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27 results on '"Salazar, Felix"'

2. Figure S4 from 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

Author

Chan, Ann M., primary, Olafsen, Tove, primary, Tsui, Jessica, primary, Salazar, Felix B., primary, Aguirre, Brian, primary, Zettlitz, Kirstin A., primary, Condro, Michael, primary, Wu, Anna M., primary, Braun, Jonathan, primary, Gordon, Lynn K., primary, Ashki, Negin, primary, Whitelegge, Julian, primary, Xu, Shili, primary, Ikotun, Oluwatayo, primary, Lee, Jason Thanh, primary, and Wadehra, Madhuri, primary

Published
2024
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3. Data from 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

Author

Chan, Ann M., primary, Olafsen, Tove, primary, Tsui, Jessica, primary, Salazar, Felix B., primary, Aguirre, Brian, primary, Zettlitz, Kirstin A., primary, Condro, Michael, primary, Wu, Anna M., primary, Braun, Jonathan, primary, Gordon, Lynn K., primary, Ashki, Negin, primary, Whitelegge, Julian, primary, Xu, Shili, primary, Ikotun, Oluwatayo, primary, Lee, Jason Thanh, primary, and Wadehra, Madhuri, primary

Published
2024
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4. Supplemental Tables from 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

Author

Chan, Ann M., primary, Olafsen, Tove, primary, Tsui, Jessica, primary, Salazar, Felix B., primary, Aguirre, Brian, primary, Zettlitz, Kirstin A., primary, Condro, Michael, primary, Wu, Anna M., primary, Braun, Jonathan, primary, Gordon, Lynn K., primary, Ashki, Negin, primary, Whitelegge, Julian, primary, Xu, Shili, primary, Ikotun, Oluwatayo, primary, Lee, Jason Thanh, primary, and Wadehra, Madhuri, primary

Published
2024
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5. Supplementary Data from 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

Author

Chan, Ann M., primary, Olafsen, Tove, primary, Tsui, Jessica, primary, Salazar, Felix B., primary, Aguirre, Brian, primary, Zettlitz, Kirstin A., primary, Condro, Michael, primary, Wu, Anna M., primary, Braun, Jonathan, primary, Gordon, Lynn K., primary, Ashki, Negin, primary, Whitelegge, Julian, primary, Xu, Shili, primary, Ikotun, Oluwatayo, primary, Lee, Jason Thanh, primary, and Wadehra, Madhuri, primary

Published
2024
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6. 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

Author

Chan, Ann M., primary, Olafsen, Tove, additional, Tsui, Jessica, additional, Salazar, Felix B., additional, Aguirre, Brian, additional, Zettlitz, Kirstin A., additional, Condro, Michael, additional, Wu, Anna M., additional, Braun, Jonathan, additional, Gordon, Lynn K., additional, Ashki, Negin, additional, Whitelegge, Julian, additional, Xu, Shili, additional, Ikotun, Oluwatayo, additional, Lee, Jason Thanh., additional, and Wadehra, Madhuri, additional

Published
2024
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7. Mature Spinal Teratoma: A Case Report

Author

Del Pino-Camposeco, Jorge, primary, Villanueva-Castro, Eliezer, additional, Canela-Calderon, Obet, additional, Ponce-Gómez, Juan Antonio, additional, Salazar Felix, Noe Alejandro, additional, and Arriada-Mendicoa, Juan Nicasio, additional

Published
2024
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8. Abstract A088: Radiopharmaceutical therapy for pancreatic cancer: Engineered anti-prostate stem cell antigen (PSCA) antibody demonstrates targeted imaging and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)

Author

Chen, Bao Ying, primary, Ahmed, Saad N., additional, Salazar, Felix, additional, Jaiswal, Sunidhi, additional, Farshbaf, Masoud, additional, Chean, Jennifer, additional, Sherman, Anakim, additional, Hong, Teresa, additional, Yazaki, Paul J., additional, Olafsen, Tove, additional, Zettlitz, Kirstin A., additional, and Wu, Anna M., additional

Published
2024
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12. Epidemiology of Intracranial Meningiomas in Mexico: Cohort of the National Institute of Neurology and Neurosurgery During the Last Decade

Author

Alvaro-Heredia, Juan Antonio, primary, Salazar Felix, Noe Alejandro, additional, López-Valencia, German, additional, Moncada-Habib, Tomas, additional, Castro-Vega, Jorge Ivan, additional, Rodríguez-Hernández, Luis A, additional, Mondragón-Soto, Michel, additional, Muñuzuri-Camacho, Marco Antonio, additional, Alvaro-Heredia, Isidro, additional, and González-Aguilar, Alberto, additional

Published
2023
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22. Surface irregularity factor as a parameter to evaluate the fatigue damage state of CFRP

Author

Zuluaga Ramírez, Pablo, Frövel, Malte, Belenguer Dávila, Tomás, Salazar, Felix, Zuluaga Ramírez, Pablo, Frövel, Malte, Belenguer Dávila, Tomás, and Salazar, Felix

Abstract

Received: 18 September 2015 / Accepted: 30 October 2015 / Published: 11 November 2015 Este artículo pertenece al Número Especial: "Failure analysis in materials"., This work presents an optical non-contact technique to evaluate the fatigue damage state of CFRP structures measuring the irregularity factor of the surface. This factor includes information about surface topology and can be measured easily on field, by techniques such as optical perfilometers. The surface irregularity factor has been correlated with stiffness degradation, which is a well-accepted parameter for the evaluation of the fatigue damage state of composite materials. Constant amplitude fatigue loads (CAL) and realistic variable amplitude loads (VAL), representative of real in- flight conditions, have been applied to “dog bone” shaped tensile specimens. It has been shown that the measurement of the surface irregularity parameters can be applied to evaluate the damage state of a structure, and that it is independent of the type of fatigue load that has caused the damage. As a result, this measurement technique is applicable for a wide range of inspections of composite material structures, from pressurized tanks with constant amplitude loads, to variable amplitude loaded aeronautical structures such as wings and empennages, up to automotive and other industrial applications., Instituto Nacional de Técnica Aeroespacial (INTA), Ministerio de Economía y Competetividad (MINECO), Sección Deptal. de Óptica (Óptica), Fac. de Óptica y Optometría, TRUE, pub

Published
2023

23. Optical sensing of the fatigue damage state of CFRP under realistic aeronautical load sequences

Author

Zuloaga-Ramirez, Pablo, Arconada, Alvaro, Frövel, Malte, Belenguer, Tomas, Salazar, Felix, Zuloaga-Ramirez, Pablo, Arconada, Alvaro, Frövel, Malte, Belenguer, Tomas, and Salazar, Felix

Abstract

We present an optical sensing methodology to estimate the fatigue damage stateof structures made of carbon fiber reinforced polymer (CFRP), by measuring variations on the surface roughness. Variable amplitude loads (VAL), which represent realistic loads during aeronautical missions of fighter aircraft (FALSTAFF) have been applied to coupons until failure. Stiffness degradation and surface roughness variations have been measured during the life of the coupons obtaining a Pearson correlation of 0.75 between both variables. The data were compared with a previous study for Constant Amplitude Load (CAL) obtaining similar results. Conclusions suggest that the surface roughness measured in strategic zones is a useful technique for structural health monitoring of CFRP structures, and that it is independent of the type of load applied. Surface roughness can be measured in the field by optical techniques such as speckle, confocal perfilometers and interferometry, among others., Sección Deptal. de Óptica (Óptica), Fac. de Óptica y Optometría, TRUE, pub

Published
2023

24. Abstract 5372: CD3 and CD8 targeting of ionizable lipid nanoparticles for in vivo mRNA delivery to T cells

Author

Robinson, Elise R., primary, Kare, Aris J., additional, Kheirolomoom, Azadeh, additional, Inayathullah, Mohammed, additional, Tumbale, Spencer K., additional, Wu, Bo, additional, Raie, Marina N., additional, Seo, Jai W., additional, Salazar, Felix B., additional, Paulmurugan, Ramasamy, additional, Wu, Anna M., additional, and Ferrara, Katherine W., additional

Published
2022
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25. Sistema de monitoreo de medidas de bioseguridad con contador para permitir acceso a personas

Author

Villagomez Salazar, Felix Enrique, Coronel Alarcón, Joshua Ronny, and Cevallos Robalino, Lenin Estuardo

Subjects
DESARROLLO, HERRAMIENTAS TECNOLÓGICAS, SOFTWARE, WEB
Abstract

El presente proyecto de titulación presenta una cabina para el control del ingreso de usuarios que cumplan ciertas normas de bioseguridad establecidas, como lo son, el uso de la mascarilla, la ausencia de fiebre y un conteo de aforo máximo. The presents degree project presents a booth to control the entry of users who meet certain established biosafety standards, such as the use of the mask, the absence of fever and a maximum capacity count.

Published
2022

27. 89Zr-ImmunoPET Shows Therapeutic Efficacy of Anti-CD20-IFNα Fusion Protein in a Murine B-cell Lymphoma Model.

Author

Zettlitz KA, Salazar FB, Yamada RE, Trinh KR, Vasuthasawat A, Timmerman JM, Morrison SL, and Wu AM

Subjects
Animals, Cell Line, Tumor, Humans, Mice, Mice, Inbred C3H, Positron-Emission Tomography methods, Tissue Distribution, Zirconium therapeutic use, Lymphoma, B-Cell drug therapy, Radioisotopes therapeutic use
Abstract

Antibody-mediated tumor delivery of cytokines can overcome limitations of systemic administration (toxicity, short half-lives). Previous work showed improved antitumor potency of anti-CD20-IFNα fusion proteins in preclinical mouse models of B-cell lymphoma. Although tumor targeting is mediated by the antibody part of the fusion protein, the cytokine component might strongly influence biodistribution and pharmacokinetics, as a result of its affinity, size, valency, and receptor distribution. Here, we used immunoPET to study the in vivo biodistribution and tumor targeting of the anti-CD20 rituximab-murine IFNα1 fusion protein (Rit-mIFNα) and compared it with the parental mAb (rituximab, Rit). Rit-mIFNα and Rit were radiolabeled with zirconium-89 (89Zr, t1/2 78.4 hours) and injected into C3H mice bearing syngeneic B-cell lymphomas (38C13-hCD20). Dynamic [(2 hours post injection (p.i.)] and static (4, 24, and 72 hours) PET scans were acquired. Ex vivo biodistribution was performed after the final scan. Both 89Zr-Rit-mIFNα and 89Zr-Rit specifically target hCD20-expressing B-cell lymphoma in vivo. 89Zr-Rit-mIFNα showed specific uptake in tumors (7.6 ± 1.0 %ID/g at 75 hours p.i.), which was significantly lower than 89Zr-Rit (38.4 ± 9.9 %ID/g, P < 0.0001). ImmunoPET studies also revealed differences in the biodistribution, 89Zr-Rit-mIFNα showed rapid blood clearance and high accumulation in the liver compared with 89Zr-Rit. Importantly, immunoPET clearly revealed a therapeutic effect of the single 89Zr-Rit-mIFNα dose, resulting in smaller tumors and fewer lymph node metastases compared with mice receiving 89Zr-Rit. Mice receiving 89Zr-Rit-mIFNα had enlarged spleens, suggesting that systemic immune activation contributes to therapeutic efficacy in addition to the direct antitumoral activity of IFNα. In conclusion, immunoPET allows the noninvasive tracking and quantification of the antibody-cytokine fusion protein and helps understand the in vivo behavior and therapeutic efficacy., (©2022 American Association for Cancer Research.)

Published
2022
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