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Your search keyword '"Rulin Qian"' showing total 4 results
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4 results on '"Rulin Qian"'

1. Feasibility and safety of expandable mediastinoscopic and laparoscopic radical esophagectomy

Author

Weidong Zhang, Dong Cui, Kefeng Shi, Maolin Chen, Binbin Zhang, and Rulin Qian

Subjects
expandable mediastinoscope, radical esophagectomy, esophageal cancer, feasibility, safety, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundAt present, minimally invasive radical esophagectomy is the main surgical method for esophageal cancer treatment, but it has inherent limitations. We have developed a novel method of radical esophagectomy without thoracotomy to improve this situation, namely, by using EMLE. We evaluated the feasibility and safety of expandable mediastinoscopic and laparoscopic radical esophagectomy (EMLE) through a retrospective analysis.MethodsFrom January 2019 to June 2022, we successfully performed 106 cases of radical resection of esophageal cancer with this new surgical technique, gradually improved the surgical path, and recorded the perioperative data and postoperative complications of all patients.ResultsThe operation was successfully performed in all patients except for two patients who required a switch to open surgery. The mean operation time was 171.11 ± 33.29 min and the mean intraoperative blood loss was 93.53 ± 56.32 ml. The mean number of removed lymph nodes was 23.59 ± 5.42. The postoperative complications included pneumonia (3.77%), recurrent laryngeal nerve palsy (1.89%), anastomotic leak (14.15%), pleural effusion (5.66%), chylothorax (2.83%), and reoperation (4.72%). All complications were graded I–III per the Clavien–Dindo classification. No perioperative death was recorded.ConclusionExpandable mediastinoscopic and laparoscopic radical esophagectomy is feasible for radical resection of esophageal cancer, with good therapeutic effect and safety. Because of its minimal impact on patients and convenient operation, it is a novel surgical option for patients with esophageal cancer and is expected to become a standard surgical method for radical esophagectomy in the future.

Published
2023
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2. Video-assisted mediastinoscopic and laparoscopic transhiatal esophagectomy for esophageal cancer

Author

Rulin Qian, Dong Cui, Guolei Wang, Kefeng Shi, Tao Lin, Baoping Lang, Zhe Jin, Xiao Zhang, Xionghuai Hua, and Binbin Zhang

Subjects
medicine.medical_specialty, Chyle, Esophageal Neoplasms, medicine.medical_treatment, Lymph node biopsy, Mediastinal tumor, Mediastinoscopy, Postoperative Complications, Humans, Medicine, Prospective Studies, Laparoscopy, Lymph node, Retrospective Studies, medicine.diagnostic_test, business.industry, Esophageal cancer, medicine.disease, Surgery, Esophagectomy, medicine.anatomical_structure, Lymph Node Excision, Esophageal Squamous Cell Carcinoma, business
Abstract

Mediastinoscopy was originally applied for lymph node biopsy and mediastinal tumor resection. Improved video imaging with spreadable working channels enabled mediastinoscopy for inspection and tissue biopsy in the superior mediastinum but it is rarely used in minimally invasive esophageal cancer surgery. In this prospective trial, the practicability and security of spreadable video-assisted mediastinoscopic combined with laparoscopic transhiatal esophagectomy (VAME) with video-assisted thoracoscopic esophagectomy (VATE) were compared. A total of 200 eligible patients with esophageal squamous cell carcinoma were randomly divided into VAME or VATE groups. Early postoperative outcomes and lymph node dissection between the two groups were compared. The operation time was significantly shorter (164.3 ± 47.0 min vs. 265.4 ± 47.2 min, P

Published
2021

3. Up-regulation of microRNA miR-101-3p enhances sensitivity to cisplatin via regulation of small interfering RNA (siRNA) Anti-human AGT4D and autophagy in non-small-cell lung carcinoma (NSCLC)

Author

Yu Feng, Dong Cui, and Rulin Qian

Subjects
Small interfering RNA, autophagy, Lung Neoplasms, Autophagy-Related Proteins, Mice, Nude, Bioengineering, Antineoplastic Agents, NSCLC, Applied Microbiology and Biotechnology, Flow cytometry, Mice, Downregulation and upregulation, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, microRNA, medicine, Animals, Humans, Viability assay, miR-101-3p, RNA, Small Interfering, Cisplatin, medicine.diagnostic_test, Chemistry, Autophagy, General Medicine, Up-Regulation, Gene Expression Regulation, Neoplastic, MicroRNAs, Apoptosis, Drug Resistance, Neoplasm, cisplatin sensitivity, Cancer research, TP248.13-248.65, medicine.drug, Biotechnology, Research Article, Research Paper
Abstract

The emergence of drug resistance hinders the treatment of malignant tumors, and autophagy plays an important role in tumor chemotherapy resistance. However, its mechanism in non-small cell lung cancer (NSCLC) has not been well-researched. We aim to investigate the role of miR-101-3p in cisplatin-resistant via regulation of autophagy-related protein 4D (ATG4D) and autophagy. Cell viability, apoptosis, fluorescence intensity of GFP-LC3 and RFP-GFP-LC3 were determined using Cell Counting Kit-8 (CCK-8) assay, flow cytometry, and Laser scanning confocal microscope analysis, respectively. The levels of LC3II/LC3I, P62 and ATG4D were detected by Western blot. The results showed that the sensitivity to cisplatin in NSCLC cells was up-regulated by miR-101-3p mimics treatment, inducing promoting cell apoptosis and inhibiting autophagy. Further mechanistic study identified that ATG4D was a direct target of miR-101-3p. Moreover, ATG4D siRNA also could reverse miR-101-3p inhibitor-induced the up-regulation of ATG4D and the ration of LC3II/LC3I, the down-regulation of p62 expression. Our findings indicated that miR-101-3p could regulate sensitivity to cisplatin of NSNCC cells by regulating autophagy mediated by ATG4D. Therefore, miR-101-3p may act as a potential therapeutic target for the treatment of NSCLC.

Published
2021

4. Clinical Characteristics of Malignant Pulmonary Sclerosing Pneumocytoma Based on a Study of 46 Cases Worldwide

Author

Weidong Zhang, Dong Cui, Yaqian Liu, Kefeng Shi, Xia Gao, and Rulin Qian

Subjects
Oncology, Cancer Management and Research
Abstract

Weidong Zhang,1 Dong Cui,1 Yaqian Liu,2 Kefeng Shi,1 Xia Gao,3 Rulin Qian1 1Department of Thoracic Surgery, Henan Provincial Chest Hospital, Zhengzhou City, Henan Province, People’s Republic of China; 2Medical Records and Statistics Room, Henan Provincial Chest Hospital, Zhengzhou City, Henan Province, People’s Republic of China; 3Department of Cardiovascular Surgery, Henan Provincial Chest Hospital, Zhengzhou City, Henan Province, People’s Republic of ChinaCorrespondence: Rulin Qian; Xia Gao, Henan Provincial Chest Hospital, Room 1, Weiwu Road, Zhengzhou City, Henan Province, 450003, People’s Republic of China, Email qianrulin0371@163.com; gaoxia03712022@163.comObjective: To analyze the clinical characteristics of patients with malignant pulmonary sclerosing pneumocytoma (PSP) with metastasis, recurrence, and growth and to improve clinicians’ understanding of PSP in patients with malignant tumor characteristics.Methods: A total of 46 PSP patients with malignant tumor characteristics were identified in the literature search and compared with 38 patients with benign PSP diagnosed and treated in our hospital in the past 5 years. We explored the pathogenesis, clinical symptoms, diagnostic methods, treatment strategies and prognosis of PSP patients with malignant tumor.Results: The characteristics of young age (≤ 41 years old), larger tumor (≥ 36mm), lymph node metastasis and distribution in East Asians are indicative of PSP with malignant potential. Such patients should undergo segmental resection or lobectomy, combined with necessary lymph node dissection or biopsy. All patients with PSP should have an entire course of follow-up management, because they may have an adverse prognosis such as recurrence, growth, metastasis, and even death.Conclusion: PSP has the potential for malignancy. Anatomical lobectomy or segmental resection combined with lymph node dissection should be performed in PSP with some specific characteristics. Inappropriate diagnosis and treatment may lead to poor prognosis in PSP patients.Keywords: pulmonary sclerosing pneumocytoma, malignant tumor, metastasis, recurrence, growth, treatment and diagnosis

Published
2022

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