R., Theroine, C., Thorne, J., Terranova, F., Thomas, J., Tolba, T., Torres-Sanchez, P., Trachanas, E., Tsenov, R., Uggerhoj, U. I., Vankova-Kirilova, G., Vassilopoulos, N., Wagner, R., Wang, X., Wildner, E., Wolke, M., Wurtz, J., Yiu, S. C., Yoon, S. G., Young, A. R., Zanini, L., Zejma, J., Zerzion, D., Zimmer, O., Zormpa, O., and Zou, Y.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world's brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches)., Comment: 121 pages, updated version after referee comments

Published
2022
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5. The Danish Atrial Fibrillation Registry: A Multidisciplinary National Pragmatic Initiative for Monitoring and Supporting Quality of Care Based on Data Retrieved from Administrative Registries

Author

Frost L, Joensen AM, Dam-Schmidt U, Qvist I, Brinck M, Brandes A, Davidsen U, Pedersen OD, Damgaard D, Mølgaard I, Bedsted R, Damgaard Møller Schlünsen A, Grijota Chousa M, Andersen J, Pedersen AR, Johnsen SP, and Vinter N

Subjects
atrial fibrillation, quality indicators, quality of care, Infectious and parasitic diseases, RC109-216
Abstract

Lars Frost,1,2 Albert Marni Joensen,3 Ulla Dam-Schmidt,4 Ina Qvist,5 Margit Brinck,6 Axel Brandes,7,8 Ulla Davidsen,4 Ole Dyg Pedersen,9 Dorte Damgaard,10 Inge Mølgaard,11 Robert Bedsted,11 Anders Damgaard Møller Schlünsen,12 Miriam Grijota Chousa,12 Julie Andersen,12 Asger Roer Pedersen,1 Søren Paaske Johnsen,13 Nicklas Vinter1,13 1Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark; 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 3Department of Cardiology, North Denmark Regional Hospital, Hjørring, Denmark; 4Department of Cardiology, Bispebjerg Hospital, Copenhagen University Hospitals, Copenhagen, Denmark; 5Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; 6Department of Cardiology, Odense University Hospital, Odense, Denmark; 7Department of Cardiology, Esbjerg Hospital – University Hospital of Southern Denmark, Esbjerg, Denmark; 8Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; 9Department of Cardiology, Zealand University Hospital, Roskilde, Denmark; 10Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; 11Patient Representative, Aalborg and Roskilde, Denmark; 12The Danish Clinical Quality Program – National Clinical Registries (RKKP), Aarhus, Denmark; 13Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkCorrespondence: Lars Frost, Diagnostic Centre, University Clinic for Development of Innovative Patient Pathways, Silkeborg Regional Hospital; Department of Clinical Medicine, Aarhus University, Falkevej 3, Silkeborg, 8600, Denmark, Tel +45 23988590, Email larfrost@rm.dkAim: The Danish Atrial Fibrillation (AF) Registry monitors and supports improvement of quality of care for all AF patients in Denmark. This report describes the registry’s administrative and organizational structure, data sources, data flow, data analyses, annual reporting, and feedback between the registry, clinicians, and the administrative system. We also report the selection process of the quality indicators and the temporal trends in results from 2017– 2021.Methods and Results: The Danish AF Registry aims for complete registration and monitoring of care for all patients diagnosed with AF in Denmark. Administrative registries provide data on contacts to general practice, contacts to private cardiology practice, hospital contacts, medication prescriptions, updated vital status information, and biochemical test results. The Danish Stroke Registry provides information on stroke events. From 2017 to 2021, the proportion with a reported echocardiography among incident AF patients increased from 39.9% (95% CI: 39.3– 40.6) to 82.6% (95% CI: 82.1– 83.1). The initiation of oral anticoagulant therapy among patients with incident AF and a CHA2DS2-VASc score of ≥ 1 in men and ≥ 2 in women increased from 85.3% (95% CI: 84.6– 85.9) to 90.4% (95% CI: 89.9– 91.0). The 1-year and 2-year persistence increased from 85.2% (95% CI: 84.5– 85.9) to 88.7% (95% CI: 88.0– 89.3), and from 85.4% (95% CI: 84.7– 86.2) to 88.2% (95% CI: 87.5– 88.8), respectively. The 1-year risk of ischemic stroke among prevalent patients with AF decreased from 0.88% (95% CI: 0.83– 0.93) to 0.71% (95% CI: 0.66– 0.75). Variation in clinical performance between the five administrative Danish regions was reduced.Conclusion: Continuous nationwide monitoring of quality indicators for AF originating from administrative registries is feasible and supportive of improvements of quality of care.Keywords: atrial fibrillation, quality indicators, quality of care

Published
2023

6. A Narrative Review of Early Intervention for Eating Disorders: Barriers and Facilitators

Author

Mills R, Hyam L, and Schmidt U

Subjects
anorexia nervosa, bulimia nervosa, help-seeking, treatment seeking, mental health, Pediatrics, RJ1-570
Abstract

Regan Mills,1 Lucy Hyam,1 Ulrike Schmidt1,2 1Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders (CREW), King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; 2Eating Disorders Outpatient Service, South London and Maudsley NHS Foundation Trust, London, UKCorrespondence: Regan Mills, Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders (CREW), King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK, Email regan.mills@kcl.ac.ukAbstract: Eating disorders (EDs) are serious psychiatric illnesses that typically develop during adolescence and emerging adulthood. Early intervention is important for improved outcomes for young people with EDs, yet help-seeking is low and individuals often have a significantly protracted start to treatment, suggesting that early intervention is not well established in the ED field. Previous reviews on facilitators and barriers to early intervention for EDs largely cover perceived barriers related to patient variables and perspectives, whereas clinician-, service-, and healthcare system-related facilitators and barriers are less frequently reviewed. The aim of this review is to synthesize the literature on barriers to and facilitators of early intervention for EDs, regarding patient-, clinician-, service-, and healthcare system-related factors. A narrative review was conducted by searching for relevant peer-reviewed, English-language articles published up until July 2023 on PubMed and PsychINFO. The search was conducted in two steps. First, key search terms were used to identify existing reviews and meta-analyses on facilitators and barriers to early intervention for EDs. Then, additional search terms were added to search for primary and secondary research on patient/family, clinician, service, and healthcare system-related barriers and facilitators. The identified literature shows that, after overcoming intrinsic, motivational barriers (such as self-stigma, denial, and ambivalence), help-seeking individuals may be met with long service waiting lists and limited treatment options. Despite these barriers, there is ongoing research into early intervention in practice, which aims to reach underserved populations and facilitate early intervention despite high service demands and shortages of trained healthcare professionals. Funding for ED research and services has historically been low, and there is also a research-practice gap. This highlights the need for increased consideration of, and funding for early intervention for EDs, to remove barriers as well as facilitate discussions around how to make early intervention programs scalable and sustainable.Keywords: anorexia nervosa, bulimia nervosa, help-seeking, treatment seeking, mental health

Published
2023

7. A non-depolarizing CuTi neutron supermirror guide for PERC

Author

Hollering, A., Rebrova, N., Klauser, C., Lauer, Th., Märkisch, B., and Schmidt, U.

Subjects
Physics - Instrumentation and Detectors
Abstract

Neutron guides are used to transport slow neutrons from sources to experiments. Conventional neutron supermirror guides use alternating thin layers based on nickel and titanium. Due to the magnetic properties of nickel, their neutron reflection properties are spin-dependent, in particular when exposed to high magnetic fields. Motivated by the requirements of precision experiments on neutron beta decay, we present novel supermirrors based on copper and titanium, which preserve the neutron beam polarization. These show excellent reflectivity and prove to be very stable even when exposed to high temperatures.

Published
2021
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8. Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Author

Judge, PK, Staplin, N, Mayne, KJ, Wanner, C, Green, JB, Hauske, SJ, Emberson, JR, Preiss, D, Ng, SYA, Roddick, AJ, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Massey, D, Landray, MJ, Baigent, C, Haynes, R, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, Almaraz, R, Almasarwah, R, Almeida, J, Aloisi, A, Al-Rabadi, L, Alscher, D, Alvarez, P, Al-Zeer, B, Amat, M, Ambrose, C, Ammar, H, An, Y, Andriaccio, L, Ansu, K, Apostolidi, A, Arai, N, Araki, H, Araki, S, Arbi, A, Arechiga, O, Armstrong, S, Arnold, T, Aronoff, S, Arriaga, W, Arroyo, J, Arteaga, D, Asahara, S, Asai, A, Asai, N, Asano, S, Asawa, M, Asmee, MF, Aucella, F, Augustin, M, Avery, A, Awad, A, Awang, IY, Awazawa, M, Axler, A, Ayub, W, Azhari, Z, Baccaro, R, Badin, C, Bagwell, B, Bahlmann-Kroll, E, Bahtar, AZ, Bains, D, Bajaj, H, Baker, R, Baldini, E, Banas, B, Banerjee, D, Banno, S, Bansal, S, Barberi, S, Barnes, S, Barnini, C, Barot, C, Barrett, K, Barrios, R, Bartolomei Mecatti, B, Barton, I, Barton, J, Basily, W, Bavanandan, S, Baxter, A, Becker, L, Beddhu, S, Beige, J, Beigh, S, Bell, S, Benck, U, Beneat, A, Bennett, A, Bennett, D, Benyon, S, Berdeprado, J, Bergler, T, Bergner, A, Berry, M, Bevilacqua, M, Bhairoo, J, Bhandari, S, Bhandary, N, Bhatt, A, Bhattarai, M, Bhavsar, M, Bian, W, Bianchini, F, Bianco, S, Bilous, R, Bilton, J, Bilucaglia, D, Bird, C, Birudaraju, D, Biscoveanu, M, Blake, C, Bleakley, N, Bocchicchia, K, Bodine, S, Bodington, R, Boedecker, S, Bolduc, M, Bolton, S, Bond, C, Boreky, F, Boren, K, Bouchi, R, Bough, L, Bovan, D, Bowler, C, Bowman, L, Brar, N, Braun, C, Breach, A, Breitenfeldt, M, Brettschneider, B, Brewer, A, Brewer, G, Brindle, V, Brioni, E, Brown, C, Brown, H, Brown, L, Brown, R, Brown, S, Browne, D, Bruce, K, Brueckmann, M, Brunskill, N, Bryant, M, Brzoska, M, Bu, Y, Buckman, C, Budoff, M, Bullen, M, Burke, A, Burnette, S, Burston, C, Busch, M, Bushnell, J, Butler, S, Büttner, C, Byrne, C, Caamano, A, Cadorna, J, Cafiero, C, Cagle, M, Cai, J, Calabrese, K, Calvi, C, Camilleri, B, Camp, S, Campbell, D, Campbell, R, Cao, H, Capelli, I, Caple, M, Caplin, B, Cardone, A, Carle, J, Carnall, V, Caroppo, M, Carr, S, Carraro, G, Carson, M, Casares, P, Castillo, C, Castro, C, Caudill, B, Cejka, V, Ceseri, M, Cham, L, Chamberlain, A, Chambers, J, Chan, CBT, Chan, JYM, Chan, YC, Chang, E, Chant, T, Chavagnon, T, Chellamuthu, P, Chen, F, Chen, J, Chen, P, Chen, TM, Chen, Y, Cheng, C, Cheng, H, Cheng, MC, Ching, CH, Chitalia, N, Choksi, R, Chukwu, C, Chung, K, Cianciolo, G, Cipressa, L, Clark, S, Clarke, H, Clarke, R, Clarke, S, Cleveland, B, Cole, E, Coles, H, Condurache, L, Connor, A, Convery, K, Cooper, A, Cooper, N, Cooper, Z, Cooperman, L, Cosgrove, L, Coutts, P, Cowley, A, Craik, R, Cui, G, Cummins, T, Dahl, N, Dai, H, Dajani, L, D'Amelio, A, Damian, E, Damianik, K, Danel, L, Daniels, C, Daniels, T, Darbeau, S, Darius, H, Dasgupta, T, Davies, J, Davies, L, Davis, A, Davis, J, Davis, L, Dayanandan, R, Dayi, S, Dayrell, R, De Nicola, L, Debnath, S, Deeb, W, Degenhardt, S, DeGoursey, K, Delaney, M, DeRaad, R, Derebail, V, Dev, D, Devaux, M, Dhall, P, Dhillon, G, Dienes, J, Dobre, M, Doctolero, E, Dodds, V, Domingo, D, Donaldson, D, Donaldson, P, Donhauser, C, Donley, V, Dorestin, S, Dorey, S, Doulton, T, Draganova, D, Draxlbauer, K, Driver, F, Du, H, Dube, F, Duck, T, Dugal, T, Dugas, J, Dukka, H, Dumann, H, Durham, W, Dursch, M, Dykas, R, Easow, R, Eckrich, E, Eden, G, Edmerson, E, Edwards, H, Ee, LW, Eguchi, J, Ehrl, Y, Eichstadt, K, Eid, W, Eilerman, B, Ejima, Y, Eldon, H, Ellam, T, Elliott, L, Ellison, R, Emberson, J, Epp, R, Er, A, Espino-Obrero, M, Estcourt, S, Estienne, L, Evans, G, Evans, J, Evans, S, Fabbri, G, Fajardo-Moser, M, Falcone, C, Fani, F, Faria-Shayler, P, Farnia, F, Farrugia, D, Fechter, M, Fellowes, D, Feng, F, Fernandez, J, Ferraro, P, Field, A, Fikry, S, Finch, J, Finn, H, Fioretto, P, Fish, R, Fleischer, A, Fleming-Brown, D, Fletcher, L, Flora, R, Foellinger, C, Foligno, N, Forest, S, Forghani, Z, Forsyth, K, Fottrell-Gould, D, Fox, P, Frankel, A, Fraser, D, Frazier, R, Frederick, K, Freking, N, French, H, Froment, A, Fuchs, B, Fuessl, L, Fujii, H, Fujimoto, A, Fujita, A, Fujita, K, Fujita, Y, Fukagawa, M, Fukao, Y, Fukasawa, A, Fuller, T, Funayama, T, Fung, E, Furukawa, M, Furukawa, Y, Furusho, M, Gabel, S, Gaidu, J, Gaiser, S, Gallo, K, Galloway, C, Gambaro, G, Gan, CC, Gangemi, C, Gao, M, Garcia, K, Garcia, M, Garofalo, C, Garrity, M, Garza, A, Gasko, S, Gavrila, M, Gebeyehu, B, Geddes, A, Gentile, G, George, A, George, J, Gesualdo, L, Ghalli, F, Ghanem, A, Ghate, T, Ghavampour, S, Ghazi, A, Gherman, A, Giebeln-Hudnell, U, Gill, B, Gillham, S, Girakossyan, I, Girndt, M, Giuffrida, A, Glenwright, M, Glider, T, Gloria, R, Glowski, D, Goh, BL, Goh, CB, Gohda, T, Goldenberg, R, Goldfaden, R, Goldsmith, C, Golson, B, Gonce, V, Gong, Q, Goodenough, B, Goodwin, N, Goonasekera, M, Gordon, A, Gordon, J, Gore, A, Goto, H, Gowen, D, Grace, A, Graham, J, Grandaliano, G, Gray, M, Greene, T, Greenwood, G, Grewal, B, Grifa, R, Griffin, D, Griffin, S, Grimmer, P, Grobovaite, E, Grotjahn, S, Guerini, A, Guest, C, Gunda, S, Guo, B, Guo, Q, Haack, S, Haase, M, Haaser, K, Habuki, K, Hadley, A, Hagan, S, Hagge, S, Haller, H, Ham, S, Hamal, S, Hamamoto, Y, Hamano, N, Hamm, M, Hanburry, A, Haneda, M, Hanf, C, Hanif, W, Hansen, J, Hanson, L, Hantel, S, Haraguchi, T, Harding, E, Harding, T, Hardy, C, Hartner, C, Harun, Z, Harvill, L, Hasan, A, Hase, H, Hasegawa, F, Hasegawa, T, Hashimoto, A, Hashimoto, C, Hashimoto, M, Hashimoto, S, Haskett, S, Hawfield, A, Hayami, T, Hayashi, M, Hayashi, S, Hazara, A, Healy, C, Hecktman, J, Heine, G, Henderson, H, Henschel, R, Hepditch, A, Herfurth, K, Hernandez, G, Hernandez Pena, A, Hernandez-Cassis, C, Herzog, C, Hewins, S, Hewitt, D, Hichkad, L, Higashi, S, Higuchi, C, Hill, C, Hill, L, Himeno, T, Hing, A, Hirakawa, Y, Hirata, K, Hirota, Y, Hisatake, T, Hitchcock, S, Hodakowski, A, Hodge, W, Hogan, R, Hohenstatt, U, Hohenstein, B, Hooi, L, Hope, S, Hopley, M, Horikawa, S, Hosein, D, Hosooka, T, Hou, L, Hou, W, Howie, L, Howson, A, Hozak, M, Htet, Z, Hu, X, Hu, Y, Huang, J, Huda, N, Hudig, L, Hudson, A, Hugo, C, Hull, R, Hume, L, Hundei, W, Hunt, N, Hunter, A, Hurley, S, Hurst, A, Hutchinson, C, Hyo, T, Ibrahim, FH, Ibrahim, S, Ihana, N, Ikeda, T, Imai, A, Imamine, R, Inamori, A, Inazawa, H, Ingell, J, Inomata, K, Inukai, Y, Ioka, M, Irtiza-Ali, A, Isakova, T, Isari, W, Iselt, M, Ishiguro, A, Ishihara, K, Ishikawa, T, Ishimoto, T, Ishizuka, K, Ismail, R, Itano, S, Ito, H, Ito, K, Ito, M, Ito, Y, Iwagaitsu, S, Iwaita, Y, Iwakura, T, Iwamoto, M, Iwasa, M, Iwasaki, H, Iwasaki, S, Izumi, K, Izumi, T, Jaafar, SM, Jackson, C, Jackson, Y, Jafari, G, Jahangiriesmaili, M, Jain, N, Jansson, K, Jasim, H, Jeffers, L, Jenkins, A, Jesky, M, Jesus-Silva, J, Jeyarajah, D, Jiang, Y, Jiao, X, Jimenez, G, Jin, B, Jin, Q, Jochims, J, Johns, B, Johnson, C, Johnson, T, Jolly, S, Jones, L, Jones, S, Jones, T, Jones, V, Joseph, M, Joshi, S, Judge, P, Junejo, N, Junus, S, Kachele, M, Kadoya, H, Kaga, H, Kai, H, Kajio, H, Kaluza-Schilling, W, Kamaruzaman, L, Kamarzarian, A, Kamimura, Y, Kamiya, H, Kamundi, C, Kan, T, Kanaguchi, Y, Kanazawa, A, Kanda, E, Kanegae, S, Kaneko, K, Kang, HY, Kano, T, Karim, M, Karounos, D, Karsan, W, Kasagi, R, Kashihara, N, Katagiri, H, Katanosaka, A, Katayama, A, Katayama, M, Katiman, E, Kato, K, Kato, M, Kato, N, Kato, S, Kato, T, Kato, Y, Katsuda, Y, Katsuno, T, Kaufeld, J, Kavak, Y, Kawai, I, Kawai, M, Kawase, A, Kawashima, S, Kazory, A, Kearney, J, Keith, B, Kellett, J, Kelley, S, Kershaw, M, Ketteler, M, Khai, Q, Khairullah, Q, Khandwala, H, Khoo, KKL, Khwaja, A, Kidokoro, K, Kielstein, J, Kihara, M, Kimber, C, Kimura, S, Kinashi, H, Kingston, H, Kinomura, M, Kinsella-Perks, E, Kitagawa, M, Kitajima, M, Kitamura, S, Kiyosue, A, Kiyota, M, Klauser, F, Klausmann, G, Kmietschak, W, Knapp, K, Knight, C, Knoppe, A, Knott, C, Kobayashi, M, Kobayashi, R, Kobayashi, T, Koch, M, Kodama, S, Kodani, N, Kogure, E, Koizumi, M, Kojima, H, Kojo, T, Kolhe, N, Komaba, H, Komiya, T, Komori, H, Kon, SP, Kondo, M, Kong, W, Konishi, M, Kono, K, Koshino, M, Kosugi, T, Kothapalli, B, Kozlowski, T, Kraemer, B, Kraemer-Guth, A, Krappe, J, Kraus, D, 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2024
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9. Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial

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Staplin, N, Haynes, R, Judge, PK, Wanner, C, Green, JB, Emberson, J, Preiss, D, Mayne, KJ, Ng, SYA, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Petrini, M, Seidi, S, Landray, MJ, Baigent, C, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, Almaraz, R, Almasarwah, R, Almeida, J, Aloisi, A, Al-Rabadi, L, Alscher, D, Alvarez, P, Al-Zeer, B, Amat, M, Ambrose, C, Ammar, H, An, Y, Andriaccio, L, Ansu, K, Apostolidi, A, Arai, N, Araki, H, Araki, S, Arbi, A, Arechiga, O, Armstrong, S, Arnold, T, Aronoff, S, Arriaga, W, Arroyo, J, Arteaga, D, Asahara, S, Asai, A, Asai, N, Asano, S, Asawa, M, Asmee, MF, Aucella, F, Augustin, M, Avery, A, Awad, A, Awang, IY, Awazawa, M, Axler, A, Ayub, W, Azhari, Z, Baccaro, R, Badin, C, Bagwell, B, Bahlmann-Kroll, E, Bahtar, AZ, Bains, D, Bajaj, H, Baker, R, Baldini, E, Banas, B, Banerjee, D, Banno, S, Bansal, S, Barberi, S, Barnes, S, Barnini, C, Barot, C, Barrett, K, Barrios, R, Bartolomei Mecatti, B, Barton, I, Barton, J, Basily, W, Bavanandan, S, Baxter, A, Becker, L, Beddhu, S, Beige, J, Beigh, S, Bell, S, Benck, U, Beneat, A, Bennett, A, Bennett, D, Benyon, S, Berdeprado, J, Bergler, T, Bergner, A, Berry, M, Bevilacqua, M, Bhairoo, J, Bhandari, S, Bhandary, N, Bhatt, A, Bhattarai, M, Bhavsar, M, Bian, W, Bianchini, F, Bianco, S, Bilous, R, Bilton, J, Bilucaglia, D, Bird, C, Birudaraju, D, Biscoveanu, M, Blake, C, Bleakley, N, Bocchicchia, K, Bodine, S, Bodington, R, Boedecker, S, Bolduc, M, Bolton, S, Bond, C, Boreky, F, Boren, K, Bouchi, R, Bough, L, Bovan, D, Bowler, C, Bowman, L, Brar, N, Braun, C, Breach, A, Breitenfeldt, M, Brettschneider, B, Brewer, A, Brewer, G, Brindle, V, Brioni, E, Brown, C, Brown, H, Brown, L, Brown, R, Brown, S, Browne, D, Bruce, K, Brueckmann, M, Brunskill, N, Bryant, M, Brzoska, M, Bu, Y, Buckman, C, Budoff, M, Bullen, M, Burke, A, Burnette, S, Burston, C, Busch, M, Bushnell, J, Butler, S, Büttner, C, Byrne, C, Caamano, A, Cadorna, J, Cafiero, C, Cagle, M, Cai, J, Calabrese, K, Calvi, C, Camilleri, B, Camp, S, Campbell, D, Campbell, R, Cao, H, Capelli, I, Caple, M, Caplin, B, Cardone, A, Carle, J, Carnall, V, Caroppo, M, Carr, S, Carraro, G, Carson, M, Casares, P, Castillo, C, Castro, C, Caudill, B, Cejka, V, Ceseri, M, Cham, L, Chamberlain, A, 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2024
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11. Particle physics at the European Spallation Source

Author

Abele, H., Alekou, A., Algora, A., Andersen, K., Baeßler, S., Barron-Pálos, L., Barrow, J., Baussan, E., Bentley, P., Berezhiani, Z., Beßler, Y., Bhattacharyya, A.K., Bianchi, A., Bijnens, J., Blanco, C., Kraljevic, N. Blaskovic, Blennow, M., Bodek, K., Bogomilov, M., Bohm, C., Bolling, B., Bouquerel, E., Brooijmans, G., Broussard, L.J., Buchan, O., Burgman, A., Calén, H., Carlile, C.J., Cederkall, J., Chanel, E., Christiansen, P., Cirigliano, V., Collar, J.I., Collins, M., Crawford, C.B., Morales, E. Cristaldo, Cupiał, P., D’Alessi, L., Damian, J.I. M., Danared, H., Dancila, D., de André, J.P.A.M., Delahaye, J.P., Degenkolb, S., Di Julio, D.D., Dracos, M., Dunne, K., Efthymiopoulos, I., Ekelöf, T., Eklund, L., Eshraqi, M., Esteban, I., Fanourakis, G., Farricker, A., Fernandez-Martinez, E., Ferreira, M.J., Fertl, M., Fierlinger, P., Folsom, B., Frank, A., Fratangelo, A., Friman-Gayer, U., Fukuda, T., Fynbo, H.O.U., Sosa, A. Garcia, Gazis, N., Gålnander, B., Geralis, Th., Ghosh, M., Gokbulut, G., Gomez-Cadenas, J.J., Gonzalez-Alonso, M., Gonzalez, F., Halić, L., Happe, C., Heil, P., Heinz, A., Herde, H., Holl, M., Jenke, T., Jenssen, M., Jericha, E., Johansson, H.T., Johansson, R., Johansson, T., Kamyshkov, Y., Topaksu, A. Kayis, Kildetoft, B., Kirch, K., Kliček, B., Klinkby, E., Kolevatov, R., Konrad, G., Kozioł, M., Krhač, K., Kupść, A., Łacny, Ł., Larizgoitia, L., Lewis, C.M., Lindroos, M., Lychagin, E., Lytken, E., Maiano, C., Marciniewski, P., Markaj, G., Märkisch, B., Marrelli, C., Martins, C., Meirose, B., Mezzetto, M., Milas, N., Milstead, D., Monrabal, F., Muhrer, G., Nepomuceno, A., Nesvizhevsky, V., Nilsson, T., Novella, P., Oglakci, M., Ohlsson, T., Olvegård, M., Oskarsson, A., Ota, T., Park, J., Patrzalek, D., Perrey, H., Persoz, M., Petkov, G., Piegsa, F.M., Pistillo, C., Poussot, P., Privitera, P., Rataj, B., Ries, D., Rizzi, N., Rosauro-Alcaraz, S., Rozpedzik, D., Saiang, D., Santoro, V., Schmidt, U., Schober, H., Schulthess, I., Silverstein, S., Simón, A., Sina, H., Snamina, J., Snow, W.M., Soldner, T., Stavropoulos, G., Stipčević, M., Szybiński, B., Takibayev, A., Tang, Z., Tarkeshian, R., Theroine, C., Thorne, J., Terranova, F., Thomas, J., Tolba, T., Torres-Sánchez, P., Trachanas, E., Tsenov, R., Uggerhøj, U.I., Vankova-Kirilova, G., Vassilopoulos, N., Wagner, R., Wang, X., Wildner, E., Wolke, M., Wurtz, J., Yiu, S.C., Yoon, S.G., Young, A.R., Zanini, L., Zejma, J., Zerzion, D., Zimmer, O., Zormpa, O., and Zou, Y.

Published
2023
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12. D.4 Safety and efficacy of delandistrogene moxeparvovec versus placebo in Duchenne muscular dystrophy (EMBARK): Pivotal Phase 3 primary results

Author

Mendell, JR, primary, Muntoni, F, additional, McDonald, CM, additional, Mercuri, EM, additional, Ciafaloni, E, additional, Komaki, H, additional, Leon-Astudillo, C, additional, Nascimento, A, additional, Proud, C, additional, Schara-Schmidt, U, additional, Veerapandiyan, A, additional, Zaidman, CM, additional, Guridi, M, additional, Murphy, AP, additional, Reid, C, additional, Wandel, C, additional, Darton, E, additional, Mason, S, additional, Potter, RA, additional, Singh, T, additional, Zhang, W, additional, Fontoura, P, additional, Elkins, JS, additional, and Rodino-Klapac, LR, additional

Published
2024
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19. NDT of smart structures

Author

Krohn, N., primary, Dillenz, A., additional, Döttinger, C., additional, Lütze, S., additional, Nixdorf, K., additional, Busse, G., additional, Dürr, J., additional, Herold-Schmidt, U., additional, Flock, M., additional, and Voit-Nitschmann, R., additional

Published
2021
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20. Qualität von Schulsystemen: theoretische Grundlagen und empirische Befunde

Author

Betz, Tanja, Feldhoff, Tobias, Bauer, Petra, Schmidt, Uwe, Schmidt-Hertha, Bernhard, Betz, T ( Tanja ), Feldhoff, T ( Tobias ), Bauer, P ( Petra ), Schmidt, U ( Uwe ), Schmidt-Hertha, B ( Bernhard ), Maag Merki, Katharina; https://orcid.org/0000-0002-0215-1684, Wullschleger, Andrea; https://orcid.org/0000-0003-4390-3835, Altrichter, Herbert, Betz, Tanja, Feldhoff, Tobias, Bauer, Petra, Schmidt, Uwe, Schmidt-Hertha, Bernhard, Betz, T ( Tanja ), Feldhoff, T ( Tobias ), Bauer, P ( Petra ), Schmidt, U ( Uwe ), Schmidt-Hertha, B ( Bernhard ), Maag Merki, Katharina; https://orcid.org/0000-0002-0215-1684, Wullschleger, Andrea; https://orcid.org/0000-0003-4390-3835, and Altrichter, Herbert

Abstract

In diesem Kapitel geht es um den Beitrag der ‚Makroebene‘ des Schulsystems zur Qualität schulischer Prozesse und Ergebnisse. Nach einem Überblick über die Entwicklung des Forschungsbereiches werden im zweiten Abschnitt grundlegende Begriffe geklärt: Wie ist die Makroebene Schulsystem strukturiert und an welchen Merkmalen könnte ihre Qualität abgelesen werden? Danach wird der empirische Forschungsstand an drei Beispielen, der Erforschung von Schulstrukturen, des internationalen Vergleichs von Schüler:innenleistungen sowie der Untersuchung von Governance-Reformen diskutiert.

Published
2024

22. Particle physics at the European Spallation Source

Author

Abele, H, Alekou, A, Algora, A, Andersen, K, Baessler, S, Barron-Palos, L, Barrow, J, Baussan, E, Bentley, P, Berezhiani, Z, Bessler, Y, Bhattacharyya, A, Bianchi, A, Bijnens, J, Blanco, C, Kraljevic, N, Blennow, M, Bodek, K, Bogomilov, M, Bohm, C, Bolling, B, Bouquerel, E, Brooijmans, G, Broussard, L, Buchan, O, Burgman, A, Calen, H, Carlile, C, Cederkall, J, Chanel, E, Christiansen, P, Cirigliano, V, Collar, J, Collins, M, Crawford, C, Morales, E, Cupial, P, D'Alessi, L, Damian, J, Danared, H, Dancila, D, de Andre, J, Delahaye, J, Degenkolb, S, Di Julio, D, Dracos, M, Dunne, K, Efthymiopoulos, I, Ekelof, T, Eklund, L, Eshraqi, M, Esteban, I, Fanourakis, G, Farricker, A, Fernandez-Martinez, E, Ferreira, M, Fertl, M, Fierlinger, P, Folsom, B, Frank, A, Fratangelo, A, Friman-Gayer, U, Fukuda, T, Fynbo, H, Sosa, A, Gazis, N, Galnander, B, Geralis, T, Ghosh, M, Gokbulut, G, Gomez-Cadenas, J, Gonzalez-Alonso, M, Gonzalez, F, Halic, L, Happe, C, Heil, P, Heinz, A, Herde, H, Holl, M, Jenke, T, Jenssen, M, Jericha, E, Johansson, H, Johansson, R, Johansson, T, Kamyshkov, Y, Topaksu, A, Kildetoft, B, Kirch, K, Klicek, B, Klinkby, E, Kolevatov, R, Konrad, G, Koziol, M, Krhac, K, Kupsc, A, Lacny, L, Larizgoitia, L, Lewis, C, Lindroos, M, Lychagin, E, Lytken, E, Maiano, C, Marciniewski, P, Markaj, G, Markisch, B, Marrelli, C, Martins, C, Meirose, B, Mezzetto, M, Milas, N, Milstead, D, Monrabal, F, Muhrer, G, Nepomuceno, A, Nesvizhevsky, V, Nilsson, T, Novella, P, Oglakci, M, Ohlsson, T, Olvegard, M, Oskarsson, A, Ota, T, Park, J, Patrzalek, D, Perrey, H, Persoz, M, Petkov, G, Piegsa, F, Pistillo, C, Poussot, P, Privitera, P, Rataj, B, Ries, D, Rizzi, N, Rosauro-Alcaraz, S, Rozpedzik, D, Saiang, D, Santoro, V, Schmidt, U, Schober, H, Schulthess, I, Silverstein, S, Simon, A, Sina, H, Snamina, J, Snow, W, Soldner, T, Stavropoulos, G, Stipcevic, M, Szybinski, B, Takibayev, A, Tang, Z, Tarkeshian, R, Theroine, C, Thorne, J, Terranova, F, Thomas, J, Tolba, T, Torres-Sanchez, P, Trachanas, E, Tsenov, R, Uggerhoj, U, Vankova-Kirilova, G, Vassilopoulos, N, Wagner, R, Wang, X, Wildner, E, Wolke, M, Wurtz, J, Yiu, S, Yoon, S, Young, A, Zanini, L, Zejma, J, Zerzion, D, Zimmer, O, Zormpa, O, Zou, Y, Abele H., Alekou A., Algora A., Andersen K., Baessler S., Barron-Palos L., Barrow J., Baussan E., Bentley P., Berezhiani Z., Bessler Y., Bhattacharyya A. K., Bianchi A., Bijnens J., Blanco C., Kraljevic N. B., Blennow M., Bodek K., Bogomilov M., Bohm C., Bolling B., Bouquerel E., Brooijmans G., Broussard L. J., Buchan O., Burgman A., Calen H., Carlile C. J., Cederkall J., Chanel E., Christiansen P., Cirigliano V., Collar J. I., Collins M., Crawford C. B., Morales E. C., Cupial P., D'Alessi L., Damian J. I. M., Danared H., Dancila D., de Andre J. P. A. M., Delahaye J. P., Degenkolb S., Di Julio D. D., Dracos M., Dunne K., Efthymiopoulos I., Ekelof T., Eklund L., Eshraqi M., Esteban I., Fanourakis G., Farricker A., Fernandez-Martinez E., Ferreira M. J., Fertl M., Fierlinger P., Folsom B., Frank A., Fratangelo A., Friman-Gayer U., Fukuda T., Fynbo H. O. U., Sosa A. G., Gazis N., Galnander B., Geralis T., Ghosh M., Gokbulut G., Gomez-Cadenas J. J., Gonzalez-Alonso M., Gonzalez F., Halic L., Happe C., Heil P., Heinz A., Herde H., Holl M., Jenke T., Jenssen M., Jericha E., Johansson H. T., Johansson R., Johansson T., Kamyshkov Y., Topaksu A. K., Kildetoft B., Kirch K., Klicek B., Klinkby E., Kolevatov R., Konrad G., Koziol M., Krhac K., Kupsc A., Lacny L., Larizgoitia L., Lewis C. M., Lindroos M., Lychagin E., Lytken E., Maiano C., Marciniewski P., Markaj G., Markisch B., Marrelli C., Martins C., Meirose B., Mezzetto M., Milas N., Milstead D., Monrabal F., Muhrer G., Nepomuceno A., Nesvizhevsky V., Nilsson T., Novella P., Oglakci M., Ohlsson T., Olvegard M., Oskarsson A., Ota T., Park J., Patrzalek D., Perrey H., Persoz M., Petkov G., Piegsa F. M., Pistillo C., Poussot P., Privitera P., Rataj B., Ries D., Rizzi N., Rosauro-Alcaraz S., Rozpedzik D., Saiang D., Santoro V., Schmidt U., Schober H., Schulthess I., Silverstein S., Simon A., Sina H., Snamina J., Snow W. M., Soldner T., Stavropoulos G., Stipcevic M., Szybinski B., Takibayev A., Tang Z., Tarkeshian R., Theroine C., Thorne J., Terranova F., Thomas J., Tolba T., Torres-Sanchez P., Trachanas E., Tsenov R., Uggerhoj U. I., Vankova-Kirilova G., Vassilopoulos N., Wagner R., Wang X., Wildner E., Wolke M., Wurtz J., Yiu S. C., Yoon S. G., Young A. R., Zanini L., Zejma J., Zerzion D., Zimmer O., Zormpa O., Zou Y., Abele, H, Alekou, A, Algora, A, Andersen, K, Baessler, S, Barron-Palos, L, Barrow, J, Baussan, E, Bentley, P, Berezhiani, Z, Bessler, Y, Bhattacharyya, A, Bianchi, A, Bijnens, J, Blanco, C, Kraljevic, N, Blennow, M, Bodek, K, Bogomilov, M, Bohm, C, Bolling, B, Bouquerel, E, Brooijmans, G, Broussard, L, Buchan, O, Burgman, A, Calen, H, Carlile, C, Cederkall, J, Chanel, E, Christiansen, P, Cirigliano, V, Collar, J, Collins, M, Crawford, C, Morales, E, Cupial, P, D'Alessi, L, Damian, J, Danared, H, Dancila, D, de Andre, J, Delahaye, J, Degenkolb, S, Di Julio, D, Dracos, M, Dunne, K, Efthymiopoulos, I, Ekelof, T, Eklund, L, Eshraqi, M, Esteban, I, Fanourakis, G, Farricker, A, Fernandez-Martinez, E, Ferreira, M, Fertl, M, Fierlinger, P, Folsom, B, Frank, A, Fratangelo, A, Friman-Gayer, U, Fukuda, T, Fynbo, H, Sosa, A, Gazis, N, Galnander, B, Geralis, T, Ghosh, M, Gokbulut, G, Gomez-Cadenas, J, Gonzalez-Alonso, M, Gonzalez, F, Halic, L, Happe, C, Heil, P, Heinz, A, Herde, H, Holl, M, Jenke, T, Jenssen, M, Jericha, E, Johansson, H, Johansson, R, Johansson, T, Kamyshkov, Y, Topaksu, A, Kildetoft, B, Kirch, K, Klicek, B, Klinkby, E, Kolevatov, R, Konrad, G, Koziol, M, Krhac, K, Kupsc, A, Lacny, L, Larizgoitia, L, Lewis, C, Lindroos, M, Lychagin, E, Lytken, E, Maiano, C, Marciniewski, P, Markaj, G, Markisch, B, Marrelli, C, Martins, C, Meirose, B, Mezzetto, M, Milas, N, Milstead, D, Monrabal, F, Muhrer, G, Nepomuceno, A, Nesvizhevsky, V, Nilsson, T, Novella, P, Oglakci, M, Ohlsson, T, Olvegard, M, Oskarsson, A, Ota, T, Park, J, Patrzalek, D, Perrey, H, Persoz, M, Petkov, G, Piegsa, F, Pistillo, C, Poussot, P, Privitera, P, Rataj, B, Ries, D, Rizzi, N, Rosauro-Alcaraz, S, Rozpedzik, D, Saiang, D, Santoro, V, Schmidt, U, Schober, H, Schulthess, I, Silverstein, S, Simon, A, Sina, H, Snamina, J, Snow, W, Soldner, T, Stavropoulos, G, Stipcevic, M, Szybinski, B, Takibayev, A, Tang, Z, Tarkeshian, R, Theroine, C, Thorne, J, Terranova, F, Thomas, J, Tolba, T, Torres-Sanchez, P, Trachanas, E, Tsenov, R, Uggerhoj, U, Vankova-Kirilova, G, Vassilopoulos, N, Wagner, R, Wang, X, Wildner, E, Wolke, M, Wurtz, J, Yiu, S, Yoon, S, Young, A, Zanini, L, Zejma, J, Zerzion, D, Zimmer, O, Zormpa, O, Zou, Y, Abele H., Alekou A., Algora A., Andersen K., Baessler S., Barron-Palos L., Barrow J., Baussan E., Bentley P., Berezhiani Z., Bessler Y., Bhattacharyya A. K., Bianchi A., Bijnens J., Blanco C., Kraljevic N. B., Blennow M., Bodek K., Bogomilov M., Bohm C., Bolling B., Bouquerel E., Brooijmans G., Broussard L. J., Buchan O., Burgman A., Calen H., Carlile C. J., Cederkall J., Chanel E., Christiansen P., Cirigliano V., Collar J. I., Collins M., Crawford C. B., Morales E. C., Cupial P., D'Alessi L., Damian J. I. M., Danared H., Dancila D., de Andre J. P. A. M., Delahaye J. P., Degenkolb S., Di Julio D. D., Dracos M., Dunne K., Efthymiopoulos I., Ekelof T., Eklund L., Eshraqi M., Esteban I., Fanourakis G., Farricker A., Fernandez-Martinez E., Ferreira M. J., Fertl M., Fierlinger P., Folsom B., Frank A., Fratangelo A., Friman-Gayer U., Fukuda T., Fynbo H. O. U., Sosa A. G., Gazis N., Galnander B., Geralis T., Ghosh M., Gokbulut G., Gomez-Cadenas J. J., Gonzalez-Alonso M., Gonzalez F., Halic L., Happe C., Heil P., Heinz A., Herde H., Holl M., Jenke T., Jenssen M., Jericha E., Johansson H. T., Johansson R., Johansson T., Kamyshkov Y., Topaksu A. K., Kildetoft B., Kirch K., Klicek B., Klinkby E., Kolevatov R., Konrad G., Koziol M., Krhac K., Kupsc A., Lacny L., Larizgoitia L., Lewis C. M., Lindroos M., Lychagin E., Lytken E., Maiano C., Marciniewski P., Markaj G., Markisch B., Marrelli C., Martins C., Meirose B., Mezzetto M., Milas N., Milstead D., Monrabal F., Muhrer G., Nepomuceno A., Nesvizhevsky V., Nilsson T., Novella P., Oglakci M., Ohlsson T., Olvegard M., Oskarsson A., Ota T., Park J., Patrzalek D., Perrey H., Persoz M., Petkov G., Piegsa F. M., Pistillo C., Poussot P., Privitera P., Rataj B., Ries D., Rizzi N., Rosauro-Alcaraz S., Rozpedzik D., Saiang D., Santoro V., Schmidt U., Schober H., Schulthess I., Silverstein S., Simon A., Sina H., Snamina J., Snow W. M., Soldner T., Stavropoulos G., Stipcevic M., Szybinski B., Takibayev A., Tang Z., Tarkeshian R., Theroine C., Thorne J., Terranova F., Thomas J., Tolba T., Torres-Sanchez P., Trachanas E., Tsenov R., Uggerhoj U. I., Vankova-Kirilova G., Vassilopoulos N., Wagner R., Wang X., Wildner E., Wolke M., Wurtz J., Yiu S. C., Yoon S. G., Young A. R., Zanini L., Zejma J., Zerzion D., Zimmer O., Zormpa O., and Zou Y.

Abstract

Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world's brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches).

Published
2023

23. P41 EMBARK, a Phase 3 trial evaluating safety and efficacy of delandistrogene moxeparvovec in DMD: study design and baseline characteristics

Author

Muntoni, F., primary, Mercuri, E., additional, Schara-Schmidt, U., additional, Komaki, H., additional, Richardson, J., additional, Singh, T., additional, Guridi, M., additional, Mason, S., additional, Murphy, A., additional, Yu, L., additional, Reid, C., additional, Darton, E., additional, Wandel, C., additional, and Mendell, J., additional

Published
2023
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27. O09 Bi-allelic variants of FILIP1 cause congenital myopathy, dysmorphism and neurological defects

Author

Roos, A., primary, van der Ven, P., additional, Alrohaif, H., additional, Kölbel, H., additional, Heil, L., additional, Della Marina, A., additional, Weis, J., additional, Töpf, A., additional, Vorgerd, M., additional, Schara-Schmidt, U., additional, Gangfuss, A., additional, Evangelista, T., additional, Hentschel, A., additional, Grüneboom, A., additional, Fuerst, D., additional, Kuechler, A., additional, Tzschach, A., additional, Depienne, C., additional, and Lochmüller, H., additional

Published
2023
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32. Telemedicine in Neuromuscular Diseases During Covid-19 Pandemic: ERN-NMD European Survey.

Author

El-Hassar, L., Amara, A., Sanson, B., Lacatus, O., Amir Belhouchet, A., Kroneman, M., Claeys, K., Plançon, J.P., Rodolico, C., Primiano, G., Trojsi, F., Filosto, M., Mongini, T.E., Bortolani, S., Monforte, M., Carraro, E., Maggi, L., Ricci, F., Silani, V., Orsucci, D., Créange, A., Péréon, Y., Stojkovic, T., Beek, N.A. van der, Toscano, A., Pareyson, D., Attarian, S., Bergh, P.Y.K. Van den, Remiche, G., Hoeijmakers, J.G.J., Badrising, U., Voermans, N.C., Kaindl, A.M., Schara-Schmidt, U., Schoser, B., Gazzerro, E., Haberlová, J., Voháňka, S., Pál, E., Molnar, M.J., Leonardis, L., Tournev, I.L., Osorio, A.N., Olivé, M., Muelas, N., Alonso-Perez, J., Plá, F., Visser, Marianne de, Siciliano, G., Sacconi, S., El-Hassar, L., Amara, A., Sanson, B., Lacatus, O., Amir Belhouchet, A., Kroneman, M., Claeys, K., Plançon, J.P., Rodolico, C., Primiano, G., Trojsi, F., Filosto, M., Mongini, T.E., Bortolani, S., Monforte, M., Carraro, E., Maggi, L., Ricci, F., Silani, V., Orsucci, D., Créange, A., Péréon, Y., Stojkovic, T., Beek, N.A. van der, Toscano, A., Pareyson, D., Attarian, S., Bergh, P.Y.K. Van den, Remiche, G., Hoeijmakers, J.G.J., Badrising, U., Voermans, N.C., Kaindl, A.M., Schara-Schmidt, U., Schoser, B., Gazzerro, E., Haberlová, J., Voháňka, S., Pál, E., Molnar, M.J., Leonardis, L., Tournev, I.L., Osorio, A.N., Olivé, M., Muelas, N., Alonso-Perez, J., Plá, F., Visser, Marianne de, Siciliano, G., and Sacconi, S.

Abstract

Item does not contain fulltext, BACKGROUND: Telemedicine (TM) contributes to bridge the gap between healthcare facilities and patients' homes with neuromuscular disease (NMD) because of mobility issues. However, its deployment is limited due to difficulties evaluating subtle neurological signs such as mild weakness or sensory deficits. The COVID-19 pandemic has disrupted healthcare delivery worldwide, necessitating rapid measures implementation by health care providers (HCPs) to protect patients from acquiring SARS-CoV-2 while maintaining the best care and treatment. OBJECTIVES: Given the challenges faced by remote healthcare assistance of NMD patients, we aim to evaluate the use of TM in NMD during the COVID-19 pandemic. METHODS: Based on the Model for Assessment-of-Telemedicine-Applications (MAST), we conducted a survey amongst clinicians of the ERN EURO NMD (European-Reference-Network-for-Rare-Neuromuscular-Diseases). RESULTS: Based on 42 responses over 76 expected ones, our results show that the COVID-19 pandemic significantly increased the number of HCPs using TM (from 60% to 100%). The TM types most used during the COVID-19 period are teleconsultation and consultation by phone, particularly in the context of symptoms worsening in NMD patients with COVID-19 infection. Most European HCPs were satisfied when using TM but as a complementary option to physical consultations. Many responses addressed the issue of technical aspects needing improvement, particularly for elderly patients who need caregivers' assistance for accessing the TM platform. CONCLUSIONS: TM has been essential during COVID-19, but its use still presents some limitations for NMD patients with cognitive deficits or for first-time diagnosis. Thus, TM should be used as complement to, rather than substitute, for face-to-face consultations.

Published
2023

33. Safety and efficacy of tamoxifen in boys with Duchenne muscular dystrophy (TAMDMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

Author

Henzi, B.C., Schmidt, S., Nagy, S., Rubino-Nacht, D., Schaedelin, S., Putananickal, N., Stimpson, G., Amthor, H., Childs, A.M., Deconinck, N., Groot, I.J.M. de, Horrocks, I., Houwen-van Opstal, S.L.S., Laugel, V., Lopez Lobato, M., Madruga Garrido, M., Nascimento Osorio, A., Schara-Schmidt, U., Spinty, S., Moers, A. von, Lawrence, F., Hafner, P., Dorchies, O.M., Fischer, D., Henzi, B.C., Schmidt, S., Nagy, S., Rubino-Nacht, D., Schaedelin, S., Putananickal, N., Stimpson, G., Amthor, H., Childs, A.M., Deconinck, N., Groot, I.J.M. de, Horrocks, I., Houwen-van Opstal, S.L.S., Laugel, V., Lopez Lobato, M., Madruga Garrido, M., Nascimento Osorio, A., Schara-Schmidt, U., Spinty, S., Moers, A. von, Lawrence, F., Hafner, P., Dorchies, O.M., and Fischer, D.

Abstract

Item does not contain fulltext, BACKGROUND: Drug repurposing could provide novel treatment options for Duchenne muscular dystrophy. Because tamoxifen-an oestrogen receptor regulator-reduced signs of muscular pathology in a Duchenne muscular dystrophy mouse model, we aimed to assess the safety and efficacy of tamoxifen in humans as an adjunct to corticosteroid therapy over a period of 48 weeks. METHODS: We did a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial at 12 study centres in seven European countries. We enrolled ambulant boys aged 6·5-12·0 years with a genetically confirmed diagnosis of Duchenne muscular dystrophy and who were on stable corticosteroid treatment for more than 6 months. Exclusion criteria included ophthalmological disorders, including cataracts, and haematological disorders. We randomly assigned (1:1) participants using an online randomisation tool to either 20 mg tamoxifen orally per day or matched placebo, stratified by centre and corticosteroid intake. Participants, caregivers, and clinical investigators were masked to treatment assignments. Tamoxifen was taken in addition to standard care with corticosteroids, and participants attended study visits for examinations every 12 weeks. The primary efficacy outcome was the change from baseline to week 48 in scores on the D1 domain of the Motor Function Measure in the intention-to-treat population (defined as all patients who fulfilled the inclusion criteria and began treatment). This study is registered with ClinicalTrials.gov (NCT03354039) and is completed. FINDINGS: Between May 24, 2018, and Oct 14, 2020, 95 boys were screened for inclusion, and 82 met inclusion criteria and were initially enrolled into the study. Three boys were excluded after initial screening due to cataract diagnosis or revoked consent directly after screening, but before randomisation. A further boy assigned to the placebo group did not begin treatment. Therefore, 40 individuals assigned tamoxifen and 38 allocated placebo were inc

Published
2023

34. URANOS v1.0 – the Ultra Rapid Adaptable Neutron-Only Simulation for environmental research

Author

Köhli, M., Schrön, Martin, Zacharias, Steffen, Schmidt, U., Köhli, M., Schrön, Martin, Zacharias, Steffen, and Schmidt, U.

Abstract

The understanding of neutron transport by Monte Carlo simulations led to major advancements towards precise interpretation of measurements. URANOS (Ultra Rapid Neutron-Only Simulation) is a free software package which has been developed in the last few years in cooperation with particle physics and environmental sciences, specifically for the purposes of cosmic-ray neutron sensing (CRNS). Its versatile user interface and input/output scheme tailored for CRNS applications offers hydrologists straightforward access to model individual scenarios and to directly perform advanced neutron transport calculations. The geometry can be modeled layer-wise, whereas in each layer a voxel geometry is extruded using a two-dimensional map from pixel images representing predefined materials and allowing for the construction of objects on the basis of pixel graphics without a three-dimensional editor. It furthermore features predefined cosmic-ray neutron spectra and detector configurations and also allows for a replication of important site characteristics of study areas – from a small pond to the catchment scale. The simulation thereby gives precise answers to questions like from which location do neutrons originate? How do they propagate to the sensor? What is the neutron's response to certain environmental changes? In recent years, URANOS has been successfully employed by a number of studies, for example, to calculate the cosmic-ray neutron footprint, signals in complex geometries like mobile applications on roads, urban environments and snow patterns.

Published
2023

35. Stellenwert der laparoskopischen Chirurgie des Kolonkarzinoms in der klinischen Routine

Author

Kube, R., Ptok, H., Steinert, R., Sahm, M., Schmidt, U., Gastinger, I., and Lippert, H.

Abstract

Zusammenfassung: Hintergrund: Anhand der vorliegenden Daten der bundesweiten Qualitätssicherungsstudie“Kolon-/Rektumkarzinome (Primärtumor)” soll der Stellenwert der laparoskopischen Chirurgie des Kolonkarzinoms im klinischen Versorgungsalltag in Deutschland dargestellt werden. Methodik: Die vom 01.01.2000 bis 31.12.2003 erfassten Patienten mit einer Kolonkarzinomresektion wurden in Abhängigkeit vom Zugangsweg (laparoskopisch vs. Konversion vs. offen) hinsichtlich der perioperativen Ergebnisse und dem onkologischen Langzeitergebnis verglichen. Ergebnisse: Von 21.721 Patienten mit einem Kolonkarzinom wurden 949 (4,4%) in laparoskopischer Intention operiert. Diese Patienten waren jünger (p<0,001), hatten eine günstigere ASA-Klassifikation (p<0,001) und ein günstigeres UICC-Tumorstadium (p<0,001). Ihre Gesamtmorbidität (p<0,001), die Hospitalletalität (p=0,001) und die Verweildauer (p<0,001) waren geringer, die Rate der intraoperativen und spezifischen Komplikationen unterschied sich nicht. Die Konversionsrate betrug 19%. In der Konversionsgruppe wurde die höchste Gesamtmorbidität und längste Verweildauer festgestellt, die Letalität war gegenüber den Patienten mit definitivem laparoskopischen Vorgehen um den Faktor 3 erhöht. Schlussfolgerungen: Im Untersuchungszeitraum war das offene Vorgehen Standard der chirurgischen Versorgung des Kolonkarzinoms. Nur ein kleiner, selektierter Patientenanteil (Alter, ASA, UICC-Stadien) wurde laparoskopisch operiert. Durch die Selektion wurden in dieser Gruppe im Vergleich zu dem offenen Vorgehen bessere frühpostoperative und onkologische Ergebnisse erreicht. Ein Risikofaktor für die Verschlechterung der Ergebnisse stellte die Konversion dar, deren Anteil bei 19% lag. Zum Erreichen optimaler Ergebnisse sollten laparoskopische Eingriffe beim Kolonkarzinom an einem selektierten Krankengut und von erfahrenen Operateuren durchgeführt werden.

Published
2024
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36. Givinostat in Duchenne Muscular Dystrophy: Effect on Disease Milestones.

Author

McDonald, C., Servais, L., Munell, F., Schmidt, U. Schara, Bettini, E., Comi, G., Blaschek, A., Johannsen, J., Cazzaniga, S., Bettica, P., Vandenborne, K., and Mercuri, E.

Subjects
DUCHENNE muscular dystrophy, HISTONE deacetylase inhibitors, PATIENT experience, NATURAL history, DISEASE progression
Abstract

The article discusses the efficacy and safety of Givinostat, a histone deacetylase inhibitor, in the treatment of Duchenne muscular dystrophy (DMD). The study compared 148 boys treated with Givinostat to 197 boys enrolled in natural history studies who were treated with steroids. The results showed that Givinostat delayed disease progression milestones, such as the age at which patients experienced certain physical limitations, beyond what was observed with standard steroid treatment. These findings confirm the efficacy of Givinostat demonstrated in previous studies. [Extracted from the article]

Published
2023
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37. Givinostat in DMD: Results of the EPIDYS Study with Particular Attention to NSAA.

Author

Mercuri, E., Brogna, C., Mah, J. K., Goemans, N., Niks, E., Müller-Felber, W., Blaschek, A., Schmidt, U. Schara, Johannsen, J., Cazzaniga, S., Bettica, P., and McDonald, C.

Subjects
PHYSICAL mobility, DUCHENNE muscular dystrophy, HISTONE deacetylase inhibitors, MUSCLE strength
Abstract

The article discusses the results of the EPIDYS study, which evaluated the efficacy and safety of Givinostat, a novel histone deacetylase inhibitor, in ambulant patients with Duchenne muscular dystrophy (DMD). The study found that Givinostat demonstrated a statistically significant difference in the time to climb 4 standard stairs compared to the placebo. The treatment also showed positive effects on secondary endpoints, including physical function, muscle strength, and muscle fat fraction. Givinostat was generally well-tolerated, with reversible side effects related to thrombocytopenia and hypertriglyceridemia. The study concludes that Givinostat has clinically important effects on physical function in boys with DMD. [Extracted from the article]

Published
2023
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41. VP.20 Cathepsin D as biomarker in CSF of nusinersen-treated patients with spinal muscular atrophy

Author

Schorling, D., primary, Kölbel, H., additional, Hentschel, A., additional, Pechmann, A., additional, Meyer, N., additional, Wirth, B., additional, Rombo, R., additional, Consortium, A. SMArtCARE, additional, Sickmann, A., additional, Kirschner, J., additional, Schara-Schmidt, U., additional, Lochmüller, H., additional, and Roos, A., additional

Published
2022
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42. P.04 New developments and data highlights in the international myotubular and centronuclear myopathy patient registry

Author

McDonald, S., primary, Bullivant, J., additional, Lennox, A., additional, den Hollander, A., additional, Saegert, C., additional, Lynch, O., additional, Moat, D., additional, Graham, R., additional, Schara-Schmidt, U., additional, Bönnemann, C., additional, Jungbluth, H., additional, Buj-Bello, A., additional, Dowling, J., additional, and Marini-Bettolo, C., additional

Published
2022
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45. Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK

Author

A Martineau, Brett N. Adey, Gerome Breen, Papadia S, Maughan B, Alicia J. Peel, Jessica Mundy, Stirrups K, Matthew Richardson, Linger R, Ammar Al-Chalabi, Holt H, Melanie J. Davies, David Veale, Alish B. Palmos, Kirstin L. Purves, Y. Lin, Huebel C, Bristow S, Katherine N. Thompson, Evangelos Vassos, Ward C, Bradley J, Young Ks, Colette R. Hirsch, ter Kuile A, Gursharan Kalsi, Kingston N, Andrea Danese, Timothy R Nicholson, Georgina Krebs, Chaudhuri Kr, Sharon Stevelink, Thalia C. Eley, Bright S, Christopher Rayner, Pollak T, Chinnery P, Matthew Hotopf, Lee Yt, York K, Hegemann L, Dina Monssen, Moukhtarian T, Christine E. Parsons, Henry C. Rogers, and Schmidt U

Subjects
Psychiatry and Mental health, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Pandemic, Medicine, Anxiety, medicine.symptom, business, Psychiatry, Applied Psychology, Depression (differential diagnoses)
Abstract

Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It is important to identify which individuals are at greatest risk of worsening symptoms. This study aimed to examine changes in depression, anxiety and post-traumatic stress disorder (PTSD) symptoms using prospective and retrospective symptom change assessments, and to find and examine the effect of key risk factors. Method Online questionnaires were administered to 34 465 individuals (aged 16 years or above) in April/May 2020 in the UK, recruited from existing cohorts or via social media. Around one-third (n = 12 718) of included participants had prior diagnoses of depression or anxiety and had completed pre-pandemic mental health assessments (between September 2018 and February 2020), allowing prospective investigation of symptom change. Results Prospective symptom analyses showed small decreases in depression (PHQ-9: −0.43 points) and anxiety [generalised anxiety disorder scale – 7 items (GAD)-7: −0.33 points] and increases in PTSD (PCL-6: 0.22 points). Conversely, retrospective symptom analyses demonstrated significant large increases (PHQ-9: 2.40; GAD-7 = 1.97), with 55% reported worsening mental health since the beginning of the pandemic on a global change rating. Across both prospective and retrospective measures of symptom change, worsening depression, anxiety and PTSD symptoms were associated with prior mental health diagnoses, female gender, young age and unemployed/student status. Conclusions We highlight the effect of prior mental health diagnoses on worsening mental health during the pandemic and confirm previously reported sociodemographic risk factors. Discrepancies between prospective and retrospective measures of changes in mental health may be related to recall bias-related underestimation of prior symptom severity.

Published
2022

46. Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK

Author

Young, K. S., primary, Purves, K. L., additional, Hübel, C., additional, Davies, M. R., additional, Thompson, K. N., additional, Bristow, S., additional, Krebs, G., additional, Danese, A., additional, Hirsch, C., additional, Parsons, C. E., additional, Vassos, E., additional, Adey, B. N., additional, Bright, S., additional, Hegemann, L., additional, Lee, Y. T., additional, Kalsi, G., additional, Monssen, D., additional, Mundy, J., additional, Peel, A. J., additional, Rayner, C., additional, Rogers, H. C., additional, ter Kuile, A., additional, Ward, C., additional, York, K., additional, Lin, Y., additional, Palmos, A. B., additional, Schmidt, U., additional, Veale, D., additional, Nicholson, T. R., additional, Pollak, T. A., additional, Stevelink, S. A. M., additional, Moukhtarian, T., additional, Martineau, A. R., additional, Holt, H., additional, Maughan, B., additional, Al-Chalabi, A., additional, Chaudhuri, K. Ray, additional, Richardson, M. P., additional, Bradley, J. R., additional, Chinnery, P. F., additional, Kingston, N., additional, Papadia, S., additional, Stirrups, K. E., additional, Linger, R., additional, Hotopf, M., additional, Eley, T. C., additional, and Breen, G., additional

Published
2022
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48. POS0180 THE EFFICACY AND SAFETY OF A FIXED-DOSE COMBINATION OF APOCYNIN AND PAEONOL IN SYMPTOMATIC KNEE OA: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIAL

Author

Bihlet, A. R., primary, Byrjalsen, I., additional, Andersen, J. R., additional, Metnik, A., additional, Reynolds, A., additional, Larkins, N., additional, Alexandersen, P., additional, Rovsing, H., additional, Schmidt, U., additional, Moots, R., additional, and Conaghan, P. G., additional

Published
2022
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49. Mitochondrial diseases mimicking autoimmune diseases of the CNS and good response to steroids initially

Author

Marina, A. Della, Bertolini, A., Wegener-Panzer, A., Flotats-Bastardas, M., Reinhardt, T., Naggar, I. El, Distelmaier, F., Blaschek, A., Schara-Schmidt, U., Brunet, T., Wagner, M., Smirnov, D., Prokisch, H., Wortmann, S.B., Rostasy, K., Marina, A. Della, Bertolini, A., Wegener-Panzer, A., Flotats-Bastardas, M., Reinhardt, T., Naggar, I. El, Distelmaier, F., Blaschek, A., Schara-Schmidt, U., Brunet, T., Wagner, M., Smirnov, D., Prokisch, H., Wortmann, S.B., and Rostasy, K.

Abstract

Item does not contain fulltext, INTRODUCTION: Neuroimmunological diseases such as autoimmune encephalitis (AE) or acquired demyelinating syndromes (ADS), can present with neurological symptoms and imaging features that are indistinguishable from mitochondrial diseases (MD) in particular at initial presentation. METHODS: Retrospective analysis of the clinical, laboratory and neuroimaging features of five patients who presented with signs of a neuroimmunological disease but all had pathological pathogenic variants in genes related to mitochondrial energy metabolism. RESULTS: Four patients presented with an acute neurological episode reminiscent of a possible AE and one patient with a suspected ADS at initial presentation. MRI findings were compatible with neuroimmunological diseases in all patients. In two children cerebrospinal fluid (CSF) studies revealed a mildly elevated cell count, two had elevated CSF lactate, none had oligoclonal bands (OCBs). All patients improved rapidly with intravenous steroids or immunoglobulins. Four patients had one or more relapses. Three patients showed worsening of their neurological symptoms with subsequent episodes and one patient died. Relapses in conjunction with new and progressive neurological symptoms, led to additional work-up which finally resulted in different genetic diagnosis of MD in all patients (MT-TL1, MT-ND5, APOA1-BP, HPDL, POLG). DISCUSSION: We would like to draw attention to a subset of patients with MD initially presenting with signs and symptoms mimicking neuroimmunological. Absence of CSF pleocytosis, elevated CSF lactate and progressive, relapsing course should trigger further (genetic) investigations in search of a MD even in patients with good response initially to immunomodulating therapies.

Published
2022

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