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1. 67 - PSORIASIS INDUCIDA POR TERAPIA ANTI-TNF EN ENFERMEDAD INFLAMATORIA INTESTINAL: ANÁLISIS DEL MANEJO TERAPÉUTICO Y EVOLUCIÓN DE AMBAS ENFERMEDADES EN UN ESTUDIO DE COHORTES A NIVEL NACIONAL

Author

Segura, Patricia Sanz, primary, Gomollón, Fernando, additional, Argumánez, Víctor, additional, Vela, Milagros, additional, Fernández-Clotet, Agnès, additional, Muñoz, Roser, additional, de la Filia, Irene García, additional, Prada, María García, additional, Rosique, Juan Ángel Ferrer, additional, García, María José, additional, de Francisco, Ruth, additional, Arias, Lara, additional, Barrio, Jesús, additional, Guerra, Iván, additional, Diaz, Ángel Ponferrada, additional, Gisbert, Javier P., additional, Carrillo-Palau, Marta, additional, Calvet, Xavier, additional, Mosquera, Lucía Márquez-, additional, Gros, Beatriz, additional, Cañete, Fiorella, additional, Monfort, David, additional, Domínguez, Rosa Eva Madrigal, additional, Roncero, Óscar, additional, Laredo, Viviana, additional, Montoro, Miguel, additional, Muñoz, Carmen, additional, López-Cauce, Beatriz, additional, Lorente, Rufo, additional, Coronel, Ana Fuentes, additional, Vega, Pablo, additional, Martín-Arranz, María Dolores, additional, Peña, Elena, additional, Varela, Pilar, additional, Casas-Deza, Diego, additional, Olivares, Sonsoles, additional, Pajares, Ramón, additional, Lucendo, Alfredo J., additional, Abizanda, Eva Sesé, additional, Mateu, Belén Botella, additional, García, Sonia García, additional, Domènech, Eugeni, additional, and García-López, Santiago, additional

Published
2023
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2. Long-Term Outcomes of Biological Therapy in Crohn's Disease Complicated With Internal Fistulizing Disease: BIOSCOPE Study From GETECCU

Author

Manuel Barreiro-de, Acosta, Agnès, Fernández-Clotet, Francisco, Mesonero, Francisco Javier, García-Alonso, María José, Casanova, Margarita, Fernández-de la Varga, Fiorella, Cañete, Luisa, de Castro, Ana, Gutiérrez, Beatriz, Sicilia, Victoria, Cano, Olga, Merino, Ruth, de Francisco, Irene, González-Partida, Gerard, Surís, Leyanira, Torrealba, Rocío, Ferreiro-Iglesias, Beatriz, Castro, Lucía, Márquez, Ana, Sobrino, Ainara, Elorza, Xavier, Calvet, Pilar, Varela, Raquel, Vicente, Luis, Bujanda, Laura, Lario, Noemí, Manceñido, Mariana F, García-Sepulcre, Eva, Iglesias, Cristina, Rodríguez, Marta, Piqueras, Juan Ángel, Ferrer Rosique, Alfredo J, Lucendo, Olga, Benítez, Melody, García, David, Olivares, Carlos, González-Muñoza, Beatriz, López-Cauce, Victor Jair, Morales Alvarado, Katerina, Spicakova, Alicia, Brotons, Fernando, Bermejo, Pedro, Almela, Nahia, Ispízua, Pau, Gilabert, Carlos, Tardillo, Fernando, Muñoz, Pablo, Navarro, Rosa Eva, Madrigal Domínguez, Pau, Sendra, Esther, Hinojosa, Empar, Sáinz, María Dolores, Martín-Arranz, Daniel, Carpio, Elena, Ricart, Berta, Caballol, Laura, Núñez, Jesús, Barrio, Javier P, Gisbert, Marisa, Iborra, Margalida, Calafat, Vicent, Hernández, Roser Muñoz, Pérez, José Luis, Cabriada, Eugeni, Domènech, and Iago, Rodríguez-Lago

Subjects
Hepatology, Gastroenterology
Abstract

The prevalence of penetrating complications in Crohn's disease (CD) increases progressively over time, but evidence on the medical treatment in this setting is limited. The aim of this study was to evaluate the effectiveness of biologic agents in CD complicated with internal fistulizing disease.Adult patients with CD-related fistulae who received at least one biologic agent for this condition from the prospectively-maintained ENEIDA registry were included. Exclusion criteria involved those receiving biologics for perianal disease, enterocutaneous, rectovaginal, anastomotic or periostomal fistulae. The primary endpoint was fistula-related surgery. Predictive factors associated with surgery and fistula closure were evaluated by multivariate logistic regression and survival analyses.A total of 760 patients from 53 hospitals (673 receiving anti-TNFs, 69 ustekinumab, and 18 vedolizumab) were included. After a median follow-up of 56 months (IQR, 26-102), 240 patients required surgery, with surgery rates of 32%, 41%, 24% among those under anti-TNF, vedolizumab, or ustekinumab, respectively. Fistula closure was observed in 24% of patients. Older patients, ileocolonic disease, entero-urinary fistulae, or an intestinal stricture distal to the origin of the fistula were associated with a higher risk of surgery, while non-smokers, and combination therapy with an immunomodulator reduced this risk.Biologic therapy is beneficial in approximately three quarters of patients with fistulizing CD, achieving fistula closure in 24%. However, around one third still undergo surgery due to refractory disease. Some patient and lesion-related factors can identify patients who will obtain more benefit from these drugs.

Published
2023
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3. 67 - PSORIASIS INDUCIDA POR TERAPIA ANTI-TNF EN ENFERMEDAD INFLAMATORIA INTESTINAL: ANÁLISIS DEL MANEJO TERAPÉUTICO Y EVOLUCIÓN DE AMBAS ENFERMEDADES EN UN ESTUDIO DE COHORTES A NIVEL NACIONAL

Author

Patricia Sanz Segura, Fernando Gomollón, Víctor Argumánez, Milagros Vela, Agnès Fernández-Clotet, Roser Muñoz, Irene García de la Filia, María García Prada, Juan Ángel Ferrer Rosique, María José García, Ruth de Francisco, Lara Arias, Jesús Barrio, Iván Guerra, Ángel Ponferrada Diaz, Javier P. Gisbert, Marta Carrillo-Palau, Xavier Calvet, Lucía Márquez- Mosquera, Beatriz Gros, Fiorella Cañete, David Monfort, Rosa Eva Madrigal Domínguez, Óscar Roncero, Viviana Laredo, Miguel Montoro, Carmen Muñoz, Beatriz López-Cauce, Rufo Lorente, Ana Fuentes Coronel, Pablo Vega, María Dolores Martín-Arranz, Elena Peña, Pilar Varela, Diego Casas-Deza, Sonsoles Olivares, Ramón Pajares, Alfredo J. Lucendo, Eva Sesé Abizanda, Belén Botella Mateu, Sonia García García, Eugeni Domènech, and Santiago García-López

Subjects
Hepatology, Gastroenterology
Published
2023
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