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Apple production is a vital sector of agriculture in Nepal, significantly impacting local livelihoods and the regional economy. This study, conducted in Jumla District, Nepal, from January to July 2022, aims to comprehensively assess apple production, including its existing conditions, economic implications, marketing and challenges. The research hypothesizes that while apple production in Jumla District contributes significantly to the local economy, it faces challenges related to pest and disease management, marketing, and adoption of modern practices. Using Statistical Package for Social Science (SPSS), descriptive statistics were computed based on data collected from a sample of 80 respondents selected through simple random sampling. The result revealed that agriculture constituted the primary source of income for 73.75% of the population, with an average landholding size of 0.3428 ha and an apple-growing land area of 0.3164 ha. Income from apple production, along with vegetables and fruits, was a major income source. The average annual sales of apple production were 7.291 t/ha. Labor costs accounted for 45.67% of the total cost of apple production, with an average total production cost of NPR 238,097.2 and average gross returns of NPR 485,500. Apple productivity was 9.71 t/ha, demonstrating its economic viability with net returns of NPR 247,402.80 per ha and benefit cost ratio of 2.039. However, the study found that farm produce only sufficed for 6-9 months, with pest and disease incidence and marketing issues as major challenges. Interventions should address pest and disease management, marketing strategies, and modern practices adoption to enhance sustainable and profitable apple production in Jumla. Efforts to extend farm produce sufficiency should also be explored, highlighting apple production's potential and the need for targeted support to overcome challenges and foster sector development.

This Special Issue, titled ‘Vaccination and Global Health,’ compiles 11 broad-ranging papers, each exploring critical facets of vaccination, public health, and global healthcare systems [...]

Abstract Background Annexin A2 contributes to several key cellular functions and processes, including membrane repair. Effective repair prevents cell death and degeneration, especially in skeletal or cardiac muscle, epithelia, and endothelial cells. To maintain cell integrity after damage, mammalian cells activate multiple membrane repair mechanisms. One protein family that facilitates membrane repair processes are the Ca2+‐regulated phospholipid‐binding annexins. Body Annexin A2 facilitates repair in association with S100A10 and related S100 proteins by forming a plug and linking repair to other physiologic functions. Deficiency of annexin A2 enhances cellular degeneration, exacerbating muscular dystrophy and degeneration. Downstream of repair, annexin A2 links the membrane with the cytoskeleton, calcium‐dependent endocytosis, exocytosis, cell proliferation, transcription, and apoptosis to extracellular roles, including vascular fibrinolysis, and angiogenesis. These roles regulate cardiovascular disease progression. Finally, annexin A2 protects cancer cells from membrane damage due to immune cells or chemotherapy. Since these functions are regulated by post‐translational modifications, they represent a therapeutic target for reducing the negative consequences of annexin A2 expression. Conclusion Thus, connecting the roles of annexin A2 in repair to its other physiologic functions represents a new translational approach to treating muscular dystrophy and cardiovascular diseases without enhancing its pro‐tumorigenic activities.