Search

This research work is designed to overcome the problems associated with the poorly aqueous soluble drug. Fenofibrate (FENO) being a BCS Class II drug shows low solubility with high permeability. Compatibility of the drug and polymer studies was done by FTIR. Physical mixtures (PM) of the drug and polymer HPMCAS were prepared by the trituration method. Fenofibrate solid dispersions (SD) were prepared by a common solvent technique ascribed to feasibility on a laboratory scale. The physical state of formulations was characterized by powder XRD and TGA. Solubility of a pure drug (FENO), Physical mixture, and SD were found to be 0.3, 0.78±0.15 to 1.15±0.28, and 2.17±0.37 to 3.25±0.14 mg/ml respectively. Percentage yield and percentage drug content were determined and found within a satisfactory range. The maximum cumulative percentage of drug release from the pure drug (FENO), Physical mixture, and SD was found to be 34.5%, 72.1 and 97.2% respectively at 60 minutes. A microscopy (SEM) study found that the prepared solid dispersion has porous morphology. The present study establishes the increased bioavailability of the optimized batch when compared with the pure FENO. There was a significant (50%) increase in absorption of Fenofibrate observed from the in vitro everted gut sac model. SD of FENO was developed successfully. The solubility of FENO was ameliorated significantly while compared with API (pure FENO). This research work found the formulation of SD preferable technique to enhance solubility and enhance dissolution of lipophilic drugs. [ABSTRACT FROM AUTHOR]

This research work designed to overcome the problems associated with poorly aqueous soluble drug. Fenofibrate (FENO) being BCS Class II drug shows low solubility but permeability is high. Compatibility of the drug and polymer studies was done by FTIR. Physical mixtures (PM) of the drug and polymer HPMCAS were prepared by trituration method. Fenofibrate solid dispersions (SD) were prepared by common solvent technique ascribed feasibility in laboratory scale. Physical state of formulations was characterized by powder XRD, TGA. Solubility of pure drug (FENO), Physical mixture and SD found to be 0.3, 0.78±0.15 to 1.15±0.28 and 2.17±0.37 to 3.25±0.14 mg/ml respectively. Percentage yield and percentage drug content were determined and found within satisfactory range. The maximum cumulative percentage of drug release from pure drug (FENO), Physical mixture and SD found to be 34.5%, 72.1 and 97.2% respectively at 60 minutes. Microscopy (SEM) study was found that the prepared solid dispersion has porous morphology. The present study establishes the increased bioavailability of the optimized batch when compared with the pure FENO. There was significant (50%) increase in absorption of Fenofibrate observed from the in vitro everted gut sac model. SD of FENO was developed successfully. The solubility of FENO was ameliorated significantly while compared with API (pure FENO). This research work found formulation of SD preferable technique to enhance solubility and enhance dissolution of lipophilic drugs. [ABSTRACT FROM AUTHOR]

The present work describes the synthesis of a new class of glycolipids with systematic variations in the linkage region, as well as in the aglycon part using Cu(I) catalyzed click reaction. The linkage region between sugar and the aglycon part was diversified using amide, amido-triazole and 5-benzoyl triazole moieties. The structural diversity of glycolipids was further amplified by incorporating several polar peptide foldamer groups such as triazole, amide, peptide, or N-aryl peptoid in the aglycon part. The newly designed glycolipids were derived from the amalgamation of different peptide bond mimics. This work reports the first use of N-aryl peptoid in the synthesis of glycolipids. The newly synthesized glycolipids were characterized using different spectroscopic and spectrometric analyses. The impact of the amide bond as well as the triazole ring in the linkage region on the morphology of the glycolipids was analysed by comparing their self-assemblies using SEM analysis. The geometries of the glycolipids were also optimized using density functional theory and the optimized structures were found to be minima in the potential energy surfaces. [ABSTRACT FROM AUTHOR]

Mahua oil cake (Bassia latifolia) is one of the non-conventional ingredients which are generally used as manure for horticultural crops. However, mahua oil cake can also be used as cheap source of nutrient for fish replacing conventional plant ingredient by solid state fermentation. Solid state fermentation of mahua oil cake was done by mixed strain of microbes (Sachharomyces cerevisiae and Bacillus subtilis) through a standard set of procedures which improved the quality of mahua oil cake by increase in crude protein, decrease in crude fibre and decrease in anti-nutritional factors like total tannin and saponin. To evaluate the fermented mahua oil cake in rohu, six iso‑nitrogenous feeds for rohu (Labeo rohita) were formulated and prepared incorporating fermented mahua oil cake at different levels i.e. 0, 10, 20, 30, 40 and 50% replacing soyabean meal and other feed ingredients and fed to rohu fingerlings in different treatment groups for 120 days period. Fish fed diets with 20% of mahua oil cake significantly improved (p < 0.05) growth performance, feed conversion ratio, digestibility of nutrients and immunological parameters like lysozyme, myeloperoxidase and haemagglutination compared to diets without fermented mahua oil cake. However, fish fed diets with 40% fermented mahua oil cake resulted non-significant difference (p > 0.05) in growth performance, nutrient digestibility and immunological parameters compared to diets without fermented mahua oil cake. The present study might suggest incorporation of solid state fermented mahua oil cake up to 40% level without interfering growth, digestibility and immunological parameters in L. rohita fingerlings. [ABSTRACT FROM AUTHOR]