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The effects of adding 3% of natural preparations based on marl and mild paprika mixed with garlic (MPGar), ginger (MPGin) and/or turmeric (MPT) on the laying performance and egg qualities were studied in laying hens from 48 to 53 weeks. One hundred and twenty-eight H&N strain laying hens were randomly allocated to 4 treatments (8 replicates and 4 hens per replicate). Hens were fed the following diets for six weeks, respectively: 1) basal diet (control group without any addition); 2) the basal diet added with 30 g/kg of MPGar complex; 3) the basal diet added with 30 g/kg of MPGin complex; 4) the basal diet added with 30 g/kg of MPT complex. Laying performance (number, egg weight, egg mass, feed conversion ratio), egg qualities (albumen and yolk weight, Haugh units, yolk colour) and the eggshell strength were evaluated weekly. The results of this study showed that mixtures of natural preparations significantly improve the laying percentage, the egg mass and feed conversion ratio (P˂0.05). Moreover, compared to the control group, the yolk (%), the Haugh units and the yolk colour were impacted significantly in hens receiving the experimental diets (P˂0.05). On the other hand, although not significant, the mixtures (MPGar) and (MPGin) seem to improve the shell thickness (+2.4% and +1.7%, respectively). Results of this experiment highlight the value of marl and spices mixture to improve the laying performances and egg qualities. [ABSTRACT FROM AUTHOR]

We aimed to investigate ampicillin (AMP) mechanisms in microbiota-gut-brain axis. We evaluated its effect on two gut and brain regions and behavioral performances. We administred AMP (1 g/l) to BALB/c mice for 21 days. Then, we analyzed body weigth change, stool consistency scoring, gut length, intestinal microbiota composition, nitric oxide synthase 2 (NOS2) expression and tissue integrity. We subsequently evaluated NOS2, GFAP, CD68 and NFL cerebral expression and spatial memory.Interestingly, our data showed gut microbiota disruption, NOS2 upregulation and tissue damage, associated to cerebral NOS2, GFAP, CD68 and NFL over-expression and behavioral alteration. Antiobiotic therapy should be prescribed with great caution., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2023. Published by Elsevier B.V.)

Since the first detection of rabbit hemorrhagic disease (RHD), the rabbit hemorrhagic disease virus (RHDV) has been responsible for high morbidity and mortality worldwide, both in domestic and in wild rabbits. Despite the apparent control of RHD in rabbitries through vaccination, several studies highlighted the rapid evolution of RHDV by recombination, which may facilitate the emergence of new pathogenic strains. The aim of this study was to confirm the presence and characterize RHDV in Algeria. For this, rabbit samples were collected in the north of Algeria, between 2018 and 2021, from small farms where the virus was suspected after the sudden death of a high number of rabbits, and from healthy hunted wild rabbits. The domestic rabbits revealed clinical signs and lesions that were suggestive of RHD. RT-PCR showed that 79.31% of the domestic rabbit samples were positive for RHDV, while in 20.69%, including the hunted rabbits, the virus was not detected. Phylogenetic analysis of the Algerian strains allowed the confirmation and identification as GI.2 (RHDV2), and showed a close relation to GI.3P-GI.2 recombinant strains, suggesting a potential introduction from other countries, with an older strain potentially originated from neighboring Tunisia, while more recent isolates grouped with strains from North America. Our study reports for the first time the presence of GI.2 (RHDV2) in Algeria with multiple routes of introduction. Consequently, we propose that RHDV control in Algeria should be based on epidemiological surveys in association with an adequate prophylactic program., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Sahraoui, Lahouassa, Maziz-Bettahar, Lopes, Almeida, Ainbaziz and Abrantes.)