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1. A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections

Author

Ljubomir Buturovic, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan, Mark Gillett, Rahul Santram, Maryam Shojaei, Raquel Almansa, Jose Ángel Nieto, Sonsoles Muñoz, Carmen Herrero, Nikolaos Antonakos, Panayiotis Koufargyris, Marina Kontogiorgi, Georgia Damoraki, Oliver Liesenfeld, James Wacker, Uros Midic, Roland Luethy, David Rawling, Melissa Remmel, Sabrina Coyle, Yiran E. Liu, Aditya M. Rao, Denis Dermadi, Jiaying Toh, Lara Murphy Jones, Michele Donato, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis, and Timothy E. Sweeney

Subjects
Medicine, Science
Abstract

Abstract Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including COVID-19. We developed a logistic regression-based classifier for the severity of viral infections and validated it in multiple viral infection settings including COVID-19. We used training data (N = 705) from 21 retrospective transcriptomic clinical studies of influenza and other viral illnesses looking at a preselected panel of host immune response messenger RNAs. We selected 6 host RNAs and trained logistic regression classifier with a cross-validation area under curve of 0.90 for predicting 30-day mortality in viral illnesses. Next, in 1417 samples across 21 independent retrospective cohorts the locked 6-RNA classifier had an area under curve of 0.94 for discriminating patients with severe vs. non-severe infection. Next, in independent cohorts of prospectively (N = 97) and retrospectively (N = 100) enrolled patients with confirmed COVID-19, the classifier had an area under curve of 0.89 and 0.87, respectively, for identifying patients with severe respiratory failure or 30-day mortality. Finally, we developed a loop-mediated isothermal gene expression assay for the 6-messenger-RNA panel to facilitate implementation as a rapid assay. With further study, the classifier could assist in the risk assessment of COVID-19 and other acute viral infections patients to determine severity and level of care, thereby improving patient management and reducing healthcare burden.

Published
2022
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2. Proteomic profiling of lung diffusion impairment in the recovery stage of SARS‐CoV‐2–induced ARDS

Author

María C. García‐Hidalgo, Jessica González, Iván D. Benítez, Paola Carmona, Sally Santisteve, Anna Moncusí‐Moix, Clara Gort‐Paniello, Fátima Rodríguez‐Jara, Marta Molinero, Manel Perez‐Pons, Gerard Torres, Jesús Caballero, Carme Barberà, Ana P. Tedim, Raquel Almansa, Adrián Ceccato, Laia Fernández‐Barat, Ricard Ferrer, Dario Garcia‐Gasulla, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo‐Martin, Antoni Torres, Ferran Barbé, David de Gonzalo‐Calvo, and CIBERESUCICOVID Project (COV20/00110, ISCIII)

Subjects
Medicine (General), R5-920
Published
2022
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3. Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine

Author

Cajander, Sara, Kox, Matthijs, Scicluna, Brendon P, Weigand, Markus A, Mora, Raquel Almansa, Flohé, Stefanie B, Martin-Loeches, Ignacio, Lachmann, Gunnar, Girardis, Massimo, Garcia-Salido, Alberto, Brunkhorst, Frank M, Bauer, Michael, Torres, Antoni, Cossarizza, Andrea, Monneret, Guillaume, Cavaillon, Jean-Marc, Shankar-Hari, Manu, Giamarellos-Bourboulis, Evangelos J, Winkler, Martin Sebastian, Skirecki, Tomasz, Osuchowski, Marcin, Rubio, Ignacio, Bermejo-Martin, Jesus F, Schefold, Joerg C, and Venet, Fabienne

Published
2024
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4. Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine

Author

Cajander, Sara, primary, Kox, Matthijs, additional, Scicluna, Brendon P, additional, Weigand, Markus A, additional, Mora, Raquel Almansa, additional, Flohé, Stefanie B, additional, Martin-Loeches, Ignacio, additional, Lachmann, Gunnar, additional, Girardis, Massimo, additional, Garcia-Salido, Alberto, additional, Brunkhorst, Frank M, additional, Bauer, Michael, additional, Torres, Antoni, additional, Cossarizza, Andrea, additional, Monneret, Guillaume, additional, Cavaillon, Jean-Marc, additional, Shankar-Hari, Manu, additional, Giamarellos-Bourboulis, Evangelos J, additional, Winkler, Martin Sebastian, additional, Skirecki, Tomasz, additional, Osuchowski, Marcin, additional, Rubio, Ignacio, additional, Bermejo-Martin, Jesus F, additional, Schefold, Joerg C, additional, and Venet, Fabienne, additional

Published
2023
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5. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Author

Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, Salvador Resino, Luis Tamayo, Pablo Ryan Murua, Elena Bustamante-Munguira, Elena Gallego Curto, Alejandro Úbeda-Iglesias, María del Carmen de la Torre, Ángel Estella, Sandra Campos-Fernández, Ignacio Martínez Varela, Felipe Pérez-García, Lorenzo Socias, Juan López Messa, Pablo Vidal-Cortés, Víctor Sagredo Meneses, Milagros González-Rivera, Nieves Carbonell, David de Gonzalo-Calvo, María Cruz Martín Delgado, Luis Jorge Valdivia, Caridad Martín-López, Ruth Noemí Jorge García, Emilio Maseda, Ana Loza-Vázquez, David J Kelvin, Ferrán Barbé, Antoni Torres, Alicia Ortega, Amanda de la Fuente, Raquel Almansa, Tamara Postigo, Noelia Jorge, Ana P Tedim, Laura González-González, Lara Sánchez Recio, Wysali Trapiello, José Ángel Berezo, Rubén Herrán-Monge, Jesús Blanco, Pedro Enríquez, Isidoro Martínez, María Martín-Vicente, María José Muñoz-Gómez, Vicente Más, Mónica Vázquez, Olga Cano, Amalia Martínez de la Gándara, Covadonga Rodríguez, Gloria Andrade, Gloria Renedo, Juan Bustamante-Munguira, Ramón Cicuendez Ávila, María Salgado-Villén, Enrique Berruguilla-Pérez, Estel Güell, Fernando Javier Casadiego Monachello, María Recuerda Núñez, Juan Manuel Sánchez Calvo, Yhivian Peñasco-Martín, María Teresa García Unzueta, Adrián Ceccato, Laia Fernández-Barat, María Teresa Bouza Vieiro, Ana Moreno-Romero, Leire Pérez Bastida, Lorena del Río-Carbajo, Noelia Albalá Martínez, José Manuel Gómez, María Luisa Blasco, Jesús Caballero, Carme Barberà, Jessica González, María Teresa Nieto, Jorge Nieto-del Olmo, Estefanía Prol-Silva, Joan Canseco-Ribas, Jose María Eiros, Instituto de Salud Carlos III, Canadian Institutes of Health Research, Li Ka Shing Foundation, European Society of Clinical Microbiology and Infectious Diseases, Centro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), and Unión Europea. Fondo Social Europeo (ESF/FSE)

Subjects
Microbiology (medical), Infectious Diseases, Spain, Virology, COVID-19, Microbiology
Abstract

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero (2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16-0·55; p

Published
2023

6. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Catia Cillóniz, Anna Motos, Tatiana Castañeda, Albert Gabarrús, Ferran Barbé, Antoni Torres, Víctor D. Gumucio-Sanguino, Rafael Mañez, Jordi Solé-Violan, Felipe Rodríguez de Castro, Fernando Suarez-Sipmann, Ruth Noemí Jorge García, María Mora Aznar, Mateu Torres, María Martinez, Cynthia Alegre, Jordi Riera, Sofía Contreras, Juan Manuel Pericas, Ricard Ferrer, Jesús Caballero, Javier Trujillano, Montse Vallverdú, Miguel León, Mariona Badía, Begoña Balsera, Lluís Servià, Judit Vilanova, Silvia Rodríguez, Neus Montserrat, Silvia Iglesias, Javier Prados, Sula Carvalho, Mar Miralbés, Josman Monclou, Gabriel Jiménez, Jordi Codina, Estela Val, Pablo Pagliarani, Jorge Rubio, Dulce Morales, Andrés Pujol, Àngels Furro, Beatriz García, Gerard Torres, Javier Vengoechea, David de Gonzalo-Calvo, Jessica González, Silvia Gomez, José M. Gómez, Nieves Franco, José Barberán, Guillermo M Albaiceta, Lorena Forcelledo Espina, Emilio García Prieto, Paula Martín Vicente, Cecilia del Busto Martínez, Pablo Vidal-Cortés, José Luis García Garmendia, María Aguilar Cabello, Carmen Eulalia Martínez Fernández, Nieves Carbonell, María Luisa Blasco Cortés, Ainhoa Serrano Lázaro, Mar Juan Díaz, Aaron Blandino Ortiz, Rosario Menendez, Luis Jorge Valdivia, María Victoria Boado, Susana Sancho Chinesta, Maria del Carmen de la Torre, Ignacio Martínez Varela, María Teresa Bouza Vieiro, Inés Esmorís Arijón, David Campi Hermoso, Rafaela Nogueras Salinas, Teresa Farre Monjo, Ramon Nogue Bou, Gregorio Marco Naya, Carme Barberà, Núria Ramon Coll, Mercedes Catalán-González, Juan Carlos Montejo-González, Gloria Renedo Sanchez-Giron, Juan Bustamante-Munguira, Elena Bustamante-Munguira, Ramon Cicuendez Avila, Nuria Mamolar Herrera, Raquel Almansa, Alicia Ortega, Jesús Bermejo-Martin, Víctor Sagredo, Jose Añon, Alexander Agrifoglio, Lucia Cachafeiro, Emilio Maseda, Lorenzo Socias, Mariana Andrea Novo, Albert Figueras, Maria Teresa Janer, Laura Soliva, Marta Ocón, Luisa Clar, J Ignacio Ayestarán, Yhivian Peñasco, Sandra Campos Fernández, Mireia Serra-Fortuny, Eva Forcadell-Ferreres, Immaculada Salvador-Adell, Neus Bofill, Berta Adell-Serrano, Josep Pedregosa Díaz, Núria Casacuberta-Barberà, Luis Urrelo-Cerrón, Àngels Piñol-Tena, Ferran Roche-Campo, Amalia Martínez de la Gándara, Pablo Ryan Murúa, Covadonga Rodríguez Ruíz, Laura Carrión García, Juan I Lazo Álvarez, José Ángel Lorente, Ana Loza-Vázquez, Desire Macias Guerrero, Arturo Huerta, Daniel Tognetti, Carlos García Redruello, David Mosquera Rodríguez, Eva María Menor Fernández, Sabela Vara Adrio, Vanesa Gómez Casal, Marta Segura Pensado, María Digna Rivas Vilas, Amaia García Sagastume, Raul de Pablo Sánchez, David Pestaña Laguna, Tommaso Bardi, Rosario Amaya Villar, Carmen Gómez Gonzalez, Maria Luisa Gascón Castillo, José Garnacho-Montero, María Luisa Cantón-Bulnes, Judith Marin-Corral, Cristina Carbajales Pérez, Joan Ramon Masclans, Ana Salazar Degracia, Judit Bigas, Rosana Muñoz-Bermúdez, Clara Vilà-Vilardel, Francisco Parrilla, Irene Dot, Ana Zapatero, Yolanda Díaz, María Pilar Gracia, Purificación Pérez, Andrea Castellví, Cristina Climent, Lidia Serra, Laura Barbena, Iosune Cano, Pilar Ricart, Alba Herraiz, Pilar Marcos, Laura Rodríguez, Maria Teresa Sariñena, Ana Sánchez, Alejandro Úbeda, María Cruz Martin Delgado, Elena Gallego, Juan Fernando Masa Jimenez, Gemma Gomà, Emi Díaz, Mercedes Ibarz, Diego De Mendoza, Enric Barbeta, Victoria Alcaraz-Serrano, Joan Ramon Badia, Manuel Castella, Leticia Bueno, Adrian Ceccato, Andrea Palomeque, Laia Fernandez Barat, Pamela Conde, Javier Fernández, Albert Gabarrus, Karsa Kiarostami, Alexandre López-Gavín, Cecilia L Mantellini, Carla Speziale, Nil Vázquez, Hua Yang, Minlan Yang, Carlos Ferrando, Pedro Castro, Marta Arrieta, Jose Maria Nicolas, Rut Andrea, Marta Barroso, Raquel Pérez, Sergio Álvarez, Dario Garcia-Gasulla, Adrián Tormos, Luis Tamayo Lomas, Cesar Aldecoa, Rubén Herrán-Monge, José Ángel Berezo García, Pedro Enríquez Giraudo, Pablo Cardinal Fernández, Alberto Rubio López, Orville Báez Pravia, Juan López Messa, Leire Pérez Bastida, Antonjo Alvarez Ruiz, José Trenado, Anna Parera Pous, Cristóbal Galbán, Ana López Lago, Eva Saborido Paz, Patricia Barral Segade, Ana Balan Mariño, Manuel Valledor Mendez, Raúl de Frutos, Luciano Aguilera, Felipe Pérez-García, Esther López-Ramos, Ángela Leonor Ruiz-García, Belén Beteré, Rafael Blancas, Cristina Dólera, Gloria Perez Planelles, Enrique Marmol Peis, Maria Dolores Martinez Juan, Miriam Ruiz Miralles, Eva Perez Rubio, Maria Van der Hofstadt Martin-Montalvo, Ángel Sánchez-Miralles, Tatiana Villada Warrington, Juan Carlos Pozo-Laderas, Angel Estrella, Sara Guadalupe Moreno Cano, Federico Gordo, Basilisa Martinez Palacios, Maite Nieto, Maria Teresa Nieto, Sergio Ossa, Ana Ortega, Miguel Sanchez, and Bitor Santacoloma

Subjects
Microbiology (medical), Infectious Diseases
Published
2022

7. One-year mortality after ICU admission due to COVID-19 infection

Author

Mª Luisa Blasco, Judith Marin-Corral, Pedro Castro Rebollo, Jordi Riera del Brio, Jesus F Bermejo-Martin, Clara Vilà-Vilardell, JOSE GARNACHO-MONTERO, Leticia Bueno Freire, Albert Gabarrús, Felipe Pérez-García, Antonio Torres, JESUS CABALLERO, Raquel Almansa, Eva Forcadell-Ferreres, Laia Fernandez Barat, Jose Trenado Álvarez, Felipe Rodríguez de Castro, Raúl De Pablo Sánchez, Rut Andrea, Rafael Manez, Ricard Ferrer, Luis Servia Goixart, and Manuel Castella

Subjects
Hospitalization, Intensive Care Units, Letter, SARS-CoV-2, COVID-19, Humans, Critical Care and Intensive Care Medicine, Retrospective Studies
Published
2022
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8. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study

Author

Antoni, Torres, Ana, Motos, Catia, Cillóniz, Adrián, Ceccato, Laia, Fernández-Barat, Albert, Gabarrús, Jesús, Bermejo-Martin, Ricard, Ferrer, Jordi, Riera, Raquel, Pérez-Arnal, Dario, García-Gasulla, Oscar, Peñuelas, José Ángel, Lorente, David, de Gonzalo-Calvo, Raquel, Almansa, Rosario, Menéndez, Andrea, Palomeque, Rosario Amaya, Villar, José M, Añón, Ana, Balan Mariño, Carme, Barberà, José, Barberán, Aaron, Blandino Ortiz, Maria Victoria, Boado, Elena, Bustamante-Munguira, Jesús, Caballero, María Luisa, Cantón-Bulnes, Cristina, Carbajales Pérez, Nieves, Carbonell, Mercedes, Catalán-González, Raul, de Frutos, Nieves, Franco, Cristóbal, Galbán, Víctor D, Gumucio-Sanguino, Maria Del Carmen, de la Torre, Emili, Díaz, Ángel, Estella, Elena, Gallego, José Luis, García Garmendia, José M, Gómez, Arturo, Huerta, Ruth Noemí Jorge, García, Ana, Loza-Vázquez, Judith, Marin-Corral, María Cruz, Martin Delgado, Amalia, Martínez de la Gándara, Ignacio, Martínez Varela, Juan, López Messa, Guillermo M, Albaiceta, Maite, Nieto, Mariana Andrea, Novo, Yhivian, Peñasco, Felipe, Pérez-García, Juan Carlos, Pozo-Laderas, Pilar, Ricart, Victor, Sagredo, Angel, Sánchez-Miralles, Susana, Sancho Chinesta, Mireia, Serra-Fortuny, Lorenzo, Socias, Jordi, Solé-Violan, Fernando, Suarez-Sipmann, Luis, Tamayo Lomas, José, Trenado, Alejandro, Úbeda, Luis Jorge, Valdivia, Pablo, Vidal, Ferran, Barbé, and Bitor, Santacoloma

Subjects
Infecciones por coronavirus, Critical Illness, Enfermedad transmisible, COVID-19, Critical Care and Intensive Care Medicine, Respiration, Artificial, COVID-19 Drug Treatment, Tratamiento médico, Intensive Care Units, Adrenal Cortex Hormones, Intensive care, Corticosteroids, Humans, Steroids, Precision Medicine, Critically ill
Abstract

Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19. Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. The primary outcome was 90-day mortality. Subsequent analyses in clinically relevant subgroups by age, ICU baseline illness severity, organ damage, laboratory findings and mechanical ventilation were performed. High doses of corticosteroids (≥ 12 mg/day equivalent dexamethasone dose), early administration of corticosteroid treatment (< 7 days since symptom onset) and long term of corticosteroids (≥ 10 days) were also investigated. Results: Between February 2020 and October 2021, 4226 patients were included. Of these, 3592 (85%) patients had received systemic corticosteroids during hospitalisation. In the propensity-adjusted multivariable analysis, the use of corticosteroids was protective for 90-day mortality in the overall population (HR 0.77 [0.65-0.92], p = 0.003) and in-hospital mortality (SHR 0.70 [0.58-0.84], p < 0.001). Significant effect modification was found after adjustment for covariates using propensity score for age (p = 0.001 interaction term), Sequential Organ Failure Assessment (SOFA) score (p = 0.014 interaction term), and mechanical ventilation (p = 0.001 interaction term). We observed a beneficial effect of corticosteroids on 90-day mortality in various patient subgroups, including those patients aged ≥ 60 years; those with higher baseline severity; and those receiving invasive mechanical ventilation at ICU admission. Early administration was associated with a higher risk of 90-day mortality in the overall population (HR 1.32 [1.14-1.53], p < 0.001). Long-term use was associated with a lower risk of 90-day mortality in the overall population (HR 0.71 [0.61-0.82], p < 0.001). No effect was found regarding the dosage of corticosteroids. Moreover, the use of corticosteroids was associated with an increased risk of nosocomial bacterial pneumonia and hyperglycaemia. Conclusion: Corticosteroid in ICU-admitted patients with COVID-19 may be administered based on age, severity, baseline inflammation, and invasive mechanical ventilation. Early administration since symptom onset may prove harmful. Instituto de Salud Carlos III de Madrid (ISCIII) (COV20/00110) Centro de Investigacion Biomedica En Red-Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III European Commission Miguel Servet 2020: CP20/00041 Instituto de Salud Carlos III (PI19/00207) 41.787 JCR (2022) Q1, 2/35 Critical Care Medicine 4.344 SJR (2022) Q1, 2/98 Critical Care and Intensive Care Medicine No data IDR 2022 UEM

Published
2022

9. N-antigenemia detection by a rapid lateral flow test predicts 90-day mortality in COVID-19: A prospective cohort study

Author

Raquel Almansa, Jose María Eiros, David de Gonzalo-Calvo, Tamara Postigo, Alicia Ortega, Raul Lopez-Izquierdo, Anna Moncusí-Moix, Clara Gort-Paniello, Marta Dominguez-Gil, Amanda de la Fuente, Laura González-González, Tania Luis-García, Nadia García-Mateo, Ana P. Tedim, Fátima Rodríguez-Jara, Noelia Jorge, Jessica González, Gerard Torres, Oliver Norberto Gutiérrez-Pérez, Maria José Villegas, Sonia Campo, Eva Ayllon, Tomás Ruiz Albi, Julio de Frutos Arribas, Ainhoa Arroyo Domingo, Jesica Abadia-Otero, Julia Gómez Barquero, Wysali Trapiello, Luis Javier Garcia Frade, Luis Inglada, Felix del Campo, Jesús F. Bermejo-Martin, Ferran Barbé, and Antoni Torres

Subjects
Microbiology (medical), Infectious Diseases, COVID-19 Testing, SARS-CoV-2, COVID-19, Humans, General Medicine, Prospective Studies, Antibodies, Viral
Abstract

To evaluate if the detection of N antigen of SARS-CoV-2 in plasma by a rapid lateral flow test predicts 90-day mortality in COVID-19 patients hospitalized at the wards.The presence of N-antigenemia was evaluated in the first 36 hours after hospitalization in 600 unvaccinated COVID-19 patients, by using the Panbio COVID-19 Ag Rapid Test Device from Abbott (Abbott Laboratories Inc., Chicago, IL, USA). The impact of N-antigenemia on 90-day mortality was assessed by multivariable Cox regression analysis.Prevalence of N-antigenemia at hospitalization was higher in nonsurvivors (69% (82/118) vs. 52% (250/482); p 0.001). The patients with N-antigenemia showed more frequently RNAemia (45.7% (148/324) vs. 19.8% (51/257); p 0.001), absence of anti-SARS-CoV-2 N antibodies (80.7% (264/327) vs. 26.6% (69/259); p 0.001) and absence of S1 antibodies (73.4% (240/327) vs. 23.6% (61/259); p 0.001). The patients with antigenemia showed more frequently acute respiratory distress syndrome (30.1% (100/332) vs. 18.7% (50/268); p = 0.001) and nosocomial infections (13.6% (45/331) vs. 7.9% (21/267); p = 0.026). N-antigenemia was a risk factor for increased 90-day mortality in the multivariable analysis (HR, 1.99 (95% CI,1.09-3.61), whereas the presence of anti-SARS-CoV-2 N-antibodies represented a protective factor (HR, 0.47 (95% CI, 0.26-0.85).The presence of N-antigenemia or the absence of anti-SARS-CoV-2 N-antibodies after hospitalization is associated to increased 90-day mortality in unvaccinated COVID-19 patients. Detection of N-antigenemia by using lateral flow tests is a quick, widely available tool that could contribute to early identify those COVID-19 patients at risk of deterioration.

Published
2022

10. Higher frequency of comorbidities in fully vaccinated patients admitted to the ICU due to severe COVID-19: a prospective, multicentre, observational study

Author

Isciii, Alexandre López-Gavín, Rosario Menéndez, Laia Fernández-Barat, Albert Gabarrus, Anna Motos, Ferran Roche-Campo, Susana Sancho Chinesta, David de Gonzalo-Calvo, José A. Lorente, Raquel Pérez-Arnal, Adrian Ceccato, Ferran Barbé, Alejandro Rodriguez, Raquel Almansa, Judith Marin-Corral, Ricard Ferrer, Oscar Peñuelas, Antoni Torres, Pilar Ricart, Jesus F. Bermejo-Martin, Dario Garcia-Gasulla, Lorenzo Socias, Jordi Riera, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. Departament de Ciències de la Computació

Subjects
Pulmonary and Respiratory Medicine, 2019-20 coronavirus outbreak, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, Comorbidity, Vacunes, Infeccions per coronavirus, COVID-19 (Malaltia), Comorbidities, Informàtica::Aplicacions de la informàtica [Àrees temàtiques de la UPC], COVID-19 (Disease), Comorbiditat, Research Letter, Humans, Medicine, Prospective Studies, Vaccines, business.industry, SARS-CoV-2, COVID-19, Vaccination, Hospitalization, Intensive Care Units, ICU, Observational study, business, Vaccine response
Abstract

Severe COVID-19 disease requiring ICU admission is possible in the fully vaccinated population, especially in those with immunocompromised status and other comorbidities. Interventions to improve vaccine response might be necessary in this population. Peer Reviewed "Article signat per 23 autors/es: Anna Motos, Alexandre López-Gavín, Jordi Riera, Adrián Ceccato, Laia Fernández-Barat, Jesús F. Bermejo-Martin, Ricard Ferrer, David de Gonzalo-Calvo, Rosario Menéndez, Raquel Pérez-Arnal, Dario García-Gasulla, Alejandro Rodriguez, Oscar Peñuelas, José Ángel Lorente, Raquel Almansa, Albert Gabarrus, Judith Marin-Corral, Pilar Ricart, Ferran Roche-Campo, Susana Sancho Chinesta, Lorenzo Socias, Ferran Barbé, Antoni Torres on behalf of the CIBERESUCICOVID Project (COV20/00110, ISCIII)"

Published
2022

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