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The aim of this work is to draw attention to the peculiarities of long-lived patient functioning and to assess the state of health in a 100-year-old patient, her cognitive functions and life factors contributing to active longevity. Materials and methods. We have described and analyzed a case of the 100-year-old female patient’s health, the influence of factors for active aging prolongation (nutrition, physical activity, labor, psychological state, hobbies) on a specific example, conducted a review of the scientific literature regarding the reasons for longevity and people’s lifestyles. Results. According to projections for demographic prospects, by 2050, the number of elderly people in the world will increase to 16 %, and every sixth person will be older than 65 years. Thus, in the EU countries, the expected life expectancy for men is 74–77 years, women ‒ 80–82 years. Based on forecasts, the number of people aged 80 and over will triple: from 143 million in 2019 to 426 million in 2050. Therefore, the relevance of maintaining active longevity is beyond doubt. Examples of long-lived people on the planet have been analyzed and given. The presented clinical case is the 100-year-old woman who underwent a full clinical examination. Her physical and mental state as well as cognitive functions have been evaluated. The life and occupational trajectories, her hobby (singing), social activity, eating habits have been analyzed. Biological age has also been assessed. The biological age of our patient has been determined by metabolic laboratory parameters: complete blood count, creatinine, bilirubin, lipid levels, blood glucose, urea, AST, ALT, albumin, electrolytes. Conclusions. According to the conducted study, the biological age of the patient is 93 years, that is 7 years younger than the chronologic age. Our patient is not overweight, has daily walks lasting up to 1-2 hours, lives alone, but enjoys communicating with friendly people, has been adhering to a balanced diet over the past 40 years. The following are of great importance to the patient: a normal mental state, work after retirement, especially creative work, a positive attitude to life, communication with positive people, music and singing. Thus, a person can live up to 100 years without significant health problems.

Nucleotide-binding oligomerization domain-like receptors (NOD-like receptors) are cytosolic signaling receptors of innate immune cells recognizing ligands derived from bacteria, viruses, fungi and protozoa. They can initiate apoptosis and pro-inflammatory cytokines production. Meanwhile, the role of decidual NOD-like receptors in pathogenesis of early miscarriages remains unknown. Aim: to study NOD-like receptor (NOD1, NOD2, NLRP1, NLRP3, NLRC4) messenger ribonucleic acid (mRNA) expression in decidual tissue from patients with missedand spontaneous abortions compared to progressive pregnancy.Materials and Methods. NOD1, NOD2, NLRP1, NLRP3, NLRC4 and pathway protein receptorinteracting-serine/threonine-protein kinase 2 (RIP-2) mRNA expression in decidua from 34 patients with missed abortions (group I), 34 patients with spontaneous abortions (group II) and 57 women with progressive pregnancy admitted for artificial abortion (group III, control group) were analyzed by reverse transcription quantitative polymerase chain reaction (PCR) at gestational age of 6–10 weeks. Exclusion criteria were as follows: endocrine disorders, severe extragenital diseases, antiphospholipid syndrome, inherited thrombophilia, uterine malformations and fetal chromosomal abnormalities. Samples were collected by uterine abrasion. Results. It was found that mRNA expression of NOD2 was significantly higher in decidua from patients with missed and spontaneous abortions, whereas for RIP-2 (related to relevant signaling pathway) – in women with missed abortions. A moderate positive correlation between gestational age and mRNA expression for NOD2 (R = 0.48; p = 0.01) and RIP-2 (R = 0.41; p = 0.007) was observed in subjects with progressive pregnancy. In contrast, women with missed abortions showed a moderate negative correlation between body weight and mRNA expression for NOD2 (R = –0.46; p = 0.03) and RIP-2 (R = –0.51; p = 0.02) whereas spontaneous abortions was associated with moderate negative correlation between RIP-2 mRNA expression and body weight (R= –0.47; p=0.04) as well as body mass index (R= –0.48; p = 0.04) along with moderate positive correlation with age of menarche (R = 0.46; p = 0.04). However, compared with progressive pregnancy no significant differences were found in expression level form NOD1, NLRP1, NLRP3 and NLRC4 mRNA in decidua from patients with missed and spontaneous abortions. Conclusion. Elevated NOD2 mRNA expression was observed in decidua from patients with missed and spontaneous abortions compared to progressive pregnancy paralleled with upregulated RIP-2 mRNA expression in missed abortions. Finally, it was found that NOD1, NLRP1, NLRP3 and NLRC4 were not involved in pathogenesis of miscarriages.