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Your search keyword '"Sabrina Mueller"' showing total 8 results
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8 results on '"Sabrina Mueller"'

1. Switching within out of class following first-line TNFi failure in ulcerative colitis: real-world outcomes from a German claims data analysis

Author

Evi Zhuleku, Daniel Wirth, Riikka Nissinen, Ivana Bravatà, Despina Ziavra, Andreas Duva, Jennifer Lee, Andreas Fuchs, Sabrina Mueller, Thomas Wilke, and Bernd Bokemeyer

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background: Biologic agents have demonstrated efficacy in treating ulcerative colitis (UC); however, treatment failure to tumor necrosis factor inhibitors (TNFi) is common in the real world. Data on preferential sequencing in clinical practice after failure remain limited. Objectives: This study aimed to evaluate real-world outcomes of patients cycling to TNFis or switching to non-TNFi biologics following first-line failure with TNFis. Design: Retrospective cohort study in Germany. Methods: Adult patients with UC were identified using administrative claims data from 1 May 2014 to 30 June 2022 provided by a statutory sickness fund. Patients newly initiating first-line therapy with TNFis and then switching to another agent were identified. Patients were defined as within-class switched (WCS), if they cycled to another TNFi, or outside-class switchers (OCS), if they switched to a non-TNFi biologic [ustekinumab (UST) or vedolizumab (VDZ)] and followed from index (switch date) to death, insurance end, or study end on 30 June 2022. Inverse probability of treatment weighting (IPTW) was performed to adjust for differences in baseline characteristics between groups, and weighted Cox regression models were used to compare primary (time to discontinuation and second treatment switch) and secondary outcomes (corticosteroid-free drug survival). Results: We identified 166 patients initiating TNFis and switching to a subsequent treatment (mean age: 42.9 years, 49.4% female). Following IPTW, there were 71 and 76 patients in the WCS and OCS groups, respectively. Compared to OCS, WCS were more likely to discontinue the new therapy [hazard ratio (HR), 1.82, 95% confidence interval (CI), 1.14–2.89, p = 0.012], and switch a second time (HR, 3.46, 95% CI, 1.89–6.36, p

Published
2024
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3. Association between asthma control and healthcare costs: Results from a German linked data study

Author

Thomas Wilke, Hartmut Timmermann, Sabrina Mueller, Fraence Hardtstock, Victoria Unmuessig, Robert R Welte, and Ulf Maywald

Subjects
Health Policy
Abstract

Background: This study aimed to evaluate differences in healthcare resource utilization and cost among patients with controlled and uncontrolled asthma. Methods: Claims data from a German sickness fund was linked to patient survey data. Outpatient physicians enrolled patients and assessed asthma control using the ACTTM questionnaire. All-cause and asthma-specific healthcare resource use (HCRU)/costs were compared descriptively and based on multivariable models using a continuous ACTTM score. Results: Overall, 492 asthma patients were included (mean age: 53.8, 73.8% female). The mean/median ACTTM score was 19.9/20.7, with 183 patients (37.2%) classified as having uncontrolled asthma (mean ACTTM score Conclusion: Considering continuous patient care, improving asthma control is not only desirable from a clinical perspective, but could also be an effective approach to reduce asthma-related HCRU and cost burden.

Published
2022

4. Effects of Single Pill Combinations Compared to Identical Multi Pill Therapy on Outcomes in Hypertension, Dyslipidemia and Secondary Cardiovascular Prevention: The START-Study

Author

Thomas Wilke, Burkhard Weisser, Hans-Georg Predel, Roland E Schmieder, Sven Wassmann, Anton Gillessen, Jörg Blettenberg, Ulf Maywald, Olaf Randerath, Sabrina Mueller, and Michael Böhm

Subjects
Integrated Blood Pressure Control, Internal Medicine, Cardiology and Cardiovascular Medicine
Abstract

Thomas Wilke,1 Burkhard Weisser,2 Hans-Georg Predel,3 Roland Schmieder,4 Sven Wassmann,5 Anton Gillessen,6 Jörg Blettenberg,7 Ulf Maywald,8 Olaf Randerath,9 Sabrina Mueller,10 Michael Böhm11 1Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM)/Institute for Pharmacoeconomics and Pharmaceutical Logistics, Wismar, Germany; 2Institute of Sports Science, Christian-Albrechts-University of Kiel, Kiel, Germany; 3Institute of Cardiology and Sports Medicine, German Sport University, Cologne, Germany; 4Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University Erlangen Nürnberg, Erlangen, Germany; 5Faculty of Medicine, Cardiology Pasing, Munich and University of the Saarland, Homburg/Saar, Germany; 6Department of Internal Medicine, Herz-Jesu-Hospital, Münster, Germany; 7Practice Dr. J. Blettenberg, Lindlar, Germany; 8AOK PLUS – The Health Insurance for Sachsen und Thüringen; GB Medicines/Remedies, Dresden, Germany; 9Medical Department, APONTIS PHARMA GmbH & Co.KG, Monheim, Germany; 10Ingress-Health HWM GmbH, Wismar, Germany; 11Clinic for Internal Medicine III, University Clinic of Saarland, Saarland University, Homburg/Saar, GermanyCorrespondence: Thomas Wilke, Institute of Pharmacoeconomics and Medication Logistics, University of Wismar, Alter Holzhafen 19, Wismar, 23966, Germany, Tel +4938417581014, Fax +4938417581011, Email Thomas.wilke@ipam-wismar.deAim: Current guidelines for the treatment of arterial hypertension (AH) or cardiovascular (CV) prevention recommend combination drug treatments with single pill combinations (SPC) to improve adherence to treatment. We aimed to assess whether the SPC concept is clinically superior to multi pill combination (MPC) with identical drugs.Methods and Results: In an explorative study, we analyzed anonymized claims data sets of patients treated with CV drugs for hypertension and/or CV disorders who were insured by the German AOK PLUS statutory health fund covering 01/07/2012-30/06/2018. Patients at age ≥ 18 years who received either a SPC or MPC with identical drugs were followed for up to one year. A one to one propensity score matching (PSM) was applied within patient groups who started identical drug combinations, and results were reported as incidence rate ratios (IRRs) as well as hazard ratios (HRs). After PSM, data from 59,336 patients were analyzed. In 30 out of 56 IRR analyses, superiority of SPC over MPC was shown. In 5 out of 7 comparisons, the HR for the composite outcome of all-cause death and all-cause hospitalizations was in favor of the SPC regimen (SPC versus MPC): valsartan/amlodipine: HR=0.87 (95% CI: 0.84– 0.91, p ≤ 0.001); candesartan/amlodipine: 0.77 (95% CI: 0.65– 0.90, p = 0.001); valsartan/amlodipine/hydrochlorothiazide: HR=0.68 (95% CI: 0.61– 0.74, p ≤ 0.001); ramipril/amlodipine: HR=0.80 (95% CI: 0.77– 0.83, p ≤ 0.001); acetylsalicylic acid (ASA)/atorvastatin/ramipril: HR=0.64 (95% CI: 0.47– 0.88, p = 0.005).Conclusion: SPC regimens are associated with a lower incidence of CV events and lower all-cause mortality in clinical practice. SPC regimens should generally be preferred to improve patient’s prognosis.Keywords: single pill, adherence, cardiovascular outcomes, mortality, prognosis, clinical practice

Published
2022

5. Adaptation and validation of the Adherence Barriers Questionnaire for HIV Patients on Antiretroviral Therapy (ABQ-HIV) for the Brazilian context

Author

Míria Dantas Pereira, Sabrina Müeller, and Victor Santana Santos

Subjects
Hospital Care, Hospital Information Systems, Benchmarking, Indicators (Statistic), Unified Health System, Medicine, Public aspects of medicine, RA1-1270
Abstract

Despite significant advancements in antiretroviral therapy (ART) for HIV, adherence remains a challenge. While Brazil has validated scales for treatment adherence, few assess treatment adherence barriers. This underscores the necessity for validated questionnaires on adherence barriers to identify patient-specific challenges and enhance strategies for ART adherence. This study aimed to adapt and validate the Adherence Barriers Questionnaire for HIV Patients on Antiretroviral Therapy (ABQ-HIV), a 17-item questionnaire assessing the adherence barriers to ART, for the Brazilian context and to evaluate its psychometric properties in HIV patients. A methodological study on the psychometric properties and factorial structure of ABQ-HIV was conducted. The study followed seven steps: consent of the original authors, two translations, synthesis of the translations, expert committee, back-translation, pre-test, and reliability test. A high content validity index (0.93) was achieved with the expert committee. The study sample consisted of 230 adults with HIV, with 37.0 (29.3-45.0) years as the median age (IQR), and 52.2% were male. The exploratory factor analysis with a three subscales structure of 17 items showed good interpretability (Bartlett’s sphericity (1167.2 [136]; p < 0.001) and Kaiser-Meyer-Olkin = 0.602) and internal consistency (α = 0.76; Ω = 0.76). The fit indicators were satisfactory (χ2 = 89.931; df = 88; p > 0.005; RMSEA = 0.010; RMSR = 0.07; CFI = 0.996; GFI = 0.940; AGFI = 0.907; NNFI = 0.995). The Brazilian version of ABQ-HIV is a potential instrument for identifying specific barriers to adherence to ART in adults living with HIV in Brazil.

Published
2024
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6. Neue kirchliche Gemeinschaftsformen entwickeln : Eine Handreichung

Author

Sabrina Müller, Patrick Todjeras, Sabrina Müller, and Patrick Todjeras

Abstract

Kirchliche Gemeinschaft innovativ denken, entwickeln und gestalten. Glaube, Liturgie und Nach­folge theologisch neu verorten. Eine Willkommenskultur leben, sodass Menschen jenseits des kirchlichen Stammpublikums einen Ort der Zuge­hörigkeit finden. Sabrina Müller und Patrick Todjeras entwickeln anhand von ekklesiologischen und wissenschaft­lichen Kriterien Design und Methode für eine qua­litative Evaluation von Entwicklungsprozessen kirchlicher Gemeinschaftsformen. Und sie erproben diese an zwei neuen kirchlichen Orten der Kirchgemeinde Zürich: dem Stadtkloster und dem Cafébetrieb mit Co­-Workingspace Zytlos. So ana­lysieren sie die neue Gemeinschaftsform auf ihre Vitalität hin und erfassen ihre Innen-­ und Aussen­wahrnehmung im Rahmen ihrer Entstehungspro­zesse. Entstanden ist eine Handreichung, die zeigt, dass und wie Evaluation zur Weiterentwicklung beitragen kann.

Published
2024

7. Churches Online in Times of Corona : Die CONTOC-Studie: Empirische Einsichten, Interpretationen und Perspektiven

Author

Thomas Schlag, Ilona Nord, Wolfgang Beck, Arnd Bünker, Georg Lämmlin, Sabrina Müller, Johann Pock, Martin Rothgangel, Thomas Schlag, Ilona Nord, Wolfgang Beck, Arnd Bünker, Georg Lämmlin, Sabrina Müller, Johann Pock, and Martin Rothgangel

Subjects
COVID-19 (Disease)--Religious aspects, Internet in church work, Church work, Social media
Abstract

Die CONTOC-Studie hat in ökumenischer und internationaler Ausrichtung die digitale kirchliche Praxis unter den Bedingungen der Corona-Pandemie im Frühsommer 2020 erforscht. Dieser Band dokumentiert die Rahmenbedingungen und Umfrageergebnisse in den beteiligten Ländern. Daran schließen sich Perspektiven zu den zukünftigen Herausforderungen für die digitale Angebotspraxis und das Selbstverständnis der kirchlichen Akteur•innen an. Churches Online in Times of Corona. The CONTOC study: Empirical insights, interpretations and perspectives The CONTOC study has explored digital church practice under the conditions of the COVID-19 pandemic in the early summer of 2020 in an ecumenical and international way. This volume documents the framework conditions and survey results in the participating countries. This is followed by perspectives on the future challenges for the digital practice and the selfunderstanding of church actors.

Published
2024

8. Transformative Homiletik. Jenseits der Kanzel : (M)achtsam predigen in einer sich verändernden Welt

Author

Sabrina Müller, Jasmine Suhner, Sabrina Müller, and Jasmine Suhner

Subjects
Preaching
Abstract

Predigen ist in zutiefst wirkungsvoller, seelenvoller und sinnvoller Weise möglich. Vielerorts geschieht dies schon, auch jenseits der Kanzel, ohne als Predigt anerkannt zu sein. Die Autorinnen prüfen die unhinterfragten Machtansprüche einer frontalen Predigt und bieten alternative, feministische und postkoloniale Ansätze. Partizipation statt Kanzelmacht unterstützt durch die göttliche Geistkraft, die RUACH, wollen sie die Predigt transformieren in einer sich transformierende Welt. Der dritte Band der Reihe'Interdisziplinäre Studien zur Transformation'(IST)

Published
2023

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