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Your search keyword '"Ram, Chetan"' showing total 9 results
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9 results on '"Ram, Chetan"'

5. Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice

Author

Syed, Abu Mohammad, primary, Kundu, Sourav, additional, Ram, Chetan, additional, Kulhari, Uttam, additional, Kumar, Akhilesh, additional, Mugale, Madhav Nilakanth, additional, Mohapatra, Purusottam, additional, Murty, Upadhyayula Suryanarayana, additional, and Sahu, Bidya Dhar, additional

Published
2022
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8. A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases.

Author

Syed, Abu Mohammad, Ram, Chetan, Murty, Upadhyayula Suryanarayana, and Sahu, Bidya Dhar

Abstract

Cardiovascular diseases (CVDs) are an ever‐growing problem and are the most common cause of death worldwide. The uncontrolled production of reactive oxygen species (ROS) and the activation of ROS associated with various cell signaling pathways with oxidative cellular damage are the most common pathological conditions connected with CVDs including endothelial dysfunction, hypercontractility of vascular smooth muscle, cardiac hypertrophy and heart failure. The nuclear factor E2‐related factor 2 (Nrf2) is a basic leucine zipper redox transcription factor, together with its negative regulator, kelch‐like ECH‐associated protein 1 (Keap1), which serves as a key regulator of cellular defense mechanisms to combat oxidative stress and associated diseases. Multiple lines of evidence described here support the cardiac protective property of Nrf2 in various experimental models of cardiac related disease conditions. In this review, we emphasized the molecular mechanisms of Nrf2 and described the detailed outline of current findings on the therapeutic possibilities of the Nrf2 activators specifically from herbal origin in various CVDs. Based on evidence from various preclinical experimental models, we have highlighted the activation of Nrf2 pathway as a budding therapeutic option for the prevention and treatment of CVDs, which needs further investigation and validation in the clinical settings. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review

Author

Jha, Ankush Kumar, Gairola, Shobhit, Kundu, Sourav, Doye, Pakpi, Syed, Abu Mohammad, Ram, Chetan, Kulhari, Uttam, Kumar, Naresh, Murty, Upadhyayula Suryanarayana, and Sahu, Bidya Dhar

Abstract

Plant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet needs more exploration. The current review is related to nootkatone, drafted through a literature search using research articles and books from different sources, including Science Direct, Google Scholar, Elsevier, PubMed, and Scopus. It has been reported to possess a wide range of pharmacological activities such as anti-inflammatory, anticancer, antibacterial, hepatoprotective, neuroprotective, and cardioprotective. Although preclinical studies in experimental animal models suggest that nootkatone has therapeutic potential, it is further warranted to evaluate its toxicity and pharmacokinetic parameters before being applied to humans. Hence, in the present review, we have summarized the scientific knowledge on nootkatone with a particular emphasis on its pharmacological properties to encourage researchers for further exploration in preclinical and clinical settings.

Published
2022
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