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1. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid‐Induced Osteoporosis

Author

Humphrey, Mary Beth, Russell, Linda, Danila, Maria I, Fink, Howard A, Guyatt, Gordon, Cannon, Michael, Caplan, Liron, Gore, Sara, Grossman, Jennifer, Hansen, Karen E, Lane, Nancy E, S., Nina, Magrey, Marina, McAlindon, Tim, Robinson, Angela Byun, Saha, Sumona, Womack, Charles, Abdulhadi, Basma, Charles, Julia F, Cheah, Jonathan TL, Chou, Sharon, Goyal, Itivrita, Haseltine, Katherine, Jackson, Lesley, Mirza, Reza, Moledina, Iram, Punni, Emma, Rinden, Tim, Turgunbaev, Marat, Wysham, Katherine, Turner, Amy S, and Uhl, Stacey

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Osteoporosis, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Management of diseases and conditions, 7.3 Management and decision making, Musculoskeletal, Good Health and Well Being, Adult, Child, Humans, United States, Rheumatology, Glucocorticoids, Bone Density, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science
Abstract

ObjectiveThe objective is to update recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) for patients with rheumatic or nonrheumatic conditions receiving >3 months treatment with glucocorticoids (GCs) ≥2.5 mg daily.MethodsAn updated systematic literature review was performed for clinical questions on nonpharmacologic, pharmacologic treatments, discontinuation of medications, and sequential therapy. Grading of Recommendations Assessment, Development and Evaluation approach was used to rate the certainty of evidence. A Voting Panel achieved ≥70% consensus on the direction (for or against) and strength (strong or conditional) of recommendations.ResultsFor adults beginning or continuing >3 months of GC treatment, we strongly recommend as soon as possible after initiation of GCs, initial assessment of fracture risks with clinical fracture assessment, bone mineral density with vertebral fracture assessment or spinal x-ray, and Fracture Risk Assessment Tool if ≥40 years old. For adults at medium, high, or very high fracture risk, we strongly recommend pharmacologic treatment. Choice of oral or intravenous bisphosphonates, denosumab, or parathyroid hormone analogs should be made by shared decision-making. Anabolic agents are conditionally recommended as initial therapy for those with high and very high fracture risk. Recommendations are made for special populations, including children, people with organ transplants, people who may become pregnant, and people receiving very high-dose GC treatment. New recommendations for both discontinuation of osteoporosis therapy and sequential therapies are included.ConclusionThis guideline provides direction for clinicians and patients making treatment decisions for management of GIOP. These recommendations should not be used to limit or deny access to therapies.

Published
2023

2. Yield of Serial Testing for Tuberculosis Exposure in Patients With Inflammatory Bowel Diseases: One Test is Not Enough

Author

Kaur, Manreet, Dassopoulos, Themistocles, Snapper, Scott B., Korzenik, Joshua R., Bohm, Matthew, Raffals, Laura, Poonam, Beniwal-Patel, Hudesman, David, Russ, Kirk, Brook, Loren, Pekow, Joel, Cross, Raymond, Wong, Uni, Bishu, Shrinivas, Bewtra, Meenakshi, Lewis, James D., Duerr, Richard, Saha, Sumona, Caldera, Freddy, Scoville, Elizabeth, Deepak, Parakkal, Ciorba, Matthew, and Lapp, Sean L.

Published
2024
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3. Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts

Author

Wolf, Douglas C., Hron, Bridget, Hanson, John S., Mohanty, Sanjib P., Fogel, Ronald P., Levy, L. Campbell, Iskandar, Heba N., Fischer, Monika, Cohen, Benjamin, Swaminath, Arun, Kane, Sunanda, McCabe, Robert P., Jr., Yen, Eugene F., Hanauer, Stephen B., Hudesman, David P., Afzali, Anita, Kelly, Colleen, Weber, John R., Mahadevan, Uma, Herfarth, Hans, Katz, Jeffery, Taleban, Sasha, Rubin, David T., Yachyshyn, Bruce, Reynolds, Gorman J., Gerich, Mark, Dryden, Gerald W., Quezada, Sandra, Higgins, Peter D.R., Shmidt, Eugenia, Lewis, James D., Schwartz, Marc B., Flynn, Ann D., Saha, Sumona, Horst, Sara N., Chiorean, Michael, Green, Patrick D., Scherl, Ellen J., Sandler, Robert, Brotherton, Carol, Albenberg, Lindsey, Valentine, John F., Suskind, David, Meyer, Andrea, Compher, Charlene W., Bewtra, Meenakshi, Kaur, Manreet, Dassopoulos, Themistocles, Snapper, Scott B., Korzenik, Joshua R., Bohm, Matthew, Raffals, Laura, Beniwal-Patel, Poonam, Hudesman, David, Russ, Kirk, Brook, Loren, Pekow, Joel, Cross, Raymond, Wong, Uni, Bishu, Shrinivas, Duerr, Richard, Caldera, Freddy, Scoville, Elizabeth, Deepak, Parakkal, Ciorba, Matthew, Daniel, Scott G., Li, Hongzhe, Hao, Fuhua, Patterson, Andrew D., Hecht, Aaron L., Brensinger, Colleen M., Wu, Gary D., and Bittinger, Kyle

Published
2024
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5. Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial

Author

Aguilar, Humberto, Ahmad, Tariq, Akriviadis, Evangelos, Aldeguer Mante, Xavier, Allez, Matthieu, Altorjay, Istvan, Ananthakrishnan, Ashwin, Andersen, Vibeke, Andreu Garcia, Montserrat, Armuzzi, Alessandro, Aumais, Guy, Avni-Biron, Irit, Axler, Jeffrey, Ayub, Kamran, Jr., Baert, Filip, Bafutto, Mauro, Bamias, George, Bassan, Isaac, Baum, Curtis, Beaugerie, Laurent, Behm, Brian, Bekal, Pradeep, Bennett, Michael, Bermejo San Jose, Fernando, Bernstein, Charles, Bettenworth, Dominik, Bhaskar, Sudhir, Biancone, Livia, Bilir, Bahri, Blaeker, Michael, Bloom, Stuart, Bohman, Verle, Jr., Bosques Padilla, Francisco Javier, Bossuyt, Peter, Bouhnik, Yoram, Bouma, Gerd, Bourdages, Raymond, Brand, Stephan, Bressler, Brian, Brückner, Markus, Buening, Carsten, Carbonnel, Franck, Caves, Thomas, Chapman, Jonathon, Cheon, Jae Hee, Chiba, Naoki, Chioncel, Camelia, Christodoulou, Dimitrios, Clodi, Martin, Cohen, Albert, Corazza, Gino Roberto, Corlin, Richard, Cosintino, Rocco, Cummings, Fraser, Dalal, Robin, Danese, Silvio, De Maeyer, Marc, De Magalhães Francesconi, Carlos Fernando, De Silva, Aminda, Debinski, Henry, Desreumaux, Pierre, Dewit, Olivier, D'Haens, Geert, Di Felice Boratto, Sandra, Ding, John Nik, Dixon, Tyler, Dryden, Gerald, Jr., Du Vall, George Aaron, Ebert, Matthias, Echarri Piudo, Ana, Ehehalt, Robert, Elkhashab, Magdy, Ennis, Craig, Etzel, Jason, Fallingborg, Jan, Feagan, Brian, Fejes, Roland, Ferraz de Campos Mazo, Daniel, Ferreira de Almeida Borges, Valéria, Fischer, Andreas, Fixelle, Alan, Fleisher, Mark, Fowler, Sharyle, Freilich, Bradley, Friedenberg, Keith, Fries, Walter, Fulop, Csaba, Fumery, Mathurin, Fuster, Sergio, G Kiss, Gyula, Garcia Lopez, Santiago, Gassner, Sonja, Gill, Kanwar, Gilletta de Saint Joseph, Cyrielle, Ginsburg, Philip, Gionchetti, Paolo, Goldin, Eran, Goldis, Adrian-Eugen, Gomez Jaramillo, Hector Alejandro, Gonciarz, Maciej, Gordon, Glenn, Green, Daniel, Grimaud, Jean-Charles, Guajardo Rodriguez, Rogelio, Gurzo, Zoltan, Gutierrez, Alexandra, Gyökeres, Tibor, Hahm, Ki Baik, Hanauer, Stephen, Hanson, John, Harlan III, William, Hasselblatt, Peter, Hayee, Buhussain, Hebuterne, Xavier, Hendy, Peter, Heyman, Melvin, Higgins, Peter, Hilal, Raouf, Hindryckx, Pieter, Hoentjen, Frank, Hoffmann, Peter, Holtkamp-Endemann, Frank, Holtmann, Gerald, Horvat, Gyula, Howaldt, Stefanie, Huber, Samuel, Ibegbu, Ikechukwu, Iborra Colomino, Maria Isabel, Irving, Peter, Isaacs, Kim, Jagarlamudi, Kiran, Jain, Rajesh, Jankiel Miszputen, Sender, Jansen, Jeroen, Jones, Jennifer, Juillerat, Pascal, Karagiannis, John, Karyotakis, Nicholas, Kaser, Arthur, Katz, Lior, Katz, Seymour, Katz, Leo, Kaur, Nirmal, Kazenaite, Edita, Khanna, Reena, Khurana, Sunil, Kim, Joo Sung, Kim, Young-Ho, Kim, Sung Kook, Kim, Dongwoo, Klaus, Jochen, Kleczkowski, Dariusz, Kohout, Pavel, Korczowski, Bartosz, Kouklakis, Georgios, Koutroubakis, Ioannis, Krause, Richard, Kristof, Tunde, Kronborg, Ian, Krummenerl, Annette, Kupcinskas, Limas, Laborda Molteni, Jorge, Laharie, David, Lahat-zok, Adi, Lee, Jonghun, Lee, Kang-Moon, Leong, Rupert, Levine, Henry, Limdi, Jimmy, Lindsay, James, Lodhia, Nilesh, Loftus, Edward, Longman, Randy, Lopez Serrano, Pilar, Louis, Edouard, Louzada Pereira, Maria Helena, Lowe, John, Lueth, Stefan, Lukas, Milan, Maconi, Giovanni, Macrae, Finlay, Madi-Szabo, Laszlo, Mahadevan-Velayos, Uma, Malluta, Everson Fernando, Mana, Fazia, Mannon, Peter, Mantzaris, Gerasimos, Marin Jimenez, Ignacio, Martin Arranz, Maria Dolores, Mateescu, Radu-Bogdan, Mazzoleni, Felipe, Meder, Agnieszka, Melzer, Ehud, Mertens, Jessica, Mimidis, Konstantinos, Mitchell, Brent, Molnar, Tamas, Moore, Gregory, Morales Garza, Luis Alonso, Mountifield, Reme, Muls, Vinciane, Murray, Charles, Nagy, Bela, Neurath, Markus, Nguyen, Augustin, Panaccione, Remo, Pandak, William, Panes Diaz, Julian, Park, Jihye, Pastorelli, Luca, Patel, Bhaktasharan, Peck-Radosavljevic, Markus, Pecsi, Gyula, Peerani, Farhad, Perez Gisbert, Javier, Pesta, Martin, Petryka, Robert, Peyrin-Biroulet, Laurent, Phillips, Raymond, Pierik, Marieke, Pratha, Vijayalakshmi, Prochazka, Vlastimil, Racz, Istvan, Radford-Smith, Graham, Ramos Castañeda, Daniel, Ramos Júnior, Odery, Regula, Jaroslaw, Reimund, Jean-Marie, Robbins, Bryan, Roblin, Xavier, Rogai, Francesca, Rogler, Gerhard, Rozciecha, Jerzy, Rubin, David, Ruiz Flores, Azalia Yuriria, Rupinski, Maciej, Rydzewska, Grazyna, Saha, Sumona, Saibeni, Simone, Salamon, Agnes, Sallo, Zoltan, Salzberg, Bruce, Samuel, Douglas, Samuel, Sunil, Sandborn, William, Savarino, Edoardo Vincenzo, Schirbel, Anja, Schnabel, Robert, Schreiber, Stefan, Scott, John, Sedghi, Shahriar, Seibold, Frank, Seidelin, Jakob, Seidler, Ursula, Shaban, Ahmad, Shafran, Ira, Sheikh, Aasim, Sherman, Alex, Shirin, Haim, Smolinski, Patryk, Song, Geun Am, Soufleris, Konstantinos, Speight, Alexander, Staessen, Dirk, Stallmach, Andreas, Staun, Michael, Stein, Daniel, Steinhart, Hillary, Stifft, Jonathas, Stokesberry, David, Sturm, Andreas, Sultan, Keith, Szekely, Gyorgy, Tagore, Kuldeep, Tanno, Hugo, Thin, Lena, Thiwan, Syed, Thomas, Carlton, Tichy, Michal, Toth, Gabor Tamas, Tulassay, Zsolt, Ulbrych, Jan, Valentine, John, Varga, Marta, Vasconcellos, Eduardo, Vaughn, Byron, Velasco, Brenda, Velazquez, Francisco, Vermeire, Severine, Villa, Erica, Vincze, Aron, Vogelsang, Harald, Volfova, Miroslava, Vuitton, Lucine, Vyhnalek, Petr, Wahab, Peter, Walldorf, Jens, Waterman, Mattitiahu, Weber, John, Weiss, L. Michael, Wiechowska-Kozlowska, Anna, Wiesner, Elise, Witthoeft, Thomas, Wohlman, Robert, Wozniak-Stolarska, Barbara, Yacyshyn, Bruce, Ye, Byong-Duk, Younes, Ziad, Yukie Sassaki, Lígia, Zaltman, Cyrla, Zeuzem, Stefan, Hart, Ailsa, Long, Millie, Loftus, Edward V, Jr, Ostad-Saffari, Elham, Scalori, Astrid, Oh, Young S, Tole, Swati, Chai, Akiko, Pulley, Jennifer, Lacey, Stuart, and Sandborn, William J

Published
2022
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6. Surgery for Crohn’s Disease Is Associated with a Dysbiotic Microbiome and Metabolome: Results from Two Prospective Cohorts

Author

Lewis, James D., primary, Daniel, Scott G., additional, Li, Hongzhe, additional, Hao, Fuhua, additional, Patterson, Andrew D., additional, Hecht, Aaron, additional, Brensinger, Colleen M., additional, Wu, Gary D., additional, Bittinger, Kyle, additional, Wolf, Douglas C., additional, Hron, Bridget, additional, Hanson, John S., additional, Mohanty, Sanjib P., additional, Fogel, Ronald P., additional, Levy, L. Campbell, additional, Iskandar, Heba N., additional, Fischer, Monika, additional, Cohen, Benjamin, additional, Swaminath, Arun, additional, Kane, Sunanda, additional, McCabe, Robert P., additional, Yen, Eugene F., additional, Hanauer, Stephen B., additional, Hudesman, David P., additional, Afzali, Anita, additional, Kelly, Colleen, additional, Weber, John R., additional, Mahadevan, Uma, additional, Herfarth, Hans, additional, Katz, Jeffery, additional, Taleban, Sasha, additional, Rubin, David T., additional, Yachyshyn, Bruce, additional, Reynolds, Gorman J., additional, Gerich, Mark, additional, Dryden, Gerald W., additional, Quezada, Sandra, additional, Higgins, Peter D.R., additional, Shmidt, Eugenia, additional, Lewis, James D., additional, Schwartz, Marc B., additional, Flynn, Ann D., additional, Saha, Sumona, additional, Horst, Sara N., additional, Chiorean, Michael, additional, Green, Patrick D., additional, Scherl, Ellen J., additional, Sandler, Robert, additional, Brotherton, Carol, additional, Albenberg, Lindsey, additional, Valentine, John F., additional, Suskind, David, additional, Meyer, Andrea, additional, Compher, Charlene W., additional, Bewtra, Meenakshi, additional, Kaur, Manreet, additional, Dassopoulos, Themistocles, additional, Snapper, Scott B., additional, Korzenik, Joshua R., additional, Bohm, Matthew, additional, Raffals, Laura, additional, Beniwal-Patel, Poonam, additional, Hudesman, David, additional, Russ, Kirk, additional, Brook, Loren, additional, Pekow, Joel, additional, Cross, Raymond, additional, Wong, Uni, additional, Bishu, Shrinivas, additional, Duerr, Richard, additional, Caldera, Freddy, additional, Scoville, Elizabeth, additional, Deepak, Parakkal, additional, and Ciorba, Matthew, additional

Published
2024
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8. Contributors

Author

Abdelwahab, Mahmoud, primary, Ahmed, Mahmoud S., additional, Armstrong, Sarah, additional, Berlin, Cheston M., additional, Best, Brookie M., additional, Bottone-Post, Carolyn, additional, Clark, Shannon M., additional, Costantine, Maged M., additional, Crobarger, Kala R., additional, Dolin, Cara D., additional, Fisher, Jeffrey W., additional, Flockhart, David A., additional, Fouche-Camargo, Jeffrey S., additional, Fraser, William D., additional, Grasch, Jennifer L., additional, Haas, David M., additional, Halbert, Lee-Ann, additional, Hardy, Isabelle, additional, Harrison, Carmen V., additional, Hebert, Mary F., additional, Hess, Henry M., additional, Komorowski, Janelle, additional, Li, Miao, additional, Lutz, Megan, additional, Mattison, Donald R., additional, Mehta, Darshan, additional, Momper, Jeremiah D., additional, Monsivais, Luis A., additional, Namazy, Jennifer A., additional, Pacheco, Luis, additional, Ramirez-Cruz, Maria P., additional, Rayburn, William F., additional, Reed, Michael D., additional, Robertson, Sharon E., additional, Rytting, Erik, additional, Ryu, Rachel, additional, Saha, Sumona, additional, Schatz, Michael, additional, Schilder, Jeanne M., additional, Seifert, Steven A., additional, Soljak, Harry, additional, Trout, Kimberly K., additional, Waltz, Jennifer, additional, Yang, Xiaoxia, additional, and Youmans, Andrew, additional

Published
2022
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9. Characterization of idiopathic chronic diarrhea and associated intestinal inflammation and preliminary observations of effects of vagal nerve stimulation in a non‐human primate.

Author

Populin, Luis C., Rajala, Abigail Z., Matkowskyj, Kristina A., Saha, Sumona, Zeng, Weifeng, Christian, Bradley, McVea, Andrew, Tay, Emmy Xue, Mueller, Ellie M., Malone, Margaret E., Brust‐Mascher, Ingrid, McMillan, Alan B., Ludwig, Kip A., Suminski, Aaron J., Reardon, Colin, and Furness, John B.

Subjects
INFLAMMATORY bowel diseases, VAGUS nerve stimulation, IRRITABLE colon, POSITRON emission tomography, RHESUS monkeys
Abstract

Background: Diarrhea is commonly associated with irritable bowel syndrome, inflammatory bowel disease, microscopic colitis, and other gastrointestinal dysfunctions. Spontaneously occurring idiopathic chronic diarrhea is frequent in rhesus macaques, but has not been used as a model for the investigation of diarrhea or its treatment. We characterized this condition and present preliminary data demonstrating that left vagal nerve stimulation provides relief. Methods: Stool consistency scores were followed for up to 12 years. Inflammation was assessed by plasma C‐reactive protein, [18F]fluorodeoxyglucose (FDG) uptake, measured by positron emission tomography (PET), multiplex T cell localization, endoscopy and histology. The vagus was stimulated for 9 weeks in conscious macaques, using fully implanted electrodes, under wireless control. Key Results: Macaques exhibited recurrent periods of diarrhea for up to 12 years, and signs of inflammation: elevated plasma C‐reactive protein, increased bowel FDG uptake and increased mucosal T helper1 T‐cells. The colon and distal ileum were endoscopically normal, and histology revealed mild colonic inflammation. Application of vagal nerve stimulation to conscious macaques (10 Hz, 30 s every 3 h; 24 h a day for 9 weeks) significantly reduced severity of diarrhea and also reduced inflammation, as measured by FDG uptake and C‐reactive protein. Conclusions and Inferences: These macaques exhibit spontaneously occurring diarrhea with intestinal inflammation that can be reduced by VNS. The data demonstrate the utility of this naturally occurring primate model to study the physiology and treatments for chronic diarrhea and the neural control circuits influencing diarrhea and inflammation that are not accessible in human subjects. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD)

Author

Raffals, Laura E, Saha, Sumona, Bewtra, Meenakshi, Norris, Cecile, Dobes, Angela, Heller, Caren, O’Charoen, Sirimon, Fehlmann, Tara, Sweeney, Sara, Weaver, Alandra, Bishu, Shrinivas, Cross, Raymond, Dassopoulos, Themistocles, Fischer, Monika, Yarur, Andres, Hudesman, David, Parakkal, Deepak, Duerr, Richard, Caldera, Freddy, Korzenik, Joshua, Pekow, Joel, Wells, Katerina, Bohm, Matthew, Perera, Lilani, Kaur, Manreet, Ciorba, Matthew, Snapper, Scott, Scoville, Elizabeth A, Dalal, Sushila, Wong, Uni, and Lewis, James D

Published
2022
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14. Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis.

Author

Motwani, Kiran K., Alizadeh, Madeline, Abutaleb, Ameer, Grossman, Jennifer, Wellington, Jennifer, Cross, Raymond K., Russ, Kirk, Bewtra, Meena, Lewis, James, Cross, Raymond, Wong, Uni, Snapper, Scott, Korzenik, Josh, Bishu, Shrinivas, Duerr, Rick, Saha, Sumona, Caldera, Freddy, Raffals, Laura, Shukla, Richa, and Dassopoulos, Themistocles

Subjects
CROHN'S disease, PREMENSTRUAL syndrome, ULCERATIVE colitis, PATIENT reported outcome measures, FISHER exact test, DISEASE remission
Abstract

Background: Patient-reported outcomes (PROs), such as the short CD activity index (sCDAI) and partial Mayo Score (PMS), are used to define clinical remission in IBD, but may not represent the true degree of inflammation and endoscopy is invasive. Non-invasive testing options include c-reactive protein (CRP) and fecal calprotectin (FCP). Aim: The aim of this study was to assess the degree of correlation of non-invasive biomarkers with PROs and the impact other clinical variables can have on their levels. Methods: We reviewed data collected from the prospective cohort, Study of a Prospective Adult Research Cohort with IBD (SPARC-IBD), comprised of over 3000 patients from 17 tertiary referral centers. Demographic and clinical variables were analyzed by disease type, disease severity was based on PROs, and baseline CRP and FCP were measured. For comparative analysis, we performed Fisher's exact test and Welch's t test, where p < 0.05 was significant. Results: 1547 patients were included; 63% had CD, 56% were female, with an average disease duration of 13.6 years. CRP and FCP were associated with symptom severity in inflammatory CD. CRP was useful to differentiate symptoms across different disease locations in CD, whereas FCP was associated with symptom severity in Crohn's colitis only. For UC, FCP was able to distinguish symptom severity better in distal UC, whereas in extensive or pancolitis, it was useful only to distinguish severe symptoms from other categories of symptom severity. Conclusion: PROs correlate with CRP and FCP; however, disease location and phenotype impact their ability to distinguish symptom severity. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Micronutrient Deficiencies in Patients With Inflammatory Bowel Disease.

Author

Le, Todd A., Saha, Sumona, and Shields, Bridget E.

Subjects
INFLAMMATORY bowel diseases, ALOPECIA areata, FOLIC acid, CALPROTECTIN, DEFICIENCY diseases, VITAMIN B12, VITAMIN B6, NUTRITIONAL assessment
Abstract

This article discusses the micronutrient deficiencies that can occur in patients with inflammatory bowel disease (IBD) and their associated cutaneous manifestations. It emphasizes the importance of monitoring and treating these deficiencies for improved prognosis, mortality, and quality of life. The most common deficiencies observed in patients with IBD include iron, zinc, calcium, vitamin D, and vitamins B6, B9, and B12. The article provides guidance on monitoring and supplementing each micronutrient and highlights the challenges of interpreting laboratory values due to the effects of inflammation and medications used to treat IBD. [Extracted from the article]

Published
2024
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16. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid‐Induced Osteoporosis

Author

Humphrey, Mary Beth, primary, Russell, Linda, additional, Danila, Maria I., additional, Fink, Howard A., additional, Guyatt, Gordon, additional, Cannon, Michael, additional, Caplan, Liron, additional, Gore, Sara, additional, Grossman, Jennifer, additional, Hansen, Karen E., additional, Lane, Nancy E., additional, Ma, Nina S., additional, Magrey, Marina, additional, McAlindon, Tim, additional, Robinson, Angela Byun, additional, Saha, Sumona, additional, Womack, Charles, additional, Abdulhadi, Basma, additional, Charles, Julia F., additional, Cheah, Jonathan T. L., additional, Chou, Sharon, additional, Goyal, Itivrita, additional, Haseltine, Katherine, additional, Jackson, Lesley, additional, Mirza, Reza, additional, Moledina, Iram, additional, Punni, Emma, additional, Rinden, Tim, additional, Turgunbaev, Marat, additional, Wysham, Katherine, additional, Turner, Amy S., additional, and Uhl, Stacey, additional

Published
2023
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17. S887 Health-Related Social Needs & Disease Activity Are Independently Associated With Moderate-to-Severe IBD-Related Disability

Author

Tse, Chung Sang, primary, Shah, Samir A., additional, Saha, Sumona, additional, Taleban, Sasha, additional, Horst, Sara, additional, Lutz, Megan, additional, Fiske, Hannah, additional, Weng, Chien-Hsiang, additional, Hunt, Melissa G., additional, Brown, Lily, additional, Bonhomme, Brittaney, additional, Kuehnel, Robert, additional, Weaver, Alandra, additional, Cross, Raymond, additional, Long, Millie D., additional, and Lewis, James, additional

Published
2023
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22. Structural brain morphometry differences and similarities between young patients with Crohn's disease in remission and healthy young and old controls.

Author

Benjamin Yeske, Jiancheng Hou, Chu, Daniel Y., Adluru, Nagesh, Nair, Veena A., Beniwal-Patel, Poonam, Saha, Sumona, and Prabhakaran, Vivek

Subjects
CROHN'S disease, DISEASE remission, INFLAMMATORY bowel diseases, MORPHOMETRICS, CONTROL (Psychology)
Abstract

Introduction: Crohn's disease (CD), one of the main phenotypes of inflammatory bowel disease (IBD), can affect any part of the gastrointestinal tract. It can impact the function of gastrointestinal secretions, as well as increasing the intestinal permeability leading to an aberrant immunological response and subsequent intestinal inflammation. Studies have reported anatomical and functional brain changes in Crohn's Disease patients (CDs), possibly due to increased inflammatory markers and microglial cells that play key roles in communicating between the brain, gut, and systemic immune system. To date, no studies have demonstrated similarities between morphological brain changes seen in IBD and brain morphometry observed in older healthy controls. Methods: For the present study, twelve young CDs in remission (M = 26.08 years, SD = 4.9 years, 7 male) were recruited from an IBD Clinic. Data from 12 young age-matched healthy controls (HCs) (24.5 years, SD = 3.6 years, 8 male) and 12 older HCs (59 years, SD = 8 years, 8 male), previously collected for a different study under a similar MR protocol, were analyzed as controls. T1 weighted images and structural image processing techniques were used to extract surface-based brain measures, to test our hypothesis that young CDs have different brain surface morphometry than their age-matched young HCs and furthermore, appear more similar to older HCs. The phonemic verbal fluency (VF) task (the Controlled Oral Word Association Test, COWAT) (Benton, 1976) was administered to test verbal cognitive ability and executive control. Results/Discussion: On the whole, CDs had more brain regions with differences in brain morphometry measures when compared to the young HCs as compared to the old HCs, suggesting that CD has an effect on the brain that makes it appear more similar to old HCs. Additionally, our study demonstrates this atypical brain morphometry is associated with function on a cognitive task. These results suggest that even younger CDs may be showing some evidence of structural brain changes that demonstrate increased resemblance to older HC brains rather than their similarly aged healthy counterparts. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Yield of Serial Testing for Tuberculosis Exposure in Patients With Inflammatory Bowel Diseases: One Test is Not Enough

Author

Lapp, Sean L., primary, Bewtra, Meenakshi, additional, Lewis, James D., additional, Kaur, Manreet, additional, Dassopoulos, Themistocles, additional, Snapper, Scott B., additional, Korzenik, Joshua R., additional, Bohm, Matthew, additional, Raffals, Laura, additional, Poonam, Beniwal-Patel, additional, Hudesman, David, additional, Russ, Kirk, additional, Brook, Loren, additional, Pekow, Joel, additional, Cross, Raymond, additional, Wong, Uni, additional, Bishu, Shrinivas, additional, Duerr, Richard, additional, Saha, Sumona, additional, Caldera, Freddy, additional, Scoville, Elizabeth, additional, Deepak, Parakkal, additional, and Ciorba, Matthew, additional

Published
2023
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26. Tutorial on adult enteral tube feeding: Indications, placement, removal, complications, and ethics.

Author

Ley, Dana, Austin, Kerstin, Wilson, Kelley Anastasia, and Saha, Sumona

Subjects
TUBE feeding, ENTERAL feeding, PERCUTANEOUS endoscopic gastrostomy, GASTRIC outlet obstruction, FEEDING tubes, EUSTACHIAN tube, PYLORUS
Abstract

Enteral nutrition, generally preferred to parenteral nutrition, is indicated when patients cannot meet their energy and metabolic demands. Gastrostomy tubes are placed directly into the stomach (either endoscopically, surgically, or radiologically) through the abdominal wall. Routine gastrostomy tube care is important to maintain well‐functioning tubes. Postpyloric feeding tubes are preferable to gastric feeding tubes if patients have a history of aspiration, gastroesophageal reflux, severe gastroparesis, and/or recurrent nausea and vomiting. Feeding jejunostomy tubes are placed surgically and are indicated if gastric feeding is unsafe or impossible. Dual‐lumen gastrojejunostomy tubes are used when both gastric decompression and feeding are desired. The general risks of enteral tube feeding include diarrhea, metabolic derangements, and aspiration. Additional complications for gastrostomy tubes, which can arise at any time, include tube dysfunction (clogging or deterioration), infection, bleeding, peristomal leakage, ulceration, gastric outlet obstruction, and accidental removal. After percutaneous endoscopic gastrostomy placement, there are also early or late complications that may occur. Multiple factors should be considered in the decision‐making process for feeding tube placement. It is important to be realistic about the patient's prognosis and goals and to discuss the risks and benefits ahead of time. Consultation with palliative care or clinical ethics specialists should be considered in certain clinical scenarios. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Higher Cell-Mediated Immune Responses in Patients With Inflammatory Bowel Disease on Anti-TNF Therapy After COVID-19 Vaccination

Author

Caldera, Freddy, primary, Farraye, Francis A, additional, Necela, Brian M, additional, Cogen, Davitte, additional, Saha, Sumona, additional, Wald, Arnold, additional, Daoud, Nader D, additional, Chun, Kelly, additional, Grimes, Ian, additional, Lutz, Megan, additional, Van Helden, Sean R, additional, Swift, Melanie D, additional, Virk, Abinash, additional, Bharucha, Adil E, additional, Patel, Tushar C, additional, Gores, Gregory J, additional, Chumsri, Saranya, additional, Hayney, Mary S, additional, and Knutson, Keith L, additional

Published
2022
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29. Su1489: HUMORAL IMMUNOGENICITY OF THREE SARS-COV-2 MRNA VACCINE DOSES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Author

Schell, Trevor, primary, Knutson, Keith, additional, Saha, Sumona, additional, Wald, Arnold, additional, Phan, Hiep S., additional, Almasry, Mazen, additional, Chun, Kelly Y., additional, Grimes, Ian C., additional, Lutz, Megan, additional, Hayney, Mary S., additional, Farraye, Francis A., additional, and Caldera, Freddy, additional

Published
2022
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33. Cell-Mediated Immune Response after COVID 19 Vaccination in Patients with Inflammatory Bowel Disease

Author

Caldera, Freddy, primary, Farraye, Francis, additional, Necela, Brian, additional, Cogen, Davitte, additional, Saha, Sumona, additional, Wald, Arnold, additional, Daoud, Nader, additional, Chun, Kelly, additional, Grimes, Ian, additional, Lutz, Megan, additional, Swift, Melanie D, additional, Virk, Abinash, additional, Bharucha, Adil E, additional, Patel, Tushar, additional, Gores, Gregory J, additional, Chumsri, Saranya, additional, Hayney, Mary S., additional, and Knuttson, Keith L, additional

Published
2022
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34. Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial

Author

Peyrin-Biroulet, Laurent, primary, Hart, Ailsa, additional, Bossuyt, Peter, additional, Long, Millie, additional, Allez, Matthieu, additional, Juillerat, Pascal, additional, Armuzzi, Alessandro, additional, Loftus, Edward V, additional, Ostad-Saffari, Elham, additional, Scalori, Astrid, additional, Oh, Young S, additional, Tole, Swati, additional, Chai, Akiko, additional, Pulley, Jennifer, additional, Lacey, Stuart, additional, Sandborn, William J, additional, Aguilar, Humberto, additional, Ahmad, Tariq, additional, Akriviadis, Evangelos, additional, Aldeguer Mante, Xavier, additional, Altorjay, Istvan, additional, Ananthakrishnan, Ashwin, additional, Andersen, Vibeke, additional, Andreu Garcia, Montserrat, additional, Aumais, Guy, additional, Avni-Biron, Irit, additional, Axler, Jeffrey, additional, Ayub, Kamran, additional, Baert, Filip, additional, Bafutto, Mauro, additional, Bamias, George, additional, Bassan, Isaac, additional, Baum, Curtis, additional, Beaugerie, Laurent, additional, Behm, Brian, additional, Bekal, Pradeep, additional, Bennett, Michael, additional, Bermejo San Jose, Fernando, additional, Bernstein, Charles, additional, Bettenworth, Dominik, additional, Bhaskar, Sudhir, additional, Biancone, Livia, additional, Bilir, Bahri, additional, Blaeker, Michael, additional, Bloom, Stuart, additional, Bohman, Verle, additional, Bosques Padilla, Francisco Javier, additional, Bouhnik, Yoram, additional, Bouma, Gerd, additional, Bourdages, Raymond, additional, Brand, Stephan, additional, Bressler, Brian, additional, Brückner, Markus, additional, Buening, Carsten, additional, Carbonnel, Franck, additional, Caves, Thomas, additional, Chapman, Jonathon, additional, Cheon, Jae Hee, additional, Chiba, Naoki, additional, Chioncel, Camelia, additional, Christodoulou, Dimitrios, additional, Clodi, Martin, additional, Cohen, Albert, additional, Corazza, Gino Roberto, additional, Corlin, Richard, additional, Cosintino, Rocco, additional, Cummings, Fraser, additional, Dalal, Robin, additional, Danese, Silvio, additional, De Maeyer, Marc, additional, De Magalhães Francesconi, Carlos Fernando, additional, De Silva, Aminda, additional, Debinski, Henry, additional, Desreumaux, Pierre, additional, Dewit, Olivier, additional, D'Haens, Geert, additional, Di Felice Boratto, Sandra, additional, Ding, John Nik, additional, Dixon, Tyler, additional, Dryden, Gerald, additional, Du Vall, George Aaron, additional, Ebert, Matthias, additional, Echarri Piudo, Ana, additional, Ehehalt, Robert, additional, Elkhashab, Magdy, additional, Ennis, Craig, additional, Etzel, Jason, additional, Fallingborg, Jan, additional, Feagan, Brian, additional, Fejes, Roland, additional, Ferraz de Campos Mazo, Daniel, additional, Ferreira de Almeida Borges, Valéria, additional, Fischer, Andreas, additional, Fixelle, Alan, additional, Fleisher, Mark, additional, Fowler, Sharyle, additional, Freilich, Bradley, additional, Friedenberg, Keith, additional, Fries, Walter, additional, Fulop, Csaba, additional, Fumery, Mathurin, additional, Fuster, Sergio, additional, G Kiss, Gyula, additional, Garcia Lopez, Santiago, additional, Gassner, Sonja, additional, Gill, Kanwar, additional, Gilletta de Saint Joseph, Cyrielle, additional, Ginsburg, Philip, additional, Gionchetti, Paolo, additional, Goldin, Eran, additional, Goldis, Adrian-Eugen, additional, Gomez Jaramillo, Hector Alejandro, additional, Gonciarz, Maciej, additional, Gordon, Glenn, additional, Green, Daniel, additional, Grimaud, Jean-Charles, additional, Guajardo Rodriguez, Rogelio, additional, Gurzo, Zoltan, additional, Gutierrez, Alexandra, additional, Gyökeres, Tibor, additional, Hahm, Ki Baik, additional, Hanauer, Stephen, additional, Hanson, John, additional, Harlan III, William, additional, Hasselblatt, Peter, additional, Hayee, Buhussain, additional, Hebuterne, Xavier, additional, Hendy, Peter, additional, Heyman, Melvin, additional, Higgins, Peter, additional, Hilal, Raouf, additional, Hindryckx, Pieter, additional, Hoentjen, Frank, additional, Hoffmann, Peter, additional, Holtkamp-Endemann, Frank, additional, Holtmann, Gerald, additional, Horvat, Gyula, additional, Howaldt, Stefanie, additional, Huber, Samuel, additional, Ibegbu, Ikechukwu, additional, Iborra Colomino, Maria Isabel, additional, Irving, Peter, additional, Isaacs, Kim, additional, Jagarlamudi, Kiran, additional, Jain, Rajesh, additional, Jankiel Miszputen, Sender, additional, Jansen, Jeroen, additional, Jones, Jennifer, additional, Karagiannis, John, additional, Karyotakis, Nicholas, additional, Kaser, Arthur, additional, Katz, Lior, additional, Katz, Seymour, additional, Katz, Leo, additional, Kaur, Nirmal, additional, Kazenaite, Edita, additional, Khanna, Reena, additional, Khurana, Sunil, additional, Kim, Joo Sung, additional, Kim, Young-Ho, additional, Kim, Sung Kook, additional, Kim, Dongwoo, additional, Klaus, Jochen, additional, Kleczkowski, Dariusz, additional, Kohout, Pavel, additional, Korczowski, Bartosz, additional, Kouklakis, Georgios, additional, Koutroubakis, Ioannis, additional, Krause, Richard, additional, Kristof, Tunde, additional, Kronborg, Ian, additional, Krummenerl, Annette, additional, Kupcinskas, Limas, additional, Laborda Molteni, Jorge, additional, Laharie, David, additional, Lahat-zok, Adi, additional, Lee, Jonghun, additional, Lee, Kang-Moon, additional, Leong, Rupert, additional, Levine, Henry, additional, Limdi, Jimmy, additional, Lindsay, James, additional, Lodhia, Nilesh, additional, Loftus, Edward, additional, Longman, Randy, additional, Lopez Serrano, Pilar, additional, Louis, Edouard, additional, Louzada Pereira, Maria Helena, additional, Lowe, John, additional, Lueth, Stefan, additional, Lukas, Milan, additional, Maconi, Giovanni, additional, Macrae, Finlay, additional, Madi-Szabo, Laszlo, additional, Mahadevan-Velayos, Uma, additional, Malluta, Everson Fernando, additional, Mana, Fazia, additional, Mannon, Peter, additional, Mantzaris, Gerasimos, additional, Marin Jimenez, Ignacio, additional, Martin Arranz, Maria Dolores, additional, Mateescu, Radu-Bogdan, additional, Mazzoleni, Felipe, additional, Meder, Agnieszka, additional, Melzer, Ehud, additional, Mertens, Jessica, additional, Mimidis, Konstantinos, additional, Mitchell, Brent, additional, Molnar, Tamas, additional, Moore, Gregory, additional, Morales Garza, Luis Alonso, additional, Mountifield, Reme, additional, Muls, Vinciane, additional, Murray, Charles, additional, Nagy, Bela, additional, Neurath, Markus, additional, Nguyen, Augustin, additional, Panaccione, Remo, additional, Pandak, William, additional, Panes Diaz, Julian, additional, Park, Jihye, additional, Pastorelli, Luca, additional, Patel, Bhaktasharan, additional, Peck-Radosavljevic, Markus, additional, Pecsi, Gyula, additional, Peerani, Farhad, additional, Perez Gisbert, Javier, additional, Pesta, Martin, additional, Petryka, Robert, additional, Peyrin-Biroulet, Laurent, additional, Phillips, Raymond, additional, Pierik, Marieke, additional, Pratha, Vijayalakshmi, additional, Prochazka, Vlastimil, additional, Racz, Istvan, additional, Radford-Smith, Graham, additional, Ramos Castañeda, Daniel, additional, Ramos Júnior, Odery, additional, Regula, Jaroslaw, additional, Reimund, Jean-Marie, additional, Robbins, Bryan, additional, Roblin, Xavier, additional, Rogai, Francesca, additional, Rogler, Gerhard, additional, Rozciecha, Jerzy, additional, Rubin, David, additional, Ruiz Flores, Azalia Yuriria, additional, Rupinski, Maciej, additional, Rydzewska, Grazyna, additional, Saha, Sumona, additional, Saibeni, Simone, additional, Salamon, Agnes, additional, Sallo, Zoltan, additional, Salzberg, Bruce, additional, Samuel, Douglas, additional, Samuel, Sunil, additional, Sandborn, William, additional, Savarino, Edoardo Vincenzo, additional, Schirbel, Anja, additional, Schnabel, Robert, additional, Schreiber, Stefan, additional, Scott, John, additional, Sedghi, Shahriar, additional, Seibold, Frank, additional, Seidelin, Jakob, additional, Seidler, Ursula, additional, Shaban, Ahmad, additional, Shafran, Ira, additional, Sheikh, Aasim, additional, Sherman, Alex, additional, Shirin, Haim, additional, Smolinski, Patryk, additional, Song, Geun Am, additional, Soufleris, Konstantinos, additional, Speight, Alexander, additional, Staessen, Dirk, additional, Stallmach, Andreas, additional, Staun, Michael, additional, Stein, Daniel, additional, Steinhart, Hillary, additional, Stifft, Jonathas, additional, Stokesberry, David, additional, Sturm, Andreas, additional, Sultan, Keith, additional, Szekely, Gyorgy, additional, Tagore, Kuldeep, additional, Tanno, Hugo, additional, Thin, Lena, additional, Thiwan, Syed, additional, Thomas, Carlton, additional, Tichy, Michal, additional, Toth, Gabor Tamas, additional, Tulassay, Zsolt, additional, Ulbrych, Jan, additional, Valentine, John, additional, Varga, Marta, additional, Vasconcellos, Eduardo, additional, Vaughn, Byron, additional, Velasco, Brenda, additional, Velazquez, Francisco, additional, Vermeire, Severine, additional, Villa, Erica, additional, Vincze, Aron, additional, Vogelsang, Harald, additional, Volfova, Miroslava, additional, Vuitton, Lucine, additional, Vyhnalek, Petr, additional, Wahab, Peter, additional, Walldorf, Jens, additional, Waterman, Mattitiahu, additional, Weber, John, additional, Weiss, L. Michael, additional, Wiechowska-Kozlowska, Anna, additional, Wiesner, Elise, additional, Witthoeft, Thomas, additional, Wohlman, Robert, additional, Wozniak-Stolarska, Barbara, additional, Yacyshyn, Bruce, additional, Ye, Byong-Duk, additional, Younes, Ziad, additional, Yukie Sassaki, Lígia, additional, Zaltman, Cyrla, additional, and Zeuzem, Stefan, additional

Published
2022
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36. Approach to Inflammatory Bowel Disease in Pregnancy.

Author

LEY, DANA and SAHA, SUMONA

Subjects
*PREMATURE rupture of fetal membranes, *INFLAMMATORY bowel diseases, *PREGNANCY, *RESTORATIVE proctocolectomy, *PREGNANCY complications, *HIGH-risk pregnancy
Abstract

The article discusses the diagnosis and management of inflammatory bowel disease (IBD) in pregnancy. Topics explored include the necessity of comprehensive pre-conception counseling to women with IBD, the non-invasive methods which may be considered to monitor IBD activity in pregnant women, and the considerations for pregnancy and lactation outlined for IBD medications such as corticosteroids, methotrexate, and sulfasalazine.

Published
2022

39. Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD).

Author

Raffals, Laura E, Saha, Sumona, Bewtra, Meenakshi, Norris, Cecile, Dobes, Angela, Heller, Caren, O'Charoen, Sirimon, Fehlmann, Tara, Sweeney, Sara, Weaver, Alandra, Bishu, Shrinivas, Cross, Raymond, Dassopoulos, Themistocles, Fischer, Monika, Yarur, Andres, Hudesman, David, Parakkal, Deepak, Duerr, Richard, Caldera, Freddy, and Korzenik, Joshua

Published
2022
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41. Correction to: Correlation Between Plasma and Fecal Biomarkers and Patient‑Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis.

Author

Motwani, Kiran K., Alizadeh, Madeline, Abutaleb, Ameer, Grossman, Jennifer, Wellington, Jennifer, Cross, Raymond K., Russ, Kirk, Bewtra, Meena, Lewis, James, Cross, Raymond, Wong, Uni, Snapper, Scott, Korzenik, Josh, Bishu, Shrinivas, Duerr, Rick, Saha, Sumona, Caldera, Freddy, Raffals, Laura, Shukla, Richa, and Dassopoulos, Themistocles

Subjects
CROHN'S disease, ULCERATIVE colitis, BIOMARKERS, TREATMENT effectiveness
Abstract

This document is a correction notice for an article titled "Correlation Between Plasma and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis." The original article contained errors in the title and discussion section, where "serum biomarkers" was incorrectly used instead of "plasma biomarkers." The corrected title should read "Correlation Between Plasma and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis." Additionally, the discussion section has been amended to reflect the accurate information. The correction notice is provided by multiple authors and the publisher, Springer Nature, remains neutral in terms of jurisdictional claims and institutional affiliations. [Extracted from the article]

Published
2024
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42. Special situations: Performance of endoscopy while pregnant

Author

Austin, Kerstin, Schoenberger, Haley, and Saha, Sumona

Abstract

The rates of women entering the field of gastroenterology have been increasing over the past several years. Most of these women enter the field during childbearing years. At the same time, the procedural demands placed on endoscopists have been increasing as well. With these changes in demographics to the physicians performing endoscopy, more attention should be paid to the physical demands of scoping while pregnant. In this paper, we focus on several common, overlapping injuries that are frequently encountered during pregnancy and while performing endoscopy. Additionally, ergonomic modifications and strategies are outlined for both the pregnant and postpartum endoscopist. Given the lack of data in this area, dedicated studies aimed at this specific population would help guide further recommendations.

Published
2024
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43. Safety of Rotavirus Vaccination in Infants That Were Exposed to Biologics In Utero: A Systematic Review.

Author

Schell TL, Fass L, Hitchcock ME, Farraye FA, Hayney MS, Saha S, and Caldera F

Abstract

Background: In infants that were exposed to biologics in utero, gastroenterology societal guidelines have either recommended against administration of the live rotavirus vaccine until 6-12 months of age or until serum biologic levels are undetectable. We performed a systematic review to evaluate the safety of rotavirus vaccination in biologic-exposed infants., Methods: EMBASE, PubMed, Scopus, and Cochrane databases were searched from 2006 to 2024 for original data reporting on the safety of rotavirus vaccination in infants that were exposed to anti-tumor necrosis factors (TNFs) (ie, infliximab, adalimumab, golimumab, certolizumab) and non-TNF biologics (ie, vedolizumab, ustekinumab, rizankizumab, mirikizumab) in utero., Results: A database search yielded 7185 screening results of which 10 studies met inclusion criteria. There were over 300 instances of rotavirus vaccination in biologic-exposed infants (n = 162 exposed to anti-TNFs, n = 142 exposed to non-TNF biologics). Biologic-exposed infants were not at an increased risk of severe adverse events or adverse events of any severity related to rotavirus vaccination., Conclusions: Administration of the live rotavirus vaccine appears to be safe in biologic-exposed infants. As such, with careful examination of the risks and benefits, there may be a role for rotavirus vaccination in this population., (© The Author(s) 2024. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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