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ObjectiveTo describe the participation of racial and ethnic minority groups (REMGs) in gynecologic oncology trials.MethodsGynecologic oncology studies registered on ClinicalTrials.gov between 2007 and 2020 were identified. Trials with published results were analyzed based on reporting of race/ethnicity in relation to disease site and trial characteristics. Expected enrollment by race/ethnicity was calculated and compared to actual enrollment, adjusted for 2010 US Census population data.Results2146 gynecologic oncology trials were identified. Of published trials (n = 252), 99 (39.3%) reported race/ethnicity data. Recent trials were more likely to report these data (36% from 2007 to 2009; 51% 2013-2015; and 53% from 2016 to 2018, p = 0.01). Of all trials, ovarian cancer trials were least likely to report race/ethnicity data (32.1% vs 39.3%, p = 0.011). Population-adjusted under-enrollment for Blacks was 7-fold in ovarian cancer, Latinx 10-fold for ovarian and 6-fold in uterine cancer trials, Asians 2.5-fold in uterine cancer trials, and American Indian and Alaska Native individuals 6-fold in ovarian trials. Trials for most disease sites have enrolled more REMGs in recent years - REMGs made up 19.6% of trial participants in 2007-2009 compared to 38.1% in 2016-2018 (p

OBJECTIVES: To evaluate outcomes and cost-effectiveness of targeted therapy sequencing for metastatic and recurrent cervical cancer. METHOD: Models were simulated based on phase II and III trials on bevacizumab (bev) from GOG-240, cemiplimab (cemi) from GOG 3016, pembrolizumab (pembro) from KEYNOTE-826, and tisotumab vedotin (tiso) from GOG 3023. Costs were based on IBM Micromedex RED BOOK™ and company listed costs. RESULTS: For [chemo + bev → chemo], total cost was $125,918.04, with median overall survival (mOS) of 21.8 months, and cost-effectiveness ratio (CER) of $119,835.79. For [chemo + bev → cemi], total cost was $187,562.99 with mOS of 28.5 months and CER of $162,039.16. For [chemo + bev + pembro → chemo], total cost was $319,963.78 with mOS 32.9 months and CER of $249,930.10. For [chemo + bev + pembro → tiso], total cost was $455,204.45, with mOS 36.5 months and CER of $320,072.99. CONCLUSION: The combination of immunotherapies and biologics have significantly increased overall survival, but with associated higher costs, primarily related to drug costs.

As society embraces technology to support collaboration anywhere and at anytime, there is a growing opportunity for artificial agents to support such collaboration. However, little seems known about how such agents impact the behavioural performance of human teams. To answer this, we devised a Wizard of Oz study where teams of 3 participants located and corralled targets into a containment area in a virtual desert environment. The Wizard played the role of an artificial intelligent operator who had a map view showing the location of participants, targets and the containment area, and could verbally communicate this information. The Wizard operated under two conditions: they could solely use the map view to decide what responses to utter (non-responsive interaction) or could also listen to participant queries (responsive interaction). The results revealed that participant performance was unaffected by responsive interaction condition, despite having a significantly more favourable perception of a responsive agent.

While communication is an essential part of life, it is not always easy and effortless. This is especially true when talking with someone in a noisy environment. Although communicating in noise is often the rule rather than the exception, very little research has investigated the behavioral processes individuals might use to minimize miscommunication when listening becomes challenged. Here we explored synergistic speech and movement processes that 22 pairs of adults used to hear and be heard when (mis)communicating in noise. The results revealed intricate dynamics both with respect to acoustic optimization of the speech produced and heard, as well as how individuals modulate interpersonal distance and behavioral coordination patterns.

Intention prediction often plays a crucial role in successful social interaction. Previous studies have attempted to understand this skill by focusing on the role of movement kinematics in isolation. However, this approach is limited as the same kinematics typically map to multiple action possibilities (affordances) and as a result, individual's also employ contextual information to predict others' intentions. In this study we present preliminary findings from a qualitative study aimed at investigating intention prediction in naturalistic contexts. Participants viewed an individual reaching for a cup with one of two object-directed intentions: to drink OR to clear the table. A third non-object-directed intention was also included where the observed individual placed their hand on the table next to the cup. For each intention the contextual information was varied by changing the environmental scene between (1) cups full of juice, (2) almost empty cups, and (3) half-empty cups. The findings reveal that participants perceived the cup's functional (most salient) affordance - drink - for the intention so far as the movement kinematics specified an object-directed intention (drink or clear) with a context that clearly afforded it (full and half-full cups). However, participants were also sensitive to the kinematic differences between the object-directed intentions when the context made the functional affordance seem improbable (almost empty cups).

Humans are social animals. Human cognition evolved in a social context. Human cognition develops in a social context. Thus, both the internal mechanisms of cognition and the information we use are social. In this workshop, we aim to extend the boundaries of cognitive sciences beyond individual minds. Following the lead of Dingemanse et al. (2023), we put interaction in focus as a complementary starting point for the study of human cognition.

Perceptual-motor tasks offer redundant solutions to achieve a goal. However, not all solutions are equally robust to error-producing variability and thus, skill learning requires the search for behaviors that are error-tolerant. Throwing a ball to hit a target is a skill that has been studied via the “skittles” task, a simplified 2-dimensional throwing environment. The study investigated whether participants learning the skittles task benefit from task scaffolding via the placements of targets provided by either a human confederate posing as a teacher, or by the participant. These groups were compared to a third sample who received an unstructured curriculum consisting of randomly placed targets. The results demonstrate that participants in the unstructured training condition were better able to perceive the task’s underlying solution geometry, compared to scaffolding provided by a human. Future work will explore methods to design training curricula that are more efficient in facilitating perceptual-motor skill development.

Solving problems with others not only reduces the time required to complete a challenge but may also enable the discovery of novel strategies that qualitatively change how a problem is approached. At the dyadic level, the laboratory-based ‘shepherding task’ demonstrated that, when tasked to contain evasive agents to a centralized location, some participants discover a non-obvious but optimal strategy to solve the task. This paper quantified the interactions between participants engaged in the task using Multidimensional Cross-Recurrence Quantification Analysis (MdCRQA), applied to each participant’s gaze and hand movements. The results demonstrated that strategy discoverers exhibited greater amounts of incidental coupling than non-discoverers prior to discovery. Once discovered, the strategy reduced the strength of coupling between participants, indicating that the strategy also reduced coordination demands. Future work will investigate whether differences in problem-solving can be attributable to differences in the perceptual features participants use which scaffold the discovery of task-optimal solutions.

Collaboration and teaming are critical for solving complex problems. However, little is known about how group dynamics affect teaming behaviours and, ultimately, problem-solving effectiveness. The present study aimed to validate a novel measure of the dynamics of team communication – here termed turn-taking entropy – and to investigate what aspects of those dynamics affect collaborative-problem-solving performance. Thirty-two teams of 4 were asked to complete a simulated crisis-response task in which they had to rank 15 items in order of their importance to their team’s survival (first individually and then as a team). Group responses were better than the aggregated individual responses of team members (suggesting teaming benefits), and were better when team members had task-relevant skills and knowledge. However, response quality was not significantly related to task completion time. Additionally, the proposed entropy measure appeared to capture group communication dynamics, and appeared to differentiate stable an unstable patterns of communication. Implications and directions for future research are discussed.

Modeling human navigation and route selection in complex environments has used path planning in the past and more recently, dynamical models. The current study modeled the navigational movement trajectories of human herder agents tasked with corralling an autonomous target agent into a specified containment zone. Analyses of trajectories of participants completing a first-person herding game revealed that their movement entailed sequential (i) approach and then (ii) corral phases that were invariant to the initial location of the herder and target agents. More importantly, the trajectories of human herders could be captured using a low-dimensional environmentally coupled dynamical model. The novelty of this work is in extending the previous research in modeling navigational behaviors of humans to include moving targets that need to be manipulated into a desired position. Implications of the findings for the development of artificial agents for human-machine herding, as well as more general human-machine teaming are discussed.

Deep reinforcement learning (DRL) is capable of training agents that exceed human-levels of performance in multi-agent tasks. However, the behaviors exhibited by these agents are not guaranteed to be human-like or human-compatible. This poses a problem if the goal is to design agents capable of collaborating with humans or augmenting human actions in cooperative or team-based tasks. Indeed, recommender systems designed to augment human decision-making need to not only recommend actions that align with the task goal, but which also maintain coordinative behaviors between agents. The current study simultaneously explored skill learning performance of human learners when working alongside different artificial agents (AAs) during a collaborative problem-solving task, as well as evaluated the effectiveness of the same AAs as action decision recommender systems to aid learning. The action decisions of the AAs were either modelled by a heuristic model based on human performance or by a deep neural network trained by reinforcement learning using self-play. In addition to evaluating skill learning performance, the current study also tested the congruence between the decisions of the AAs with actual decisions made by humans. Results demonstrate that the performance of humans was significantly worse when working alongside the DRL AA compared to the heuristic AA. Additionally, the action decisions participants made also showed less allignment with the recommendations made by the DRL AA.

Agents trained using deep reinforcement learning (DRL) are capable of meeting or exceeding human-levels of performance in multi-agent tasks. However, the behaviors exhibited by these agents are not guaranteed to be human-like or human-compatible. This poses a problem if the goal is to design agents capable of collaborating with humans in cooperative or team-based tasks. Previous approaches to encourage the development of human-compatible agents have relied on pre-recorded human data during training. However, such data is not available for the majority of everyday tasks. Importantly, research on human perceptual-motor behavior has found that task-directed behavior is often low-dimensional and can be decomposed into a defined set of dynamical perceptual-motor primitives (DPMPs). Accordingly, we propose a hierarchical approach to simplify DRL training by defining the action dynamics of agents using DPMPs at the lower level, while using DRL to train the decision-making dynamics of agents at the higher level. We evaluate our approach using a multi-agent shepherding task used to study human and multi-agent coordination. Our hierarchical, DRL-DPMP approach resulted in agents which trained faster than vanilla, black-box DRL agents. Further, the hierarchical agents reached higher levels of performance not only when interacting with each other during self-play, but also when completing the task alongside agents embodying models of novice and expert human behavior. Finally, the hierarchical DRL-DPMP agents developed decision-making policies that outperformed heuristic-based agents used in previous research in human-agent coordination.

Interpersonal coordination is a key determinant of successful social interaction but is disrupted for people who experience social anxiety. Effective coordination rests on individuals directing their attention toward others, an effect well-documented in previous literature. Yet, little research has considered the concurrent behaviour of interaction partners. Using a novel virtual reality task, we investigated how partner gaze (i.e., direct vs. averted) influenced the emergence of interpersonal coordination. The results revealed two novel effects: (i) spontaneous coordination was diminished in the averted (cf. direct) gaze condition; (ii) spontaneous coordination was positively related to symptoms of social anxiety, but only when partner gaze was averted. This latter finding contrasts the extant literature and points to interaction intensity as a factor governing the social anxiety-coordination association. More broadly, this work provides further evidence that emergent patterns of interpersonal coordination fluctuate as a function of changes in social context and the behaviour of others.

Social cognition is shaped by cultural and social-psychological contexts. Depending on the social cues displayed, the cognitive processes that emerge during embodied social interactions can vary. This study explored the influence of gender diverse social cues on interpersonal coordination and decision-making during dyadic interaction in virtual reality. Participants embodied either a transgender or cisgender avatar and interacted with a transgender confederate (human-controlled virtual agent). Results suggest that transgender embodied women and men displayed more interpersonal affiliation, via their coordination dynamics with the confederate, after an explicit gender identity disclosure. Additionally, cognitive flexibility for ambiguous decisions was influenced by attributions of responsibility made toward the confederate. However, cisgender embodied men did not substantially change their decision-making behaviours or increase their coordination with the confederate. Viscerally taking on the perspective and appearance of a transgender person, achieved through virtual embodiment and interaction, may support positive interactions between cisgender and transgender communities.

Social motor coordination (SMC), defined as the intentional or unintentional coordination of movement between individuals in a social setting, has been linked to greater feelings of rapport and social connectedness. Here, we investigated this relationship using a silent disco paradigm where groups of 3 or 4 individuals danced to either the same music or different music. Visual information was manipulated by initially separating the participants with curtains (2 minutes), after which the curtains were opened (10 minutes). Head movements were recorded with a wireless motion tracking system attached to the silent disco headphones. Rapport and social connectedness measures were obtained using questionnaires completed after participation in the silent disco. Results showed that groups who listened to the same music exhibited a greater degree of SMC than groups that listened to different music. Greater degrees of SMC were also observed when group members were able to see one another. Finally, greater SMC was associated with perceptions of increased self-other overlap and interaction quality.

Behavior intervention plans (BIPs) are intended to help educators systematically support students with behavioral problems at school. Previous research confirms that the effectiveness of a BIP depends on the degree to which the plan is technically adequate and implemented with integrity. What remains unclear from the literature is how professional experience and environmental variables impact technical adequacy, treatment integrity, and student outcomes. The purpose of this study was to explore these relationships using data collected from a survey of members' experiences with the BIP implementation team. The researchers collected BIPs from local school districts and then surveyed members of the implementation team regarding their professional qualifications, training, involvement in the BIP development process, treatment integrity, and perceived impact on student outcomes. Results from two multiple regression models predicting treatment integrity and student outcomes suggest that practitioners' perceptions of BIP quality significantly predicted treatment integrity. Additionally, training, BIP quality, and treatment integrity significantly predicted student outcomes. These findings suggest that practitioners' perceptions of BIP quality may play an important role in predicting treatment integrity but improving student outcomes requires technical adequacy and targeted professional development.

Older patients and those who require interpreters are least likely to use telehealth for gynecologic oncology care, showing disparities which continued after statewide vaccinations.

Ciliated cell markers expressed in epithelial ovarian cancers (EOC) are associated with improved survival. We examined the distribution of cells expressing ciliated cell markers in various EOC histologies and stages. Immunohistochemistry and/or multiplex immunofluorescence were used to determine the expression of FOXJ1 and/or CAPS (ciliated cell markers) in tissue microarrays including 4 normal fallopian tubes, 6 normal endometria, 16 cystadenomas, 25 borderline tumors, 21 low-grade carcinomas, and 118 high-grade carcinomas (HGSOC) (46 serous, 29 endometrioid, 30 clear cell, 13 mucinous). CAPS+ cells were observed in normal fallopian tubes and endometria and in ~85% of serous benign and borderline tumors and low-grade carcinomas but only in

With artificial intelligence technologies becoming commonplace today, enhancing the efficiency of human-artificial agent (AA) interactions has become increasingly important. A growing body of research has revealed how dynamic motor primitives (DMPs) of human perceptual-motor behavior can be used to create ‘human-like’ AAs, primarily focusing on cooperative tasks. Using air hockey as a representative task, the current experiment is the first part of a large study aimed at determining the utility of DMP-based models for developing ‘human-like’ competitive AAs. Participants played against a preliminary DMP model and the differences in their behaviors were analyzed. Based on these observed differences, a revised model is proposed, with preliminary results revealing that the new model exhibits behaviors more consistent with those of humans. A major implication of this work is that it presents a framework for creating ‘human-like’ AAs that capture the essential human decision and movement dynamics without requiring large human gameplay datasets.

Joint pick and place tasks occur in many interpersonal scenarios, such as when two people pick up and pass dishes. Previous studies have demonstrated that low-dimensional models can accurately capture the dynamics of pick and place motor behaviors in a controlled 2D environment. The current study models the dynamics of pick-up and pass decisions within a less restrictive virtual reality mediated 3D joint pick and place task. Findings indicate that reach-normalized distance measures, between participants and objects/targets, could accurately predict pick-up and pass decisions. Findings also reveal that participants took longer to pick-up objects where division of labor boundaries were less obvious and tended to pass in locations maximizing the dyad’s efficiency. This study supports the notion that individuals are more likely to engage in interpersonal behavior when a task goal is perceived as difficult or unattainable (i.e., not afforded). Implications of findings for human-artificial agent interactions are discussed.

Perceptual-motor tasks offer redundant solutions to achieve a goal. However, not all solutions are equally robust to error-producing noise or variability and thus, skill learning can be viewed as a search process to identify behaviors that are error-tolerant. Throwing a ball to hit a target is one such example of a complex perceptual-motor skill that has been studied in the laboratory via the virtual “skittles” task, a simplified 2D task involving throwing a tetherball around a pole to hit a target. We implemented the task as a Unity3D environment (code here: https://github.com/ShortFox/SkittlesTaskEnvironment/) which enables participants to complete the task with a computer mouse and replicated key findings from previous research. Our implementation allows for remote data collection and can serve as a pedagogical tool to teach concepts in skill acquisition. Future work will use this task to explore human versus machine skill acquisition by leveraging Unity’s MLAgents reinforcement learning package.

Behavior intervention plans (BIPs) are intended to help educators systematically support students with behavioral problems at school. Previous research confirms that the effectiveness of a BIP depends on the degree to which the plan is technically adequate and implemented with integrity. What remains unclear from the literature is how professional experience and environmental variables impact technical adequacy, treatment integrity, and student outcomes. The purpose of this study was to explore these relationships using data collected from a survey of members' experiences with the BIP implementation team. The researchers collected BIPs from local school districts and then surveyed members of the implementation team regarding their professional qualifications, training, involvement in the BIP development process, treatment integrity, and perceived impact on student outcomes. Results from two multiple regression models predicting treatment integrity and student outcomes suggest that practitioners' perceptions of BIP quality significantly predicted treatment integrity. Additionally, training, BIP quality, and treatment integrity significantly predicted student outcomes. These findings suggest that practitioners' perceptions of BIP quality may play an important role in predicting treatment integrity but improving student outcomes requires technical adequacy and targeted professional development., Author(s): Cade T. Charlton [sup.1], Danielle Marie Green Rigby [sup.2], Sara E. Moulton [sup.1], Christian V. Sabey [sup.1], Michael J. Richardson [sup.3] Author Affiliations: (1) grid.253294.b, 0000 0004 1936 9115, [...]

Background: Recess has been shown to increase total daily energy expenditure, which may favorably impact body mass index by decreasing adiposity. This study examines associations between recess participation and adiposity. Methods: The study sample included male (N = 1434) and female (N = 1409) children 5 to 11 years of age participating in the 2013-2016 National Health and Nutrition Examination Survey. Overweight and obesity were defined using age- and sex-specific percentiles. Recess participation interview questions were answered via proxy response. Results: Compared to a referent group participating in recess 5 days/week for >30 minutes/day and independent of demographic and behavioral factors, analysis revealed significantly greater odds of obesity in females reporting no recess participation (odds ratio 1.80; 95% confidence interval, 1.03-3.15, p = 0.03). Furthermore, minority females were consistently found to possess greater odds of overweight and obesity independent of recess participation time. Only Mexican American boys were found to have greater odds of obesity independent of participation recess time. Conclusions: In a large nationally representative sample of US children, reporting no recess was associated with significantly greater odds of obesity in females. Minority females were also more likely to be overweight and obese and Mexican American boys are more likely to be obese independent of recess participation time.

The purpose of this explanatory mixed methods study was to understand how 9th grade honors and general education language arts students made course enrollment decisions through the lens of the Expectancy-Value (E-V) theory. A survey was administered to 9th grade students (N = 118) attending a public high school with the overall mean score indicating fairly high reading motivation. A point biserial correlation analysis was conducted next to determine any significant correlations between course selection and the E-V expectancies for success and task values. Attainment was the only task value reporting a positive and statistically significant correlation. Six students with either high, medium, or low reading motivation were interviewed from which four themes emerged: expectancy for success and reader identity, utility and usefulness of reading in the future, cost and enjoyment associated with reading, and attainment and course enrollment decisions. Implications and recommendations for educators and researchers are provided.