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1. Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study

Author

Afroze, Farzana, Khoshnevisan, Farnaz, Harawa, Philliness Prisca, Islam, Zahidul, Bourdon, Celine, Khoswe, Stanley, Islam, Munirul, Sarker, Shafiqul Alam, Islam, Farhana, Sayeem Bin Shahid, Abu Sadat Mohammad, Joosten, Koen, Hulst, Jessie M., Eneya, Chisomo, Walson, Judd L., Berkley, James A., Potani, Isabel, Voskuijl, Wieger, Ahmed, Tahmeed, Chisti, Mohammod Jobayer, and Bandsma, Robert H. J.

Published
2024
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2. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Ashraful, Nahar Begum, SM Khodeza, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, Yilmaz, Omer H, Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, and Syed, Sana

Published
2024
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3. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, and Denno, Donna M

Published
2024
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4. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Zyambo, Kanekwa, Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, and Denno, Donna M

Published
2024
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5. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Zyambo, Kanekwa, Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Jr, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Ömer H Yilmaz, Raghavan, Shyam S, Moskaluk, Christopher A, and Liu, Ta-Chiang

Published
2024
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6. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Jr., Tarr, Phillip I, and Denson, Lee A

Published
2024
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7. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Jr., and Ali, S Asad

Published
2024
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8. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Jr, Sullivan, Peter B, and Tarr, Phillip I

Published
2024
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9. Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

Author

Nuzhat, Sharika, Palit, Parag, Mahfuz, Mustafa, Islam, Md Ridwan, Hasan, SM Tafsir, Islam, M Munirul, Sarker, Shafiqul A, Kyle, David J, Flannery, Robin L, Vinjamuri, Anita, Lebrilla, Carlito B, and Ahmed, Tahmeed

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Nutrition, Clinical Research, Reproductive health and childbirth, Zero Hunger, Female, Humans, Infant, Milk, Human, Mothers, Nutritional Status, Oligosaccharides, Single-Blind Method
Abstract

Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pilot clinical trial (NCT0366657). A total of 45 breastmilk samples from mothers of

Published
2022

11. A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning

Author

Vatanen, Tommi, Ang, Qi Yan, Siegwald, Léa, Sarker, Shafiqul Alam, Le Roy, Caroline I., Duboux, Stéphane, Delannoy-Bruno, Omar, Ngom-Bru, Catherine, Boulangé, Claire L., Stražar, Martin, Avila-Pacheco, Julian, Deik, Amy, Pierce, Kerry, Bullock, Kevin, Dennis, Courtney, Sultana, Shamima, Sayed, Sharika, Rahman, Mahbubar, Ahmed, Tahmeed, Modesto, Monica, Mattarelli, Paola, Clish, Clary B., Vlamakis, Hera, Plichta, Damian R., Sakwinska, Olga, and Xavier, Ramnik J.

Published
2022
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12. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multi-country analysis

Author

Ehsan, Lubaina, primary, Coomes, David, additional, Kelly, Paul, additional, Greene, Adam R., additional, Ali, S. Asad, additional, Mulenga, Chola, additional, Denno, Donna M., additional, VanBuskirk, Kelley, additional, Raghib, Muhammad Faraz, additional, Mahfuz, Mustafa, additional, Moore, Sean R., additional, Hossain, M. Shabab, additional, Ahmed, Tahmeed, additional, Sullivan, Peter B., additional, Moskaluk, Christopher A., additional, Syed, Sana, additional, Ahmed, Kumail, additional, Ahmed, Sheraz, additional, Alam, Md. Ashraful, additional, Begum, S.M. Khodeza Nahar, additional, Das, Subhasish, additional, Denson, Lee A., additional, Fahim, Shah Mohammad, additional, Gazi, Md. Amran, additional, Hasan, Md. Mehedi, additional, Hotwani, Aneeta, additional, Iqbal, Junaid, additional, Jamil, Zehra, additional, Kabir, Furqan, additional, Liu, Ta-Chiang, additional, Mazumder, Ramendra Nath, additional, Ragahavan, Shyam S., additional, Rahman, Masudur, additional, Rahman, Najeeb, additional, Sadiq, Kamran, additional, Sarker, Shafiqul Alam, additional, Tarr, Phillip I., additional, Tearney, Guillermo J., additional, Umrani, Fayaz, additional, Umutesi, Grace, additional, and Yilmaz, Omer H., additional

Published
2024
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13. Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition:a longitudinal study

Author

Afroze, Farzana, Khoshnevisan, Farnaz, Harawa, Philliness Prisca, Islam, Zahidul, Bourdon, Celine, Khoswe, Stanley, Islam, Munirul, Sarker, Shafiqul Alam, Islam, Farhana, Sayeem Bin Shahid, Abu Sadat Mohammad, Joosten, Koen, Hulst, Jessie M., Eneya, Chisomo, Walson, Judd L., Berkley, James A., Potani, Isabel, Voskuijl, Wieger, Ahmed, Tahmeed, Chisti, Mohammod Jobayer, Bandsma, Robert H.J., Afroze, Farzana, Khoshnevisan, Farnaz, Harawa, Philliness Prisca, Islam, Zahidul, Bourdon, Celine, Khoswe, Stanley, Islam, Munirul, Sarker, Shafiqul Alam, Islam, Farhana, Sayeem Bin Shahid, Abu Sadat Mohammad, Joosten, Koen, Hulst, Jessie M., Eneya, Chisomo, Walson, Judd L., Berkley, James A., Potani, Isabel, Voskuijl, Wieger, Ahmed, Tahmeed, Chisti, Mohammod Jobayer, and Bandsma, Robert H.J.

Abstract

There is scarce data on energy expenditure in ill children with different degrees of malnutrition. This study aimed to determine resting energy expenditure (REE) trajectories in hospitalized malnourished children during and after hospitalization. We followed a cohort of children in Bangladesh and Malawi (2–23 months) with: no wasting (NW); moderate wasting (MW), severe wasting (SW), or edematous malnutrition (EM). REE was measured by indirect calorimetry at admission, discharge, 14-and-45-days post-discharge. 125 children (NW, n = 23; MW, n = 29; SW, n = 51; EM, n = 22), median age 9 (IQR 6, 14) months, provided 401 REE measurements. At admission, the REE of children with NW and MW was 67 (95% CI [58, 75]) and 70 (95% CI [63, 76]) kcal/kg/day, respectively, while REE in children with SW was higher, 79 kcal/kg/day (95% CI [74, 84], p = 0.018), than NW. REE in these groups was stable over time. In children with EM, REE increased from admission to discharge (65 kcal/kg/day, 95% CI [56, 73]) to 79 (95% CI [72, 86], p = 0.0014) and was stable hereafter. Predictive equations underestimated REE in 92% of participants at all time points. Recommended feeding targets during the acute phase of illness in severely malnourished children exceeded REE. Acutely ill malnourished children are at risk of being overfed when implementing current international guidelines.

Published
2024

14. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental Enteric Dysfunction (EED) is an acquired disorder of asymptomatic altered gut function, the etiology of which is unknown. EED is postulated to be a major contributor to growth faltering in early childhood in regions where early-life enteropathogenic carriage is prevalent. Few studies have examined the critical organ (the upper small bowel) with enteropathogens in the evolution of small bowel disease.

Published
2024
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15. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., and Zyambo, Kanekwa

Abstract

Validated biomarkers could catalyze environmental enteric dysfunction (EED) research.

Published
2024
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16. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Yilmaz, Ömer H, Raghavan, Shyam S, Moskaluk, Christopher A, Liu, Ta-Chiang, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder associated with growth impairment, delayed neurocognitive development, and impaired oral vaccine responses.

Published
2024
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17. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Tarr, Phillip I, Denson, Lee A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an inflammatory condition of the small intestine that is prevalent in children residing in low- and middle-income countries. EED is accompanied by profound histopathologic changes in the small bowel, loss of absorptive capacity, increased intestinal permeability, increased microbial translocation, and nutrient loss.

Published
2024
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18. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Sullivan, Peter B, Tarr, Phillip I, Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, and Umrani, Fayaz

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic acquired disorder characterized by upper small bowel inflammation, villus blunting, and gut permeability. It is a major contributor to poor growth in childhood as well as other highly consequential outcomes such as delayed neuorcognitive development. After decades of intermittent interest in this entity, we are now seeing a resurgence in the field of EED. However, recent studies have been hampered by a lack of investigation of the target tissue—the upper small bowel. In 2016, the EEDBI (Environmental Enteric Dysfunction Biopsy Initiative) Consortium was established as a common scientific platform across 3 independent EED biopsy cohort studies in Bangladesh, Pakistan, and Zambia. Two centers in the United States recruited comparison groups of children undergoing endoscopy for clinical indications. The EEDBI Consortium goal was to augment the contributions of the individual centers and answer high-level questions amenable to analysis and interpretation across the studies. Here, we describe the Consortium and its cohorts and recruitment procedures across studies. We also offer details applicable to all papers in this supplement, which describe EED mucosal histology, morphometry, immunohistochemistry, and transcriptomics as well as histology relationship to pathogens and biomarkers.

Published
2024
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19. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Ali, S Asad, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, and Yilmaz, Omer H.

Abstract

Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic systemic inflammation.

Published
2024
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20. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, Syed, Sana, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Begum, SM Khodeza Nahar, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Md Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes.

Published
2024
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21. Detection and absolute quantification of Lactiplantibacillus plantarum ATCC 202195 by quantitative real-time PCR

Author

Shawon, Jakaria, primary, Pell, Lisa G., additional, Kabir, Mamun, additional, Evans, Kara, additional, Hasan, Mehedi, additional, Li, Grace, additional, Qamar, Huma, additional, Starke, Cody W. E., additional, Kurukulasuriya, Shakya, additional, Al Mahmud, Abdullah, additional, Sherman, Philip M., additional, Sarker, Shafiqul Alam, additional, Roth, Daniel E., additional, and Haque, Rashidul, additional

Published
2023
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24. Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh

Author

Hossain, Md. Shabab, primary, Begum, S. M. Khodeza Nahar, additional, Rahman, M Masudur, additional, Parvez, Mashud, additional, Mazumder, Ramendra Nath, additional, Sarker, Shafiqul Alam, additional, Hasan, Md. Mehedi, additional, Fahim, Shah Mohammad, additional, Gazi, Md. Amran, additional, Das, Subhasish, additional, Mahfuz, Mustafa, additional, and Ahmed, Tahmeed, additional

Published
2023
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26. Comparisons of the Rome III and Rome IV criteria for diagnosis of irritable bowel syndrome in Indian and Bangladeshi communities and internal shifts in the diagnostic categories of bowel disorders of gut–brain interactions.

Author

Ghoshal, Uday C., Rahman, M. Masudur, Pratap, Nitesh, Misra, Asha, Sarker, Shafiqul Alam, Hasan, Mahmud, Bangdiwala, Shrikant I., Palsson, Olafur S., and Sperber, Ami D.

Subjects
IRRITABLE colon, COMMUNITIES, DIAGNOSIS, PHYSICIANS, MENTAL depression, ABDOMINAL pain, ANXIETY disorders
Abstract

Background: Although the Rome IV criteria are the most recent criteria to diagnose irritable bowel syndrome (IBS), their sensitivity has been shown to be low in Chinese and Western populations. There are scanty data comparing the Rome III and Rome IV criteria in diagnosis of IBS in the Indian and Bangladeshi populations where abdominal pain, an essential component of diagnosis of IBS by the Rome IV criteria, is less in frequency and of lower severity. Methods: We analyzed the Indian and Bangladeshi data from the Rome Global Epidemiology Study to compare diagnostic sensitivity of the Rome III and Rome IV criteria for IBS, internal shifts in diagnostic categories of disorders of gut–brain interaction (DGBI), the severity of IBS diagnosed by the Rome III and Rome IV criteria, and consultation patterns in these populations. Key Results: The Rome IV criteria were less sensitive than the Rome III criteria to diagnose IBS in these populations, and the subjects with Rome III IBS shifted internally to other DGBI when the Rome IV criteria were applied. Moreover, Rome IV IBS subjects had greater symptom severity than the Rome III IBS. A third of people fulfilling diagnostic criteria for IBS consulted doctors, and those diagnosed using Rome IV criteria, those with higher anxiety and depression symptom score, lower global physical health score, and greater IBS symptom severity score had greater correlation coefficients with doctors' consultation. Conclusions and Inferences: The Rome IV diagnostic criteria for IBS are less sensitive than the Rome III criteria in Indian and Bangladesh communities. Application of the Rome IV criteria to people who meet the Rome III IBS criteria selects a subgroup of people with greater severity of symptoms, and hence, Rome IV IBS is more strongly associated with physician consultation. These findings may have important bearing in future iterations of the Rome criteria for a broader global applicability. [ABSTRACT FROM AUTHOR]

Published
2023
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27. A comprehensive intervention package including an egg- and milk-based snack improves the linear growth and dietary diversity of children under two years children in rural Bangladesh: A community-based cluster randomized controlled trial

Author

Ara, Gulshan, primary, Sanin, Kazi Istiaque, additional, Khanam, Mansura, additional, Sarker, Shafiqul Alam, additional, Tofail, Fahmida, additional, Nahar, Baitun, additional, Chowdhury, Imran Ahmed, additional, Boitchi, Anika Bushra, additional, Gibson, Sarah, additional, Afsana, Kaosar, additional, Askari, Sufia, additional, and Ahmed, Tahmeed, additional

Published
2022
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28. Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh

Author

Hossain, Md. Shabab, primary, Begum, S. M. Khodeza Nahar, additional, Rahman, M Masudur, additional, Parvez, Mashud, additional, Mazumder, Ramendra Nath, additional, Sarker, Shafiqul Alam, additional, Hasan, Md. Mehedi, additional, Fahim, Shah Mohammad, additional, Gazi, Md. Amran, additional, Das, Subhasish, additional, Mahfuz, Mustafa, additional, and Ahmed, Tahmeed, additional

Published
2022
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29. Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition

Author

Barratt, Michael J., primary, Nuzhat, Sharika, additional, Ahsan, Kazi, additional, Frese, Steven A., additional, Arzamasov, Aleksandr A., additional, Sarker, Shafiqul Alam, additional, Islam, M. Munirul, additional, Palit, Parag, additional, Islam, Md Ridwan, additional, Hibberd, Matthew C., additional, Nakshatri, Swetha, additional, Cowardin, Carrie A., additional, Guruge, Janaki L., additional, Byrne, Alexandra E., additional, Venkatesh, Siddarth, additional, Sundaresan, Vinaik, additional, Henrick, Bethany, additional, Duar, Rebbeca M., additional, Mitchell, Ryan D., additional, Casaburi, Giorgio, additional, Prambs, Johann, additional, Flannery, Robin, additional, Mahfuz, Mustafa, additional, Rodionov, Dmitry A., additional, Osterman, Andrei L., additional, Kyle, David, additional, Ahmed, Tahmeed, additional, and Gordon, Jeffrey I., additional

Published
2022
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30. Changing Epidemiology of Acute Respiratory Infections in Under-Two Children in Dhaka, Bangladesh

Author

Vidal, Karine, primary, Sultana, Shamima, additional, Patron, Alberto Prieto, additional, Salvi, Irene, additional, Shevlyakova, Maya, additional, Foata, Francis, additional, Rahman, Mahbubur, additional, Deeba, Iztiba Mallik, additional, Brüssow, Harald, additional, Ahmed, Tahmeed, additional, Sakwinska, Olga, additional, and Sarker, Shafiqul Alam, additional

Published
2022
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31. Evaluation of SIMESON, a training program to improve access to quality health care for pregnant women and newborn in different healthcare facilities of northern Bangladesh.

Author

Das, Rina, Farzana, Fahmida Dil, Sultana, Zakia, Mukherji, Kallol, Baayo, Adnan, Sultana, Marufa, Ali, Nausad, Chisti, Mohammod Jobayer, Sarker, Shafiqul Alam, Ahmed, Tahmeed, and Faruque, ASG

Subjects
MEDICAL quality control, MATERNAL health services, HEALTH services accessibility, EVALUATION of human services programs, PROFESSIONS, SCIENTIFIC observation, RESEARCH methodology, MEDICAL care costs, INTERVIEWING, ABILITY, TRAINING, PROFESSIONAL competence, NURSES, QUESTIONNAIRES, POSTNATAL care, PERSONNEL management
Abstract

Aim: The study aims to explore the current knowledge and skills of healthcare providers already trained by SIMESON (simulation for essential skills for obstetrical and neonatal care), in reviewing perinatal health situations including current status of healthcare facilities and cost estimation. Design: It was an observational study. Methods: Cost estimation following both quantitative and qualitative approaches was also attempted. Result: Knowledge and skills of 88 healthcare providers about the provision of normal delivery and immediate postpartum care, management of postpartum haemorrhage (PPH), retained placenta and use of bag and mask ventilation to help a baby breathe were found to be considerably strengthened following SIMESON training. During the 6 months after training, there were 477 PPH cases managed successfully with only one death; neonatal deaths observed were 6.6/1,000 live births; twice the number of facility deliveries; and 80% use rate of Ambu bag for helping baby breathe. The estimated cost per trainee was 395.68 USD, and 5.85 USD per beneficiary. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Bifidobacterium infantistreatment promotes weight gain in Bangladeshi infants with severe acute malnutrition

Author

Barratt, Michael J., Nuzhat, Sharika, Ahsan, Kazi, Frese, Steven A., Arzamasov, Aleksandr A., Sarker, Shafiqul Alam, Islam, M. Munirul, Palit, Parag, Islam, Md Ridwan, Hibberd, Matthew C., Nakshatri, Swetha, Cowardin, Carrie A., Guruge, Janaki L., Byrne, Alexandra E., Venkatesh, Siddarth, Sundaresan, Vinaik, Henrick, Bethany, Duar, Rebbeca M., Mitchell, Ryan D., Casaburi, Giorgio, Prambs, Johann, Flannery, Robin, Mahfuz, Mustafa, Rodionov, Dmitry A., Osterman, Andrei L., Kyle, David, Ahmed, Tahmeed, and Gordon, Jeffrey I.

Abstract

Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longumsubspecies infantisis a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infantisis lower in 3- to 24-month-old Bangladeshi infants with severe acute malnutrition (SAM) compared to their healthy age-matched counterparts. A single-blind, placebo-controlled trial (SYNERGIE) was conducted in 2- to 6-month-old Bangladeshi infants with SAM. A commercial U.S. donor–derived B. infantisstrain (EVC001) was administered daily with or without the HMO lacto-N-neotetraose for 28 days. This intervention increased fecal B. infantisabundance in infants with SAM, although to levels still 10- to 100-fold lower than in untreated healthy controls. EVC001 treatment promoted weight gain that was associated with reduced intestinal inflammation markers in infants with SAM. We cultured fecal B. infantisstrains from Bangladeshi infants and colonized gnotobiotic mice with these cultured strains. The gnotobiotic mice were fed a diet representative of that consumed by 6-month-old Bangladeshi infants, with or without HMO supplementation. One B. infantisstrain, Bg_2D9, expressing two gene clusters involved in uptake and utilization of N-glycans and plant-derived polysaccharides, exhibited superior fitness over EVC001. The fitness advantage of Bg_2D9 was confirmed in a gnotobiotic mouse model of mother-to-infant gut microbiota transmission where dams received a pretreatment fecal community from a SAM infant in the SYNERGIE trial. Whether Bg_2D9 is superior to EVC001 for treating malnourished infants who consume a diet with limited breastmilk requires further clinical testing.

Published
2022
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