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24 results on '"Rishi Paliwal"'

1. Recent developments in intranasal drug delivery of nanomedicines for the treatment of neuropsychiatric disorders

Author

Anglina Kisku, Ambresh Nishad, Saurabh Agrawal, Rishi Paliwal, Ashok Kumar Datusalia, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, and Kunjbihari Sulakhiya

Subjects
nanoformulation, intranasal drug delivery, phytochemical and synthetic nanoformulation, nanomedicines, neuropsychiatric disorder, Medicine (General), R5-920
Abstract

Neuropsychiatric disorders are multifaceted syndromes with confounding neurological explanations. It includes anxiety, depression, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia, Tourette’s syndrome, delirium, dementia, vascular cognitive impairment, and apathy etc. Globally, these disorders occupy 15% of all diseases. As per the WHO, India has one of the largest populations of people with mental illnesses worldwide. The blood-brain barrier (BBB) makes it extremely difficult to distribute medicine to target cells in the brain tissues. However, it is possible through novel advancements in nanotechnology, molecular biology, and neurosciences. One such cutting-edge delivery method, nose-to-brain (N2B) drug delivery using nanoformulation (NF), overcomes traditional drug formulation and delivery limitations. Later offers more controlled drug release, better bioavailability, improved patient acceptance, reduced biological interference, and circumvention of BBB. When medicines are delivered via the intranasal (IN) route, they enter the nasal cavity and go to the brain via connections between the olfactory and trigeminal nerves and the nasal mucosa in N2B. Delivering phytochemical, bioactive and synthetic NF is being investigated with the N2B delivery strategy. The mucociliary clearance, enzyme degradation, and drug translocations by efflux mechanisms are significant issues associated with N2B delivery. This review article discusses the types of neuropsychiatric disorders and their treatment with plant-derived as well as synthetic drug-loaded NFs administered via the IN-delivery system. In conclusion, this review provided a comprehensive and critical overview of the IN applicability of plant-derived NFs for psychiatric disorders.

Published
2024
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3. Tyrosine kinase inhibitors as next generation oncological therapeutics: Current strategies, limitations and future perspectives

Author

Sumeet Katke, Rishi Paliwal, Akash Chaurasiya, Aishwarya Shinde, and Kanan Panchal

Subjects
Drug, Kinase, business.industry, media_common.quotation_subject, Cancer, Antineoplastic Agents, Protein-Tyrosine Kinases, Bioinformatics, medicine.disease, Drug Delivery Systems, Neoplasms, Drug delivery, medicine, Humans, Tissue Distribution, Pharmacology (medical), Signal transduction, Adverse effect, Protein kinase A, business, Protein Kinase Inhibitors, Tyrosine kinase, Signal Transduction, media_common
Abstract

Protein kinases, a class of enzymes that govern various biological phenomena at a cellular level, are responsible for signal transduction in cells that regulate cellular proliferation, differentiation, and growth. Protein kinase enzyme mutation results in abnormal cell division leading to a pathological condition like cancer. Tyrosine kinase (TK) inhibitors, which helps as a potential drug candidate for the treatment of cancer, are continuously being developed. Majority of these drug candidates are being administered as conventional oral dosage form, which provides limited safety and efficacy due to non-specific delivery and uncontrolled biodistribution resulting into the adverse effects. A controlled drug delivery approach for the delivery of TK inhibitors may be a potential strategy with significant safety and efficacy profile. Novel drug delivery strategies provide target-specific drug delivery, improved pharmacokinetic behaviour, and sustained release leading to lower doses and dosing frequency with significantly reduced side effects. Along with basic aspects of tyrosine kinase, this review discusses various aspects related to the application of tyrosine kinase inhibitors in clinical oncological setting. Furthermore, the limitations/challenges and formulation advancements related to this class of candidates particularly for cancer management have been reviewed. It is expected that innovations in drug delivery approaches for TK inhibitors using novel techniques will surely provide a new insights for improved cancer treatment and patients' life quality.

Published
2022
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4. Current Scenario and Future Prospects of Adverse Drug Reactions (ADRs) Monitoring and Reporting Mechanisms in the Rural Areas of India

Author

Kunjbihari Sulakhiya, Shalini Shukla, Priyanka Sharma, Priya Gupta, Shikha Pandey, Reshu Agrawal, Deepak Rathour, Dharmendra Kumar Kewat, Ramu Singh, Sunil Kumar Thakur, and Rishi Paliwal

Subjects
Pharmacology, Pharmacology (medical), Toxicology
Abstract

Background: Pharmacovigilance (PV) deals with the detection, collection, assessment, understanding, and prevention of adverse effects associated with drugs. The objective of PV is to ensure the safety of the medicines and patients by monitoring and reporting all adverse drug reactions (ADRs) associated with prescribed medicine usage. Findings have indicated that about 0.2-24% of hospitalization cases are due to ADRs, of which 3.7% of patients have lethal ADRs. The reasons include the number of prescribed drugs, an increased number of new medicines in the market, an inadequate PV system for ADR monitoring, and a need for more awareness and knowledge about ADR reporting. Severe ADRs lead to enhanced hospital stays, increased treatment costs, risk of death, and many medical and economic consequences. Therefore, ADR reporting at its first instance is essential to avoid further harmful effects of the prescribed drugs. In India, the rate of ADR reporting is less than 1%, whereas worldwide, it is 5% due to a need for more awareness about PV and ADR monitoring among healthcare providers and patients. Aim: The main objective of this review is to highlight the current scenario and possible futuristic ways of ADR reporting methods in rural areas of India. Method: We have searched the literature using PubMed, Google scholar, Indian citation index to retrieve the resources related to ADR monitoring and reporting in India's urban and rural areas. Results: Spontaneous reporting is the most commonly used PV method to report ADRs in India's urban and rural areas. Evidence revealed that no effective ADR reporting mechanisms developed in rural areas causing underreporting of ADR, thus increasing the threat to the rural population. Conclusion: Hence, PV and ADR reporting awareness among healthcare professionals and patients, telecommunication, telemedicine, use of social media and electronic medical records, and artificial intelligence are the potential approaches for prevention, monitoring, and reporting of ADR in rural areas.

Published
2023
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6. Contributors

Author

Ashish Kumar Agrawal, Thomson Santosh Alex, null Alka, Souravh Bais, Bigul Yogeshver Bhardwaj, Deepali Bhogale, Rohit Bhosale, Gaurav Chaudhary, Aiswarya Chaudhuri, Ankita Dadwal, Rajiv Dahiya, Sunita Dahiya, Ashish Garg, Laxmikant Gautam, Rohan Ghadi, A.K. Goyal, Ghanshyam Das Gupta, Madhu Gupta, Prem N. Gupta, Swati Gupta, Umesh Gupta, Ayushi Jain, Gaurav Kumar Jain, Sanyog Jain, Heena Kazi, Rameshroo Kenwat, Roop K. Khar, Kaushik Kuche, Bhupinder Kumar, Vinay Kumar, Amrita Kumari, Damanpreet K. Lang, Viney Lather, Sharad Mangal, Priyanka Maurya, Farhan Mazahir, Neeraj Mishra, Nidhi Mishra, R.K. Narang, Raquibun Nisha, Kumar Nishchay, Riyaz Ali Osmani, Ravi Raj Pal, Amit Kumar Palai, Rishi Paliwal, Shivani Rai Paliwal, Pritish Kumar Panda, Pawan Kumar Pandey, Deepti Pandita, Aravind Sai Patha, Tanvi Patil, Vandana Patravale, Neelam Poonia, Shiv Kumar Prajapati, Vineet Kumar Rai, Neha Raina, M. Ramchandani, Radha Rani, G. Rath, Rakesh Kumar Sahoo, Kamalpreet Kaur Sandha, Shubhini A. Saraf, M. Senthil Kumar, Priya Shrivastava, Ekta Singh, Himani Singh, Neelu Singh, Priya Singh, Samipta Singh, Vijay Singh, Sofiya Tarannum, Rudra Vaghela, null Vakar, Amit Verma, L.V. Vigneshwaran, Nikhar Vishwakarma, Suresh P. Vyas, and Awesh K. Yadav

Published
2023
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8. List of contributors

Author

CO Adetunji, null Ankit, Hira Aslam, MO Bamigboye, Najla Bentrad, Swati Bhati, Monika Bhattu, Dheeraj Bisht, Kemal Çetin, Anik Kumar Das, Adil Denizli, Santanu Dhara, Kamal Dua, CA Eziukwu, Hareem Fatima, Anshuman Gaurav, Deepak K Gupta, Humaira Hussain, A Inobeme, Suyambulingam Jone Kirubavathy, Shikha Kapil, Deepika Kathuria, T Kelani, Anglina Kisku, Deepak Kumar, Krishan Kumar, Suneel Kumar, Cansu İlke Kuru, Kalpana Madgula, M Maliki, Padmavati Manchikanti, JT Mathew, Sayan Mukherjee, Gunjan Nagpure, Arunadevi Natarajan, Vanya Nayak, Muhammad Yasin Naz, E Olori, BI Onyeachu, Ajay Pal, Nirmalya Pal, Rishi Paliwal, Mrituanjay D Pandey, Sadanand Pandey, Jhansi Lakshmi Parimi, Shruthy D. Pattathil, Lakshmi Madhuri Peddada, Ekta Poonia, Rishi Raj, Narender Ranga, Rohit Ranga, Nadia Razdan, Soumi Sadhu, Arpit Sand, Akshansh Sharma, Ishan Sharma, Monu Kumar Shukla, Shazia Shukrullah, Anita Singh, Jay Singh, Kshitij RB Singh, Ravindra Pratap Singh, Sachin Kumar Singh, Kunjbihari Sulakhiya, Houcine Touati, Jaya Tuteja, Fulden Ulucan-Karnak, Meenakshi Verma, Aparna Vyas, Yashraj Yadav, and Koray Şarkaya

Published
2023
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11. An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Author

Shiv Kumar Prajapati, Akanksha Malaiya, Gaurav Mishra, Dolly Jain, Payal Kesharwani, Nishi Mody, Amirhossein Ahmadi, Rishi Paliwal, and Ankit Jain

Subjects
Pharmacology, Plants, Medicinal, SARS-CoV-2, Drug Discovery, Humans, Comprehension, Antiviral Agents, Drugs, Chinese Herbal, COVID-19 Drug Treatment
Abstract

The coronavirus disease (COVID-19) has relentlessly spread all over the world even after the advent of vaccines. It demands management, treatment, and prevention as well with utmost safety and effectiveness. It is well researched that herbal medicines or natural products have shown promising outcomes to strengthen immunity with antiviral potential against SARS-COV-2.Our objective is to provide a comprehensive insight into the preventive and therapeutic effects of herbal medicines and products (Ayurvedic) for pre-and post-COVID manifestations.The database used in the text is collected and compiled from Scopus, PubMed, Nature, Elsevier, Web of Science, bioRxiv, medRxiv, American Chemical Society, and clinicaltrials.gov up to January 2022. Articles from non-academic sources such as websites and news were also retrieved. Exploration of the studies was executed to recognize supplementary publications of research studies and systematic reviews. The keywords, such as "SARS-COV-2, coronavirus, COVID-19, herbal drugs, immunity, herbal immunomodulators, infection, herbal antiviral drugs, and WHO recommendation" were thoroughly searched. Chemical structures were drawn using the software Chemdraw Professional 15.0.0.160 (PerkinElmer Informatics, Inc.).A plethora of literature supports that the use of herbal regimens not only strengthen immunity but can also treat SARS-COV-2 infection with minimal side effects. This review summarizes the mechanistic insights into herbal therapy engaging interferons and antibodies to boost the response against SARS-COV-2 infection, several clinical trials, and in silico studies (computational approaches) on selected natural products including, Ashwagandha, Guduchi, Yashtimadhu, Tulsi, etc. as preventive and therapeutic measures against COVID. We have also emphasized the exploitation of herbal medicine-based pharmaceutical products along with perspectives for unseen upcoming alike diseases.According to the current state of art and cutting-edge research on herbal medicines have showed a significant promise as modern COVID tools. Since vaccination cannot be purported as a long-term cure for viral infections, herbal/natural medicines can only be considered a viable alternative to current remedies, as conceived from our collected data to unroot recurring viral infections.

Published
2022

16. Contributors

Author

Mayur Aalhate, Amit Alexander, null Alka, Reddy Gayathri Aparnasai, Mohammad Bayat, Preeti Bisht, Sonal Dixit, Debapriya Garabadu, Ashish Garg, Davood Gheidari, Surbhi Gupta, Tanisha Gupta, Umesh Gupta, Mayank Handa, Shagufta Haque, Krishna Jadhav, Ashish Jain, Sanjay K. Jain, Navjot Kaur, Rameshroo Kenwat, Vaishali Khare, S.T.V. Sai Krishna, Pramod Kumar, Vanktesh Kumar, Vinay Kumar, Banwari Lal, Waibiangki Lyngdoh, Srushti Mahajan, Sandeep Kr Maharana, Thatikayala Mahender, Indrani Maji, Jinu Mathew, Priyanka Maurya, Nidhi Mishra, Pallav Namdeo, Raquibun Nisha, Ravi Raj Pal, Rishi Paliwal, Shivani Rai Paliwal, Nikita Panicker, Debashish Paramanik, Chitta Ranjan Patra, Rajesh Singh Pawar, null Raghuraj, Sarjana Raikwar, Sarita Rani, Eupa Ray, Munindra Ruwali, Rakesh Kumar Sahoo, Sanjeev Kumar Sahu, Shubhini A. Saraf, Gaurav Saraogi, Aakriti Sethi, Satish Shilpi, Rahul Shukla, Neelu Singh, Pankaj Kumar Singh, Priya Singh, Sanjiv Singh, Vijay Singh, null Smily, Vaibhavi Srivastava, M.S. Sudheesh, Kunjbihari Sulakhiya, Rewati Raman Ujjwal, Kalpesh Vaghasiya, Rahul Kumar Verma, and Awesh K. Yadav

Published
2022
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20. List of contributors

Author

Valamla Bhavana, Erem Bilensoy, Padakanti Sandeep Chary, Bhushan P. Chaudhari, Balak Das Kurmi, Vividha Dhapte, Nazlı Erdoğar, A. Fernandez-Carballido, A.I. Fraguas-Sanchez, Bharti Gajbe, Kavita R. Gajbhiye, Virendra Gajbhiye, Laxmikant Gautam, Pengbo Guo, Umesh Gupta, Tanweer Haider, Priyanka Jain, Rupshee Jain, Vikas Jain, Neha Jaiswal, Nan Ji, Indu Lata Kanwar, Rameshroo Kenwat, Hitesh Kumar, Vinay Kumar, Gopal C. Kundu, Ipsita G. Kundu, Akanksha Malaiya, C. Martin-Sabroso, Farhan Mazahir, Abhishesh Kumar Mehata, Neelesh Kumar Mehra, Barnalee Mishra, Vijay Mishra, Yachana Mishra, Aliesha Moudgil, Madaswamy S. Muthu, Rishi Paliwal, Shivani Rai Paliwal, Vikas Pandey, Anil T. Pawar, N.N.V. Radharani, Naveen Rajana, Sarita Rani, Rakesh Kumar Sahoo, Priya Shrivastava, Mansha Singhai, Viswas Raja Solomon, Vandana Soni, Murtaza M. Tambuwala, Chalet Tan, A.I. Torres-Suarez, Shourya Tripathi, Cem Varan, Gamze Varan, Sanjana Varma, Matte Kasi Viswanadh, S.P. Vyas, Wucheng Wen, Ho Lun Wong, Hui Yi Xue, Amit Singh Yadav, and Awesh K. Yadav

Published
2022
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21. Contributors

Author

Javed Ahmad, Mohammad Zaki Ahmad, Faraat Ali, Nabil K. Alruwaili, Sultan Alshehri, Archana Bagre, Valamla Bhavana, Padakanti Sandeep Chary, Shashank Chaturvedi, Shivani Chauhan, Akash Chaurasiya, Anuj Garg, Urvashee Gogoi, Anamika Sahu Gulbake, Syed Sarim Imam, Keerti Jain, Archita Jha, Hae-Won Kim, Pramod Kumar, Amal G. Kurian, Thiagarajan Madheswaran, Neelesh Kumar Mehra, Awanish Mishra, Nidhi Mishra, Pragya Shakti Mishra, Abdul Aleem Mohammed, Saba Naqvi, Puja Nayak, Rishi Paliwal, Shivani Rai Paliwal, Kanan Panchal, Jithendra Panneerselvam, Poonam Parashar, Nilosha Parveen, Anup K. Patel, Kapil D. Patel, Parth R. Patel, Kalyani Pathak, Yashwant Pathak, Naveen Rajana, Suraj Singh S. Rathod, Riya Saikia, Ravi Sheshala, Neelu Singh, Rajendra K. Singh, Shashi Bala Singh, Raghu Raj Singh Thakur, Ankita Tiwari, Lalitkumar Vora, and Ameeduzzafar Zafar

Published
2022
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23. Nanomedicine, Nanotheranostics and Nanobiotechnology : Fundamentals and Applications

Author

Rishi Paliwal, Shivani Rai Paliwal, Rishi Paliwal, and Shivani Rai Paliwal

Subjects
Nanobiotechnology, Nanostructures--Therapeutic use, Nanomedicine
Abstract

Nanosized particles explored for therapeutics and diagnosis-related research areas need the latest updated information for budding researchers as well as academicians. Nanomedicine, nanotheranostics, and nanobiotechnology have been contemporary technological tools for diverse biomedical, pharmaceutical, and diagnostic solutions. The present book is divided into two sections.The first section is dedicated to exclusive book chapters related to nanomedicine such as its history, regulatory aspects, scale-up, and regulatory toxicology. Additionally, this section includes chapters focusing on the application domain of nanomedicine for targeted cancer therapy, rheumatoid arthritis management, psoriasis treatment, ocular delivery, topical applications, oral bioavailability enhancement, and pulmonary delivery.The second section is composed of chapters in the area of nanotheranostics and applications of nanobiotechnology. In brief, the latest topics such as gold nanoparticles in diagnostics and therapy, nanoparticles for siRNA delivery, carbon nanotubes for gene delivery, nanoparticles for vaccine delivery, nanobiotechnology in cell-based nanomedicines, nanotechnology in regenerative medicine, and nanocarriers in delivery of proteins and peptides are complied.KEY FEATURES A total of 26 emerging topics are covered in the book on cutting-edge research areas at the multi-disciplinary level. The chapters focus on fundamentals and applications, making the book attractive for beginners as well as experts. The chapters are written by well-known experts of the field in a simple scientific style with figures, schemes, and illustrations.

Published
2024

24. Targeted Nanomedicine for Breast Cancer Therapy

Author

Shivani Rai Paliwal, Rishi Paliwal, Shivani Rai Paliwal, and Rishi Paliwal

Subjects
Public health--Great Britain, Public Health
Abstract

Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry.Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available. - Highlights promising breast cancer targets to help design nanomedicines and stimuli-triggered methods for cancer imaging and treatments - Provides in-depth exploration of targeted breast cancer therapy, along with highlights to quickly understand the most important points - Explores cutting-edge research in the area of targeted nanomedicine and drug delivery, including nanotheranostics for breast cancer therapy

Published
2022

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