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4. Pick Your Threshold: A Comparison Among Different Methods of Anaerobic Threshold Evaluation in Heart Failure Prognostic Assessment

Author

Farina, Stefania, Pezzuto, Beatrice, Apostolo, Anna, Palermo, Pietro, Contini, Mauro, Gugliandolo, Paola, Mattavelli, Irene, Della Rocca, Michele, Gallo, Giovanna, Moscucci, Federica, Iorio, Anita, Halasz, Geza, Capelli, Bruno, Binno, Simone, Pacileo, Giuseppe, Valente, Fabio, Vastarella, Rossella, Zaffalon, Denise, Carriere, Cosimo, Masè, Marco, Cittar, Marco, Di Lenarda, Andrea, Caravita, Sergio, Viganò, Elena, Marchese, Giovanni, Ricci, Roberto, Arcari, Luca, Scrutinio, Domenico, Battaia, Elisa, Moretti, Michele, Matassini, Maria Vittoria, Shkoza, Matilda, Herberg, Roland, Cittadini, Antonio, Salzano, Andrea, Marra, Alberto, Lafranca, Eluisa, Vitale, Giuseppe, Salvioni, Elisabetta, Mapelli, Massimo, Bonomi, Alice, Magrì, Damiano, Piepoli, Massimo, Frigerio, Maria, Paolillo, Stefania, Corrà, Ugo, Raimondo, Rosa, Lagioia, Rocco, Badagliacca, Roberto, Filardi, Pasquale Perrone, Senni, Michele, Correale, Michele, Cicoira, Mariantonietta, Perna, Enrico, Metra, Marco, Guazzi, Marco, Limongelli, Giuseppe, Sinagra, Gianfranco, Parati, Gianfranco, Cattadori, Gaia, Bandera, Francesco, Bussotti, Maurizio, Re, Federica, Vignati, Carlo, Lombardi, Carlo, Scardovi, Angela B., Sciomer, Susanna, Passantino, Andrea, Emdin, Michele, Passino, Claudio, Santolamazza, Caterina, Girola, Davide, De Martino, Fabiana, and Agostoni, Piergiuseppe

Published
2022
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7. What about chronotropic incompetence in heart failure with mildly reduced ejection fraction? Clinical and prognostic implications from the Metabolic Exercise combined with Cardiac and Kidney Indexes score dataset

Author

Magrì, Damiano, primary, Gallo, Giovanna, additional, Piepoli, Massimo, additional, Salvioni, Elisabetta, additional, Mapelli, Massimo, additional, Vignati, Carlo, additional, Fiori, Emiliano, additional, Muthukkattil, Melwyn Luis, additional, Corrà, Ugo, additional, Metra, Marco, additional, Paolillo, Stefania, additional, Maruotti, Antonello, additional, Di Loro, Pierfrancesco Alaimo, additional, Senni, Michele, additional, Lagioia, Rocco, additional, Scrutinio, Domenico, additional, Emdin, Michele, additional, Passino, Claudio, additional, Parati, Gianfranco, additional, Sinagra, Gianfranco, additional, Correale, Michele, additional, Badagliacca, Roberto, additional, Sciomer, Susanna, additional, Di Lenarda, Andrea, additional, Agostoni, Piergiuseppe, additional, and Filardi, Pasquale Perrone, additional

Published
2023
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8. What about chronotropic incompetence in heart failure with mildly reduced ejection fraction? Clinical and prognostic implications from the Metabolic Exercise combined with Cardiac and Kidney Indexes score dataset.

Author

Magrì, Damiano, Gallo, Giovanna, Piepoli, Massimo, Salvioni, Elisabetta, Mapelli, Massimo, Vignati, Carlo, Fiori, Emiliano, Muthukkattil, Melwyn Luis, Corrà, Ugo, Metra, Marco, Paolillo, Stefania, Maruotti, Antonello, Loro, Pierfrancesco Alaimo Di, Senni, Michele, Lagioia, Rocco, Scrutinio, Domenico, Emdin, Michele, Passino, Claudio, Parati, Gianfranco, and Sinagra, Gianfranco

Published
2024
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10. Pick Your Threshold

Author

Salvioni, Elisabetta, primary, Mapelli, Massimo, additional, Bonomi, Alice, additional, Magrì, Damiano, additional, Piepoli, Massimo, additional, Frigerio, Maria, additional, Paolillo, Stefania, additional, Corrà, Ugo, additional, Raimondo, Rosa, additional, Lagioia, Rocco, additional, Badagliacca, Roberto, additional, Filardi, Pasquale Perrone, additional, Senni, Michele, additional, Correale, Michele, additional, Cicoira, Mariantonietta, additional, Perna, Enrico, additional, Metra, Marco, additional, Guazzi, Marco, additional, Limongelli, Giuseppe, additional, Sinagra, Gianfranco, additional, Parati, Gianfranco, additional, Cattadori, Gaia, additional, Bandera, Francesco, additional, Bussotti, Maurizio, additional, Re, Federica, additional, Vignati, Carlo, additional, Lombardi, Carlo, additional, Scardovi, Angela B., additional, Sciomer, Susanna, additional, Passantino, Andrea, additional, Emdin, Michele, additional, Passino, Claudio, additional, Santolamazza, Caterina, additional, Girola, Davide, additional, Zaffalon, Denise, additional, De Martino, Fabiana, additional, Agostoni, Piergiuseppe, additional, Farina, Stefania, additional, Pezzuto, Beatrice, additional, Apostolo, Anna, additional, Palermo, Pietro, additional, Contini, Mauro, additional, Gugliandolo, Paola, additional, Mattavelli, Irene, additional, Della Rocca, Michele, additional, Gallo, Giovanna, additional, Moscucci, Federica, additional, Iorio, Anita, additional, Halasz, Geza, additional, Capelli, Bruno, additional, Binno, Simone, additional, Pacileo, Giuseppe, additional, Valente, Fabio, additional, Vastarella, Rossella, additional, Carriere, Cosimo, additional, Masè, Marco, additional, Cittar, Marco, additional, Di Lenarda, Andrea, additional, Caravita, Sergio, additional, Viganò, Elena, additional, Marchese, Giovanni, additional, Ricci, Roberto, additional, Arcari, Luca, additional, Scrutinio, Domenico, additional, Battaia, Elisa, additional, Moretti, Michele, additional, Matassini, Maria Vittoria, additional, Shkoza, Matilda, additional, Herberg, Roland, additional, Cittadini, Antonio, additional, Salzano, Andrea, additional, Marra, Alberto, additional, Lafranca, Eluisa, additional, and Vitale, Giuseppe, additional

Published
2022
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11. Revisiting a Prognosticating Algorithm from Cardiopulmonary Exercise Testing in Chronic Heart Failure (from the MECKI Score Population)

Author

Corrà, Ugo, primary, Piepoli, Massimo Francesco, additional, Giordano, Andrea, additional, Doni, Francesco, additional, Magini, Alessandra, additional, Bonomi, Alice, additional, Salvioni, Elisabetta, additional, Lagioia, Rocco, additional, Limongelli, Giuseppe, additional, Paolillo, Stefania, additional, Magrì, Damiano, additional, Filardi, Pasquale Perrone, additional, Sinagra, Gianfranco, additional, Scardovi, Angela B., additional, Metra, Marco, additional, Senni, Michele, additional, Scrutinio, Domenico, additional, Raimondo, Rosa, additional, Emdin, Michele, additional, Cattadori, Gaia, additional, Parati, Gianfranco, additional, Re, Federica, additional, Cicoira, Mariantonietta, additional, Minà, Chiara, additional, Correale, Michele, additional, Frigerio, Maria, additional, Perna, Enrico, additional, Bussotti, Maurizio, additional, Battaia, Elisa, additional, Guazzi, Marco, additional, Bandera, Francesco, additional, Badagliacca, Roberto, additional, Lenarda, Andrea Di, additional, Maggioni, Aldo, additional, Passino, Claudio, additional, Sciomer, Susanna, additional, Pacileo, Giuseppe, additional, Mapelli, Massimo, additional, Vignati, Carlo, additional, Clemenza, Francesco, additional, Lombardi, Carlo, additional, and Agostoni, Piergiuseppe, additional

Published
2022
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13. Old and new equations for maximal heart rate prediction in patients with heart failure and reduced ejection fraction on beta-blockers treatment: results from the MECKI score data set

Author

Magrì, Damiano, primary, Piepoli, Massimo, additional, Gallo, Giovanna, additional, Corrà, Ugo, additional, Metra, Marco, additional, Paolillo, Stefania, additional, Filardi, Pasquale Perrone, additional, Maruotti, Antonello, additional, Salvioni, Elisabetta, additional, Mapelli, Massimo, additional, Vignati, Carlo, additional, Senni, Michele, additional, Limongelli, Giuseppe, additional, Lagioia, Rocco, additional, Scrutinio, Domenico, additional, Emdin, Michele, additional, Passino, Claudio, additional, Parati, Gianfranco, additional, Sinagra, Gianfranco, additional, Correale, Michele, additional, Badagliacca, Roberto, additional, Sciomer, Susanna, additional, Di Lenarda, Andrea, additional, and Agostoni, Piergiuseppe, additional

Published
2022
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18. Malnutrition in patients admitted to in-hospital cardiac rehabilitation: Clinical correlates and association with mortality.

Author

Passantino, Andrea, Guida, Pietro, Rizzo, Caterina, Carbonara, Rosa, Ruggieri, Roberta, and Scrutinio, Domenico

Subjects
CARDIAC rehabilitation, MALNUTRITION, NUTRITIONAL assessment, SERUM albumin, CARDIAC surgery, TREATMENT programs, ARM circumference
Abstract

Malnutrition is highly prevalent among hospitalized patients; thus, an accurate identification of malnutrition could improve the outcome of these patients. The aim of the present paper was to apply multiple methods to evaluate the prevalence of malnutrition and clinical correlates in patients admitted to in-hospital cardiac rehabilitation. We performed a prospective study of 426 patients admitted to in-hospital cardiac rehabilitation: 282 (66.2%) had undergone a major cardiac surgery and 144 (34.8%) had experienced heart failure. The albumin level and mini nutritional assessment (MNA) scores were applied to evaluate the nutritional status of these patients. Serum albumin levels were < 3.5 g/dl in 147 (34.5%) patients, and MNA scores were < 24 in 179 (42.0%) patients. Patients with malnutrition or a risk of malnutrition had lower haemoglobin values, lower EuroQol scores and poorer functional status. Female gender, age, functional status and cumulative illness rating scale severity were predictors of malnutrition. Over a median follow-up of 47 months, MNA scores <24 were associated with higher mortality, even after correction for confounding variables. In conclusion, in patients admitted to in-hospital cardiac rehabilitation, malnutrition and risk of malnutrition frequently occur and are associated with poor functional status, higher clinical complication rates and long-term mortality. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Revisiting a Prognosticating Algorithm from Cardiopulmonary Exercise Testing in Chronic Heart Failure (from the MECKI Score Population)

Author

Ugo Corrà, Massimo Francesco Piepoli, Andrea Giordano, Francesco Doni, Alessandra Magini, Alice Bonomi, Elisabetta Salvioni, Rocco Lagioia, Giuseppe Limongelli, Stefania Paolillo, Damiano Magrì, Pasquale Perrone Filardi, Gianfranco Sinagra, Angela B. Scardovi, Marco Metra, Michele Senni, Domenico Scrutinio, Rosa Raimondo, Michele Emdin, Gaia Cattadori, Gianfranco Parati, Federica Re, Mariantonietta Cicoira, Chiara Minà, Michele Correale, Maria Frigerio, Enrico Perna, Maurizio Bussotti, Elisa Battaia, Marco Guazzi, Francesco Bandera, Roberto Badagliacca, Andrea Di Lenarda, Aldo Maggioni, Claudio Passino, Susanna Sciomer, Giuseppe Pacileo, Massimo Mapelli, Carlo Vignati, Francesco Clemenza, Carlo Lombardi, Piergiuseppe Agostoni, Corrà, Ugo, Piepoli, Massimo Francesco, Giordano, Andrea, Doni, Francesco, Magini, Alessandra, Bonomi, Alice, Salvioni, Elisabetta, Lagioia, Rocco, Limongelli, Giuseppe, Paolillo, Stefania, Magrì, Damiano, Filardi, Pasquale Perrone, Sinagra, Gianfranco, Scardovi, Angela B, Metra, Marco, Senni, Michele, Scrutinio, Domenico, Raimondo, Rosa, Emdin, Michele, Cattadori, Gaia, Parati, Gianfranco, Re, Federica, Cicoira, Mariantonietta, Minà, Chiara, Correale, Michele, Frigerio, Maria, Perna, Enrico, Bussotti, Maurizio, Battaia, Elisa, Guazzi, Marco, Bandera, Francesco, Badagliacca, Roberto, Lenarda, Andrea Di, Maggioni, Aldo, Passino, Claudio, Sciomer, Susanna, Pacileo, Giuseppe, Mapelli, Massimo, Vignati, Carlo, Clemenza, Francesco, Lombardi, Carlo, and Agostoni, Piergiuseppe

Subjects
Heart Failure, Oxygen Consumption, Adrenergic beta-Antagonists, Exercise Test, Humans, Stroke Volume, HFrEF, Prognosis, Cardiology and Cardiovascular Medicine, Algorithms, Ventricular Function, Left
Abstract

Cardiopulmonary exercise testing is a prognostic tool in heart failure with reduced left ventricular ejection fraction (HFrEF). Prognosticating algorithms have been proposed, but none has been validated. In 2017, a predictive algorithm, based on peak oxygen consumption (VO2), ventilatory response to exercise (ventilation [VE] carbon dioxide production [VCO2], the VE/VCO2 slope), exertional oscillatory ventilation (EOV), and peak respiratory exchange ratio, was recommended, according treatment with β blockers: patients with HFrEF registered in the metabolic exercise test data combined with cardiac and kidney indexes (MECKIs) database were used to validated this algorithm. According to the inclusion/exclusion criteria, 4,683 MECKI patients with HFrEF were enrolled. At 3years follow-up, the end point was cardiovascular death and urgent heart transplantation (cardiovascular events [CV]). CV events occurred in 25% in patients without β blockers, whereas those with β-blockers had 11% (p 10

Published
2022

20. Cardiac rehabilitation for old-old patients with heart failure and severe functional impairment.

Author

Scrutinio D, Guida P, Carbonara R, and Passantino A

Abstract

Background: The effects of cardiac rehabilitation (CR) in old patients with heart failure (HF) and severe functional impairment (SFI) are not well established., Methods: We studied 1397 patients with HF and severe functional impairment, defined as a six-minute walking distance (6MWD) <300 m, admitted to inpatient CR. The patients were divided into three groups: Group A (young, ≤65 years), Group B (old-young, 66 to 75 years), and Group C (old-old, >75 years). The primary outcome was an increase in 6MWD to 300 m or more after CR. We used multivariable Cox modeling to determine the association of the primary outcome with three-year mortality after discharge from CR., Results: At admission to CR, 38.5 % of the patients in group A, 40.0 % in group B, and 46.3 % in group C (p = .029) were unable to walk unassisted. Of these patients, 29.5 %, 32.6 %, and 30.2 % (p = .835), respectively, regained the ability to walk independently. Overall, 370 (26.5 %) patients achieved the primary outcome, 49.1 % in group A, 32.2 % in group B, and 15.7 % in group C (p < .001). The adjusted HR of 3-year mortality for the patients who achieved the primary outcome was 0.53 (95 %CI 0.34-0.83; p = .005) in group A, 0.49 (95 %CI 0.33-0.74; p = .001) in group B, and 0.68 (95 %CI 0.47-0.98; p = .037) in group C., Conclusions: Our findings suggest that old-old patients with HF and severe functional impairment may benefit from CR and that functional improvement may predict improved survival., Competing Interests: Declaration of competing interest None declared., (Copyright © 2024. Published by Elsevier B.V.)

Published
2024
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21. Functional limitation predicts mortality in heart failure with preserved ejection fraction.

Author

Scrutinio D, Guida P, and Passantino A

Abstract

Background: While the prognostic value of six-minute walking test (6MWT) in patients with heart failure (HF) and reduced ejection fraction has been firmly established, there are few or no data correlating the distance walked during 6MWT (6MWD) with mortality in patients with HF with preserved ejection fraction (HFpEF) METHODS: We studied 482 patients with HFpEF who had been admitted to inpatients cardiac rehabilitation. The primary outcome was 3-year all-cause mortality. The association between 6MWD and the primary outcome was assessed using multivariable models. Established risk markers were incorporated into the models., Results: 174 patients died during the 3-year follow-up. Taking the highest tertile of 6MWD (≥360 m) as reference, the adjusted hazard ratio (HR) of the primary outcome was 2.23 (95 % CI 1.31-3.78; p = .003) for the patients in the intermediate tertile (241-359 m) and 4.94 (95 % CI 2.90-8.39; p < .001) for those in the lowest tertile (≤240 m). The annual mortality rate was 25.0 % in the lowest tertile, 10.9 % in the intermediate tertile, and 5.3 % in the highest tertile. When the distance walked was normalized for age, sex, and body mass index and expressed as percent-of-predicted walking distance, the adjusted HR was 1.30 (95 % CI 0.76-2.22; p = .331) for the patients in the intermediate tertile (58.2 % to 77.6 %) and 3.52 (95 % CI 2.12-5.85; p < .001) for those in the lowest tertile (≤58.1 %)., Conclusions: Our findings suggest that measuring functional capacity by evaluating the distance that a patient can walk over a period of 6 min provides important prognostic information in HFpEF., Competing Interests: Declarations of competing interest The authors declare they have no conflict of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2024. Published by Elsevier B.V.)

Published
2024
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