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Traditionally, the ampacity of an overhead transmission line (OHTL) is a static value obtained based on adverse weather conditions, which constrains the transmission capacity. With the continuous growth of power system load, it is increasingly necessary to dynamically adjust the ampacity based on weather conditions. To this end, this paper models the heat balance relationship of the OHTL based on a BP neural network using Bayesian optimization (BO-BP). On this basis, an OHTL ampacity prediction method considering the model error is proposed. First, a two-stage current-stepping ampacity prediction model is established to obtain the initial ampacity prediction results. Then, the risk control strategy of ampacity prediction considering the model error is proposed to correct the ampacity based on the quartile of the model error to reduce the risk of the conductor overheating caused by the model error. Finally, a simulation is carried out based on the operation data of a 220-kV transmission line. The simulation results show that the accuracy of the BO-BP model is improved by more than 20% compared with the traditional heat balance equation. The proposed ampacity prediction method can improve the transmission capacity by more than 150% compared with the original static ampacity.

We generalize a real-space Chern number formula for gapped free fermions to higher orders. Using the generalized formula, we prove recent proposals for extracting thermal and electric Hall conductance from the ground state via the entanglement Hamiltonian in the special case of non-interacting fermions, providing a concrete example of the connection between entanglement and topology in quantum phases of matter.

Spinal cord injury (SCI) is a high incident rate of central nervous system disease that usually causes paralysis below the injured level. The occurrence of chronic inflammation with the axonal regeneration difficulties are the underlying barriers for the recovery of SCI patients. Current studies have paid attention to controlling the instigative and developmental process of neuro-inflammation. Ethyl pyruvate, as a derivative of pyruvate, has strong anti-inflammatory and neuroprotective functions. Herein, we reviewed the recent studies of ethyl pyruvate and high mobility group box-1 (HMGB1). We think HMGB1 that is one of the main nuclear protein mediators to cause an inflammatory response. This protein induces astrocytic activation, and promotes glial scar formation. Interestingly, ethyl pyruvate has potent inhibitory effects on HMGB1 protein, as it inhibits chronic inflammatory response by modulating the HMGB1/TLR4/NF-κB signaling pathway. This paper discusses the potential mechanism of ethyl pyruvate in inhibiting chronic inflammation after SCI. Ethyl pyruvate can be a prospective therapeutic agent for SCI.

Froth flotation is a commonly utilized beneficiation technique for effectively separating apatite from other gangue minerals, such as calcite. It is difficult to achieve good separation with fatty acid collectors due to their similar interactions with apatite and calcite. In this work, sodium N-lauroyl sarcosinate (SNLS) was used as the collector for the selective separation of calcite from apatite without a depressant. The experiments revealed that SNLS had a much better selectivity and a stronger affinity with calcite compared to apatite, with little effect on the flotation of apatite observed at a pH of 10. Fourier transform infrared (FTIR) analyses were conducted to explain the selective collector process of SNLS. The mechanism experiments demonstrate that SNLS can chemically bond to apatite and calcite minerals to produce Ca-NLS chelates. The active O atoms of the amide and carboxyl groups of SNLS accomplish this. Calcite has a greater Ca-reactivity than apatite, and as a result, the adsorption quantity on the calcite surface is greater than that on the apatite surface. FTIR analyses indicate that SNLS exhibits a greater affinity for the calcite surface than for apatite, a finding that is supported by first-principle density functional theory (DFT) calculations showing a higher adsorption energy of SNLS on the calcite surface. DFT calculations showed that SNLS forms stronger O-Ca bonds on the calcite surface and is less hindered by H2O. This work shows that the surfactant sodium N-lauroylsarcosinate (SNLS) can be an ideal collector for the flotation of phosphate minerals.

The complexity of central nervous system diseases together with their intricate pathogenesis complicate the establishment of effective treatment strategies. Presently, the superiority of adipose-derived mesenchymal stem cells (ADSCs) on neuronal injuries has attracted significant attention. Similarly, extracellular vesicles (EVs) are potential interventional agents that could identify and treat nerve injuries. Herein, we reviewed the potential effects of ADSCs and EVs on amyotrophic lateral sclerosis (ALS) injured nerves, and expound on their practical application in the clinic setting. This article predominantly focused on the therapeutic role of ADSCs concerning the pathogenesis of ALS, the protective and reparative effects of EVs on nerve injury, as well as the impact following the combined usage of ADSCs and EVs in ALS.

Abstract Background Activated regulatory T cells (aTregs) play a vital role in promoting a tumor immunosuppressive microenvironment in laryngeal squamous cell carcinoma (LSCC). However, the regulatory factors that induce the generation of aTregs are not clear. Herein, we investigated the effect of amphiregulin (AREG) on the production of aTregs in the tumor microenvironment of LSCC. Methods Immunohistochemical (IHC) analysis was conducted to examine the expression of AREG and FOXP3, and their association with clinical parameters and patient outcomes was demonstrated. The expression level of EGFRs in three functional subsets of Tregs was assessed, and the induction of CD4+ T cells into aTregs in the presence or absence of AREG or Gefitinib was analyzed using flow cytometry. Results Our results showed a higher expression level of AREG was significantly related to advanced clinical stage and worse survival, particularly with increased infiltration of Tregs in LSCC tumor tissue. The in vitro study showed that AREG significantly promoted the differentiation of aTregs, and enhanced the inhibitory effect of Tregs on T cell proliferation, which could be reversed by epidermal growth factor receptor (EGFR) inhibitors. In addition, we found that EGFR was highly expressed in aTregs, but not in other subsets of Tregs. It is suggested that AREG might induce aTregs, and enhance the immunosuppressive function of Tregs via the AREG/EGFR signal pathway. Conclusions Collectively, this study revealed the role and mechanism of AREG in negative immune regulation, and targeting AREG might be a novel immunotherapy for LSCC.

Abstract Introduction Atopic dermatitis (AD) is a chronic immuno-inflammatory skin disease. Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor approved for the treatment of mild to moderate AD. This post hoc analysis assesses the efficacy and safety of crisaborole in Chinese patients aged ≥ 2 years with mild to moderate AD. Methods We evaluated the efficacy and safety of crisaborole in Chinese patients from the vehicle-controlled, phase 3 CrisADe CLEAR study. Patients were randomly assigned 2:1 to receive crisaborole or vehicle twice daily, respectively, for 28 days. The primary endpoint was percent change from baseline in Eczema Area and Severity Index (EASI) total score at day 29. Key secondary endpoints were improvement in Investigator’s Static Global Assessment (ISGA), ISGA success, and change from baseline in weekly average Peak Pruritus Numerical Rating Scale (PP-NRS) score. Adverse events were documented. Results Of 391 patients in the overall study, 237 were from China, 157 assigned to crisaborole and 80 assigned to vehicle. A greater reduction in percent change from baseline in EASI total score at day 29 was shown in the crisaborole vs. vehicle group (least squares mean [LSM]: −66.34 [95% (confidence interval) CI −71.55 to −61.12] vs. −50.18 [95% CI −58.02 to −42.34]). Response rates for achievement of ISGA improvement (43.2% [95% CI 35.4–51.1] vs. 33.4% [95% CI 22.5–44.2]) and ISGA success (31.7% [95% CI 24.3–39.0] vs. 21.5% [95% CI 12.1–30.9]) at day 29 were higher in the crisaborole vs. vehicle group. A greater reduction in change from baseline in weekly average PP-NRS score at week 4 was observed in the crisaborole vs. vehicle group (LSM: −1.98 [95% CI −2.34 to −1.62] vs. −1.08 [95% CI −1.63 to −0.53]). No new safety signals were observed. Conclusion Crisaborole was effective and well tolerated in Chinese patients aged ≥ 2 years with mild to moderate AD. Trial Registration ClinicalTrials.gov, NCT04360187.

Abstract Background Hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis among all head-and-neck cancers, and treatment options are limited. Tumor microenvironment (TME) analysis can help identify new therapeutic targets and combined treatment strategies. Methods Six primary HPSCC tissues and two adjacent normal mucosae from six treatment-naïve patients with HPSCC were analyzed using scRNA-seq. Cell types were curated in detail, ecosystemic landscapes were mapped, and cell–cell interactions were inferred. Key results were validated with The Cancer Genome Atlas and cell biology experiments. Results Malignant HPSCC epithelial cells showed significant intratumor heterogeneity. Different subtypes exhibited distinct histological features, biological behaviors, and spatial localization, all affecting treatment selection and prognosis. Extracellular matrix cancer-associated fibroblasts (mCAFs) expressing fibroblast activation protein were the dominant CAFs in HPSCC tumors. mCAFs, constituting an aggressive CAF subset, promoted tumor cell invasion, activated endothelial cells to trigger angiogenesis, and synergized with SPP1+ tumor associated macrophages to induce tumor progression, ultimately decreasing the overall survival of patients with HPSCC. Moreover, the LAMP3+ dendritic cell subset was identified in HPSCC and formed an immunosuppressive TME by recruiting Tregs and suppressing CD8+ T cell function. Conclusions mCAFs, acting as the communication center of the HPSCC TME, enhance the invasion ability of HPSCC cells, mobilizing surrounding cells to construct a tumor-favorable microenvironment. Inhibiting mCAF activation offers a new anti-HPSCC therapeutic strategy. Graphical Abstract Video Abstract

Objectives. Despite the efficacy of surgical treatments, the high rate of recurrence in juvenile nasopharyngeal angiofibroma (JNA) after surgery remains an unresolved problem. The present study comprehensively analyzed the risk factors and characteristics of JNA recurrence, providing clinical guidance for reducing recurrence. Methods. A total of 123 patients who underwent surgery for JNA between 1997 and 2019 at a single hospital were analyzed retrospectively. Univariate and multivariate analyses were used to assess the clinical risk factors for the recurrence of JNA. The relapse-free survival and annual cumulative recurrence rates were analyzed for subgroups defined according to clinical parameters. Results. After screening, 78 of the 123 patients were included in the present study. The main risk factors associated with JNA recurrence included the year of diagnosis, tumor size, sphenoid bone invasion, Radkowski stage, surgical approach, and intraoperative bleeding. Importantly, the surgical approach and sphenoid bone invasion were independent prognostic factors affecting recurrence. Patients who underwent endoscopic surgery without sphenoid bone invasion exhibited longer relapse-free survival. In the present study, the overall cumulative recurrence rate of JNA was 38.7%, and recurrence occurred mainly in the first year after the initial surgery. Conclusion. Endoscopic surgery achieved better relapse-free survival in JNA patients, and patients with sphenoid bone invasion should be carefully explored to avoid residual JNA. The recurrence rate of JNA differed among subgroups defined based on clinical parameters and was highest in the first year after surgery. Computed tomography or magnetic resonance imaging, along with close follow-up, should be performed strictly within 1 year after the primary operation.

Memristive behaviors are demonstrated in the single-layer oxide-based devices. The conduction states can be continually modulated with different pulses or voltage sweeps. Here, the p-CuAlO2- and n-ZnO-based memristors show the opposite bias polarity dependence with the help of tip electrode. It is well known that the conductivity of p-type and n-type semiconductor materials has the opposite oxygen concentration dependence. Thus, the memristive behaviors may attribute to the oxygen ion migration in the dielectric layers for the single-layer oxide based memristors. Further, based on the redox, the model of compressing dielectric layer thickness has been proposed to explain the memristive behavior.

In this sequel (to [Phys. Rev. Res. 3, 023044(2021)], arXiv:2006.10072), we study randomly driven $(1+1)$ dimensional conformal field theories (CFTs), a family of quantum many-body systems with soluble non-equilibrium quantum dynamics. The sequence of driving Hamiltonians is drawn from an independent and identically distributed random ensemble. At each driving step, the deformed Hamiltonian only involves the energy-momentum density spatially modulated at a single wavelength and therefore induces a M\"obius transformation on the complex coordinates. The non-equilibrium dynamics is then determined by the corresponding sequence of M\"obius transformations, from which the Lyapunov exponent $\lambda_L$ is defined. We use Furstenberg's theorem to classify the dynamical phases and show that except for a few \emph{exceptional points} that do not satisfy Furstenberg's criteria, the random drivings always lead to a heating phase with the total energy growing exponentially in the number of driving steps $n$ and the subsystem entanglement entropy growing linearly in $n$ with a slope proportional to central charge $c$ and the Lyapunov exponent $\lambda_L$. On the contrary, the subsystem entanglement entropy at an exceptional point could grow as $\sqrt{n}$ while the total energy remains to grow exponentially. In addition, we show that the distributions of the operator evolution and the energy density peaks are also useful characterizations to distinguish the heating phase from the exceptional points: the heating phase has both distributions to be continuous, while the exceptional points could support finite convex combinations of Dirac measures depending on their specific type. In the end, we compare the field theory results with the lattice model calculations for both the entanglement and energy evolution and find remarkably good agreement.