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Background: Respiratory disease is a frequent cause of morbidity and mortality in Common Variable Immunodeficiencies (CVIDs), however lung function trajectories are poorly understood., Objective: To determine lung physiology measurements in CVID, their temporal trajectory and association with clinical and immunological parameters., Methods: Retrospective study from 5 Italian centres. CVIDs patients with longitudinal Pulmonary Function Tests (PFTs) measurements and available chest CT scan, were included. Applying the ERS/ATS 2021 standard, PFTs were expressed as percentile value (pct) within the normal distribution of healthy individuals, with the 5 th pct identified the lower limit of normal (LLN). The association of lung function with clinical and immunological parameters was investigated., Results: 185 CVIDs patients were included. 64% had at least one lung comorbidity (bronchiectasis 41% and Granulomatous Interstitial Lung Diseases 24%). At first spirometry, the median FEV1 was 3.07 L [IQR 2.40 - 3.80], placing at the 32 nd pct [6 th -61 st ], and the median FVC was 3.70 L [3.00 - 4.54], placing at the 29 th pct [7 th -49 th ]. 23% of patients had an FEV1 < LLN and 21% had an FVC < LLN. Switched-memory B cells <2% were associated with both FEV1