Search

Your search keyword '"Schaeffner, Elke"' showing total 174 results
Start Over Author "Schaeffner, Elke" Publication Year Range Last 3 years
174 results on '"Schaeffner, Elke"'

2. Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP.

Author

Matsushita, Kunihiro, Kaptoge, Stephen, Hageman, Steven, Sang, Yingying, Ballew, Shoshana, Grams, Morgan, Surapaneni, Aditya, Sun, Luanluan, Arnlov, Johan, Bozic, Milica, Brenner, Hermann, Brunskill, Nigel, Chang, Alex, Chinnadurai, Rajkumar, Cirillo, Massimo, Correa, Adolfo, Ebert, Natalie, Eckardt, Kai-Uwe, Gansevoort, Ron, Gutierrez, Orlando, Hadaegh, Farzad, He, Jiang, Hwang, Shih-Jen, Jafar, Tazeen, Jassal, Simerjot, Kayama, Takamasa, Kovesdy, Csaba, Landman, Gijs, Levey, Andrew, Lloyd-Jones, Donald, Major, Rupert, Miura, Katsuyuki, Muntner, Paul, Nadkarni, Girish, Nowak, Christoph, Ohkubo, Takayoshi, Pena, Michelle, Polkinghorne, Kevan, Sairenchi, Toshimi, Schaeffner, Elke, Schneider, Markus, Shalev, Varda, Shlipak, Michael, Solbu, Marit, Stempniewicz, Nikita, Tollitt, James, Valdivielso, José, van der Leeuw, Joep, Wang, Angela, Wen, Chi-Pang, Woodward, Mark, Yamagishi, Kazumasa, Yatsuya, Hiroshi, Zhang, Luxia, Dorresteijn, Jannick, Di Angelantonio, Emanuele, Visseren, Frank, Pennells, Lisa, and Coresh, Josef

Subjects
Cardiovascular disease, Chronic kidney disease, Meta-analysis, Risk prediction, Humans, Aged, Aged, 80 and over, Cardiovascular Diseases, Risk Factors, Creatinine, Renal Insufficiency, Chronic, Albuminuria, Glomerular Filtration Rate, Heart Disease Risk Factors
Abstract

AIMS: The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) and systemic coronary risk estimation 2 in older persons (SCORE2-OP), to predict CVD risk. We developed and validated an Add-on to incorporate CKD measures into these algorithms, using a validated approach. METHODS: In 3,054 840 participants from 34 datasets, we developed three Add-ons [eGFR only, eGFR + urinary albumin-to-creatinine ratio (ACR) (the primary Add-on), and eGFR + dipstick proteinuria] for SCORE2 and SCORE2-OP. We validated C-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997 719 participants from 34 different datasets. RESULTS: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved C-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57 485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI [e.g. 0.100 (0.062-0.138) for SCORE2] compared to the qualitative approach in the ESC guideline. CONCLUSION: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

Published
2023

5. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

Author

Stevens, Paul E., Ahmed, Sofia B., Carrero, Juan Jesus, Foster, Bethany, Francis, Anna, Hall, Rasheeda K., Herrington, Will G., Hill, Guy, Inker, Lesley A., Kazancıoğlu, Rümeyza, Lamb, Edmund, Lin, Peter, Madero, Magdalena, McIntyre, Natasha, Morrow, Kelly, Roberts, Glenda, Sabanayagam, Dharshana, Schaeffner, Elke, Shlipak, Michael, Shroff, Rukshana, Tangri, Navdeep, Thanachayanont, Teerawat, Ulasi, Ifeoma, Wong, Germaine, Yang, Chih-Wei, Zhang, Luxia, and Levin, Adeera

Published
2024
Full Text
View/download PDF

6. Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns

Author

Levin, Adeera, Ahmed, Sofia B., Carrero, Juan Jesus, Foster, Bethany, Francis, Anna, Hall, Rasheeda K., Herrington, Will G., Hill, Guy, Inker, Lesley A., Kazancıoğlu, Rümeyza, Lamb, Edmund, Lin, Peter, Madero, Magdalena, McIntyre, Natasha, Morrow, Kelly, Roberts, Glenda, Sabanayagam, Dharshana, Schaeffner, Elke, Shlipak, Michael, Shroff, Rukshana, Tangri, Navdeep, Thanachayanont, Teerawat, Ulasi, Ifeoma, Wong, Germaine, Yang, Chih-Wei, Zhang, Luxia, Robinson, Karen A., Wilson, Lisa, Wilson, Renee F., Kasiske, Bertram L., Cheung, Michael, Earley, Amy, and Stevens, Paul E.

Published
2024
Full Text
View/download PDF

9. Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Author

Dr. Ali Al-Aradi, Jadoul, Michel, Evenepoel, Pieter, Sood, Manish, Suri, Rita, Zuo, Li, Chen, Yuqing, Ni, Zhaohui, Chen, Xiaonong, Hou, Fanfan, Liang, Xinling, Combe, Christian, Guebre-Egziabher, Fitsum, Antonio Ureña Torres, Pablo, Kleophas, Werner, Schaeffner, Elke, Weinreich, Thomas, Brunori, Giuliano, Messa, Piergiorio, Nitta, Kosaku, Inaba, Masaaki, Fukagawa, Masafumi, Sakai, Ken, Tsuruya, Kazuhiko, Hamano, Takayuki, Honda, Hirokazu, Hoshino, Junichi, Komaba, Hirotaka, Nakano, Toshiaki, Al Helal, Bassam, Alkandari, Naser, AlRajab, Heba, Alyousef, Anas, Al Maimani, Yacoub, Alsalmi, Issa, Al Ali, Fadwa, Hamad, Abdulla, Al-Ghamdi, Saeed, Al Ghonaim, Mohammed, Al Wakeel, Jamal, Hejaili, Fayez, Karkar, Ayman, Shaheen, Faissal, Jacobson, Stefan, Christensson, Anders, Cases, Aleix, Vega Martínez, Almudena, Abdulkarim Al Obaidli, Ali, Al Rukhaimi, Mona, Hassan, Mohamed, Kareem Saleh, Abdul, Asgari, Elham, Dasgupta, Indranil, McCullough, Keith P., Morgenstern, Hal, Rayner, Hugh C., Port, Friedrich K., Jadoul, Michel Y., Akizawa, Tadao, Pisoni, Ronald L., Herman, William H., and Robinson, Bruce M.

Published
2024
Full Text
View/download PDF

11. Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium

Author

Ebert, Natalie, Schaeffner, Elke, Seegmiller, Jesse C., van Londen, Marco, Bökenkamp, Arend, Cavalier, Etienne, Delanaye, Pierre, Derain-Dubourg, Laurence, Eriksen, Bjørn O., Indridason, Olafur S., Palsson, Runolfur, Shafi, Tariq, Christensson, Anders, Bevc, Sebastjan, Carrara, Fabiola, Courbebaisse, Marie, Dalton, R. Neil, van der Giet, Markus, Melsom, Toralf, Methven, Shona, Nordin, Gunnar, Pottel, Hans, Rule, Andrew D., Trillini, Matias, and White, Christine A.

Published
2024
Full Text
View/download PDF

12. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schneider, Markus P., Schultheiss, Ulla T., Friedrich, Nele, and Nauck, Matthias

Published
2023
Full Text
View/download PDF

13. Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Al-Aly, Ziyad, Ashuntantang, Gloria E., Boor, Peter, Calice da Silva, Viviane, Coleman, Jill, Coresh, Josef, Delanaye, Pierre, Ebert, Natalie, Enghard, Philipp, Feldman, Harold I., Fisher, Lori, Flythe, Jennifer E., Fukui, Akira, Grams, Morgan E., Ix, Joseph H., Jardine, Meg J., Jha, Vivek, Ju, Wenjun, Jurish, Robert, Kalyesubula, Robert, Kashihara, Naoki, Levey, Andrew S., Levin, Adeera, Luyckx, Valerie, Małyszko, Jolanta, Manski-Nankervis, Jo-Anne, Navaneethan, Sankar D., Obrador, Greg, Ortiz, Alberto, Ortiz, John, Cardoso Dos Santos, Bento Fortunato, Sarnak, Mark J., Schaeffner, Elke, Selby, Nick M., Simpson, David M., Solá, Laura, St. Peter, Wendy L., Stevens, Paul E., Tangri, Navdeep, Tannor, Elliot Koranteng, Tchokhonelidze, Irma, Wilck, Nicola, Wong, Michelle M.Y., Eckardt, Kai-Uwe, Delgado, Cynthia, Heerspink, Hiddo J.L., Pecoits-Filho, Roberto, Ricardo, Ana C., Stengel, Bénédicte, Tonelli, Marcello, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Kramer, Holly

Published
2023
Full Text
View/download PDF

14. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Ahn, Curie, Berger, Stefan P., Caskey, Fergus J., Cho, Min Hyun, Cho, Heeyeon, Dekker, Friedo W., Diwan, Vishal, Drechsler, Christiane, Eckardt, Kai-Uwe, Evans, Marie, Ferreiro, Alejandro, Floege, Jürgen, Gadola, Liliana, Haller, Hermann, Han, Kyung Hee, Healy, Helen G., Heerspink, Hiddo Lambers, Hemmelder, Marc, Hiemstra, Thomas, Hilbrands, Luuk, Kim, Seong Heon, Klyprayong, Pinkaew, Köttgen, Anna, Kronenberg, Florian, Lamadrid, Veronica, Lee, Joo Hoo, Mark, Patrick, Matheson, Matt, Mi, Eun, Noppakun, Kajohnsak, Oefner, Peter, Panaput, Thanachai, Park, Young Seo, Prokosch, Hans-Ulrich, Reis, André, Rios, Pablo, Rosivall, Laszlo, Rotmans, Joris I., Sackeyfio, Alfred, Sangthawan, Pornpen, Schmid, Matthias, Shin, Jae Il, Silavarino, Ricardo, Sitter, Thomas, Sommerer, Claudia, Szymczak, Maciej, Torino, Claudia, Toth, Janos, van Ittersum, Frans J., Venuthurupalli, Sree Krishna, Verhaar, Marianne C., Wang, Zaimin, Wanner, Christoph, Wiecek, Andrzej, Wolf, Gunter, de Zeeuw, Dick, Zhang, Luxia, Zheng, Yuyan, Zhao, Ming-Hui, Zietse, Robert, Canney, Mark, Induruwage, Dilshani, Tang, Mila, Alencar de Pinho, Natalia, Er, Lee, Zhao, Yinshan, Djurdjev, Ognjenka, Ahn, Yo Han, Behnisch, Rouven, Calice-Silva, Viviane, Chesnaye, Nicholas C., de Borst, Martin H., Dember, Laura M., Dionne, Janis, Ebert, Natalie, Eder, Susanne, Fenton, Anthony, Fukagawa, Masafumi, Furth, Susan L., Hoy, Wendy E., Imaizumi, Takahiro, Jager, Kitty J., Jha, Vivekanand, Kang, Hee Gyung, Kitiyakara, Chagriya, Mayer, Gert, Oh, Kook-Hwan, Onu, Ugochi, Pecoits-Filho, Roberto, Reichel, Helmut, Richards, Anna, Schaefer, Franz, Schaeffner, Elke, Scheppach, Johannes B., Sola, Laura, Ulasi, Ifeoma, Wang, Jinwei, Yadav, Ashok K., Zhang, Jianzhen, Feldman, Harold I., Taal, Maarten W., Stengel, Bénédicte, and Levin, Adeera

Published
2023
Full Text
View/download PDF

15. Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease

Author

Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Paul, Rainer, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Cejka, Vladimir, Störk, Stefan, Nadal, Jennifer, Sitter, Thomas, Meiselbach, Heike, Busch, Martin, Schneider, Markus P., Saritas, Turgay, Schultheiss, Ulla T., Kotsis, Fruzsina, Wanner, Christoph, Eckardt, Kai-Uwe, and Krane, Vera

Published
2023
Full Text
View/download PDF

18. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Alberth-Schmidt, Ulrike, Marschall, Sabine, Schefler, Eugenia, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Schmidt-Ott, Kai, Zeier, Martin, Sommerer, Claudia, Aykac, Mehtap, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Müller-Krebs, Sandra, Schultheiss, Ulla T., Friedrich, Nele, Nauck, Matthias, Nußhag, Christian, Reiser, Jochen, and Hayek, Salim S.

Published
2023
Full Text
View/download PDF

20. Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort

Author

Winitzki, Doris, Zacharias, Helena U., Nadal, Jennifer, Baid-Agrawal, Seema, Schaeffner, Elke, Schmid, Matthias, Busch, Martin, Bergmann, Manuela M., Schultheiss, Ulla, Kotsis, Fruzsina, Stockmann, Helena, Meiselbach, Heike, Wolf, Gunter, Krane, Vera, Sommerer, Claudia, Eckardt, Kai-Uwe, Schneider, Markus P., Schlieper, Georg, Floege, Jürgen, and Saritas, Turgay

Published
2022
Full Text
View/download PDF

21. Guidelines or mindlines? – implementing a new CKD guideline in German primary care.

Author

Laker, Konrad, Bothe, Tim, Ebert, Natalie, Heintze, Christoph, Schaeffner, Elke, and Krüger, Karen

Subjects
TREATMENT of chronic kidney failure, MEDICAL protocols, MEDICAL quality control, RESEARCH funding, QUALITATIVE research, GENERAL practitioners, PRIMARY health care, INTERVIEWING, CLINICAL decision support systems, CONTENT analysis, PHYSICIANS' attitudes, QUANTITATIVE research, DECISION making in clinical medicine, DESCRIPTIVE statistics, RESEARCH methodology, COMMUNICATION, QUALITY assurance, DATA analysis software, PSYCHOSOCIAL factors
Abstract

Background: The development of clinical guidelines aimed at GPs is a key strategy to improving the management of chronic kidney disease (CKD). In 2019, the first CKD guideline aimed specifically at GPs practicing in Germany was published by the German College of General Practitioners and Family Physicians (DEGAM.) Aims: The aim of this study is to identify the barriers and enablers for the implementation of this guideline. The results of this project, together with quantitative evaluation against quality indicators for CKD in primary care will inform an update to the guideline. Methods: We performed 17 semi-structured interviews with GPs practicing in Berlin and Brandenburg. Transcripts were analysed using qualitative content analysis as described by Mayring. Results: We found that the perception of low clinical priority of CKD compared to other chronic diseases, opportunity cost of using guidelines, as well as poor patient understanding were significant barriers. GPs expressed that improved graphic design or integration of guideline recommendations in clinical decision support systems were enabling factors. Clinical problems concerning CKD were mostly solved by recourse to informal communication with specialists. GPs reported that they rarely consulted CKD guidelines as an aide to clinical decision making. Conclusion: The most significant barrier to use was that guidelines were not used as step-by-step decision aide in consultations with patients. Our analysis suggests that informal contact between primary and secondary care is significant conduit for evidence-based information on CKD in German primary care. Implementation projects should support the development of these relationships. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

22. #2422 Iohexol plasma clearance measurement protocol standardization—a consensus of the European Kidney Function Consortium

Author

Ebert, Natalie, primary, Schaeffner, Elke, additional, Seegmiller, Jesse C, additional, van Londen, Marco, additional, Bökenkamp, Arend, additional, Cavalier, Etienne, additional, Delanaye, Pierre, additional, Derain-Dubourg, Laurence, additional, Eriksen, Bjørn O, additional, Pálsson, Runólfur, additional, Shafi, Tariq, additional, and White, Christine A, additional

Published
2024
Full Text
View/download PDF

26. Social support and frailty progression in community-dwelling older adults

Author

Barghouth, Muhammad Helmi, Klein, Jessica, Bothe, Tim, Ebert, Natalie, Schaeffner, Elke, Mielke, Nina, Barghouth, Muhammad Helmi, Klein, Jessica, Bothe, Tim, Ebert, Natalie, Schaeffner, Elke, and Mielke, Nina

Abstract

Objectives: Despite the growing evidence regarding the influence of social factors on frailty in older adults, the effect of social support remains unclear. This study aims to assess the association between social support and frailty progression (transition and incidence) in a sample of community-dwelling older adults. Methods: Using a cohort study design, 1,059 older adults from the Berlin Initiative Study were followed up for 2.1 years. Multinomial and logistic regression analyses were performed to assess the association of social support using Oslo Social Support Scale-3 with frailty transition and incidence, respectively. Gender differences were explored using stratified analyses. Results: At baseline, frailty prevalence in the study population [mean (SD) age 84.3 (5.6) years; 55.8% women] reached 33.1% with 47.0, 29.4 and 23.6% of the participants reporting moderate, strong and poor social support, respectively. Over the follow-up period, social support was not significantly associated with the frailty transition categories in the adjusted model. Conversely, the adjusted logistic regression analysis showed that participants with poor social support had twice the odds of becoming frail compared to those with strong social support (OR 2.07; 95% CI 1.08–3.95). Gender-stratified analyses showed comparable estimates to the main analysis but were statistically non-significant. Discussion: Our study results underpin the role of social factors in frailty incidence and highlight social support as a potential target for frailty-preventing interventions in older adults. Therefore, it is important to adopt a biopsychosocial model rather than a purely biomedical model to understand and holistically improve the health of community-dwelling older adults.

Published
2024

27. Diagnostic Validity of Chronic Kidney Disease in Health Claims Data Over Time: Results from a Cohort of Community-Dwelling Older Adults in Germany

Author

Bothe,Tim, Fietz,Anne-Katrin, Schaeffner,Elke, Douros,Antonios, Pöhlmann,Anna, Mielke,Nina, Villain,Cédric, Barghouth,Muhammad, Wenning,Volker, Ebert,Natalie, Bothe,Tim, Fietz,Anne-Katrin, Schaeffner,Elke, Douros,Antonios, Pöhlmann,Anna, Mielke,Nina, Villain,Cédric, Barghouth,Muhammad, Wenning,Volker, and Ebert,Natalie

Abstract

Tim Bothe,1 Anne-Katrin Fietz,2 Elke Schaeffner,1 Antonios Douros,3– 5 Anna Pöhlmann,2 Nina Mielke,1 Cédric Villain,1,6 Muhammad Helmi Barghouth,1 Volker Wenning,7 Natalie Ebert1 1Institute of Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany; 2Institute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Berlin, Germany; 3Departments of Medicine and of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; 4Institute of Clinical Pharmacology and Toxicology, Charité – Universitätsmedizin Berlin, Berlin, Germany; 5Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada; 6Normandie Univ UNICAEN, INSERM U1075 COMETE, service de Gériatrie, CHU de Caen, Caen, France; 7AOK Nordost – Die Gesundheitskasse, Potsdam, GermanyCorrespondence: Tim Bothe, Charité – Universitätsmedizin Berlin, Institute of Public Health, Charitéplatz 1, Berlin, DE-10117, Germany, Tel +49 30 450 570054, Email tim.bothe@charite.dePurpose: The validity of ICD-10 diagnostic codes for chronic kidney disease (CKD) in health claims data has not been sufficiently studied in the general population and over time.Patients and Methods: We used data from the Berlin Initiative Study (BIS), a prospective longitudinal cohort of community-dwelling individuals aged ≥ 70 years in Berlin, Germany. With estimated glomerular filtration rate (eGFR) as reference, we assessed the diagnostic validity (sensitivity, specificity, positive [PPV], and negative predictive values [NPV]) of different claims-based ICD-10 codes for CKD stages G3-5 (eGFR < 60mL/min/1.73m²: ICD-10 N18.x-N19), G3 (eGFR 30–< 60mL/min/1.73m²: N18.3), and G4-5 (eGFR < 30mL/min/1.73m²: N18.4– 5). We analysed trends over five study visits (2009– 2019).Results: We included data of 2068 participants at baseline (2009– 2011) and 870 at follow-up 4 (2018– 2019), of whom 784 (38.9%) and 4

Published
2024

28. Diuretic prescriptions in the first year of haemodialysis: international practice patterns and associations with outcomes.

Author

Tabibzadeh, Nahid, Wang, Dongyu, Karaboyas, Angelo, Schaeffner, Elke, Jacobson, Stefan H, Vega, Almudena, Nitta, Kosaku, Bieber, Brian, Pecoits-Filho, Roberto, and Torres, Pablo Antonio Ureña

Subjects
HEMODIALYSIS patients, DIURETICS, TREATMENT effectiveness, MORTALITY, PARATHYROID hormone
Abstract

Background The use of diuretics in patients on haemodialysis (HD) is thought to maintain diuresis. However, this assumption and the optimal dose are based on little scientific evidence, and associations with clinical outcomes are unclear. Methods We reported international variations in diuretic use and loop diuretic dose across 27 759 HD patients with dialysis vintage <1 year in the Dialysis Outcomes and Practice Patterns Study phases 2–5 (2002–2015), a prospective cohort study. Doses of torsemide (4:1) and bumetanide (80:1) were converted to oral furosemide-equivalent doses. Adjusted Cox, logistic and linear regressions were used to investigate the association of diuretic use and dose with outcomes. Results Diuretic utilization varied widely by country at vintage <3 months, ranging from >80% in Germany and Sweden to <35% in the USA, at a median dose ranging from 400–500 mg/day in Germany and Sweden to <100 mg/day in Japan and the USA. Neither diuretic use nor higher doses were associated with a lower risk of all-cause mortality, a higher risk of hospitalization for fracture or elevated parathyroid hormone levels, but the prescription of higher doses (>200 mg/day) was associated with a higher risk of all-cause hospitalization. Conclusions Substantial international differences exist in diuretic prescriptions, with use and doses much higher in some European countries than the USA. The prescription and higher doses of loop diuretics was not associated with improved outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

32. Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Eckardt, Kai-Uwe, primary, Delgado, Cynthia, additional, Heerspink, Hiddo J.L., additional, Pecoits-Filho, Roberto, additional, Ricardo, Ana C., additional, Stengel, Bénédicte, additional, Tonelli, Marcello, additional, Cheung, Michael, additional, Jadoul, Michel, additional, Winkelmayer, Wolfgang C., additional, Kramer, Holly, additional, Al-Aly, Ziyad, additional, Ashuntantang, Gloria E., additional, Boor, Peter, additional, Calice da Silva, Viviane, additional, Coleman, Jill, additional, Coresh, Josef, additional, Delanaye, Pierre, additional, Ebert, Natalie, additional, Enghard, Philipp, additional, Feldman, Harold I., additional, Fisher, Lori, additional, Flythe, Jennifer E., additional, Fukui, Akira, additional, Grams, Morgan E., additional, Ix, Joseph H., additional, Jardine, Meg J., additional, Jha, Vivek, additional, Ju, Wenjun, additional, Jurish, Robert, additional, Kalyesubula, Robert, additional, Kashihara, Naoki, additional, Levey, Andrew S., additional, Levin, Adeera, additional, Luyckx, Valerie, additional, Małyszko, Jolanta, additional, Manski-Nankervis, Jo-Anne, additional, Navaneethan, Sankar D., additional, Obrador, Greg, additional, Ortiz, Alberto, additional, Ortiz, John, additional, Cardoso Dos Santos, Bento Fortunato, additional, Sarnak, Mark J., additional, Schaeffner, Elke, additional, Selby, Nick M., additional, Simpson, David M., additional, Solá, Laura, additional, St. Peter, Wendy L., additional, Stevens, Paul E., additional, Tangri, Navdeep, additional, Tannor, Elliot Koranteng, additional, Tchokhonelidze, Irma, additional, Wilck, Nicola, additional, and Wong, Michelle M.Y., additional

Published
2023
Full Text
View/download PDF

33. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Krane, Vera, additional, Saritas, Turgay, additional, Busch, Martin, additional, Schultheiss, Ulla T., additional, Meiselbach, Heike, additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Floege, Jürgen, additional, Kronenberg, Florian, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
Full Text
View/download PDF

35. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Sommerer, Claudia, primary, Müller-Krebs, Sandra, additional, Nadal, Jennifer, additional, Schultheiss, Ulla T., additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Schmid, Matthias, additional, Nußhag, Christian, additional, Reiser, Jochen, additional, Eckardt, Kai-Uwe, additional, Zeier, Martin, additional, Hayek, Salim S., additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Kraska, Detlef, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Alberth-Schmidt, Ulrike, additional, Marschall, Sabine, additional, Schefler, Eugenia, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Schmidt-Ott, Kai, additional, Sommerer, Claudia, additional, Aykac, Mehtap, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
Full Text
View/download PDF

36. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Canney, Mark, primary, Induruwage, Dilshani, additional, Tang, Mila, additional, Alencar de Pinho, Natalia, additional, Er, Lee, additional, Zhao, Yinshan, additional, Djurdjev, Ognjenka, additional, Ahn, Yo Han, additional, Behnisch, Rouven, additional, Calice-Silva, Viviane, additional, Chesnaye, Nicholas C., additional, de Borst, Martin H., additional, Dember, Laura M., additional, Dionne, Janis, additional, Ebert, Natalie, additional, Eder, Susanne, additional, Fenton, Anthony, additional, Fukagawa, Masafumi, additional, Furth, Susan L., additional, Hoy, Wendy E., additional, Imaizumi, Takahiro, additional, Jager, Kitty J., additional, Jha, Vivekanand, additional, Kang, Hee Gyung, additional, Kitiyakara, Chagriya, additional, Mayer, Gert, additional, Oh, Kook-Hwan, additional, Onu, Ugochi, additional, Pecoits-Filho, Roberto, additional, Reichel, Helmut, additional, Richards, Anna, additional, Schaefer, Franz, additional, Schaeffner, Elke, additional, Scheppach, Johannes B., additional, Sola, Laura, additional, Ulasi, Ifeoma, additional, Wang, Jinwei, additional, Yadav, Ashok K., additional, Zhang, Jianzhen, additional, Feldman, Harold I., additional, Taal, Maarten W., additional, Stengel, Bénédicte, additional, Levin, Adeera, additional, Ahn, Curie, additional, Berger, Stefan P., additional, Caskey, Fergus J., additional, Cho, Min Hyun, additional, Cho, Heeyeon, additional, Dekker, Friedo W., additional, Diwan, Vishal, additional, Drechsler, Christiane, additional, Eckardt, Kai-Uwe, additional, Evans, Marie, additional, Ferreiro, Alejandro, additional, Floege, Jürgen, additional, Gadola, Liliana, additional, Haller, Hermann, additional, Han, Kyung Hee, additional, Healy, Helen G., additional, Heerspink, Hiddo Lambers, additional, Hemmelder, Marc, additional, Hiemstra, Thomas, additional, Hilbrands, Luuk, additional, Kim, Seong Heon, additional, Klyprayong, Pinkaew, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Lamadrid, Veronica, additional, Lee, Joo Hoo, additional, Mark, Patrick, additional, Matheson, Matt, additional, Mi, Eun, additional, Noppakun, Kajohnsak, additional, Oefner, Peter, additional, Panaput, Thanachai, additional, Park, Young Seo, additional, Prokosch, Hans-Ulrich, additional, Reis, André, additional, Rios, Pablo, additional, Rosivall, Laszlo, additional, Rotmans, Joris I., additional, Sackeyfio, Alfred, additional, Sangthawan, Pornpen, additional, Schmid, Matthias, additional, Shin, Jae Il, additional, Silavarino, Ricardo, additional, Sitter, Thomas, additional, Sommerer, Claudia, additional, Szymczak, Maciej, additional, Torino, Claudia, additional, Toth, Janos, additional, van Ittersum, Frans J., additional, Venuthurupalli, Sree Krishna, additional, Verhaar, Marianne C., additional, Wang, Zaimin, additional, Wanner, Christoph, additional, Wiecek, Andrzej, additional, Wolf, Gunter, additional, de Zeeuw, Dick, additional, Zhang, Luxia, additional, Zheng, Yuyan, additional, Zhao, Ming-Hui, additional, and Zietse, Robert, additional

Published
2023
Full Text
View/download PDF

37. #5529 RED BLOOD CELL TRANSFUSION RATES IN THE INTERNATIONAL DOPPS PROGRAM (2012–2022): HEMODIALYSIS, PERITONEAL DIALYSIS, AND NON-DIALYSIS CKD POPULATIONS

Author

Karaboyas, Angelo, primary, Tu, Charlotte, additional, Hunnicutt, Jake, additional, Richards, Anna, additional, Pham, Timothy, additional, Asgari, Elham, additional, Guebre-Egziabher, Fitsum, additional, Schaeffner, Elke, additional, Lopes, Antonio Alberto, additional, Perl, Jeffrey, additional, and Pecoits-Filho, Roberto, additional

Published
2023
Full Text
View/download PDF

38. Diagnostic Validity of Chronic Kidney Disease in Health Claims Data Over Time: Results from a Cohort of Community-Dwelling Older Adults in Germany.

Author

Bothe, Tim, Fietz, Anne-Katrin, Schaeffner, Elke, Douros, Antonios, Pöhlmann, Anna, Mielke, Nina, Villain, Cédric, Barghouth, Muhammad Helmi, Wenning, Volker, and Ebert, Natalie

Subjects
CHRONIC kidney failure, OLDER patients, FRAIL elderly, GLOMERULAR filtration rate, ADULTS, OLDER people
Abstract

Purpose: The validity of ICD-10 diagnostic codes for chronic kidney disease (CKD) in health claims data has not been sufficiently studied in the general population and over time. Patients and Methods: We used data from the Berlin Initiative Study (BIS), a prospective longitudinal cohort of community-dwelling individuals aged ≥ 70 years in Berlin, Germany. With estimated glomerular filtration rate (eGFR) as reference, we assessed the diagnostic validity (sensitivity, specificity, positive [PPV], and negative predictive values [NPV]) of different claims-based ICD-10 codes for CKD stages G3-5 (eGFR < 60mL/min/1.73m²: ICD-10 N18.x-N19), G3 (eGFR 30–< 60mL/min/1.73m²: N18.3), and G4-5 (eGFR < 30mL/min/1.73m²: N18.4– 5). We analysed trends over five study visits (2009– 2019). Results: We included data of 2068 participants at baseline (2009– 2011) and 870 at follow-up 4 (2018– 2019), of whom 784 (38.9%) and 440 (50.6%) had CKD G3-5, respectively. At baseline, sensitivity for CKD in claims data ranged from 0.25 (95%-confidence interval [CI] 0.22– 0.28) to 0.51 (95%-CI 0.48– 0.55) for G3-5, depending on the included ICD-10 codes, 0.20 (95%-CI 0.18– 0.24) for G3, and 0.36 (95%-CI 0.25– 0.49) for G4-5. Over the course of 10 years, sensitivity increased by 0.17 to 0.29 in all groups. Specificity, PPVs, and NPVs remained mostly stable over time and ranged from 0.82– 0.99, 0.47– 0.89, and 0.66– 0.98 across all study visits, respectively. Conclusion: German claims data showed overall agreeable performance in identifying older adults with CKD, while differentiation between stages was limited. Our results suggest increasing sensitivity over time possibly attributable to improved CKD diagnosis and awareness. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

40. Differential prognostic utility of adiposity measures in chronic kidney disease

Author

Cejka, Vladimir, primary, Störk, Stefan, additional, Nadal, Jennifer, additional, Schmid, Matthias, additional, Sommerer, Claudia, additional, Sitter, Thomas, additional, Meiselbach, Heike, additional, Busch, Martin, additional, Schneider, Markus P., additional, Saritas, Turgay, additional, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Krane, Vera, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Zeier, Martin, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
Full Text
View/download PDF

41. Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes : An Individual-Participant Data Meta-Analysis.

Author

Grams, Morgan E, Coresh, Josef, Matsushita, Kunihiro, Ballew, Shoshana H, Sang, Yingying, Surapaneni, Aditya, Alencar de Pinho, Natalia, Anderson, Amanda, Appel, Lawrence J, Ärnlöv, Johan, Azizi, Fereidoun, Bansal, Nisha, Bell, Samira, Bilo, Henk J G, Brunskill, Nigel J, Carrero, Juan J, Chadban, Steve, Chalmers, John, Chen, Jing, Ciemins, Elizabeth, Cirillo, Massimo, Ebert, Natalie, Evans, Marie, Ferreiro, Alejandro, Fu, Edouard L, Larsson, Anders, Gutierrez, Orlando M, Herrington, William G, Hwang, Shih-Jen, Inker, Lesley A, Iseki, Kunitoshi, Jafar, Tazeen, Jassal, Simerjot K, Jha, Vivekanand, Kadota, Aya, Katz, Ronit, Köttgen, Anna, Konta, Tsuneo, Kronenberg, Florian, Lee, Brian J, Lees, Jennifer, Levin, Adeera, Looker, Helen C, Major, Rupert, Melzer Cohen, Cheli, Mieno, Makiko, Miyazaki, Mariko, Moranne, Olivier, Muraki, Isao, Naimark, David, Nitsch, Dorothea, Oh, Wonsuk, Pena, Michelle, Purnell, Tanjala S, Sabanayagam, Charumathi, Satoh, Michihiro, Sawhney, Simon, Schaeffner, Elke, Schöttker, Ben, Shen, Jenny I, Shlipak, Michael G, Sinha, Smeeta, Stengel, Benedicte, Sumida, Keiichi, Tonelli, Marcello, Valdivielso, Jose M, van Zuilen, Arjan D, Visseren, Frank L J, Wang, Angela Yee-Moon, Wen, Chi-Pang, Wheeler, David C, Yatsuya, Hiroshi, Yamagata, Kunihiro, Yang, Jae Won, Young, Ann, Zhang, Haitao, Zhang, Luxia, Levey, Andrew S, Gansevoort, Ron T, Grams, Morgan E, Coresh, Josef, Matsushita, Kunihiro, Ballew, Shoshana H, Sang, Yingying, Surapaneni, Aditya, Alencar de Pinho, Natalia, Anderson, Amanda, Appel, Lawrence J, Ärnlöv, Johan, Azizi, Fereidoun, Bansal, Nisha, Bell, Samira, Bilo, Henk J G, Brunskill, Nigel J, Carrero, Juan J, Chadban, Steve, Chalmers, John, Chen, Jing, Ciemins, Elizabeth, Cirillo, Massimo, Ebert, Natalie, Evans, Marie, Ferreiro, Alejandro, Fu, Edouard L, Larsson, Anders, Gutierrez, Orlando M, Herrington, William G, Hwang, Shih-Jen, Inker, Lesley A, Iseki, Kunitoshi, Jafar, Tazeen, Jassal, Simerjot K, Jha, Vivekanand, Kadota, Aya, Katz, Ronit, Köttgen, Anna, Konta, Tsuneo, Kronenberg, Florian, Lee, Brian J, Lees, Jennifer, Levin, Adeera, Looker, Helen C, Major, Rupert, Melzer Cohen, Cheli, Mieno, Makiko, Miyazaki, Mariko, Moranne, Olivier, Muraki, Isao, Naimark, David, Nitsch, Dorothea, Oh, Wonsuk, Pena, Michelle, Purnell, Tanjala S, Sabanayagam, Charumathi, Satoh, Michihiro, Sawhney, Simon, Schaeffner, Elke, Schöttker, Ben, Shen, Jenny I, Shlipak, Michael G, Sinha, Smeeta, Stengel, Benedicte, Sumida, Keiichi, Tonelli, Marcello, Valdivielso, Jose M, van Zuilen, Arjan D, Visseren, Frank L J, Wang, Angela Yee-Moon, Wen, Chi-Pang, Wheeler, David C, Yatsuya, Hiroshi, Yamagata, Kunihiro, Yang, Jae Won, Young, Ann, Zhang, Haitao, Zhang, Luxia, Levey, Andrew S, and Gansevoort, Ron T

Abstract

IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. OBJECTIVE: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. DESIGN, SETTING, AND PARTICIPANTS: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. EXPOSURES: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). MAIN OUTCOMES AND MEASURES: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. RESULTS: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 11 mg/g (IQR, 8-16 mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR, 6-18 mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associ

Published
2023
Full Text
View/download PDF

42. Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex

Author

Pottel, Hans, Björk, Jonas, Rule, Andrew D., Ebert, Natalie, Eriksen, Björn O., Dubourg, Laurence, Vidal-Petiot, Emmanuelle, Grubb, Anders, Hansson, Magnus, Lamb, Edmund J., Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Schaeffner, Elke, Sundin, Per-Ola, Åkesson, Anna, Larsson, Anders, Cavalier, Etienne, Bukabau, Justine B., Sumaili, Ernest K., Yayo, Eric, Monnet, Dagui, Flamant, Martin, Nyman, Ulf, Delanaye, Pierre, Pottel, Hans, Björk, Jonas, Rule, Andrew D., Ebert, Natalie, Eriksen, Björn O., Dubourg, Laurence, Vidal-Petiot, Emmanuelle, Grubb, Anders, Hansson, Magnus, Lamb, Edmund J., Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Schaeffner, Elke, Sundin, Per-Ola, Åkesson, Anna, Larsson, Anders, Cavalier, Etienne, Bukabau, Justine B., Sumaili, Ernest K., Yayo, Eric, Monnet, Dagui, Flamant, Martin, Nyman, Ulf, and Delanaye, Pierre

Abstract

Background The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is divided by the median serum creatinine level among healthy persons to control for variation related to differences in age, sex, or race). Whether a cystatin C–based EKFC equation would increase the accuracy of estimated GFR is unknown. Methods We used data from patients in Sweden to estimate the rescaling factor for the cystatin C level in adults. We then replaced rescaled serum creatinine in the EKFC eGFRcr equation with rescaled cystatin C, and we validated the resulting EKFC eGFRcys equation in cohorts of White patients and Black patients in Europe, the United States, and Africa, according to measured GFR, levels of serum creatinine and cystatin C, age, and sex. Results On the basis of data from 227,643 patients in Sweden, the rescaling factor for cystatin C was estimated at 0.83 for men and women younger than 50 years of age and 0.83+0.005×(age–50) for those 50 years of age or older. The EKFC eGFRcys equation was unbiased, had accuracy that was similar to that of the EKFC eGFRcr equation in both White patients and Black patients (11,231 patients from Europe, 1093 from the United States, and 508 from Africa), and was more accurate than the Chronic Kidney Disease Epidemiology Collaboration eGFRcys equation recommended by Kidney Disease: Improving Global Outcomes. The arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of estimated GFR over estimates from either biomarker equation alone. Conclusions The EKFC eGFRcys equation had the same mathematical form as the EKFC eGFRcr equation, but it had a scaling factor for cystatin C that did not differ acco

Published
2023
Full Text
View/download PDF

43. Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil, and Africa

Author

Delanaye, Pierre, Vidal-Petiot, Emmanuelle, Björk, Jonas, Ebert, Natalie, Eriksen, Björn O., Dubourg, Laurence, Grubb, Anders, Hansson, Magnus, Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Schaeffner, Elke, Sundin, Per-Ola, Bökenkamp, Arend, Berg, Ulla B., Åsling-Monemi, Kajsa, Åkesson, Anna, Larsson, Anders, Cavalier, Etienne, Dalton, R. Neil, Courbebaisse, Marie, Couzi, Lionel, Gaillard, Francois, Garrouste, Cyril, Jacquemont, Lola, Kamar, Nassim, Legendre, Christophe, Rostaing, Lionel, Stehlé, Thomas, Haymann, Jean-Philippe, da Silva Selistre, Luciano, Strogoff-de-Matos, Jorge P., Bukabau, Justine B., Sumaili, Ernest K., Yayo, Eric, Monnet, Dagui, Nyman, Ulf, Pottel, Hans, Flamant, Martin, Delanaye, Pierre, Vidal-Petiot, Emmanuelle, Björk, Jonas, Ebert, Natalie, Eriksen, Björn O., Dubourg, Laurence, Grubb, Anders, Hansson, Magnus, Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Schaeffner, Elke, Sundin, Per-Ola, Bökenkamp, Arend, Berg, Ulla B., Åsling-Monemi, Kajsa, Åkesson, Anna, Larsson, Anders, Cavalier, Etienne, Dalton, R. Neil, Courbebaisse, Marie, Couzi, Lionel, Gaillard, Francois, Garrouste, Cyril, Jacquemont, Lola, Kamar, Nassim, Legendre, Christophe, Rostaing, Lionel, Stehlé, Thomas, Haymann, Jean-Philippe, da Silva Selistre, Luciano, Strogoff-de-Matos, Jorge P., Bukabau, Justine B., Sumaili, Ernest K., Yayo, Eric, Monnet, Dagui, Nyman, Ulf, Pottel, Hans, and Flamant, Martin

Abstract

BACKGROUND: A new Chronic Kidney Disease Epidemiology equation without race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared to the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts. METHODS: Standardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France, (n = 4429, including 964 Black Europeans), from Brazil (n = 100), and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed. RESULTS: In White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of -0.6 and -3.2, respectively versus 5.0 mL/min/1.73m², and accuracy within 30% of 86.9 and 87.4, respectively versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value ( = concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans, and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males. CONCLUSION: In a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated, population-specific Q-values presents the best performance in the whole age range in the European and African populations included in this study.

Published
2023
Full Text
View/download PDF

44. Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP

Author

Interne Geneeskunde Vasculaire, Nefro Vasculaire Geneeskunde, Circulatory Health, MS Interne Geneeskunde, Matsushita, Kunihiro, Kaptoge, Stephen, Hageman, Steven H.J., Sang, Yingying, Ballew, Shoshana H., Grams, Morgan E., Surapaneni, Aditya, Sun, Luanluan, Arnlov, Johan, Bozic, Milica, Brenner, Hermann, Brunskill, Nigel J., Chang, Alex R., Chinnadurai, Rajkumar, Cirillo, Massimo, Correa, Adolfo, Ebert, Natalie, Eckardt, Kai Uwe, Gansevoort, Ron T., Gutierrez, Orlando, Hadaegh, Farzad, He, Jiang, Hwang, Shih Jen, Jafar, Tazeen H., Jassal, Simerjot K., Kayama, Takamasa, Kovesdy, Csaba P., Landman, Gijs W., Levey, Andrew S., Lloyd-Jones, Donald M., Major, Rupert W., Miura, Katsuyuki, Muntner, Paul, Nadkarni, Girish N., Nowak, Christoph, Ohkubo, Takayoshi, Pena, Michelle J., Polkinghorne, Kevan R., Sairenchi, Toshimi, Schaeffner, Elke, Schneider, Markus P., Shalev, Varda, Shlipak, Michael G., Solbu, Marit D., Stempniewicz, Nikita, Tollitt, James, Valdivielso, José M., Van Der Leeuw, Joep, Dorresteijn, Jannick A.N., Visseren, Frank L.J., Interne Geneeskunde Vasculaire, Nefro Vasculaire Geneeskunde, Circulatory Health, MS Interne Geneeskunde, Matsushita, Kunihiro, Kaptoge, Stephen, Hageman, Steven H.J., Sang, Yingying, Ballew, Shoshana H., Grams, Morgan E., Surapaneni, Aditya, Sun, Luanluan, Arnlov, Johan, Bozic, Milica, Brenner, Hermann, Brunskill, Nigel J., Chang, Alex R., Chinnadurai, Rajkumar, Cirillo, Massimo, Correa, Adolfo, Ebert, Natalie, Eckardt, Kai Uwe, Gansevoort, Ron T., Gutierrez, Orlando, Hadaegh, Farzad, He, Jiang, Hwang, Shih Jen, Jafar, Tazeen H., Jassal, Simerjot K., Kayama, Takamasa, Kovesdy, Csaba P., Landman, Gijs W., Levey, Andrew S., Lloyd-Jones, Donald M., Major, Rupert W., Miura, Katsuyuki, Muntner, Paul, Nadkarni, Girish N., Nowak, Christoph, Ohkubo, Takayoshi, Pena, Michelle J., Polkinghorne, Kevan R., Sairenchi, Toshimi, Schaeffner, Elke, Schneider, Markus P., Shalev, Varda, Shlipak, Michael G., Solbu, Marit D., Stempniewicz, Nikita, Tollitt, James, Valdivielso, José M., Van Der Leeuw, Joep, Dorresteijn, Jannick A.N., and Visseren, Frank L.J.

Published
2023

48. Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex

Author

Pottel, Hans, primary, Björk, Jonas, additional, Rule, Andrew D., additional, Ebert, Natalie, additional, Eriksen, Björn O., additional, Dubourg, Laurence, additional, Vidal-Petiot, Emmanuelle, additional, Grubb, Anders, additional, Hansson, Magnus, additional, Lamb, Edmund J., additional, Littmann, Karin, additional, Mariat, Christophe, additional, Melsom, Toralf, additional, Schaeffner, Elke, additional, Sundin, Per-Ola, additional, Åkesson, Anna, additional, Larsson, Anders, additional, Cavalier, Etienne, additional, Bukabau, Justine B., additional, Sumaili, Ernest K., additional, Yayo, Eric, additional, Monnet, Dagui, additional, Flamant, Martin, additional, Nyman, Ulf, additional, and Delanaye, Pierre, additional

Published
2023
Full Text
View/download PDF

49. The new, race-free, Chronic Kidney Disease Epidemiology Consortium (CKD-EPI) equation to estimate glomerular filtration rate: is it applicable in Europe? A position statement by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Author

Delanaye, Pierre, primary, Schaeffner, Elke, additional, Cozzolino, Mario, additional, Langlois, Michel, additional, Plebani, Mario, additional, Ozben, Tomris, additional, and Cavalier, Etienne, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results