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12 results on '"Rogers, Colin B."'

3. Glial changes are associated with cerebrovascular integrity in hyperhomocysteinemia‐induced VCID in mouse and human brain

Author

Weekman, Erica M, primary, Winder, Zachary, additional, Rogers, Colin B, additional, Abner, Erin L, additional, Sudduth, Tiffany L, additional, Price, Brittani R., additional, Woolums, Abigail, additional, Hawthorne, Danielle, additional, IV, Charles E Seaks, additional, Patel, Ela, additional, Dugan, Adam, additional, Fister, Shuling X, additional, Wasek, Brandi, additional, Bottiglieri, Teodoro, additional, Fardo, David W., additional, and Wilcock, Donna M., additional

Published
2023
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7. A high‐throughput single‐cell RNA expression profiling method identifies human pericyte markers

Author

Sziraki, Andras, primary, Zhong, Yu, additional, Neltner, Allison M., additional, Niedowicz, Dana M., additional, Rogers, Colin B., additional, Wilcock, Donna M., additional, Nehra, Geetika, additional, Neltner, Janna H., additional, Smith, Rebecca R., additional, Hartz, Anika M., additional, Cao, Junyue, additional, and Nelson, Peter T., additional

Published
2023
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9. Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease

Author

Sompol, Pradoldej, primary, Gollihue, Jenna L., additional, Weiss, Blaine E., additional, Lin, Ruei-Lung, additional, Case, Sami L., additional, Kraner, Susan D., additional, Weekman, Erica M., additional, Gant, John C., additional, Rogers, Colin B., additional, Niedowicz, Dana M., additional, Sudduth, Tiffany L., additional, Powell, David K., additional, Lin, Ai-Ling, additional, Nelson, Peter T., additional, Thibault, Olivier, additional, Wilcock, Donna M., additional, and Norris, Christopher M., additional

Published
2023
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11. Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue

Author

Weekman, Erica M., primary, Winder, Zach, additional, Rogers, Colin B., additional, Abner, Erin L., additional, Sudduth, Tiffany L., additional, Patel, Ela, additional, Dugan, Adam J., additional, Fister, Shuling X., additional, Wasek, Brandi, additional, Nelson, Peter T., additional, Jicha, Gregory A., additional, Bottiglieri, Teodoro, additional, Fardo, David W., additional, and Wilcock, Donna M., additional

Published
2022
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12. Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue.

Author

Weekman EM, Winder Z, Rogers CB, Abner EL, Sudduth TL, Patel E, Dugan AJ, Fister SX, Wasek B, Nelson PT, Jicha GA, Bottiglieri T, Fardo DW, and Wilcock DM

Abstract

Introduction: Vascular contributions to cognitive impairment and dementia (VCID) are a leading cause of dementia. An underappreciated, modifiable risk factor for VCID is hyperhomocysteinemia (HHcy), defined by elevated levels of plasma homocysteine, most often due to impaired B vitamin absorption in aged persons. Studies aimed at identifying neuropathologic features and gene expression profiles associated with HHcy have been lacking., Methods: A subset of research volunteers from the University of Kentucky Alzheimer's Disease Research Center longitudinal cohort came to autopsy and had ante mortem plasma homocysteine levels available. Brain tissue and blood plasma drawn closest to death were used to measure homocysteine and related metabolites in the current pilot study. Genetic expression profiles of inflammatory markers were evaluated using the Human Neuroinflammation NanoString panel. Further analyses included an evaluation of plasma homocysteine effects on amyloid beta, tau, ionized calcium-binding adaptor molecule 1, and glial fibrillary acidic protein immunohistochemistry in the frontal and occipital cortices. Analytes and other study outcomes were evaluated in relation to ante mortem HHcy status: We identified 13 persons with normal ante mortem plasma homocysteine levels (<14 µmol/L) and 18 who had high plasma homocysteine levels (≥14 µmol/L)., Results: Participants with HHcy demonstrated increased levels of several plasma homocysteine cycle metabolites such as total cysteine, S-adenosyl-homocysteine, cystathionine, and choline. Inflammatory gene expression profiles showed a general downregulation in the setting of elevated plasma homocysteine. HHcy was associated with more and longer microglial processes, but smaller and fewer astrocytes, especially in participants of older age at death. HHcy in older participants was also associated with occipital cortex microhemorrhages and increased severity of atherosclerosis throughout the cerebral vasculature., Conclusions: Increased plasma homocysteine and older age were associated with the downregulation of inflammatory gene expression markers in association with significant glial and vascular pathology changes. Impaired immune function is a plausible mechanism by which HHcy increases cerebrovascular damage leading to impaired cognitive function., Competing Interests: The authors declare they have no conflicts of interest. Author disclosures are available in the supporting information., (© 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2022
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