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This study introduces an analysis of bifurcations, chaotic dynamics, and sensitivity using the Galilean transformation applied to the perturbed non-linear Schrödinger equation (NLSE) with Kerr-law nonlinearity. Additionally, we employ the efficient Sardar sub-equation (Sse) method to derive various optical soliton solutions. Initially, we outline the general framework of the Sse method proposed. Next, we utilize a traveling wave transform on the NLSE, transforming it into a system of nonlinear ordinary differential equations (NLODEs) which are further separated into their real and imaginary components. Furthermore, we apply this method to derive new optical solitons for the NLSE equation with Kerr law. We perform exact analytical simulations of these optical soliton solutions and investigate the effects of different parameters on the soliton waves.

Background and aimsFamilial hypercholesterolemia (FH) is becoming a global burden. However, it remains underdiagnosed and undertreated worldwide. This study aimed to observe the screening rate of FH patients and department distribution among hospitalized patients using different diagnostic criteria.MethodsA total of 45,410 inpatients with LDL-C ≥3.5 mmol/L between 2008 and 2019 were included from The Second Affiliated Hospital of Nanchang University. Inpatients are diagnosed and divided into groups by Dutch Lipid Clinic Network (DLCN) criteria, Chinese-modified DLCN criteria and Chinese expert consensus (CEC) criteria.ResultsThere were 172, 1,076 and 115 inpatients included in the DLCN group, Chinese-modified DLCN group and CEC group, respectively (screening rates: 0.38%, 2.37% and 0.25%). These FH patients had a very high risk of atherosclerotic cardiovascular disease (ASCVD) (55.7%–74.4%), especially in the DLCN group and CEC group (70.4%–74.4%). More than half of the patients were in the Department of Cardiology, and other high-risk departments included Neurology, Nephrology, Vascular Surgery, Otolaryngology & Head Neck Surgery and Traditional Chinese Medicine (24.35%–31.51%). Overall, hypertension, coronary heart disease, carotid arteriosclerosis, hepatic cyst, arrhythmia, and nonalcoholic fatty liver disease were common accompanying diseases with FH.ConclusionsIt is necessary to establish appropriate diagnostic criteria and more positive treatment strategies for the FH inpatient population. In addition, promoting awareness of FH among doctors from other departments is also necessary. Therefore, developing a comprehensive management strategy for FH disease is very important.

This study suggests a new optimized model for optimum identification of the unknown variables in a Solid Oxide (SO) fuel cell. The method is conditioned by designing an improved version of metaheuristics to improve the effectiveness of the original method and using it by the Sum of Squared Error (SSE) minimization between the model and the experimental data including output voltage. The metaheuristic is based on a new improved model of a new metaheuristic, called the Red Fox Optimization Algorithm (IRFO). To assess the method’s accuracy and its consistency, it is validated by various pressure and temperature functional conditions. The results showed that the error value of the produced power by different temperatures is lower than 0.0073 kW and the error value of the output voltage by different temperatures is lower than 0.16 V which is a promising result for stack identification. Also, the achievements of the algorithm are compared with several approaches from the literature. The final results show a satisfying verification between the empirical and the optimized technique

The goal of this paper is to obtain the new explicit solutions of the Atangana conformable (AC) fractional Biswas–Milovic (BM) equation with Parabolic law nonlinearity (PLN) which is a class of Schrödinger equation (SE) using a new methodology. This methodology, which is an extension of the direct algebraic method, provides some new solutions that are the advantage of this proposed approach. To exhibit the dynamical performance of this equation, some solutions are provided and drawn.. Usage of the new extended direct algebraic method (NEDAM), it is obtained new optical solitons for the proposed model. The proposed method has a better efficiency in comparison to the existing methods and is straightforward for nonlinear evolution equations (NLEEs). Moreover, the introduced method can be programmed using Maple software to obtain new obvious solutions for Atangana conformable nonlinear evolution equations (ACNLEEs).

BACKGROUND: Although the concept of the intrarenal renin-angiotensin system (RAS) in renal disease is well-described in the literature, the precise pathogenic role and mechanism of this local system have not been directly assessed in the absence of confounding influence from the systemic RAS. The present study used novel mouse models of collecting duct (CD)--specific deletion of (pro)renin receptor (PRR) or renin together with pharmacological inhibition of soluble PRR production to unravel the precise contribution of the intrarenal RAS to renal injury induced by unilateral ureteral obstruction. METHODS: We examined the impact of CD-specific deletion of PRR, CD-specific deletion of renin, and S1P (site-1 protease) inhibitor PF429242 treatment on renal fibrosis and inflammation and the indices of the intrarenal RAS in a mouse model of unilateral ureteral obstruction. RESULTS: After 3 days of unilateral ureteral obstruction, the indices of the intrarenal RAS including the renal medullary renin content, activity and mRNA expression, and Ang (angiotensin) II content in obstructed kidneys of floxed mice were all increased. That effect was reversed with CD-specific deletion of PRR, CD-specific deletion of renin, and PF429242 treatment, accompanied by consistent improvement in renal fibrosis and inflammation. On the other hand, renal cortical renin levels were unaffected by unilateral ureteral obstruction, irrespective of the genotype. Similar results were obtained via pharmacological inhibition of S1P, the key protease for the generation of soluble PRR. CONCLUSIONS: Our results reveal that PRR-dependent/soluble PRR--dependent activation of CD renin represents a key determinant of the intrarenal RAS and, thus, obstruction-induced renal inflammation and fibrosis. [ABSTRACT FROM AUTHOR]