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14 results on '"Rosenbauer, Frank"'

2. Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Author

Frank, Daria, Patnana, Pradeep Kumar, Vorwerk, Jan, Mao, Lianghao, Gopal, Lavanya Mokada, Jung, Noelle, Hennig, Thorben, Ruhnke, Leo, Frenz, Joris Maximillian, Kuppusamy, Maithreyan, Autry, Robert, Wei, Lanying, Sun, Kaiyan, Mohammed Ahmed, Helal Mohammed, Künstner, Axel, Busch, Hauke, Müller, Heiko, Hutter, Stephan, Hoermann, Gregor, Liu, Longlong, Xie, Xiaoqing, Al-Matary, Yahya, Nimmagadda, Subbaiah Chary, Cano, Fiorella Charles, Heuser, Michael, Thol, Felicitas, Göhring, Gudrun, Steinemann, Doris, Thomale, Jürgen, Leitner, Theo, Fischer, Anja, Rad, Roland, Röllig, Christoph, Altmann, Heidi, Kunadt, Desiree, Berdel, Wolfgang E., Hüve, Jana, Neumann, Felix, Klingauf, Jürgen, Calderon, Virginie, Opalka, Bertram, Dührsen, Ulrich, Rosenbauer, Frank, Dugas, Martin, Varghese, Julian, Reinhardt, Hans Christian, von Bubnoff, Nikolas, Möröy, Tarik, Lenz, Georg, Batcha, Aarif M. N., Giorgi, Marianna, Selvam, Murugan, Wang, Eunice, McWeeney, Shannon K., Tyner, Jeffrey W., Stölzel, Friedrich, Mann, Matthias, Jayavelu, Ashok Kumar, and Khandanpour, Cyrus

Published
2023
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3. BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis

Author

Schmitt, Anja, Grimm, Melanie, Kreienkamp, Nina, Junge, Hannah, Labisch, Jan, Schuhknecht, Laurentz, Schönfeld, Caroline, Görsch, Elsa, Tibello, Alessia, Menck, Kerstin, Bleckmann, Annalen, Lengerke, Claudia, Rosenbauer, Frank, Grau, Michael, Zampieri, Mattia, Schulze-Osthoff, Klaus, Klener, Pavel, Dolnikova, Alexandra, Lenz, Georg, and Hailfinger, Stephan

Published
2023
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5. Prevalence and clinical impact of CD56 and T‐cell marker expression in acute myeloid leukaemia: A single‐centre retrospective analysis

Author

Shaforostova, Inna, primary, Call, Simon, additional, Evers, Georg, additional, Reicherts, Christian, additional, Angenendt, Linus, additional, Stelljes, Matthias, additional, Berdel, Wolfgang E., additional, Pohlmann, Alexander, additional, Mikesch, Jan‐Henrik, additional, Rosenbauer, Frank, additional, Lenz, Georg, additional, Schliemann, Christoph, additional, and Wethmar, Klaus, additional

Published
2023
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8. Germline variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Author

Frank, Daria, primary, Patnana, Pradeep Kumar, additional, Vorwerk, Jan, additional, Mao, Lianghao, additional, Mokada Gopal, Lavanya, additional, Jung, Noelle, additional, Hennig, Thorben, additional, Ruhnke, Leo, additional, Frenz, Joris Maximillian, additional, Kuppusamy, Maithreyan, additional, Autry, Robert J, additional, Wei, Lanying, additional, Sun, Kaiyan, additional, Ahmed, Helal, additional, Künstner, Axel, additional, Busch, Hauke, additional, Müller, Heiko, additional, Hutter, Stephan, additional, Hoermann, Gregor, additional, Liu, Longlong, additional, Xie, Xiaoqing, additional, Al-Matary, Yahya, additional, Nimmagadda, Subbaiah Chary, additional, Charles Cano, Fiorella, additional, Heuser, Michael, additional, Thol, Felicitas R., additional, Göhring, Gudrun, additional, Steinemann, Doris, additional, Thomale, Jürgen, additional, Leitner, Theo, additional, Fischer, Anja, additional, Rad, Roland, additional, Röllig, Christoph, additional, Altmann, Heidi, additional, Kunadt, Desiree, additional, Berdel, Wolfgang E., additional, Hüve, Jana, additional, Neumann, Felix, additional, Klingauf, Jürgen, additional, Calderon, Virginie, additional, Opalka, Bertram, additional, Dührsen, Ulrich, additional, Rosenbauer, Frank, additional, Dugas, Martin, additional, Varghese, Julian, additional, Reinhardt, H. Christian H., additional, von Bubnoff, Nikolas, additional, Möröy, Tarik, additional, Lenz, Georg, additional, Batcha, Aarif M.N., additional, Giorgi, Marianna, additional, Selvam, Murugan, additional, Wang, Eunice S., additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Stölzel, Friedrich, additional, Mann, Matthias, additional, Jayavelu, Ashok Kumar, additional, and Khandanpour, Cyrus, additional

Published
2023
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9. Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs

Author

Xie, Xiaoqing, primary, Patnana, Pradeep Kumar, additional, Frank, Daria, additional, Schütte, Judith, additional, Al-Matary, Yahya, additional, Künstner, Axel, additional, Busch, Hauke, additional, Ahmed, Helal, additional, Liu, Longlong, additional, Engel, Daniel R., additional, Dührsen, Ulrich, additional, Rosenbauer, Frank, additional, Von Bubnoff, Nikolas, additional, Lenz, Georg, additional, and Khandanpour, Cyrus, additional

Published
2023
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10. HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia

Author

Gregoricchio, Sebastian, primary, Polit, Lélia, additional, Esposito, Michela, additional, Berthelet, Jérémy, additional, Delestré, Laure, additional, Evanno, Emilie, additional, Diop, M’Boyba, additional, Gallais, Isabelle, additional, Aleth, Hanna, additional, Poplineau, Mathilde, additional, Zwart, Wilbert, additional, Rosenbauer, Frank, additional, Rodrigues-Lima, Fernando, additional, Duprez, Estelle, additional, Boeva, Valentina, additional, and Guillouf, Christel, additional

Published
2022
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11. PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells

Author

Gerlach, Katharina, primary, Popp, Vanessa, additional, Wirtz, Stefan, additional, Al-Saifi, Ragheed, additional, Gonzalez Acera, Miguel, additional, Atreya, Raja, additional, Dregelies, Theresa, additional, Vieth, Michael, additional, Fichtner-Feigl, Stefan, additional, McKenzie, Andrew N J, additional, Rosenbauer, Frank, additional, Weigmann, Benno, additional, and Neurath, Markus F, additional

Published
2022
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12. DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease

Author

Czeh, Melinda, primary, Stäble, Sina, additional, Krämer, Stephen, additional, Tepe, Lena, additional, Talyan, Sweta, additional, Carrelha, Joana, additional, Meng, Yiran, additional, Heitplatz, Barbara, additional, Schwabenland, Marius, additional, Milsom, Michael D., additional, Plass, Christoph, additional, Prinz, Marco, additional, Schlesner, Matthias, additional, Andrade-Navarro, Miguel A., additional, Nerlov, Claus, additional, Jacobsen, Sten Eirik W., additional, Lipka, Daniel B., additional, and Rosenbauer, Frank, additional

Published
2022
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13. Dexamethasone‐mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells

Author

Ahmed, Helal Mohammed Mohammed, primary, Nimmagadda, Subbaiah Chary, additional, Al‐Matary, Yahya S., additional, Fiori, Maren, additional, May, Tobias, additional, Frank, Daria, additional, Patnana, Pradeep Kumar, additional, Récher, Christian, additional, Schliemann, Christoph, additional, Mikesch, Jan‐Henrik, additional, Koenig, Thorsten, additional, Rosenbauer, Frank, additional, Hartmann, Wolfgang, additional, Tuckermann, Jan, additional, Dührsen, Ulrich, additional, Lanying, Wei, additional, Dugas, Martin, additional, Opalka, Bertram, additional, Lenz, Georg, additional, and Khandanpour, Cyrus, additional

Published
2021
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14. Dexamethasone‐mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells.

Author

Ahmed, Helal Mohammed Mohammed, Nimmagadda, Subbaiah Chary, Al‐Matary, Yahya S., Fiori, Maren, May, Tobias, Frank, Daria, Patnana, Pradeep Kumar, Récher, Christian, Schliemann, Christoph, Mikesch, Jan‐Henrik, Koenig, Thorsten, Rosenbauer, Frank, Hartmann, Wolfgang, Tuckermann, Jan, Dührsen, Ulrich, Lanying, Wei, Dugas, Martin, Opalka, Bertram, Lenz, Georg, and Khandanpour, Cyrus

Subjects
MESENCHYMAL stem cells, STROMAL cells, DEXAMETHASONE, ACUTE myeloid leukemia, LEUKEMIA
Abstract

Summary: Acute myeloid leukaemia (AML) is a haematological malignancy characterized by a poor prognosis. Bone marrow mesenchymal stromal cells (BM MSCs) support leukaemic cells in preventing chemotherapy‐induced apoptosis. This encouraged us to investigate leukaemia‐BM niche‐associated signalling and to identify signalling cascades supporting the interaction of leukaemic cells and BM MSC. Our study demonstrated functional differences between MSCs originating from leukaemic (AML MSCs) and healthy donors (HD MSCs). The direct interaction of leukaemic and AML MSCs was indispensable in influencing AML cell proliferation. We further identified an important role for Notch expression and its activation in AML MSCs contributing to the enhanced proliferation of AML cells. Supporting this observation, overexpression of the intracellular Notch domain (Notch ICN) in AML MSCs enhanced AML cells' proliferation. From a therapeutic point of view, dexamethasone treatment impeded Notch signalling in AML MSCs resulting in reduced AML cell proliferation. Concurrent with our data, Notch inhibitors had only a marginal effect on leukaemic cells alone but strongly influenced Notch signalling in AML MSCs and abrogated their cytoprotective function on AML cells. In vivo, dexamethasone treatment impeded Notch signalling in AML MSCs leading to a reduced number of AML MSCs and improved survival of leukaemic mice. In summary, targeting the interaction of leukaemic cells and AML MSCs using dexamethasone or Notch inhibitors might further improve treatment outcomes in AML patients. [ABSTRACT FROM AUTHOR]

Published
2022
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