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This paper investigates the performance of two commercial stent designs inside the normal artery for induced Von Mises Stress and radial displacement pattern. Investigation focuses on identifying the key design feature of the stent structure responsible for varied stress and displacement pattern. Two commercial stent designs, Supraflex (Stent S) and Yukon Choice (Stent T),are modeled using micro CT images and MIMICS® while idealized models are used for investigation. ANSYS Workbench is used to numerically expand the stent inside an idealized normal artery with inflation pressure. The stent and the artery are modeled using elastic-plastic and hyperelastic material models, respectively. The results suggest crucial influence of the link positioning in inducing an area of higher Von Mises Stress and stress gradient. The locations of a higher stress gradient are those in line with unbound stent crowns. Also, higher and uniform arterial displacement can be observed in the locations in line with the bound crown. Results also suggested a considerable difference in arterial distortion induced by two designs, causes for which can also be attributed to the differences in the link placement. The study suggests that the link connections play a crucial role in setting up stress field/radial displacement. Suitable modification of the link positioning can reduce the higher stress gradient and arterial distortion, which probably can reduce arterial injury. [ABSTRACT FROM AUTHOR]

Background: Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various categories of high density lipoprotein (HDL) cholesterol levels estimated during admission at the hospital and correlate the levels of HDL cholesterol with severity of CAD as measured by Gensini score. Methods: A cross-sectional study was conducted in 151 young patients (18-45 years) who were admitted at the hospital with newly diagnosed acute coronary syndrome (ACS). Tests such as electrocardiogram, cardiac enzyme assay, hematologic and biochemical tests including fasting lipid profile levels were taken into account. Results: There was an inverse relation observed between the number of vessels involvedand HDL cholesterol levels. Those with lower levels of HDL cholesterol were more vulnerable to multi-vessel CAD. However, no association was observed between HDL cholesterol and severity of CAD as measured by Gensini score. Conclusion: In young patients with acute coronary syndrome and diminished HDL cholesterol levels had a greater number of vessels involved when compared with elevated HDL cholesterol levels group. However, low HDL cholesterol levels had no association with severity of CAD as measured by Gensini score. No statistically significant association was noticed between levels of HDL cholesterol and in hospital mortality /morbidity. [ABSTRACT FROM AUTHOR]