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2. Genome-wide association study identifies high-impact susceptibility loci for HCC in North America.

Author

Hassan, Manal, Li, Donghui, Han, Younghun, Byun, Jinyoung, Hatia, Rikita, Long, Erping, Choi, Jiyeon, Kelley, Robin, Cleary, Sean, Lok, Anna, Bracci, Paige, Permuth, Jennifer, Bucur, Roxana, Yuan, Jian-Min, Singal, Amit, Jalal, Prasun, Ghobrial, R, Santella, Regina, Kono, Yuko, Shah, Dimpy, Nguyen, Mindie, Liu, Geoffrey, Parikh, Neehar, Kim, Richard, Wu, Hui-Chen, El-Serag, Hashem, Chang, Ping, Li, Yanan, Chun, Yun, Lee, Sunyoung, Gu, Jian, Hawk, Ernest, Sun, Ryan, Huff, Chad, Rashid, Asif, Amin, Hesham, Beretta, Laura, Wolff, Robert, Antwi, Samuel, Patt, Yehuda, Hwang, Lu-Yu, Klein, Alison, Zhang, Karen, Schmidt, Mikayla, White, Donna, Goss, John, Khaderi, Saira, Marrero, Jorge, Cigarroa, Francisco, Shah, Pankil, Kaseb, Ahmed, Roberts, Lewis, and Amos, Christopher

Subjects
Humans, Genome-Wide Association Study, Liver Neoplasms, Genetic Predisposition to Disease, Carcinoma, Hepatocellular, Male, Female, Middle Aged, North America, Case-Control Studies, Polymorphism, Single Nucleotide, Aged, Genetic Loci, White People
Abstract

BACKGROUND AND AIMS: Despite the substantial impact of environmental factors, individuals with a family history of liver cancer have an increased risk for HCC. However, genetic factors have not been studied systematically by genome-wide approaches in large numbers of individuals from European descent populations (EDP). APPROACH AND RESULTS: We conducted a 2-stage genome-wide association study (GWAS) on HCC not affected by HBV infections. A total of 1872 HCC cases and 2907 controls were included in the discovery stage, and 1200 HCC cases and 1832 controls in the validation. We analyzed the discovery and validation samples separately and then conducted a meta-analysis. All analyses were conducted in the presence and absence of HCV. The liability-scale heritability was 24.4% for overall HCC. Five regions with significant ORs (95% CI) were identified for nonviral HCC: 3p22.1, MOBP , rs9842969, (0.51, [0.40-0.65]); 5p15.33, TERT , rs2242652, (0.70, (0.62-0.79]); 19q13.11, TM6SF2 , rs58542926, (1.49, [1.29-1.72]); 19p13.11 MAU2 , rs58489806, (1.53, (1.33-1.75]); and 22q13.31, PNPLA3 , rs738409, (1.66, [1.51-1.83]). One region was identified for HCV-induced HCC: 6p21.31, human leukocyte antigen DQ beta 1, rs9275224, (0.79, [0.74-0.84]). A combination of homozygous variants of PNPLA3 and TERT showing a 6.5-fold higher risk for nonviral-related HCC compared to individuals lacking these genotypes. This observation suggests that gene-gene interactions may identify individuals at elevated risk for developing HCC. CONCLUSIONS: Our GWAS highlights novel genetic susceptibility of nonviral HCC among European descent populations from North America with substantial heritability. Selected genetic influences were observed for HCV-positive HCC. Our findings indicate the importance of genetic susceptibility to HCC development.

Published
2024

4. The Cholangiocarcinoma in the Young (CITY) Study: Tumor Biology, Treatment Patterns, and Survival Outcomes in Adolescent Young Adults With Cholangiocarcinoma.

Author

Pappas, Leontios, Baiev, Islam, Reyes, Stephanie, Bocobo, Andrea, Jain, Apurva, Spencer, Kristen, Le, Tri, Rahma, Osama, Maurer, Jordan, Stanton, Jen, Zhang, Karen, De Armas, Anaemy, Deleon, Thomas, Roth, Marc, Peters, Mary, Zhu, Andrew, Boyhen, Kylie, VanCott, Christine, Patel, Tushar, Roberts, Lewis, Lindsey, Stacie, Horick, Nora, Lennerz, Jochen, Iafrate, A, Goff, Laura, Mody, Kabir, Borad, Mitesh, Shroff, Rachna, Javle, Milind, Goyal, Lipika, and Kelley, Robin

Subjects
Humans, Young Adult, Adolescent, Middle Aged, Retrospective Studies, Cholangiocarcinoma, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, Biology
Abstract

PURPOSE: Increased awareness of the distinct tumor biology for adolescents and young adults (AYAs) with cancer has led to improvement in outcomes for this population. However, in cholangiocarcinoma (CCA), a paucity of data exist on the AYA population. To our knowledge, we present the largest study to date on AYA disease biology, treatment patterns, and survival outcomes in CCA. METHODS: A multi-institutional cohort of patients with CCA diagnosed with intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma (ECC) was used for analysis. Retrospective chart review was conducted on patients who were 50 years old and younger (young; n = 124) and older than 50 years (older; n = 723). RESULTS: Among 1,039 patients screened, 847 patients met eligibility (72% ICC, 28% ECC). Young patients had a larger median tumor size at resection compared with older patients (4.2 v 3.6 cm; P = .048), more commonly had N1 disease (65% v 43%; P = .040), and were more likely to receive adjuvant therapy (odds ratio, 4.0; 95% CI, 1.64 to 9.74). Tumors of young patients were more likely to harbor an FGFR2 fusion, BRAF mutation, or ATM mutation (P < .05 for each). Young patients were more likely to receive palliative systemic therapy (96% v 69%; P < .001), targeted therapy (23% v 8%; P < .001), and treatment on a clinical trial (31% v 19%; P = .004). Among patients who presented with advanced disease, young patients had a higher median overall survival compared with their older counterparts (17.7 v 13.5 months; 95% CI, 12.6 to 22.6 v 11.4 to 14.8; P = .049). CONCLUSION: Young patients with CCA had more advanced disease at resection, more commonly received both adjuvant and palliative therapies, and demonstrated improved survival compared with older patients. Given the low clinical trial enrollment and poor outcomes among some AYA cancer populations, data to the contrary in CCA are highly encouraging.

Published
2023

5. Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.

Author

Spencer, Kristen, Pappas, Leontios, Baiev, Islam, Maurer, Jordan, Bocobo, Andrea Grace, Zhang, Karen, Jain, Apurva, De Armas, Anaemy Danner, Reyes, Stephanie, Le, Tri Minh, Rahma, Osama E, Stanton, Jennifer, DeLeon, Thomas T, Roth, Marc, Peters, Mary Linton B, Zhu, Andrew X, Lennerz, Jochen K, Iafrate, A John, Boyhen, Kylie, VanCott, Christine, Roberts, Lewis R, Lindsey, Stacie, Horick, Nora, Goff, Laura Williams, Mody, Kabir, Borad, Mitesh J, Shroff, Rachna T, Kelley, Robin Kate, Javle, Milind M, and Goyal, Lipika

Subjects
Bile Ducts, Intrahepatic, Humans, Cholangiocarcinoma, Bile Duct Neoplasms, Prognosis, Risk Factors, Retrospective Studies, Patient Safety, Liver Cancer, Digestive Diseases - (Gallbladder), Rare Diseases, Liver Disease, Clinical Trials and Supportive Activities, Cancer, Clinical Research, Digestive Diseases, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundTreatment patterns for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) differ, but limited studies exist comparing them. This study examines differences in molecular profiling rates and treatment patterns in these populations, focusing on use of adjuvant, liver-directed, targeted, and investigational therapies.MethodsThis multicenter collaboration included patients with ICC or ECC treated at 1 of 8 participating institutions. Retrospective data were collected on risk factors, pathology, treatments, and survival. Comparative statistical tests were 2-sided.ResultsAmong 1039 patients screened, 847 patients met eligibility (ICC = 611, ECC = 236). Patients with ECC were more likely than those with ICC to present with early stage disease (53.8% vs 28.0%), undergo surgical resection (55.1% vs 29.8%), and receive adjuvant chemoradiation (36.5% vs 4.2%) (all P

Published
2023

6. Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort

Author

Emiloju, Oluwadunni E., Yin, Jun, Koubek, Emily, Reid, Joel M., Borad, Mitesh J., Lou, Yanyan, Seetharam, Mahesh, Edelman, Martin J., Sausville, Edward A., Jiang, Yixing, Kaseb, Ahmed O., Posey, James A., Davis, Sarah L., Gores, Gregory J., Roberts, Lewis R., Takebe, Naoko, Schwartz, Gary K., Hendrickson, Andrea E. Wahner, Kaufmann, Scott H., Adjei, Alex A., Hubbard, Joleen M., and Costello, Brian A.

Published
2024
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7. Examining the Effectiveness of Social Media for the Dissemination of Research Evidence for Health and Social Care Practitioners: Systematic Review and Meta-Analysis

Author

Sarah Roberts-Lewis, Helen Baxter, Gill Mein, Sophia Quirke-McFarlane, Fiona J Leggat, Hannah Garner, Martha Powell, Sarah White, and Lindsay Bearne

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundSocial media use has potential to facilitate the rapid dissemination of research evidence to busy health and social care practitioners. ObjectiveThis study aims to quantitatively synthesize evidence of the between- and within-group effectiveness of social media for dissemination of research evidence to health and social care practitioners. It also compared effectiveness between different social media platforms, formats, and strategies. MethodsWe searched electronic databases for articles in English that were published between January 1, 2010, and January 10, 2023, and that evaluated social media interventions for disseminating research evidence to qualified, postregistration health and social care practitioners in measures of reach, engagement, direct dissemination, or impact. Screening, data extraction, and risk of bias assessments were carried out by at least 2 independent reviewers. Meta-analyses of standardized pooled effects were carried out for between- and within-group effectiveness of social media and comparisons between platforms, formats, and strategies. Certainty of evidence for outcomes was assessed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) framework. ResultsIn total, 50 mixed-quality articles that were heterogeneous in design and outcome were included (n=9, 18% were randomized controlled trials [RCTs]). Reach (measured in number of practitioners, impressions, or post views) was reported in 26 studies. Engagement (measured in likes or post interactions) was evaluated in 21 studies. Direct dissemination (measured in link clicks, article views, downloads, or altmetric attention score) was analyzed in 23 studies (8 RCTs). Impact (measured in citations or measures of thinking and practice) was reported in 13 studies. Included studies almost universally indicated effects in favor of social media interventions, although effect sizes varied. Cumulative evidence indicated moderate certainty of large and moderate between-group effects of social media interventions on direct dissemination (standardized mean difference [SMD] 0.88; P=.02) and impact (SMD 0.76; P

Published
2024
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8. Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Author

Calvisi, Diego F., Boulter, Luke, Vaquero, Javier, Saborowski, Anna, Fabris, Luca, Rodrigues, Pedro M., Coulouarn, Cédric, Castro, Rui E., Segatto, Oreste, Raggi, Chiara, van der Laan, Luc J. W., Carpino, Guido, Goeppert, Benjamin, Roessler, Stephanie, Kendall, Timothy J., Evert, Matthias, Gonzalez-Sanchez, Ester, Valle, Juan W., Vogel, Arndt, Bridgewater, John, Borad, Mitesh J., Gores, Gregory J., Roberts, Lewis R., Marin, Jose J. G., Andersen, Jesper B., Alvaro, Domenico, Forner, Alejandro, Banales, Jesus M., Cardinale, Vincenzo, Macias, Rocio I. R., Vicent, Silve, Chen, Xin, Braconi, Chiara, Verstegen, Monique M. A., and Fouassier, Laura

Published
2023
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9. Metabolome-wide association identifies altered metabolites and metabolic pathways in the serum of patients with cholangiocarcinoma

Author

Jackson, Linsey E., Tomlinson, Jennifer L., Alva-Ruiz, Roberto, Gregory, Lindsey A., Byeon, Seul Kee, Abdelrahman, Amro M., Mun, Dong-Gi, Grant, Caroline W., Fogarty, Zachary C., Wang, Chen, Roberts, Lewis R., Graham, Rondell P., Borad, Mitesh J., Ilyas, Sumera I., Gores, Gregory J., Pandey, Akhilesh, Athreya, Arjun P., and Smoot, Rory L.

Published
2024
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10. Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD)

Author

Pinto e Vairo, Filippo, Kemppainen, Jennifer L., Vitek, Carolyn R. Rohrer, Whalen, Denise A., Kolbert, Kayla J., Sikkink, Kaitlin J., Kroc, Sarah A., Kruisselbrink, Teresa, Shupe, Gabrielle F., Knudson, Alyssa K., Burke, Elizabeth M., Loftus, Elle C., Bandel, Lorelei A., Prochnow, Carri A., Mulvihill, Lindsay A., Thomas, Brittany, Gable, Dale M., Graddy, Courtney B., Garzon, Giovanna G. Moreno, Ekpoh, Idara U., Porquera, Eva M. Carmona, Fervenza, Fernando C., Hogan, Marie C., El Ters, Mireille, Warrington, Kenneth J., Davis, III, John M., Koster, Matthew J., Orandi, Amir B., Basiaga, Matthew L., Vella, Adrian, Kumar, Seema, Creo, Ana L., Lteif, Aida N., Pittock, Siobhan T., Tebben, Peter J., Abate, Ejigayehu G., Joshi, Avni Y., Ristagno, Elizabeth H., Patnaik, Mrinal S., Schimmenti, Lisa A., Dhamija, Radhika, Sabrowsky, Sonia M., Wierenga, Klaas J., Keddis, Mira T., Samadder, Niloy Jewel J., Presutti, Richard J., Robinson, Steven I., Stephens, Michael C., Roberts, Lewis R., Faubion, Jr., William A., Driscoll, Sherilyn W., Wong-Kisiel, Lily C., Selcen, Duygu, Flanagan, Eoin P., Ramanan, Vijay K., Jackson, Lauren M., Mauermann, Michelle L., Ortega, Victor E., Anderson, Sarah A., Aoudia, Stacy L., Klee, Eric W., McAllister, Tammy M., and Lazaridis, Konstantinos N.

Published
2023
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11. Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

Author

Han, Younghun, Byun, Jinyoung, Zhu, Catherine, Sun, Ryan, Roh, Julia Y., Cordell, Heather J., Lee, Hyun-Sung, Shaw, Vikram R., Kang, Sung Wook, Razjouyan, Javad, Cooley, Matthew A., Hassan, Manal M., Siminovitch, Katherine A., Folseraas, Trine, Ellinghaus, David, Bergquist, Annika, Rushbrook, Simon M., Franke, Andre, Karlsen, Tom H., Lazaridis, Konstantinos N., McGlynn, Katherine A., Roberts, Lewis R., and Amos, Christopher I.

Published
2023
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12. Development of a Computer-aided Prediction Tool for Evaluating Brushing Samples of Biliary Strictures

Author

Norton, Daniel, Gleeson, Ferga, Abu Dayyeh, Barham K., Bofill-Garcia, Aliana, Chandrasekhara, Vinay, Gores, Gregory, Kipp, Benjamin, Law, Ryan J., Martin, John A., Petersen, Bret, Roberts, Lewis R., Storm, Andrew C., Vargas Valls, Eric J., Marya, Neil B., Hartley, Christopher, Powers, Patrick D., Bois, Melanie C., Kerr, Sarah E., Graham, Rondell P., and Levy, Michael J.

Published
2024
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14. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study

Author

Razavi-Shearer, Devin, Gamkrelidze, Ivane, Pan, Calvin, Jia, Jidong, Berg, Thomas, Gray, Richard, Lim, Young-Suk, Chen, Chien-Jen, Ocama, Ponsiano, Desalegn, Hailemichael, Abbas, Zaigham, Abdallah, Ayat, Aghemo, Alessio, Ahmadbekova, Sabohat, Ahn, Sang Hoon, Aho, Inka, Akarca, Ulus, Al Masri, Nasser, Alalwan, Abduljaleel, Alavian, Seyed, Al-Busafi, Said, Aleman, Soo, Alfaleh, Faleh, Alghamdi, Abdullah, Al-Hamoudi, Waleed, Aljumah, Abdulrahman, Al-Naamani, Khalid, Al-Rifai, Ahmad, Alserkal, Yousif, Altraif, Ibrahim, Amarsanaa, Jazag, Anderson, Motswedi, Andersson, Monique, Armstrong, Paige, Asselah, Tarik, Athanasakis, Kostas, Baatarkhuu, Oidov, Ben-Ari, Ziv, Bensalem, Aicha, Bessone, Fernando, Biondi, Mia, Bizri, Abdul Rahman, Blach, Sarah, Braga, Wornei, Brandão-Mello, Carlos, Brosgart, Carol, Brown, Kimberly, Brown, Jr, Robert, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Cabezas, Joaquin, Casanovas, Teresa, Chae, Chungman, Chan, Henry Lik Yuen, Cheinquer, Hugo, Chen, Pei-Jer, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Coffin, Carla, Contreras, Fernando, Coppola, Nicola, Cornberg, Markus, Cowie, Benjamin, Cramp, Matthew, Craxi, Antonio, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris, Dalgard, Olav, De Knegt, Robert, De Ledinghen, Victor, Dore, Gregory, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve, Elbadri, Mohammed, El-Kassas, Mohamed, El-Sayed, Manal, Estes, Chris, Etzion, Ohad, Farag, Elmobashar, Ferradini, Laurent, Ferreira, Paulo, Flisiak, Robert, Forns, Xavier, Frankova, Sona, Fung, James, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana, Gholam, Pierre, Gish, Robert, Goleij, Pouya, Gottfredsson, Magnus, Grebely, Jason, Gschwantler, Michael, Guingane, Nanelin Alice, Hajarizadeh, Behzad, Hamid, Saeed, Hamoudi, Waseem, Harris, Aaron, Hasan, Irsan, Hatzakis, Angelos, Hellard, Margaret, Hercun, Julian, Hernandez, Javier, Hockicková, Ivana, Hsu, Yao-Chun, Hu, Ching-Chih, Husa, Petr, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jelev, Deian, Jeruma, Agita, Johannessen, Asgeir, Kåberg, Martin, Kaita, Kelly, Kaliaskarova, Kulpash, Kao, Jia-Horng, Kelly-Hanku, Angela, Khamis, Faryal, Khan, Aamir, Kheir, Omer, Khoudri, Ibtissam, Kondili, Loreta, Konysbekova, Aliya, Kristian, Pavol, Kwon, Jisoo, Lagging, Martin, Laleman, Wim, Lampertico, Pietro, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice, Lee, Mei-Hsuan, Liakina, Valentina, Lukšić, Boris, Malekzadeh, Reza, Malu, Abraham, Marinho, Rui, Mendes-Correa, Maria Cássia, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mohamed, Rosmawati, Mokhbat, Jacques, Mooneyhan, Ellen, Moreno, Christophe, Mortgat, Laure, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Naveira, Marcelo, Negro, Francesco, Nersesov, Alexander, Nguyen, Van Thi Thuy, Ning, Qing, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin, Oguche, Stephen, Omuemu, Casimir, Ong, Janus, Opare-Sem, Ohene, Örmeci, Necati, Orrego, Mauricio, Osiowy, Carla, Papatheodoridis, George, Peck-Radosavljevic, Markus, Pessoa, Mário, Pham, Trang, Phillips, Richard, Pimenov, Nikolay, Pincay-Rodríguez, Loreley, Plaseska-Karanfilska, Dijana, Pop, Cora, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Rautiainen, Henna, Razavi-Shearer, Kathryn, Remak, William, Ribeiro, Sofia, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo, Robalino, Marcia, Roberts, Lewis, Roberts, Stuart, Rodríguez, Manuel, Roulot, Dominique, Rwegasha, John, Ryder, Stephen, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa, Salupere, Riina, Sanai, Faisal, Sanchez-Avila, Juan F, Saraswat, Vivek, Sargsyants, Narina, Sarrazin, Christoph, Sarybayeva, Gulya, Schréter, Ivan, Seguin-Devaux, Carole, Seto, Wai-Kay, Shah, Samir, Sharara, Ala, Sheikh, Mahdi, Shouval, Daniel, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta, Sinn, Dong Hyun, Sonderup, Mark, Sonneveld, Milan, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek-Siam, Tanaka, Junko, Tergast, Tammo, Terrault, Norah, Thompson, Alexander, Thompson, Peyton, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsang, Tak-Yin, Uzochukwu, Benjamin, Van Welzen, Berend, Vanwolleghem, Thomas, Vince, Adriana, Voeller, Alexis, Waheed, Yasir, Waked, Imam, Wallace, Jack, Wang, Cong, Weis, Nina, Wong, Grace, Wong, Vincent, Wu, Jaw-Ching, Yaghi, Cesar, Yesmembetov, Kakharman, Yip, Terry, Yosry, Ayman, Yu, Ming-Lung, Yuen, Man-Fung, Yurdaydin, Cihan, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie

Published
2023
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19. Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma

Author

Haber, Philipp K., Castet, Florian, Torres-Martin, Miguel, Andreu-Oller, Carmen, Puigvehí, Marc, Miho, Maeda, Radu, Pompilia, Dufour, Jean-Francois, Verslype, Chris, Zimpel, Carolin, Marquardt, Jens U., Galle, Peter R., Vogel, Arndt, Bathon, Melanie, Meyer, Tim, Labgaa, Ismail, Digklia, Antonia, Roberts, Lewis R., Mohamed Ali, Mohamed A., Mínguez, Beatriz, Citterio, Davide, Mazzaferro, Vincenzo, Finkelmeier, Fabian, Trojan, Jörg, Özdirik, Burcin, Müller, Tobias, Schmelzle, Moritz, Bejjani, Anthony, Sung, Max W., Schwartz, Myron E., Finn, Richard S., Thung, Swan, Villanueva, Augusto, Sia, Daniela, and Llovet, Josep M.

Published
2023
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21. Prognostication of ß-catenin (CTNNB1) in patients with HCC treated with first line immunotherapy.

Author

Shah, Priyanshi M., primary, Peersen, Anina, additional, Jatoi, Aminah, additional, McWilliams, Robert R., additional, Jin, Zhaohui, additional, Torbenson, Michael S., additional, Halfdanarson, Thorvardur Ragnar, additional, Babiker, Hani M., additional, Conboy, Caitlin, additional, Kankeu Fonkoua, Lionel Aurelien, additional, Washburn, Leslie, additional, Roberts, Lewis R., additional, Gores, Gregory J., additional, Bekaii-Saab, Tanios S., additional, Borad, Mitesh J., additional, Ou, Fang-Shu, additional, and Tran, Nguyen H., additional

Published
2024
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22. SAT-479-YI Lower frequency of PNPLA3 in african populations and divergent associations with hepatocellular carcinoma

Author

Chotiprasidhi, Perapa, primary, Espinoza, Karina Sato, additional, Ma, Jun, additional, Nartey, Yvonne, additional, Awuku, Yaw, additional, Agyei-Nkansah, Adwoa, additional, Afihene, Mary, additional, Duah, Amoako, additional, Bampoh, Sally, additional, Asibey, Shadrack, additional, Ayawin, Joshua, additional, Wang, Jun, additional, Zheng, Yinan, additional, Hou, Lifang, additional, Hawkins, Claudia, additional, Murphy, Robert, additional, Imade, Godwin, additional, Okeke, Edith, additional, Akanmu, Alani, additional, Lesi, Olufunmilayo, additional, Debes, Jose, additional, Roberts, Lewis, additional, Antwi, Samuel, additional, and Wangensteen, Kirk, additional

Published
2024
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23. The Use of Social Media for Dissemination of Research Evidence to Health and Social Care Practitioners: Protocol for a Systematic Review

Author

Sarah F Roberts-Lewis, Helen A Baxter, Gill Mein, Sophia Quirke-McFarlane, Fiona J Leggat, Hannah M Garner, Martha Powell, Sarah White, and Lindsay Bearne

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundEffective dissemination of research to health and social care practitioners enhances clinical practice and evidence-based care. Social media use has potential to facilitate dissemination to busy practitioners. ObjectiveThis is a protocol for a systematic review that will quantitatively synthesize evidence of the effectiveness of social media, compared with no social media, for dissemination of research evidence to health and social care practitioners. Social media platforms, formats, and sharing mechanisms used for effective dissemination of research evidence will also be identified and compared. MethodsElectronic database searches (MEDLINE, PsycINFO, CINAHL, ERIC, LISTA, and OpenGrey) will be conducted from January 1, 2010, to January 10, 2023, for studies published in English. Randomized, nonrandomized, pre-post study designs or case studies evaluating the effect of social media on dissemination of research evidence to postregistration health and social care practitioners will be included. Studies that do not involve social media or dissemination or those that evaluate dissemination of nonresearch information (eg, multisource educational materials) to students or members of the public only, or without quantitative data on outcomes of interest, will be excluded. Screening will be carried out by 2 independent reviewers. Data extraction and quality assessment, using either the Cochrane tool for assessing risk of bias or the Newcastle-Ottawa Scale, will be completed by 2 independent reviewers. Outcomes of interest will be reported in 4 domains (reach, engagement, dissemination, and impact). Data synthesis will include quantitative comparisons using narrative text, tables, and figures. A meta-analysis of standardized pooled effects will be undertaken, and subgroup analyses will be applied, if appropriate. ResultsSearches and screening will be completed by the end of May 2023. Data extraction and analyses will be completed by the end of July 2023, after which findings will be synthesized and reported by the end of October 2023. ConclusionsThis systematic review will summarize the evidence for the effectiveness of social media for the dissemination of research evidence to health and social care practitioners. The limitations of the evidence may include multiple outcomes or methodological heterogeneity that limit meta-analyses, potential risk of bias in included studies, and potential publication bias. The limitations of the study design may include potential insensitivity of the electronic database search strategy. The findings from this review will inform the dissemination practice of health and care research. Trial RegistrationPROSPERO CRD42022378793; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=378793 International Registered Report Identifier (IRRID)DERR1-10.2196/45684

Published
2023
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24. Correction: Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD)

Author

Pinto e Vairo, Filippo, primary, Kemppainen, Jennifer L., additional, Vitek, Carolyn R. Rohrer, additional, Whalen, Denise A., additional, Kolbert, Kayla J., additional, Sikkink, Kaitlin J., additional, Kroc, Sarah A., additional, Kruisselbrink, Teresa, additional, Shupe, Gabrielle F., additional, Knudson, Alyssa K., additional, Burke, Elizabeth M., additional, Loftus, Elle C., additional, Bandel, Lorelei A., additional, Prochnow, Carri A., additional, Mulvihill, Lindsay A., additional, Thomas, Brittany, additional, Gable, Dale M., additional, Graddy, Courtney B., additional, Garzon, Giovanna G. Moreno, additional, Ekpoh, Idara U., additional, Porquera, Eva M. Carmona, additional, Fervenza, Fernando C., additional, Hogan, Marie C., additional, El Ters, Mireille, additional, Warrington, Kenneth J., additional, Davis, John M., additional, Koster, Matthew J., additional, Orandi, Amir B., additional, Basiaga, Matthew L., additional, Vella, Adrian, additional, Kumar, Seema, additional, Creo, Ana L., additional, Lteif, Aida N., additional, Pittock, Siobhan T., additional, Tebben, Peter J., additional, Abate, Ejigayehu G., additional, Joshi, Avni Y., additional, Ristagno, Elizabeth H., additional, Patnaik, Mrinal S., additional, Schimmenti, Lisa A., additional, Dhamija, Radhika, additional, Sabrowsky, Sonia M., additional, Wierenga, Klaas J., additional, Keddis, Mira T., additional, Samadder, Niloy Jewel J., additional, Presutti, Richard J., additional, Robinson, Steven I., additional, Stephens, Michael C., additional, Roberts, Lewis R., additional, Faubion, William A., additional, Driscoll, Sherilyn W., additional, Wong-Kisiel, Lily C., additional, Selcen, Duygu, additional, Flanagan, Eoin P., additional, Ramanan, Vijay K., additional, Jackson, Lauren M., additional, Mauermann, Michelle L., additional, Ortega, Victor E., additional, Anderson, Sarah A., additional, Aoudia, Stacy L., additional, Klee, Eric W., additional, McAllister, Tammy M., additional, and Lazaridis, Konstantinos N., additional

Published
2024
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26. Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

Author

Blach, Sarah, Terrault, Norah A, Tacke, Frank, Gamkrelidze, Ivane, Craxi, Antonio, Tanaka, Junko, Waked, Imam, Dore, Gregory J, Abbas, Zaigham, Abdallah, Ayat R, Abdulla, Maheeba, Aghemo, Alessio, Aho, Inka, Akarca, Ulus S, Alalwan, Abduljaleel M, Alanko Blomé, Marianne, Al-Busafi, Said A, Aleman, Soo, Alghamdi, Abdullah S, Al-Hamoudi, Waleed K, Aljumah, Abdulrahman A, Al-Naamani, Khalid, Al Serkal, Yousif M, Altraif, Ibrahim H, Anand, Anil C, Anderson, Motswedi, Andersson, Monique I, Athanasakis, Kostas, Baatarkhuu, Oidov, Bakieva, Shokhista R, Ben-Ari, Ziv, Bessone, Fernando, Biondi, Mia J, Bizri, Abdul Rahman N, Brandão-Mello, Carlos E, Brigida, Krestina, Brown, Kimberly A, Brown, Jr, Robert S, Bruggmann, Philip, Brunetto, Maurizia R, Busschots, Dana, Buti, Maria, Butsashvili, Maia, Cabezas, Joaquin, Chae, Chungman, Chaloska Ivanova, Viktorija, Chan, Henry Lik Yuen, Cheinquer, Hugo, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Chien, Rong-Nan, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura E, Coco, Barbara, Contreras, Fernando A, Cornberg, Markus, Cramp, Matthew E, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris W, Dagher Abou, Lucy, Dalgard, Olav, Dao, Doan Y, De Ledinghen, Victor, Derbala, Moutaz F, Deuba, Keshab, Dhindsa, Karan, Djauzi, Samsuridjal, Drazilova, Sylvia, Duberg, Ann-Sofi, Elbadri, Mohammed, El-Sayed, Manal H, Esmat, Gamal, Estes, Chris, Ezzat, Sameera, Färkkilä, Martti A, Ferradini, Laurent, Ferraz, Maria Lucia G, Ferreira, Paulo R A, Filipec Kanizaj, Tajana, Flisiak, Robert, Frankova, Sona, Fung, James, Gamkrelidze, Amiran, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana S, Gholam, Pierre M, Goldis, Adrian, Gottfredsson, Magnus, Gray, Richard T, Grebely, Jason, Gschwantler, Michael, Hajarizadeh, Behzad, Hamid, Saeed S, Hamoudi, Waseem, Hatzakis, Angelos, Hellard, Margaret E, Himatt, Sayed, Hofer, Harald, Hrstic, Irena, Hunyady, Bela, Husa, Petr, Husic-Selimovic, Azra, Jafri, Wasim S M, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jerkeman, Anna, Jeruma, Agita, Jia, Jidong, Jonasson, Jon G, Kåberg, Martin, Kaita, Kelly D E, Kaliaskarova, Kulpash S, Kao, Jia-Horng, Kasymov, Omor T, Kelly-Hanku, Angela, Khamis, Faryal, Khamis, Jawad, Khan, Aamir G, Khandu, Lekey, Khoudri, Ibtissam, Kielland, Knut B, Kim, Do Young, Kodjoh, Nicolas, Kondili, Loreta A, Krajden, Mel, Krarup, Henrik Bygum, Kristian, Pavol, Kwon, Jisoo A, Lagging, Martin, Laleman, Wim, Lao, Wai Cheung, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice U, Lee, Mei-Hsuan, Li, Michael K K, Liakina, Valentina, Lim, Young-Suk, Löve, Arthur, Lukšić, Boris, Machekera, Shepherd Mufudzi, Malu, Abraham O, Marinho, Rui T, Maticic, Mojca, Mekonnen, Hailemichael D, Mendes-Correa, Maria Cássia, Mendez-Sanchez, Nahum, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mills, Mike, Mohamed, Rosmawati, Mooneyhan, Ellen, Moreno, Christophe, Muljono, David H, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Nartey, Yvonne Ayerki, Naveira, Marcelo C M, Negro, Francesco, Nersesov, Alexander V, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin S, Obekpa, Solomon A, Oguche, Stephen, Olafsson, Sigurdur, Ong, Janus P, Opare-Sem, Ohene K, Orrego, Mauricio, Øvrehus, Anne L, Pan, Calvin Q, Papatheodoridis, George V, Peck-Radosavljevic, Markus, Pessoa, Mário G, Phillips, Richard O, Pimenov, Nikolay, Plaseska-Karanfilska, Dijana, Prabdial-Sing, Nishi N, Puri, Pankaj, Qureshi, Huma, Rahman, Aninda, Ramji, Alnoor, Razavi-Shearer, Devin M, Razavi-Shearer, Kathryn, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo Y, Rizvi, S M Shahriar, Robaeys, Geert K M M, Roberts, Lewis R, Roberts, Stuart K, Ryder, Stephen D, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa S, Salupere, Riina, Sanai, Faisal M, Sanchez-Avila, Juan F, Saraswat, Vivek A, Sarrazin, Christoph, Sarybayeva, Gulya, Seguin-Devaux, Carole, Sharara, Ala I, Sheikh, Mahdi, Shewaye, Abate B, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta Y, Sonderup, Mark W, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf E, Stedman, Catherine A M, Su, Tung-Hung, Suleiman, Anita, Sypsa, Vana, Tamayo Antabak, Natalia, Tan, Soek-Siam, Tergast, Tammo L, Thurairajah, Prem H, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsereteli, Maia, Uzochukwu, Benjamin S C, Van De Vijver, David A M C, Van Santen, Daniela K, Van Vlierberghe, Hans, Van Welzen, Berend, Vanwolleghem, Thomas, Vélez-Möller, Patricia, Villamil, Federico, Vince, Adriana, Waheed, Yasir, Weis, Nina, Wong, Vincent W-S, Yaghi, Cesar G, Yesmembetov, Kakharman, Yosry, Ayman, Yuen, Man-Fung, Yunihastuti, Evy, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie A

Published
2022
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29. A nationwide cross-sectional review of in-hospital hepatitis B virus testing and disease burden estimation in Ghana, 2016 - 2021

Author

Nartey, Yvonne Ayerki, Okine, Rafiq, Seake-Kwawu, Atsu, Ghartey, Georgia, Asamoah, Yaw Karikari, Senya, Kafui, Duah, Amoako, Owusu-Ofori, Alex, Amugsi, James, Suglo, Damasus, Bampoh, Sally Afua, Hiebert, Lindsey, Njuguna, Henry, Ward, John W., Plymoth, Amelie, Roberts, Lewis Rowland, Bockarie, Ansumana Sandy, Awuku, Yaw Asante, and Obiri-Yeboah, Dorcas

Published
2022
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31. Incidence and Long-Term Outcomes of Biliary Tract Cancers in Olmsted County, Minnesota from 1976 to 2018.

Author

Nwankwo Jr., Eugene C., Guta, Amerti, Cao, Scarlett S., Yang, Ju Dong, Abdalla, Abubaker, Taha, Wesam, Larson, Joseph J., Yin, Jun, Gores, Gregory J., Cleary, Sean P., and Roberts, Lewis R.

Subjects
BILE duct tumors, POISSON distribution, GALLBLADDER tumors, SURVIVAL rate, RESEARCH funding, SEX distribution, CHOLANGIOCARCINOMA, RETROSPECTIVE studies, AGE distribution
Abstract

Simple Summary: Biliary tract cancers, which include cholangiocarcinoma, gallbladder, and ampulla of Vater cancers, are a significant health concern due to their increasing incidence and poor survival rates. Using data from the Rochester Epidemiology Project, this study tracks changes in incidence and survival rates among residents aged 20 and over in Olmsted County, Minnesota from 1976 to 2018. The findings illustrate a rise in overall biliary tract cancers from 6.53 cases to 10.25 cases per 100,000 person-years between 1976 and 2018 (p = 0.004). The incidence of intrahepatic cholangiocarcinoma has significantly increased from 0.25 to 3.93 per 100,000 person-years over the four decades, with a more pronounced increase observed in males, while gallbladder cancer incidence has decreased among women. Despite improvements in median survival times from 4.2 months to 10.8 months over the four decades (p = 0.019), the overall prognosis remains very poor. This study highlights the evolving epidemiology of these cancers and the critical need for enhanced diagnostic and treatment strategies to improve patient outcomes. Biliary tract cancers, including cholangiocarcinoma, gallbladder, and ampulla of Vater cancers, rank second among hepatobiliary cancers, known for their poor prognoses. The United States has witnessed a notable increase in intrahepatic cholangiocarcinoma incidence. This study examines the incidence and survival outcomes of biliary tract cancers in Olmsted County, Minnesota from 1976 to 2018. Using data from the Rochester Epidemiology Project (REP), residents aged 20 and above were analyzed across four eras. Incidence rates were calculated and adjusted for age and sex, and temporal trends were assessed using Poisson regression. Intrahepatic cholangiocarcinoma exhibited a significant escalation in incidence rates over time, while gallbladder cancers showed a decline among women. Median survival times for biliary tract cancers notably improved. These findings confirm the rising incidence of intrahepatic cholangiocarcinoma and suggest improving survival rates. Nevertheless, the overall prognosis for biliary tract cancers remains very poor, emphasizing the continual need for enhanced management strategies and further research. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts

Author

Asumda, Faizal Z., primary, Campbell, Nellie A., additional, Hassan, Mohamed A., additional, Fathi, Reza, additional, Vasquez Rico, Daniella F., additional, Kiem, Melanie, additional, Vang, Ethan V., additional, Kim, Yo Han, additional, Luo, Xin, additional, O’Brien, Daniel R., additional, Buhrow, Sarah A., additional, Reid, Joel M., additional, Moore, Michael J., additional, Ben-Yair, Vered Katz, additional, Levitt, Mark L., additional, Leiting, Jennifer L., additional, Abdelrahman, Amro M., additional, Zhu, Xinli, additional, Lucien, Fabrice, additional, Truty, Mark J., additional, and Roberts, Lewis R., additional

Published
2024
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36. SerpinB3/4 Expression Is Associated with Poor Prognosis in Patients with Cholangiocarcinoma

Author

Martini, Andrea, primary, Prasai, Kritika, additional, Zemla, Tyler J., additional, Ahmed, Fowsiyo Y., additional, Elnagar, Mamoun B., additional, Giama, Nasra H., additional, Guzzardo, Vincenza, additional, Biasiolo, Alessandra, additional, Fassan, Matteo, additional, Yin, Jun, additional, Pontisso, Patrizia, additional, and Roberts, Lewis R., additional

Published
2024
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37. Racial and ethnic disparities in untreated patients with hepatitis C virus‐related hepatocellular carcinoma but not in those with sustained virologic response

Author

Park, Jung Eun, primary, Nguyen, Vy H., additional, Tsai, Pei‐Chien, additional, Toyoda, Hidenori, additional, Leong, Jennifer, additional, Guy, Jennifer E., additional, Yeh, Ming‐Lun, additional, Huang, Chung‐Feng, additional, Yasuda, Satoshi, additional, Abe, Hiroshi, additional, Hsu, Yao‐Chun, additional, Tseng, Cheng‐Hao, additional, Liu, Joanne, additional, Chen, Yao‐Li, additional, Lin, Ping‐Yi, additional, Jun, Dae Won, additional, Yoshimaru, Yoko, additional, Ogawa, Eiichi, additional, Ishigami, Masatoshi, additional, Enomoto, Masaru, additional, Tamori, Akihiro, additional, Uojima, Haruki, additional, Wang, Xiao Zhong, additional, Xu, Qiang, additional, Takahashi, Hirokazu, additional, Eguchi, Yuichiro, additional, Inoue, Kaori, additional, Huang, Daniel Q., additional, Zhao, Wen Jing, additional, Chuang, Wan‐Long, additional, Dai, Chia‐Yen, additional, Huang, Jee‐Fu, additional, Barnett, Scott, additional, Maeda, Mayumi, additional, Cheung, Ramsey, additional, Landis, Charles, additional, Tanaka, Yasuhito, additional, Roberts, Lewis R., additional, Schwartz, Myron E., additional, Kumada, Takashi, additional, Yu, Ming‐Lung, additional, and Nguyen, Mindie H., additional

Published
2024
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38. Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response.

Author

Webb, Mason J., Sangsuwannukul, Thanich, van Vloten, Jacob, Evgin, Laura, Kendall, Benjamin, Tonne, Jason, Thompson, Jill, Metko, Muriel, Moore, Madelyn, Chiriboga Yerovi, Maria P., Olin, Michael, Borgatti, Antonella, McNiven, Mark, Monga, Satdarshan P. S., Borad, Mitesh J., Melcher, Alan, Roberts, Lewis R., and Vile, Richard

Subjects
T cells, TUMOR antigens, IMMUNE checkpoint inhibitors, ONCOLYTIC virotherapy, VESICULAR stomatitis, CELL populations, T cell receptors
Abstract

Although patients benefit from immune checkpoint inhibition (ICI) therapy in a broad variety of tumors, resistance may arise from immune suppressive tumor microenvironments (TME), which is particularly true of hepatocellular carcinoma (HCC). Since oncolytic viruses (OV) can generate a highly immune-infiltrated, inflammatory TME, OVs could potentially restore ICI responsiveness via recruitment, priming, and activation of anti-tumor T cells. Here we find that on the contrary, an oncolytic vesicular stomatitis virus, expressing interferon-ß (VSV-IFNß), antagonizes the effect of anti-PD-L1 therapy in a partially anti-PD-L1-responsive model of HCC. Cytometry by Time of Flight shows that VSV-IFNß expands dominant anti-viral effector CD8 T cells with concomitant relative disappearance of anti-tumor T cell populations, which are the target of anti-PD-L1. However, by expressing a range of HCC tumor antigens within VSV, combination OV and anti-PD-L1 therapeutic benefit could be restored. Our data provide a cautionary message for the use of highly immunogenic viruses as tumor-specific immune-therapeutics by showing that dominant anti-viral T cell responses can inhibit sub-dominant anti-tumor T cell responses. However, through encoding tumor antigens within the virus, oncolytic virotherapy can generate anti-tumor T cell populations upon which immune checkpoint blockade can effectively work. Oncolytic viruses create an inflamed tumour microenvironment allowing T cells to respond to immune checkpoint blockade therapy more efficiently. Authors here show that in a hepatocellular carcinoma model, a dominant anti-viral rather than anti-tumour T cell response is elicited by an oncolytic vesicular stomatitis virus, unless the virus is designed to express tumour antigens, which restores therapeutic benefit. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Augustine and Enjambment: A source for Hopkins's term 'rove over'.

Author

Roberts, Lewis

Subjects
*COMPLEXITY (Philosophy), *SPEECH, *NEGOTIATION, *AESTHETICS of art, *MUSIC theory
Abstract

This essay examines the origins of Gerard Manley Hopkins's term "rove over" in relation to enjambment in his poetry. Hopkins's approach to prosody is not systematic and encompasses various works and casual thoughts. The term "rove over" refers to the ambiguity of reading across line breaks and may have been influenced by St. Augustine's treatise on poetics, De Musica. Augustine's synthesis of rhetoric and theology in De Musica aligns with Hopkins's hybrid thinking, and there are similarities between passages in the treatise and Hopkins's writing. The article explores the connection between the terms "rove over" and "provolutio" in the works of Gerard Manley Hopkins and Augustine, both of which describe the ambivalent function of enjambment in poetry. The author suggests that Hopkins may have derived his term from Augustine's "provolutio," as both terms share structural, semantic, and phonetic similarities. The article also discusses the influence of Augustine's theological and philosophical thinking on Hopkins's work, particularly in relation to the acceptance of contradiction. The author concludes that the terms "rove over" and "provolutio" are not merely technical terms, but are linked to broader philosophical and theological concepts. [Extracted from the article]

Published
2024
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42. Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Author

Kottke, Timothy, Tonne, Jason, Evgin, Laura, Driscoll, Christopher B., van Vloten, Jacob, Jennings, Victoria A., Huff, Amanda L., Zell, Brady, Thompson, Jill M., Wongthida, Phonphimon, Pulido, Jose, Schuelke, Matthew R., Samson, Adel, Selby, Peter, Ilett, Elizabeth, McNiven, Mark, Roberts, Lewis R., Borad, Mitesh J., Pandha, Hardev, Harrington, Kevin, Melcher, Alan, and Vile, Richard G.

Published
2021
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43. Phase 1 trial of navitoclax and sorafenib in patients with refractory solid tumors with a hepatocellular carcinoma expansion cohort.

Author

Emiloju, Oluwadunni Eunice, Yin, Jun, Koubek, Emily, Reid, Joel M., Borad, Mitesh, Lou, Yanyan, Seetharam, Mahesh, Edelman, Martin Joseph, Jiang, Yixing, Kaseb, Ahmed Omar, Posey, James, Davis, S. Lindsey, Gores, Gregory J, Roberts, Lewis R., Takebe, Naoko, Wahner Hendrickson, Andrea Elisabeth, Kaufmann, Scott H., Hubbard, Joleen, and Costello, Brian Addis

Published
2024
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45. Africa Guidelines for Hepatocellular Carcinoma Buildup Process

Author

Abou-Alfa, Ghassan K., primary, Afihene, Mary, additional, Capanu, Marinela, additional, Li, Yuelin, additional, Chou, Joanne F., additional, Asombang, Akwi, additional, Alatise, Olusegun Isaac, additional, Bounedjar, Adda, additional, Cunha, Lina, additional, Mekonnen, Hailemichael Desalegn, additional, Diop, Papa Saloum, additional, Elwakil, Reda, additional, Ali, Mahamat Moussa, additional, Ndlovu, Ntokozo, additional, Ndumbalo, Jerry, additional, Makondi, Precious Takondwa, additional, Tzeuton, Christian, additional, Biachi de Castria, Tiago, additional, Agyei-Nkansah, Adwoa Afrakoma, additional, Balogun, Fiyinfolu, additional, Bougouma, Alain, additional, Atipo Ibara, Blaise Irénée, additional, Jonas, Eduard, additional, Kimani, Stephen, additional, Kingham, Peter, additional, Kurrimbukus, Reshad, additional, Hammad, Nazik, additional, Fouad, Mona, additional, El Baghdady, Noha, additional, Servais Albert Fiacre, Eloumou Bagnaka, additional, Sewram, Vikash, additional, Spearman, C. Wendy, additional, Yang, Ju Dong, additional, Roberts, Lewis R., additional, and Abdelaziz, Ashraf O., additional

Published
2023
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46. The Cholangiocarcinoma in the Young (CITY) Study: Tumor Biology, Treatment Patterns, and Survival Outcomes in Adolescent Young Adults With Cholangiocarcinoma

Author

Pappas, Leontios, primary, Baiev, Islam, additional, Reyes, Stephanie, additional, Bocobo, Andrea Grace, additional, Jain, Apurva, additional, Spencer, Kristen, additional, Le, Tri Minh, additional, Rahma, Osama E., additional, Maurer, Jordan, additional, Stanton, Jen, additional, Zhang, Karen, additional, De Armas, Anaemy Danner, additional, Deleon, Thomas T., additional, Roth, Marc, additional, Peters, Mary Linton B., additional, Zhu, Andrew X., additional, Boyhen, Kylie, additional, VanCott, Christine, additional, Patel, Tushar, additional, Roberts, Lewis R., additional, Lindsey, Stacie, additional, Horick, Nora, additional, Lennerz, Jochen K., additional, Iafrate, A. John, additional, Goff, Laura Williams, additional, Mody, Kabir, additional, Borad, Mitesh J., additional, Shroff, Rachna T., additional, Javle, Milind M., additional, Kelley, R. Katie, additional, and Goyal, Lipika, additional

Published
2023
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48. Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de‐palmitoylation

Author

Shi, Zhehao, primary, Li, Zhiming, additional, Jin, Bin, additional, Ye, Wen, additional, Wang, Luhui, additional, Zhang, Sina, additional, Zheng, Jiuyi, additional, Lin, Zixia, additional, Chen, Bo, additional, Liu, Fangting, additional, Zhang, Baofu, additional, Ding, Xiwei, additional, Yang, Zhen, additional, Shan, Yunfeng, additional, Yu, Zhengping, additional, Wang, Yi, additional, Chen, Jicai, additional, Chen, Qiang, additional, Roberts, Lewis R., additional, and Chen, Gang, additional

Published
2023
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49. IMPACT OF ARTIFICIAL INTELLIGENCE-DRIVEN WHOLE SLIDE IMAGE SCORING AND PRIORITIZATION ON USER EFFICIENCY DURING CYTOLOGIC EVALUATION OF BILIARY STRICTURES

Author

Marya, Neil, primary, Hartley, Christopher, additional, Powers, Patrick, additional, Bois, Melanie, additional, Kerr, Sarah, additional, Thangaiah, Judith Jebastin, additional, Norton, Daniel, additional, Gleeson, Ferga, additional, Francis, Mary Kittle, additional, Passow, Marie, additional, Dayyeh, Barham Abu, additional, Bofill-Garcia, Aliana, additional, Chandrasekhara, Vinay, additional, Gores, Gregory, additional, Kipp, Benjamin, additional, Law, Ryan, additional, Martin, John, additional, Petersen, Bret, additional, Voss, Jesse, additional, Zieman, Angela, additional, Roberts, Lewis, additional, Bridgeman, Amber, additional, Stai, Anthony, additional, Storm, Andrew, additional, Vargas, Eric, additional, Graham, Rondell, additional, and Levy, Michael, additional

Published
2023
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50. Non-Alcoholic Fatty Liver Disease and Liver Fibrosis in Persons with Type 2 Diabetes Mellitus in Ghana: A Study of Prevalence, Severity, and Contributing Factors Using Transient Elastography

Author

Wiafe, Yaw Amo, primary, Afihene, Mary Yeboah, additional, Anto, Enoch Odame, additional, Nmai, Richmond Ashitey, additional, Amoah-Kumi, Lois, additional, Frimpong, Joseph, additional, Dickson, Francis D., additional, Antwi, Samuel O., additional, and Roberts, Lewis R., additional

Published
2023
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