Search

Este trabajo registra rasgos diferenciadores de talento matemático en estudiantes de primero y segundo de ESO que resuelven una prueba de acceso a un programa de estímulo del talento matemático. Se comparan los estudiantes admitidos en el programa y los no admitidos, centrando el análisis en la resolución de un problema de generalización que involucra una relación funcional. Los resultados revelan la aplicación de estrategias eficientes y la consistencia entre sus respuestas. Los estudiantes admitidos destacaron por realizar regularidades completas y representar simbólicamente sus generalizaciones evidenciando estructuras más variadas, coherentes y complejas que otros estudiantes.

El gobierno abierto, la transparencia y el derecho de acceso a la información, constituyen el centro neurálgico de un buen gobierno. Las estrategias del gobierno abierto se construyen día a día considerando aspectos económicos, sociales, políticos y técnicos. En esta investigación se eligió el enfoque cualitativo, con alcance descriptivo y explicativo, se recopiló información para elaborar el marco jurídico y se evaluó al Estado de Sonora[i]. El objetivo de este trabajo es analizar los antecedentes, evolución y los resultados de gobierno abierto en el Estado de Sonora en el ejercicio 2021, incluyendo la transparencia y acceso a la información pública. Dentro de los resultados se conoció que el Índice de Percepción de la Corrupción que determina Transparency International. México se ubica en el lugar 124 de 180 países, en los años 2020 y 2021, con una puntuación de 31 puntos, donde los puntos van de 100 que denota ausencia de corrupción a 0 que revela mucha corrupción. También, se encontró que el Índice de Gobierno Abierto (IGA), que determina Métrica de gobierno abierto, con el apoyo del Instituto Nacional de Transparencia y el Centro de Investigación y Docencia Económicas en 2021, en México el IGA es de 0.48, donde 1 es un gobierno transparente y abierto a la participación ciudadana y 0 de un gobierno sin apertura. El Estado de Sonora, obtiene 0.51 y en comparación con el ÍGA de México que es de 0.48, el Estado de Sonora se encuentra por arriba de esa puntuación con 0.51.

La evaluación de la vulnerabilidad sísmica asociada a las construcciones históricas representa diversos retos metodológicos y de escala. La no linealidad en el comportamiento estructural en edificios de mampostería no reforzada, la variedad de soluciones constructivas y las incertidumbres inherentes al período de vida de estos edificios dificultan enormemente la aplicación de métodos de análisis generalizadores y representativos. Sin embargo, existen métodos paramétricos que ofrecen la posibilidad de evaluar (de manera semicuantitativa) el nivel de seguridad de un edificio ante ciertas demandas sísmicas. Tales métodos han sido diseñados y calibrados sobre la evidencia empírica (daños y colapsos) recogida tras sismos de gran magnitud, destacando una serie de parámetros que influyen significativamente el comportamiento sísmico de edificios históricos. Los modelos semánticos apoyados en estos parámetros son lo suficientemente fáciles de construir como para considerar su aplicación a escala urbana, a través del uso de herramientas como las bases de datos geográficas, métodos de visualización remota e, incluso, catálogos existentes. Este trabajo presenta una serie de experiencias realizadas en ciudades históricas mexicanas para discutir la conveniencia, limitaciones y oportunidades que estas estrategias pueden significar para una gestión y mitigación más eficaz del riesgo sísmico.

ABSTRACT: The aim was to describe the incidence and lesions caused by metazoan and protozoan parasites in Didelphis virginiana opossums in Mexico. From 2019 to 2021, twenty D. virginiana were collected from the state of Colima, Mexico. Post mortem, parasitological, and histopathological studies were performed to identify and describe their lesions and findings. All opossums(20/20) presented at least one type of parasite of the twelve found; the most abundant were nematodes 58.33% (7/12) Didelphostrongylus hayesi, Turgida turgida, Cruzia sp., Viannaia sp., Trichuris didelphis, Trichostrongylidae and Gnathostoma sp. Protozoa 25% (3/12), including Sarcocystis sp., Besnoitia sp., and Sarcocystis sp. A single specimen of Mathevotaenia sp., 8.3% (1/12), and Paragonimus mexicanus 8.3%, were identified (1/12). The most affected systems were the digestive, respiratory, and musculoskeletal. The most abundant parasites were Turgida turgida (20/20) 100%, Cruzia sp., (16/20) 80%, and Viannaia sp. (6/20) 30%, followed by Sarcocystis sp. cysts, (6/20) 30%. The associated parasitic lesions were: D. hayesi produce eosinophilic granulomatous bronchopneumonia, P. mexicanus eosinophilic focal granulomatous pneumonia, and Besnoitia sp., focal eosinophilic lymphoplasmacytic interstitial pneumonia. Gnathostoma and T. turgida caused severe eosinophilic granulomatous focal gastritis. Viannaia sp., Sarcocystis sp., Mathevotaenia sp., and Trichostrongylidae; caused diffuse eosinophilic mucosal enteritis. Cruzia sp., and T. didelphis, induced diffuse eosinophilic mucosal typhlitis. Sarcocystis sp. cysts were detected in the cytoplasm of muscle fibers without histological changes.

Resumen: La enfermedad renal crónica (ERC) tiene una alta incidencia mundial y una tendencia ascendente que afecta principalmente a personas de edad avanzada. Cuando la ERC está muy avanzada se requiere el uso de terapias renales sustitutivas para prolongar la vida (diálisis o trasplante renal) y, pese a que la diálisis mejora muchas complicaciones de la ERC, la enfermedad no revierte de manera completa. Estos pacientes presentan un aumento del estrés oxidativo, inflamación crónica y aumento de la liberación de vesículas extracelulares (VE), que provocan daño endotelial y el desarrollo de distintas enfermedades cardiovasculares (ECV). De hecho, los pacientes con ERC desarrollan de forma prematura enfermedades asociadas a una edad avanzada, como es el caso de las ECV. Las VE desempeñan un papel muy importante en el desarrollo de ECV en pacientes con ERC, ya que su número aumenta en el plasma y su contenido se modifica. Las VE de pacientes con ERC generan disfunción endotelial, senescencia y calcificación vascular. Además, los miRNA libres o transportados en las VE junto a otros componentes vehiculados en estas VE promueven disfunción endotelial, eventos trombóticos y calcificación vascular en los pacientes con ERC, entre otros efectos. En esta revisión se describen los factores clásicos y el papel de nuevos mecanismos que intervienen en el desarrollo de la ECV asociada a la ERC, con especial hincapié en el papel de las VE en el desarrollo de enfermedades cardiovasculares en un contexto de ERC. Además, se expone el papel de las VE como herramienta diagnóstica y como diana terapéutica, actuando sobre su liberación o contenido para intentar evitar el desarrollo de ECV en enfermos renales crónicos. Abstract: Chronic kidney disease (CKD) is a pathology with a high worldwide incidence and an upward trend affecting the elderly. When CKD is very advanced, the use of renal replacement therapies is required to prolong its life (dialysis or kidney transplantation). Although dialysis improves many complications of CKD, the disease does not reverse completely. These patients present an increase in oxidative stress, chronic inflammation and the release of extracellular vesicles (EVs), which cause endothelial damage and the development of different cardiovascular diseases (CVD). CKD patients develop premature diseases associated with advanced age, such as CVD. EVs play an essential role in developing CVD in patients with CKD since their number increases in plasma and their content is modified. The EVs of patients with CKD cause endothelial dysfunction, senescence and vascular calcification. In addition, miRNAs free or transported in EVs together with other components carried in these EVs promote endothelial dysfunction, thrombotic and vascular calcification in CKD, among other effects. This review describes the classic factors and focuses on the role of new mechanisms involved in the development of CVD associated with CKD, emphasizing the role of EVs in the development of cardiovascular pathologies in the context of CKD. Moreover, the review summarized the EVs’ role as diagnostic and therapeutic tools, acting on EV release or content to avoid the development of CVD in CKD patients.

Chronic kidney disease (CKD) is a pathology with a high worldwide incidence and an upward trend affecting the elderly. When CKD is very advanced, the use of renal replacement therapies is required to prolong its life (dialysis or kidney transplantation). Although dialysis improves many complications of CKD, the disease does not reverse completely. These patients present an increase in oxidative stress, chronic inflammation and the release of extracellular vesicles (EVs), which cause endothelial damage and the development of different cardiovascular diseases (CVD). CKD patients develop premature diseases associated with advanced age, such as CVD. EVs play an essential role in developing CVD in patients with CKD since their number increases in plasma and their content is modified. The EVs of patients with CKD cause endothelial dysfunction, senescence and vascular calcification. In addition, miRNAs free or transported in EVs together with other components carried in these EVs promote endothelial dysfunction, thrombotic and vascular calcification in CKD, among other effects. This review describes the classic factors and focuses on the role of new mechanisms involved in the development of CVD associated with CKD, emphasizing the role of EVs in the development of cardiovascular pathologies in the context of CKD. Moreover, the review summarized the EVs’ role as diagnostic and therapeutic tools, acting on EV release or content to avoid the development of CVD in CKD patients. Resumen: La enfermedad renal crónica (ERC) tiene una alta incidencia mundial y una tendencia ascendente que afecta principalmente a personas de edad avanzada. Cuando la ERC está muy avanzada se requiere el uso de terapias renales sustitutivas para prolongar la vida (diálisis o trasplante renal) y, pese a que la diálisis mejora muchas complicaciones de la ERC, la enfermedad no revierte de manera completa. Estos pacientes presentan un aumento del estrés oxidativo, inflamación crónica y aumento de la liberación de vesículas extracelulares (VE), que provocan daño endotelial y el desarrollo de distintas enfermedades cardiovasculares (ECV). De hecho, los pacientes con ERC desarrollan de forma prematura enfermedades asociadas a una edad avanzada, como es el caso de las ECV. Las VE desempeñan un papel muy importante en el desarrollo de ECV en pacientes con ERC, ya que su número aumenta en el plasma y su contenido se modifica. Las VE de pacientes con ERC generan disfunción endotelial, senescencia y calcificación vascular. Además, los miRNA libres o transportados en las VE junto a otros componentes vehiculados en estas VE promueven disfunción endotelial, eventos trombóticos y calcificación vascular en los pacientes con ERC, entre otros efectos. En esta revisión se describen los factores clásicos y el papel de nuevos mecanismos que intervienen en el desarrollo de la ECV asociada a la ERC, con especial hincapié en el papel de las VE en el desarrollo de enfermedades cardiovasculares en un contexto de ERC. Además, se expone el papel de las VE como herramienta diagnóstica y como diana terapéutica, actuando sobre su liberación o contenido para intentar evitar el desarrollo de ECV en enfermos renales crónicos.

Rupestrian cultural assets are remarkable examples of human occupation of the territory. As for any other cultural asset, the characterisation of rupestrian buildings is critical for their conservation and protection. However, there are a number of difficulties and challenges that are inherent in the physical singularities of these architectonic constructions, namely related to their geometrical irregularities. It is therefore important to use an appropriate approach to describe the geometry of these assets by overcoming some limitations that conventional measurement and surveying approaches have. The production of digital three-dimensional models is consequently a very useful and promising approach in this context. For most cultural assets and in particular geometrically complex objects, the approach is useful in reconstructing geometrical inner or exterior surfaces by means of photographic information. Photogrammetry is a technique used to acquire valuable and accurate three-dimensional information, which generates reliable models that also include integrated works, such as paintings or sculptures. The present work explores the suitability of this approach in the context of a remarkable case of rupestrian architecture, that of the church of San Pietro da Morrone. The building, located in the historical city of Matera (Italy), witnessed a series of transformations and varied uses, before it was abandoned in the middle of the 20th century. The experimental survey of this building provides a first insight into its geometry and a point of reference for discussing the implementation of a photogrammetric approach, its advantages, limitations and possibilities.

Glyphosate is a controversial herbicide. Its genotoxicity and presence in various ecosystems have been reported. The use of ascorbic acid and resveratrol could protect different organisms from glyphosate-induced genetic damage. In the present study, specific genetic damage induced by glyphosate was evaluated in erythrocytes of Oreochromis niloticus, Ambystoma mexicanum and human lymphocytes. Simultaneously, the antigenotoxic capacity of various concentrations of ascorbic acid and resveratrol was evaluated by means of pretreatment and simultaneous treatment protocols. The 0.03, 0.05 and 0.07 mM concentrations of glyphosate induced significant genotoxic activity (p < 0.05) in human lymphocytes and in erythrocytes of the species studied, and could cause genomic instability in these populations. The reduction in genetic damage observed in human lymphocytes exposed to high concentrations of glyphosate is only apparent: excessive genetic damage was associated with undetectable excessive tail migration length. A significant (p < 0.05) antigenotoxic effect of ascorbic acid and resveratrol was observed in all concentrations, organisms and protocols used. Both ascorbic acid and resveratrol play an important role in maintaining the integrity of DNA. Ascorbic acid in Oreochromis niloticus, Ambystoma mexicanum reduced glyphosate-induced genetic damage to a basal level. Therefore, our data indicate that these antioxidants could help preserve the integrity of the DNA of organisms exposed to glyphosate. The consumption of antioxidants is a useful tool against the genotoxicity of glyphosate.

This study presents the synthesis and characterization of TiN hard coatings as a candidate reference material for surface metrology in chemistry. TiN coatings were grown on a silicon wafer with (111) orientation using dc reactive magnetron sputtering. X-ray diffraction confirms that the diffraction phase of TiN coatings is polycrystalline, electron microscopy demonstrates that the TiN coatings presents pyramidal-shaped grains ranging from sub-micrometer to nano-size scale and with an average thickness of 666 nm. According to micro Raman results, the presence of LO phonon modes confirms that the TiN coatings are crystalline in nature and no impurities are detected. The mechanical properties at the nanoscale are evaluated using resonance tracking acoustic force atomic microscopy. The chemical composition of the TiN reveals a close 1:1 atomic ratio. The ANOVA is used to evaluate the homogeneity of the TiN via a homogeneity test according to the ISO Guide 35:2017, while, regarding the chemical composition of the Ti, the Fisher’s test demonstrates that the batch can be considered as homogeneous.

Identifying mathematically gifted students is an important objective in mathematics education. To describe skills typical of these students, researchers pose problems in several mathematical domains whose solutions require using different mathematical capacities, such as visualization, generalization, proof, creativity, etc. This paper presents an analysis of the solutions to two problems by 75 students (aged 11-14), as part of the selection test for a workshop to stimulate mathematical talent. These problems require the use of the capacity for mathematical generalization of solution methods. We define a set of descriptors of such capacity, use them to analyze students' solutions, and evaluate how well students with high capacity for generalization can be distinguished from average students. The results indicate that the two problems are suitable for identifying potential mathematically gifted students and several descriptors have high discriminatory power to identify students with high or low capacity for generalization.

Historic urban centres are, almost by definition, risk-prone areas. The buildings in the historical sites are often highly vulnerable to natural and human-made hazards, not only due to their construction and material characteristics but also because they are usually very degraded due to ineffective maintenance and conservation policies. Moreover, the recent world tourism boom has led to a significant increase in the number of people who live, work and visit these areas, which, together with land use and climate change-related impacts, make historic centres particularly exposed areas. This paper addresses the issue of assessing and managing risk in historic urban centres departing from the complexity of defining the historic city and the concept of risk, providing a comprehensive discussion on current trends and future research directions in this field. After analysing the most suitable methodologies to assess the vulnerability of these areas to different hazards, the focus is on data collection and organisation-related issues and how the different vulnerability assessment outputs can be used to manage and mitigate risk. Vulnerability and loss scenarios, evacuation and emergency planning, and retrofit and cost-benefit analyses are some of the aspects addressed herein. This discussion includes some considerations on the accuracy of these approaches and aspects related to their calibration and validation, covering from empirical calibration models to advanced artificial Intelligence-based techniques.

Initial staging of patients diagnosed with multiple myeloma (MM) can lead to negative results using conventional diagnostic imaging workup, including [18F]Fluorodesoxiglucose ([18F]FDG) PET/CT. The aim of this prospective pilot study was to evaluate the diagnostic efficacy of [18F]Fluorocholine ([18F]FCH) PET/CT in the initial staging of MM patients who were candidates for autologous bone marrow transplant. Materials and Methods: The inclusion criteria of our study were: (a) patients diagnosed with MM; (b) candidates for autologous bone marrow transplant (AT); and (c) studied with [18F]FCH PET/CT and [18F]FDG PET/CT for initial staging less than 4 weeks apart. Imaging analysis included the presence of: bone marrow infiltration, focal bone lesions, and para-medullary or extra-medullary disease, according to the proposed IMPeTus criteria. The analysis was performed per lesion, per patient, and per location. Results: The study population included ten patients. Globally, [18F]FCH PET/CT showed bone marrow uptake in all the patients and visualised 16 more focal lesions than [18F]FDG PET/CT. One patient presented a plasmacytoma, detected by both tracers. Extra-medullary and para-medullary disease was identified with different degrees of uptake by both tracers. In summary, [18F]FCH PET seemed to be superior to [18F]FDG PET/CT in detecting focal bone lesions. SUVmax values were slightly higher in [18F]FCH PET/CT than in [18F]FDG PET/CT. Conclusions: Taking into account the small study population, according to our results, [18F]FCH PET/CT could be a useful tool for staging MM patients.

Immunotherapy is based on manipulation of the immune system in order to act against tumour cells, with growing evidence especially in melanoma patients. The challenges faced by this new therapeutic tool are (i) finding valid evaluation criteria for response assessment; (ii) knowing and distinguishing between “atypical” response patterns; (iii) using PET biomarkers as predictive and response evaluation parameters and (iv) diagnosis and management of immunorelated adverse effects. This review is focused on melanoma patients analysing (a) the role of [18F]FDG PET/CT in the mentioned challenges; (b) the evidence of its efficacy. For this purpose, we performed a review of the literature, including original and review articles. In summary, although there are no clearly established or globally accepted criteria, modified response criteria are potentially appropriate for evaluation of immunotherapy benefit. In this context, [18F]FDG PET/CT biomarkers appear to be promising parameters in prediction and assessment of response to immunotherapy. Moreover, immunorelated adverse effects are recognized as predictors of early response to immunotherapy and may be associated with better prognosis and clinical benefit.

The characterisation of the seismic vulnerability of historical constructions represents a complex problem in which the typological variability, the difficulty of performing reliable large-scale assessments and dealing with a large database all play a role. Nevertheless, reducing the uncertainty regarding the structural vulnerability of the existing building stock (mostly for small and/or isolated human settlements) is key for risk assessment and management. The present work proposes a novel approach based on the integration of a series of open-source tools for assembling a vulnerability-oriented database that is linked to a series of external services for increasing its capabilities. The database was implemented in a Geographical Information System (GIS) environment and contains the survey of a seismic vulnerability index for masonry constructions based on an adapted version of the GNDT-II approach. A customised Python-based software for reading, managing and editing the database is herein presented. This program allows the execution of the most typical operations with no assistance from the GIS environment, facilitating user interaction. Furthermore, the calculations regarding the vulnerability index and levels of damage have been implemented in this program. Alternatives for distributing the database are implemented and discussed, such as cloud-based distribution and the use of the Transactional Web Feature Service (WFS-T) protocol for its virtual publishing. The entire framework herein presented is a replicable and feasible workflow that can be set even with reduced infrastructure, allowing a progressive enlargement.

We present a case study of proving by three 12-13-year-old students with different levels of mathematical giftedness. After analysing students' proofs, we conclude that: there was a relation on the consistency and the students' levels of mathematically giftedness, being the least consistent the student not mathematically gifted and the most consistent the student with the highest level of mathematical giftedness; the variability was greater in the arithmetical problems; the quality of the proofs produced increased as the level of mathematical giftedness did; the two students with a lower level did better proofs in the arithmetical than in the geometrical problems, while the student with the highest level did not show significant differences between the two areas.

Background: Age, sex, race and comorbidities are insufficient to explain why some individuals remain asymptomatic after SARS-CoV-2 infection, while others die. In this sense, the increased risk caused by the long-term exposure to air pollution is being investigated to understand the high heterogeneity of the COVID-19 infection course. Objectives: We aimed to assess the underlying effect of long-term exposure to NO2 and PM10 on the severity and mortality of COVID-19. Methods: A retrospective observational study was conducted with 2112 patients suffering COVID-19 infection. We built two sets of multivariate predictive models to assess the relationship between the long-term exposure to NO2 and PM10 and COVID-19 outcome. First, the probability of either death or severe COVID-19 outcome was predicted as a function of all the clinical variables together with the pollutants exposure by means of two regularized logistic regressions. Subsequently, two regularized linear regressions were constructed to predict the percentage of dead or severe patients. Finally, odds ratios and effects estimates were calculated. Results: We found that the long-term exposure to PM10 is a more important variable than some already stated comorbidities (i.e.: COPD/Asthma, diabetes, obesity) in the prediction of COVID-19 severity and mortality. PM10 showed the highest effects estimates (1.65, 95% CI 1.32–2.06) on COVID-19 severity. For mortality, the highest effect estimates corresponded to age (3.59, 95% CI 2.94–4.40), followed by PM10 (2.37, 95% CI 1.71–3.32). Finally, an increase of 1 µg/m3 in PM10 concentration causes an increase of 3.06% (95% CI 1.11%-4.25%) of patients suffering COVID-19 as a severe disease and an increase of 2.68% (95% CI 0.53%-5.58%) of deaths. Discussion: These results demonstrate that long-term PM10 burdens above WHO guidelines exacerbate COVID-19 health outcomes. Hence, WHO guidelines, the air quality standard established by the Directive 2008/50/EU, and that of the US-EPA should be updated accordingly to protect human health.

A Buckley–Leverett analysis with capillary pressure to model the oil displacement in fractal porous media is herein presented. The effective permeability for a non-Newtonian micellar fluid is calculated by a constitutive equation used to describe the rheological properties of a displacement fluid. The main assumption of this model involves a bundle of tortuous capillaries with a size distribution and tortuosity that follow fractal laws. The BMP model predicts two asymptotic (Newtonian) regions at low and high shear and a power-law region between the two Newtonian regions corresponding to a stress plateau. Both the stress at the wall and the fluidity are calculated using an imposed pressure gradient in order to determine the mobility of the solution. We analyze different mobility ratios to describe the behavior of the so-called self-destructive surfactants. Initially, the viscosity of the displacing fluid (micellar solution) is high; however, interactions with the porous media lead to a breakage process and degradation of the surfactant, producing low viscosity. This process is simulated by varying the applied pressure gradient. The resulting equation is of the reaction–diffusion type with various time scales; a shock profile develops in the convective time scale, as in the traditional Buckley-Leverett analysis, while at longer times diffusion effects begin to affect the profile. Predictions include shock profiles and compressive waves. These results may find application when selecting surfactants for enhanced oil recovery processes in oilfields.

Starch is a biocompatible and economical biopolymer in which interest has been shown in obtaining electrospun fibers. This research reports that cassava (CEX) and pea (PEX) starches pretreated by means of reactive extrusion (REX) improved the starches rheological properties and the availability of amylose to obtain fibers. Solutions of CEX and PEX (30–36% w/v) in 38% v/v formic acid were prepared and the rheological properties and electrospinability were studied. The rheological values indicated that to obtain continuous fibers without beads, the entanglement concentration (Ce) must be 1.20 and 1.25 times the concentration of CEX and PEX, respectively. In CEX, a higher amylose content and lower viscosity were obtained than in PEX, which resulted in a greater range of concentrations (32–36% w/v) to obtain continuous fibers without beads with average diameters ranging from 316 ± 65 nm to 394 ± 102 nm. In PEX, continuous fibers without beads were obtained only at 34% w/v with an average diameter of 170 ± 49 nm. This study showed that starches (20–35% amylose) pretreated through REX exhibited electrospinning properties to obtain fibers, opening the opportunity to expand their use in food, environmental, biosensor, and biomedical applications, as vehicles for the administration of bioactive compounds.

(1) Background: Early response after acute myocardial infarction (AMI) prevents extensive cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory interleukin-10 (IL-10), may play a key role. (2) Methods: We synthesized NIL10, a micelle-based nanoparticle, to target IL-10 receptor in mice and pigs subjected to AMI. (3) Results: Administration of NIL10 induced cardiac protection of wild-type and IL-10 knockout mice and pigs subjected to AMI. Cardiac protection was not induced in IL-10-receptor null mice, as shown by a significant recovery of cardiac function, in which inflammatory foci and fibrosis were strongly reduced, together with the finding that resolving M2-like macrophage populations were increased after day 3 of reperfusion. In addition, anti-inflammatory cytokines, including IL-4, IL-7, IL-10, IL-13, IL-16, and IL-27 were also elevated. Mechanistically, NIL10 induced activation of the IL-10 receptor/STAT-3 signaling pathway, and STAT3-dependent inhibition of nuclear translocation of pro-inflammatory NF-ĸB transcription factor. (4) Conclusions: Taken together, we propose using NIL10 as a novel therapeutic tool against AMI-induced cardiac damage.

Proof, a key topic in advanced mathematics, also forms an essential part of the formal learning experience at all levels of education. The reason is that the argumentation involved calls for pondering ideas in depth, organizing knowledge, and comparing different points of view. Geometry, characterized by the interaction between the visual appearance of geometric elements and the conceptual understanding of their meaning required to generate precise explanations, is one of the foremost areas for research on proof and argumentation. In this qualitative analysis of the arguments formulated by participants in an extracurricular mathematics stimulus program, we categorized students’ replies on the grounds of reasoning styles, representations used, and levels of generality. The problems were proposed in a lesson on a quotient set based on the similarity among triangles created with Geogebra and the responses were gathered through a Google form. By means a content analysis, the results inform about the reasoning style, the scope of the argumentation, and the representation used. The findings show that neither reasoning styles nor the representations used conditioned the level of generality, although higher levels of argumentation were favored by harmonic and analytical reasoning and the use of algebraic representations.

European countries are affected by various levels of seismic hazard, including many areas with medium to high seismicity. Heavy damage over large areas has been observed in past earthquakes in these countries, particularly in masonry buildings located in historical centers, confirming the need for enhancing the current knowledge on the seismic vulnerability of these constructions, so more informed technical and political decisions towards the mitigation of the risk can be taken. However, the characterization of building stocks for engineering purposes is still an open issue due to the enormous amount of resources that such a project would require. Nevertheless, the availability of virtual images and maps represents an outstanding opportunity for having remote approaches to urban environments. The role of on-site inspections can be complemented or even substituted by means of these remote approaches, provided it is complemented with suitable approaches. The use of these resources is not new, but the critical assessment of their capabilities and limitations deserves a critical discussion. The present paper aims at assessing the opportunities offered by web-based mapping platforms in the context of seismic vulnerability assessment of masonry buildings in old urban areas. After evaluating the advantages and shortcomings of some of the most popular web-based mapping services, an explanatory application to a set of 39 buildings located in the historic center of the city of Leiria (Portugal) is presented and critically discussed, contrasting the results obtained by using on-site and remote inspections. Two different seismic vulnerability assessment approaches are applied and analyzed herein, confirming that web-based mapping platforms can represent an efficient and cost-effective complement to traditional field surveys when the large-scale seismic vulnerability of old urban areas is of interest.

Recent research has highlighted the role of functional relationships in introducing elementary school students to algebraic thinking. This functional approach is here considered to study essential components of algebraic thinking such as generalization and its representation, as well as the strategies used by students and their connection with generalization. This paper jointly describes the strategies and representations of generalization used by a group of 33 sixth-year elementary school students, with no former algebraic training, in two generalization tasks involving a functional relationship. The strategies applied by the students differed depending on whether they were working on specific or general cases. To answer questions on near specific cases they resorted to counting or additive operational strategies. As higher values or indeterminate quantities were considered, the strategies diversified. The correspondence strategy was the most used and the common approach when students generalized. Students were able to generalize verbally as well as symbolically and varied their strategies flexibly when changing from specific to general cases, showing a clear preference for a functional approach in the latter.

There is a growing tendency to assess resilience and sustainability of critical infrastructures (CI), given the significant increment in high-impact natural hazard events affecting socio-economic welfare. Historically, these assessments have been conducted separately due to the independent evolution of each concept. However, recent contributions tend to integrate them. This paper provides a state-of-the-art review of integrated assessments for resilience and sustainability in CI, examining concepts, indicators, frameworks, and methodologies. Additionally, a Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis was performed to gain further insights into the prospects of integrated assessments. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, eligibility criteria were established, leading to the selection of twelve studies. These works were compared based on five dimensions (economic, environmental, social, technical, and governance) to highlight the differences in the indicators used. While all studies considered the social, environmental, and economic dimensions, some did not further analyze sufficient indicators to evaluate environmental and social effects, with governance often neglected. This study emphasizes the relevance of establishing common metrics for a convergent frame for the resilience and sustainability assessment. The findings presented suggest that integrated assessments lead to a more strategic use of resources toward more resilient CI. [ABSTRACT FROM AUTHOR]