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Your search keyword '"Rui Suo"' showing total 7 results
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7 results on '"Rui Suo"'

1. Quaternary Segmentation Characteristics of the Hunhe Fault, Northeast China

Author

Bo Wan, Guanghao Ha, Xiaohui Zhao, and Rui Suo

Subjects
Mishan–Dunhua fault, Hunhe fault, segmentation, seismotectonics, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

The northern segment of the Tanlu fault zone, which encompasses the Dunhua–Mishan and Yilan–Yitong fault zones, plays a critical role in the tectonic framework of Northeast China. This study focuses on the Hunhe fault, part of the Liaoning segment of the Dunhua–Mishan fault zone, which exhibits concealed characteristics and an NE–NEE orientation. We employ remote sensing and field investigations to accurately delineate the Hunhe fault’s location, scale, and tectonic activity. The findings indicate that the Hunhe fault displays significant spatial variability in tectonic activity. Some segments show evidence of late Quaternary activity, contradicting prior research that classified the Hunhe fault as an active fault during the MIS (Marine Isotope Stages) 20-103MIS 20-103- MIS6-19MIS6-19 period and assessed its seismic potential differently. Recent field investigations suggest considerable spatial variability in tectonic activity, indicating segmental characteristics. In this study, the Hunhe fault is divided into segments based on five aspects: the fault structure and movement characteristics of the fault; transverse faults and obstruction structures; geological and geomorphological characteristics; seismic features; and fault activity. The detailed segments are as follows: the Shenyang segment, the Fushun segment, the Zhangdang-Nan Zamu segment, and the Nan Zamu to Ying Emeng East section. These findings aim to enhance the understanding of the seismic hazard potential associated with the Hunhe fault, highlighting the need for ongoing research to address its complexities and implications for regional seismic risk assessment.

Published
2025
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5. Long non-coding RNA RPL34-AS1 ameliorates oxygen-glucose deprivation-induced neuronal injury via modulating miR-223-3p/IGF1R axis

Author

Xin-ya Wei, Tian-qi Zhang, Rui Suo, You-yang Qu, Yan Chen, and Yu-lan Zhu

Subjects
Neurons, Cancer Research, Caspase 3, Apoptosis, Cell Biology, Rats, Receptor, IGF Type 1, Oxygen, MicroRNAs, Glucose, Neuroprotective Agents, Proto-Oncogene Proteins c-bcl-2, Animals, Humans, RNA, Long Noncoding, Insulin-Like Growth Factor I, Ischemic Stroke, bcl-2-Associated X Protein
Abstract

Ribosomal protein L34-antisense RNA 1 (RPL34-AS1), one of the long non-coding RNAs (lncRNAs), plays an important function in regulating diverse human malignant tumors. Nevertheless, the functions of RPL34-AS1 in ischemic stroke remain unclear. The present work focused on determining the candidate targets of RPL34-AS1 and its related mechanism in ischemic injury. The oxygen-glucose deprivation (OGD/R) in vitro cell model and middle cerebral artery occlusion (MCAO) in vivo rat model were utilized to simulate the pathological process of ischemic stroke. Additionally, the CCK8, WB (detecting Bcl-2 and Bax protein levels), and caspase-3 activity assays were done to investigate the anti-apoptotic functions of RPL34-AS1. The relationship among RPL34-AS1, insulin-like growth factor 1 receptor (IGF1R), and microRNA-223-3p (miR-223-3p) was determined through luciferase reporter assay. In this study, RPL34-AS1 expression was reduced in patients suffering from ischemic stroke. The overexpression of RPL34-AS1 reduced ischemic brain damage. However, the cell viability and glucose uptake were increased, and the apoptosis rate was decreased in the OGD/R-induced neurons. Further, miR-223-3p resulted in the decreased cell viability and glucose uptake and the increased cell apoptosis to cause ischemic brain damage. Besides, the neuroprotective effects of RPL34-AS1 on OGD/R injury were partly reversed by miR-223-3p. Mechanistically, lncRNA RPL34-AS1 could function as the competing endogenous RNA (ceRNA) of miR-223-3p to regulate IGF1R. Collectively, our study demonstrated that lncRNA RPL34-AS1 attenuated OGD/R-induced neuronal injury by mediating miR-223-3p/IGF1R axis. This discovery might serve as the candidate therapeutic target for ischemic stroke.

Published
2022

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