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1. A genetic and microscopy toolkit for manipulating and monitoring regeneration in Macrostomum lignano

Author

R. Nelson Hall, Hongquan Li, Chew Chai, Sidney Vermeulen, Robin R. Bigasin, Eun Sun Song, Souradeep R. Sarkar, Jesse Gibson, Manu Prakash, Andrew Z. Fire, and Bo Wang

Subjects
CP: Stem cell research, Biology (General), QH301-705.5
Abstract

Summary: Live imaging of regenerative processes can reveal how animals restore their bodies after injury through a cascade of dynamic cellular events. Here, we present a comprehensive toolkit for live imaging of tissue regeneration in the flatworm Macrostomum lignano, including a high-throughput cloning pipeline, targeted cellular ablation, and advanced microscopy solutions. Using tissue-specific reporter expression, we examine how various structures regenerate. Enabled by a custom luminescence/fluorescence microscope, we overcome intense stress-induced autofluorescence to demonstrate genetic cellular ablation and reveal the limited regenerative capacity of neurons and their essential role during wound healing, contrasting muscle cells’ rapid regeneration after ablation. Finally, we build an open-source tracking microscope to continuously image freely moving animals throughout the week-long process of regeneration, quantifying kinetics of wound healing, nerve cord repair, body regeneration, growth, and behavioral recovery. Our findings suggest that nerve cord reconnection is highly robust and proceeds independently of regeneration.

Published
2024
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2. Breast Cancer Presenting With Intravascular Tumor Emboli in Axillary Soft Tissue: Recurrence Risk and Radiation Therapy Outcomes

Author

Reith R. Sarkar, MD, Jessica A. Lavery, PhD, Zhigang Zhang, PhD, Boris A. Mueller, MD, MPH, Melissa Zinovoy, MD, John J. Cuaron, MD, Beryl McCormick, MD, Atif J. Khan, MD, Simon N. Powell, MD, PhD, Hannah Y. Wen, MD, and Lior Z. Braunstein, MD

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: Intravascular tumor emboli in axillary soft tissue (ITE) is a rare pathologic finding in breast cancer and is associated with higher axillary nodal disease burden. The independent prognostic and predictive value of this entity is unknown, as is the role of radiation therapy for ITE. Methods and Materials: We analyzed a prospectively maintained database of breast cancer patients treated from 1992 to 2020. Patients with ITE were matched to those without (1:2) based on propensity scores to control for potential confounding factors. Locoregional (LRR) and distant recurrence (DR) were evaluated using competing risks methods accounting for death as a competing event. Overall survival (OS) and disease-free survival (DFS) were evaluated by Cox regression models. Among patients with ITE, we also evaluated whether RT improved outcomes. Results: Among 2377 total patients, 129 had ITE, of whom 126 were propensity score matched to 252 without ITE. Median follow-up from time of surgery was 5.5 years (IQR 2.3, 9.7). There were no statistically significant differences in the 5-year incidence of LRR between groups (5.4% [95% CI, 1.6%-13%] with ITE vs 10% [95% CI, 6.7%-15%] without, P = .53) or DR (24% [95% CI, 15% 35%] with ITE vs 21% [95% CI, 16%-27%] without, P = .51). Five-year OS and DFS did not differ between groups (P > .9 for both comparisons, patients with ITE vs without ITE). In analyzing the effect of RT among patients with ITE, receipt of RT was associated with significantly improved DFS (HR, 0.34, 95% CI, 0.12-0.93, P = .04). Conclusions: Patients with ITE do not exhibit significantly worse LRR, DR, DFS, or OS compared with a propensity-score-matched cohort without ITE. However, among patients with ITE, those who received RT demonstrated significantly improved DFS. Larger studies with longer follow-up are needed to evaluate the prognostic and predictive implications of ITE.

Published
2024
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4. Brine residues and organics in the Urvara basin on Ceres

Author

A. Nathues, M. Hoffmann, N. Schmedemann, R. Sarkar, G. Thangjam, K. Mengel, J. Hernandez, H. Hiesinger, and J. H. Pasckert

Subjects
Science
Abstract

The authors report the discovery of salts and fresh organic-rich exposures in the Urvara basin, possibly linked to a late resurfacing of the crater floor. These results are consistent with a deep-seated brine/salt reservoir in the crust of Ceres.

Published
2022
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5. A Rare Incidence of Sweating Sickness-Like Symptoms in a Crossbred Holstein Friesian Cow in Chattogram, Bangladesh

Author

Omar Faruq, Eti R. Sarkar, and Suchandan Sikder

Subjects
Veterinary medicine, SF600-1100
Abstract

In this report, an incidence of sweating sickness-like symptoms in a crossbred Holstein Friesian cow was diagnosed. The cow was suffering from vaporization of the skin, dehydration, wet hair coat, and matting of hair due to excessive sweating. There were several ticks, flies, and mosquitoes in tail switch and other parts of the body. Blood and urine parameters were tested. We treated the patient successfully with ivermectin as ectoparasite control, ceftiofur sodium antibiotic to treat bacterial infections, ketoprofen as analgesics and antipyretics, chlorpheniramine maleate as H2-blocker, and trichlorfon and povidone-iodine skin spray to prevent fly invasion and prevent opportunistic bacterial infection, respectively. Acyclovir and oil of turpentine were suggested to be sprayed on the floor and wall of the shed for viral and ectoparasitic control. Our treatment regime successfully recovered the cow with no recurrence.

Published
2023
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9. Taurine deficiency as a driver of aging

Author

P, Singh, primary, K, Gollapalli, additional, S, Mangiola, additional, D, Schranner, additional, MA, Yusuf, additional, M, Chamoli, additional, SL, Shi, additional, B, Lopes Bastos, additional, T, Nair, additional, A, Riermeier, additional, EM, Vayndorf, additional, JZ, Wu, additional, A, Nilakhe, additional, CQ, Nguyen, additional, M, Muir, additional, MG, Kiflezghi, additional, A, Foulger, additional, A, Junker, additional, J, Devine, additional, K, Sharan, additional, SJ, Chinta, additional, S, Rajput, additional, A, Rane, additional, P, Baumert, additional, M, Schonfelder, additional, F, Iavarone, additional, G, di Lorenzo, additional, S, Kumari, additional, A, Gupta, additional, R, Sarkar, additional, C, Khyriem, additional, AS, Chawla, additional, A, Sharma, additional, N, Sarper, additional, N, Chattopadhyay, additional, BK, Biswal, additional, C, Settembre, additional, P, Nagarajan, additional, KL, Targoff, additional, M, Picard, additional, S, Gupta, additional, V, Velagapudi, additional, AT, Papenfuss, additional, A, Kaya, additional, MG, Ferreira, additional, BK, Kennedy, additional, JK, Andersen, additional, GJ, Lithgow, additional, AM, Ali, additional, A, Mukhopadhyay, additional, A, Palotie, additional, G, Kastenmuller, additional, M, Kaeberlein, additional, H, Wackerhage, additional, B, Pal, additional, and VK, Yadav, additional

Published
2023
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10. Transmission Power and Quality of Service In MANET Routing Protocols

Author

Ratna R. Sarkar and Mohammad Zahidur Rahman

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

Wireless communication is significantly influenced by the Mobile Ad Hoc Network (MANET), which consists of nodes like mobile phones, tablets, computers, or other devices that can connect with one another. MANET is a decentralized network that communicates without using any specified infrastructure. The lack of battery power in this multihop network with no infrastructure is problematic. As a result, proper transmission power utilization must be considered. Transmission power significantly impacts the data dissemination of different routing protocols used in this MANET environment. By taking this issue into account, the performance of routing protocols is examined based on different transmission power settings. The packet delivery ratio (PDR), packet loss (PL), jitter, and Dealy all play a role in determining network service quality. This study investigates how transmission power impacts MANET routing protocols’ quality of Service (QoS). The MANET routing protocols investigated in this study include AODV, OLSR, DSDV, and DSR. NS3 is used to create the simulation environment. According to this analysis, AODV outperforms other routing protocols in overall performance.

Published
2022
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11. Rapid detection of Actinobacillus pleuropneumoniae targeting the apxIVA gene for diagnosis of contagious porcine pleuropneumonia in pigs by polymerase spiral reaction

Author

R. Sarkar, P. Roychoudhury, S. Kumar, S. Dutta, N. Konwar, P. K. Subudhi, and T. K. Dutta

Subjects
Swine Diseases, Actinobacillus Infections, Mycoplasma, Pleuropneumonia, Swine, Actinobacillus pleuropneumoniae, Animals, Real-Time Polymerase Chain Reaction, Applied Microbiology and Biotechnology
Abstract

Actinobacillus pleuropneumoniae is the primary aetiological agent of contagious porcine pleuropneumonia associated with serious economic impact on pig husbandry worldwide. Diagnosis of the disease by existing techniques including isolation and identification of bacteria followed by serotyping, serological techniques, conventional PCR, real-time PCR and LAMP assays are cumbersome, time-consuming, costly and not suitable for rapid field application. A novel isothermal polymerase chain reaction (PSR) technique is standardized for all the reagents, incubation time and incubation temperature against A. pleuropneumoniae. The sensitivity of the assay was determined against various dilutions of purified DNA and total bacterial count. The specificity of the assay was determined against 11 closely related bacterial isolates. The relative sensitivity and specificity were compared with bacterial isolation, conventional PCR and real-time PCR assays. The PSR assay for specific detection was standardized at 64°C for 30 min of incubation in a water bath. The result was visible by the naked eye after centrifugation of the reaction mixture or after incorporation of SYBR Green dye as yellowish-green fluorescence. The technique was found to be 100% specific and equally sensitive with real-time PCR and 10 times more sensitive than conventional PCR. The PSR assay could be applicable in the detection of the organisms in porcine nasal swabs spiked with A. pleuropneumoniae. This is the first-ever report on the development of PSR for specific detection of A. pleuropneumoniae and can be applied for early diagnosis at the field level.

Published
2022
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12. Experimental determination of the energy dependence of the rate of the muon transfer reaction from muonic hydrogen to oxygen for collision energies up to 0.1 eV

Author

M. Stoilov, A. Adamczak, D. Bakalov, P. Danev, E. Mocchiutti, C. Pizzolotto, G. Baldazzi, M. Baruzzo, R. Benocci, M. Bonesini, D. Cirrincione, M. Clemenza, F. Fuschino, A. D. Hillier, K. Ishida, P. J. C. King, A. Menegolli, S. Monzani, R. Ramponi, L. P. Rignanese, R. Sarkar, A. Sbrizzi, L. Tortora, E. Vallazza, A. Vacchi, Stoilov M., Adamczak A., Bakalov D., Danev P., Mocchiutti E., Pizzolotto C., Baldazzi G., Baruzzo M., Benocci R., Bonesini M., Cirrincione D., Clemenza M., Fuschino F., Hillier A.D., Ishida K., King P.J.C., Menegolli A., Monzani S., Ramponi R., Rignanese L.P., Sarkar R., Sbrizzi A., Tortora L., Vallazza E., and Vacchi A.

Subjects
Atomic, Molecular & Optical, Atomic Physics (physics.atom-ph), FOS: Physical sciences, Scattering of atoms, molecules, clusters & ion, Fine & hyperfine structure, Physics - Atomic Physics
Abstract

We report the first experimental determination of the collision-energy dependence of the muon transfer rate from the ground state of muonic hydrogen to oxygen at near-thermal energies. A sharp increase by nearly an order of magnitude in the energy range 0 - 70 meV was found that is not observed in other gases. The results set a reliable reference for quantum-mechanical calculations of low-energy processes with exotic atoms, and provide firm ground for the measurement of the hyperfine splitting in muonic hydrogen and the determination of the Zemach radius of the proton by the FAMU collaboration., 30 pages, 10 figures

Published
2023

15. Split course palliative radiotherapy for advanced lung cancer with 3D planning based analysis of outcome: a retrospective review

Author

Grace S. Ahn, James D. Murphy, Reith R Sarkar, Andrew Bruggeman, Emily I Fuster, Anna Dornisch, Andrew B. Sharabi, and Ajay Sandhu

Subjects
medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Systemic therapy, medicine, Humans, Lung cancer, Prospective cohort study, Proportional Hazards Models, Retrospective Studies, Advanced and Specialized Nursing, Lung, business.industry, Radiotherapy Planning, Computer-Assisted, Palliative Care, Hazard ratio, medicine.disease, Radiation therapy, Regimen, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Cohort, Radiation Oncology, Female, Radiology, business
Abstract

BACKGROUND Durable palliation of advanced lung cancer is a common objective for radiation oncologists. However, there is no consensus on how to deliver the radiation course. Herein we report our experience of using split course radiotherapy and our assessment of outcomes based on planning from three-dimensional (3D) simulation before each treatment course. METHODS All lung cancer patients from 2006-2020 were identified. Of these, 52 patients received a split course treatment of 50-60 Gy in 18-25 fractions intended to provide durable palliation for disease not amenable to curative therapy. Treatment involved 3D planning with repeat computed tomography (CT) simulation prior to the second course. Survival and symptomatic response were analyzed via chart review. We categorized rapid responders versus non-rapid responders from the initial radiation course based on ≥30% gross tumor volume (GTV) reduction at the second CT simulation. We evaluated the impact of response on overall survival and palliative response. RESULTS Among our cohort treated with split course palliative radiotherapy, 33 (63%) had a rapid response to initial treatment. There was no difference in survival between groups [hazard ratio (HR) =1.30, P=0.47]. There was no significant difference in palliative response rates between rapid and non-rapid responders. On multivariable analysis, only female sex (HR =0.26, P

Published
2022
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22. Treatment Patterns, Disparities, and Management Strategies Impact Clinical Outcomes in Patients with Symptomatic Severe Aortic Regurgitation

Author

Vinod H. Thourani, Shannon M. E. Murphy, Martin B. Leon, J. James Edelman, Susheel Kodali, J. Matthew Brennan, Qinyu Chen, Isabel J. Boero, and Reith R Sarkar

Subjects
medicine.medical_specialty, Practice patterns, business.industry, Regurgitation (circulation), medicine.disease, Aortic valve replacement, Internal medicine, cardiovascular system, Cardiology, Medicine, In patient, Cardiology and Cardiovascular Medicine, business, human activities
Abstract

Symptomatic severe aortic regurgitation (ssAR) is a Class I recommendation for surgical aortic valve replacement (SAVR). We sought to evaluate the practice patterns and drivers of ssAR patients rec...

Published
2021
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23. A new class of solutions to the van Dantzig problem, the Lee-Yang property, and the Riemann hypothesis

Author

T Konstantopoulos, P Patie, and R Sarkar

Subjects
Mathematics - Number Theory, Probability (math.PR), FOS: Mathematics, FOS: Physical sciences, Mathematical Physics (math-ph), Number Theory (math.NT), Mathematics - Probability, Mathematical Physics
Abstract

The purpose of this paper is to carry out an in-depth analysis of the intriguing van Dantzig problem which consists on characterizing the set $\mathbb{D}$ of analytic characteristic functions $\mathcal{F}$ which remains stable by the action of the mapping $V\mathcal{F}(t)=1/\mathcal{F}(it)$, $t\in\mathbb{R}$. % is also a characteristic function. We start by observing that the celebrated Lee-Yang property, appearing in statistical mechanics and quantum field theory, and the Riemann hypothesis can be both rephrased in terms of the van Dantzig problem, and, more specifically, in terms of the set $\mathbb{D}_L \subset \mathbb{D}$ of real-valued characteristic functions that belong to the Laguerre-P\'olya class. Motivated by these facts, we proceed by identifying several non-trivial closure properties of the set $\mathbb{D}$ and $\mathbb{D}_L$. This not only revisits but also, by means of probabilistic techniques, deepens the fascinating studies of the set of even characteristic functions in the Laguerre-P\'olya class carried out by P\'olya, de Bruijn, Lukacs, Newman and more recently by Newman and Wu, among others. We continue by providing a new class of entire functions that belong to the set $\mathbb{D}$ but not necessarily to $\mathbb{D}_L$, offering the first examples outside the set $\mathbb{D}_L$. This class, which is derived from some entire functions introduced by the second author, is in bijection with a subset of continuous negative-definite functions and includes several notable generalized hypergeometric-type functions. Besides identifying the characteristic functions, we also manage to characterize the pair of the corresponding van Dantzig random variables revealing that one of them is infinitely divisible. Finally, we investigate the possibility that the Riemann $\xi$ function belongs to this class.

Published
2022

26. Early Impact of Cardiopulmonary Bypass on Renal Function after Valve Replacement Surgery

Author

S S, Howladeer, S D, Gupta, A, Momen, M H, Rahman, P K, Biswas, S R, Sarkar, K S, Rahman, P K, Chanda, and F, Ahmed

Subjects
Cardiopulmonary Bypass, Cross-Sectional Studies, Humans, Acute Kidney Injury, Kidney, Glomerular Filtration Rate
Abstract

Renal dysfunction following cardiopulmonary bypass is well recognized. The pathophysiology of renal injury is multifactorial and culmination of the interplay of several pathophysiological mechanism. Cardiac surgery requiring cardiopulmonary bypass (CPB) is being carried out on an extended patient population of different age groups and undergoing complex surgical procedure, and thus it places them at an increased risk of renal impairment. Valve replacement surgery is a major and complex surgical procedure requiring CPB. This study was therefore designed to observe the impact of CPB and short term outcome on patients with reduced estimated Glomerular Filtration Rate (eGFR) (60-89ml/min/1.73m²) after valve replacement surgery. This cross-sectional study was conducted in the Department of Cardiac Surgery, National Institute of Cardio Vascular Diseases (NICVD) during the period of January 2015 to August 2016. After fulfillment of enrollment criteria 100 patients were studied for the purpose of the study and they were grouped in two, patients with normal eGFR (≥90ml/min/1.73m²) in Group A and patients with reduced eGFR (60-89ml/min/1.73m²) in Group B. A total of 100 patients, 50 in each group were studied for renal function alteration after valve replacement surgery under cardiopulmonary bypass. The incidence of Acute Kidney Injury (AKI) was higher in Group B. Chi-square test was done and p value was 0.011 which is statistically significant. Postoperative blood loss (ml/hr) (p=0.038), duration of Intensive Care Unit (ICU) stay (in hours) (p=0.009), postoperative hospital stay (days) (p=0.014) was significantly higher and postoperative Urine Output (ml/hr) (p=0.001) was significantly lower in patients with reduced eGFR (60-89ml/min/1.73m²) in Group B. Deterioration of renal function is more in patient with eGFR (60-89ml/min/1.73m²) after valve replacement surgery under cardiopulmonary bypass in comparison with patients with eGFR (≥90ml/min/1.73m²).

Published
2022

29. Assessing the Socio-Economic Setup of Ravangla, Sikkim, and the Vulnerability of its Community using Geoinformatics

Author

S De, D Routh, S Hazra, P Kandar, S Sarkar, S Mitra, T Bhadra, R Sarkar, M Baral, and A Rai

Subjects
General Medicine, General Chemistry
Abstract

The geoinformatics platform integrates remotely sensed data and Geographic Information Systems (GIS). It has a vast range of applications. The technique is widely used not only to study the physical aspects of a region but also to analyse the social and economic setup. The objective of this study is to understand the socio-economic setup of Ravangla, which is a small tourist town located in South Sikkim, India. The primary data have been collected from the field survey and analysed using GIS tools. The social indices such as social structure, housing condition, and the condition of basic facilities such as health, education, transport, market, and others have been analysed in the present study. GIS has been used to study the spatial distribution of these social and economic parameters. The technique has also been used to assess the socio-economic vulnerability of the community living in Ravangla. The Composite Vulnerability at the community level has been calculated based on socioeconomic parameters and a vulnerability map has been prepared. Based on the Composite Vulnerability Index, the households in the study area have been classified as Highly, Moderately, and Less Vulnerable. The GIS techniques have been used to amalgamate the socioeconomic components of vulnerability to recognize the most vulnerable households in Ravangla. The study will help planners, policymakers, and administrators to take necessary steps for mitigating socio-economic problems in the study area.

Published
2023
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30. Preface

Author

T Bhadra, K Mukherjee, A Rai, R Sarkar, P Dash, and D Das

Subjects
General Medicine, General Chemistry
Abstract

International Conference on Geospatial Science for Digital Earth Observation (GSDEO 2021) The international conference on “Geospatial Science for Digital Earth Observation” (GSDEO) 2021 was successfully held on a virtual platform of Zoom on March 26th and 27th, 2021. The conference was jointly organized by the Indian Society of Remote Sensing (ISRS), Kolkata chapter, and the Department of Geography, School of Basic and Applied Sciences, Adamas University. Due to the non-predictable behaviour of the COVID-19 second wave, which imposed restrictions on organizing offline events, the GSDEO (2021) organizing committee decided to organize the conference online, instead of postponing the event. Remotely sensed data and geographic information systems have been increasingly used together for a vast range of applications, which include land use/land cover mapping, water resource management, weather forecasting, environmental monitoring, agriculture, disaster management, etc. Currently, intensive research is being carried out using remotely sensed data on the geoinformatics platform. New developments have led to dynamic advances in recent years. The objective of the international conference on Geospatial Science for Digital Earth Observation (GSDEO 2021) was to bring the scientists, academicians, and researchers, in the field of geo-environmental sciences on a common platform to exchange ideas and their recent findings related to the latest advances and applications of geospatial science. The call for papers received an enthusiastic response from the academic community, and over 100+ participants from 50+ colleges, universities, and institutions participated in the conference. In total 50+ research papers had been presented through the virtual Zoom conference platform in GSDEO 2021. The conference witnessed the presentation of research papers from diverse applied fields of geospatial sciences, which include the application of geoinformatics in geomorphology, hydrology, urban science, land use planning, climate, and environmental studies. There were four sessions namely, TS 1: Geomorphology and Hydrology, TS 2: Urban Science, TS 3: Social Sustainability and Land Use Planning, and TS 4: Climate and Environment. Each session was further subdivided, into two parts, namely Technical Session 1-A and 1-B. Each sub-session had been designed with one keynote speech and 5 oral presentations. Oral sessions were organized in two parts and offered through live and pre-recorded components based on the preference of the presenters. The presentation session was followed by a live Q&A session. The session chairs moderated the discussions. Similarly, poster sessions were organized in three parts and offered e-poster, live, and pre-recorded components. The best presenter of each sub-session received the best paper award. Dr. Prithvish Nag, Ex-Director of NATMO & Ex Surveyor General of India delivered the inaugural speech, and Dr. P. Chakrabarti, Former Chief Scientist of the DST&B, Govt. of West Bengal delivered a special lecture after the inaugural session. Eight eminent keynote speakers, Prof. S.P. Agarwal from the Indian Institute of Remote Sensing, Prof. Ashis Kumar Paul from Vidyasagar University, Prof. Soumya Kanti Ghosh from the Indian Institute of Technology, Kharagpur, Prof. L. N. Satpati from the University of Calcutta, Prof. R.B. Singh from the University of Delhi, Dr. A.K. Raha, IFS (Retd), Prof. Gerald Mills from the University College Dublin and Prof. Sugata Hazra from Jadavpur University enriched the knowledge of participants in the field of geoinformatics by their informative lectures. The presentations and discussions widely covered the various spectrums of geoinformatics and its application in monitoring natural resources like vegetation mapping, agricultural resource monitoring, forest health assessment, water, and ocean resource management, disaster management, land resource management, water and climate studies, drought vulnerability assessment, groundwater quality monitoring, accretion mapping and the use of geospatial science in studying morphological, hydrological, and other biophysical characteristics of a region etc. Application of geoinformatics in predicting urban expansion, urban climate, disaster management, healthcare accessibility, anthropogenic resource monitoring, spatial-interaction mapping, and, sustainable regional planning were well-discussed topics of the conference. List of Committees, photos are available in the pdf.

Published
2023
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31. Monitoring Land Use & Land Cover Change in an Urban Landscape: A Case Study of Siliguri, India

Author

R Sarkar and M Baral

Subjects
General Medicine, General Chemistry
Abstract

Information related to Land use and Land Cover (LULC) change is important for conservation of natural resources and sustainable development of an area. Siliguri is one of the populated metropolitan of West Bengal, India that has witnessed rapid urbanization. The major challenge is to identify the reason and pattern of urbanization due to inadequate and insufficient data in small cities like Siliguri. This paper has mainly assessed the LU & LC change of Siliguri municipality for the period of 1991-2001, 2001-2011 and 2011-2021. The main aim of the study is to determine the pattern and direction of future expansion. Satellite images from Landsat 4-5(1991-2011) and Landsat 8(2021) were used to extract LU & LC map of the municipality. Supervised classification using maximum likelihood classification was used to developed LULC maps. The supervised classification produced good results with overall accuracy of more than 80%. The change of the LULC pattern was obtained using change detection method. Four major classes viz. Vegetation, water body, sand and built-up have been identified. The analysis shows that maximum transformation has happened in the buildup environment from other land surface features.

Published
2023
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32. Spatiotemporal Change Detection Analysis of Land Cover and Land Use using Multi-Temporal Remote Sensed Imagery and Landscape Metrics: A Sub-Catchment Level Case Study of the Bhagirathi-Hugli River, West Bengal, India

Author

S Das and R Sarkar

Subjects
General Medicine, General Chemistry
Abstract

To analyse and characterise land use-land cover (LULC) change, remote sensing (RS) data and geographic information system (GIS) approaches are required. The landscape metrics are also extensively used to explain the structure and pattern of the spatial landscape. This case study has been conducted in the area of the Bhagirathi-Hugli River banks in West Bengal. The study area’s satellite image data from various periods (1989-2017) were used to analyse the spatiotemporal variation of LULC change. The LULC fragmentation was analysed using a total of six landscape measures. Landscape metrics such as Number of Patches (NP), Largest Patch Index (LPI), Landscape Shape Index (LSI), Mean Shape Index (MSI), Contagion (CONTAG), and Shannon’s Diversity Index were used to determine the changes over four different periods. The main features of land use change were the continuous expansion of built-up area (9.30 km2), vegetation (189.14 km2), and the decrease in agricultural fallow land and water bodies from 1989 to 2017. The landscape pattern in the study area has also changed significantly. The landscape metrics indicate that the studied region had a highly fragmented landscape during the study period. The proposed technique is easy to use and can address more than one metric while selecting the appropriate setting can prove problematic.

Published
2023
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33. First detection of voltage-gated sodium channel mutations in

Author

Santana R, Sarkar, Akihiro, Kuroki, Yusuf, Özbel, Yasutaka, Osada, Satoko, Omachi, Paul K, Shyamal, Fashiur, Rahman, Shinji, Kasai, Eisei, Noiri, Yoshitsugu, Matsumoto, and Chizu, Sanjoba

Subjects
Insecticide Resistance, Bangladesh, Insecticides, Phlebotomus, Mutation, Pyrethrins, Animals, Voltage-Gated Sodium Channels
Abstract

Phlebotomus argentipes is the main vector of visceral leishmaniasis in Bangladesh and is controlled using deltamethrin, a synthetic pyrethroid, through indoor residual spraying (IRS). A mutation at L1014 (leucine at codon 1014) of the voltage-gated sodium channel (VGSC), known as a knockdown resistance (kdr) gene, is thought to be an important pyrethroid resistance mechanism. This study detected mutations at codon 1014, and at codons 1011, 1016, and 1020, which are kdr sites in other insects. The kdr relationship with deltamethrin resistance in P. argentipes from an IRS-targeted site in Bangladesh was also evaluated.Sand flies were collected from Magurjora village, Mymensingh district, Bangladesh in November 2012. A WHO cone bioassay test using deltamethrin was conducted and specimens were grouped as 'live' or 'dead'. After morphological identification, genomic DNA was used to genotype a partial VGSC gene from P. argentipes. The kdr/ pyrethroid resistance relationship was evaluated using Fisher's exact test.Targeted codons were genotyped from 8 'live' and 63 'dead' P. argentipes. All 'live' specimens had mutant alleles (L1014F and L1014S) at codon 1014. The mutant allele rate was 94% for 'live' specimens and 55% for 'dead' specimens. The mutant allele survival odds were higher for the wild-type L1014L allele, and L1014F odds were lower for L1014S. There were no mutations at codons 1011, 1016, and 1020.The L1014 mutations suggested that pyrethroid resistance had appeared in Bangladesh. Further research on kdr mutations in P. argentipes is important for the appropriate IRS.

Published
2022

34. Background splicing as a predictor of aberrant splicing in genetic disease

Author

D. Alexieva, Y. Long, R. Sarkar, H. Dhayan, E. Bruet, R. M. Winston, I. Vorechovsky, L. Castellano, and N. J. Dibb

Subjects
Gene Expression Profiling, RNA Splicing, Genetic Diseases, Inborn, Computational Biology, Cell Biology, Exons, Introns, Alternative Splicing, Gene Expression Regulation, Databases, Genetic, Mutation, Humans, Genetic Predisposition to Disease, RNA Splice Sites, Molecular Biology
Abstract

Mutations of splice sites, auxiliary splicing elements and the splicing machinery cause a wide range of genetic disease. Here we report that many of the complex effects of splicing mutations can be predicted from background splicing information, with emphasis on BRCA1, BRCA2 and DMD. Background splicing arises from very low level splicing between rarely used background splice sites and from low-level exon skipping between intron splice sites. We show how this information can be downloaded from the Snaptron database of spliced RNA, which we then compared with databases of human splice site mutations. We report that inactivating mutations of intron splice sites typically caused the non-mutated partner splice site to splice to a known background splice site in over 90% of cases and to the strongest background splice site in the large majority of cases. Consequently, background splicing information can usefully predict the effects of splice site mutations, which include cryptic splice activation and single or multiple exon skipping. In addition, de novo splice sites and splice sites involved in pseudoexon formation, recursive splicing and aberrant splicing in cancer show a 90% match to background splice sites, so establishing that the enhancement of background splicing causes a wide range of splicing aberrations. We also discuss how background splicing information can identify cryptic splice sites that might be usefully targeted by antisense oligonucleotides (ASOs) and how it might indicate possible multiple exon skipping side effects of ASOs designed to induce single exon skipping.

Published
2022

35. S. mediterranea ETS-1 regulates the function of cathepsin-positive cells and the epidermal lineage landscape via basement membrane remodeling

Author

Vinay Kumar Dubey, Souradeep R. Sarkar, Vairavan Lakshmanan, Rimple Dalmeida, Akash Gulyani, and Dasaradhi Palakodeti

Subjects
Mediterranea, Animals, Humans, Cell Differentiation, Cell Biology, Planarians, Epidermis, Cathepsins, Matrix Metalloproteinases, Basement Membrane, Transcription Factors
Abstract

Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital role in stem cell function. However, the mechanisms that modulate the function of ECM regulators in the stem cell niche are understudied. Here, we explored the role of the transcription factor (TF) ETS-1, which is expressed in the cathepsin-positive cell population, in regulating the expression of the ECM regulator, mt-mmpA, thereby modulating basement membrane thickness. In planarians, the basement membrane around the gut/inner parenchyma is thought to act as a niche for pluripotent stem cells. It has been shown that the early epidermal progenitors migrate outwards from this region and progressively differentiate to maintain the terminal epidermis. Our data shows that thickening of the basement membrane in the absence of ets-1 results in defective migration of stem cell progeny. Furthermore, the absence of ets-1 leads to a defective epidermal progenitor landscape, despite its lack of expression in those cell types. Together, our results demonstrate the active role of ECM remodeling in regulating tissue homeostasis and regeneration in the planarian Schmidtea mediterranea. This article has an associated First Person interview with one of the co-first authors of the paper.

Published
2022

36. DDX24 is required for muscle fiber organization and the suppression of wound-induced Wnt activity necessary for pole re-establishment during planarian regeneration

Author

Souradeep R. Sarkar, Vinay Kumar Dubey, Anusha Jahagirdar, Vairavan Lakshmanan, Mohamed Mohamed Haroon, Sai Sowndarya, Ramanathan Sowdhamini, and Dasaradhi Palakodeti

Subjects
Wnt Proteins, Muscle Fibers, Skeletal, Animals, RNA Interference, Cell Biology, Planarians, Molecular Biology, RNA Helicases, Developmental Biology, Body Patterning, Signal Transduction
Abstract

Planarians have a remarkable ability to undergo whole-body regeneration. Successful regeneration outcome is determined by processes like polarity establishment at the wound site, which is followed by pole (organizer) specification. Interestingly, these determinants are almost exclusively expressed by muscles in these animals. However, the molecular toolkit that enables the functional versatility of planarian muscles remains poorly understood. Here we report that SMED_DDX24, a D-E-A-D Box RNA helicase, is necessary for planarian survival and regeneration. We found that DDX24 is enriched in muscles and its knockdown disrupts muscle fiber organization. This leads to defective pole specification, which in turn results in misregulation of many positional control genes specifically during regeneration. ddx24 RNAi also upregulates wound-induced Wnt signalling. Suppressing this ectopic Wnt activity rescues the knockdown phenotype by enabling better anterior pole regeneration. To summarize, our work highlights the role of an RNA helicase in muscle fiber organization, and modulating amputation-induced wnt levels, both of which seem critical for pole re-organization, thereby regulating whole-body regeneration.

Published
2022

37. Inclusive and differential cross section measurements of single top quark production in association with a Z boson in proton-proton collisions at root s=13 TeV

Author

Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Del Valle, A. Escalante Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I Paulitsch, P. Pitters, F. M. and Schieck, J. Schofbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C-E Chekhovsky, V Litomin, A. and Makarenko, V Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Sfar, H. Rejeb Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Stylianou, N. Beghin, D. and Bilin, B. Clerbaux, B. De Lentdecker, G. Favart, L. and Grebenyuk, A. Kalsi, A. K. Lee, K. Mahdavikhorrami, M. and Makarenko, I Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. Gao, X. Cornelis, T. Dobur, D. and Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. and Roskas, C. Samalan, A. Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. and Bury, F. Caputo, C. David, P. Delaere, C. Donertas, I. S. Giammanco, A. Jaffel, K. Jain, Sa Lemaitre, V and Mondal, K. Prisciandaro, J. Taliercio, A. Teklishyn, M. and Tran, T. T. Vischia, P. Wertz, S. Alves, G. A. Hensel, C. Moraes, A. Teles, P. Rebello Alda Junior, W. L. Gallo Pereira, M. Alves Ferreira Filho, M. Barroso Malbouisson, H. Brandao Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. Damiao, D. De Jesus De Souza, S. Fonseca and Herrera, C. Mora Amarilo, K. Mota Mundim, L. Nogima, H. and Santoro, A. Silva Do Amaral, S. M. Sznajder, A. Thiel, M. and De Araujo, F. Torres Da Silva Pereira, A. Vilela Bernardes, C. A. Calligaris, L. Tomei, T. R. Fernandez Perez Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. and Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. and Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. and Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Cheng, T. Javaid, T. and Mittal, M. Yuan, L. Ahmad, M. Bauer, G. Dozen, C. and Hu, Z. Martins, J. Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Kapoor, A. and Leggat, D. Liao, H. Liu, Z-A Milosevic, V Monti, F. and Sharma, R. Tao, J. Thomas-Wilsker, J. Wang, J. Zhang, H. and Zhao, J. Agapitos, A. An, Y. Ban, Y. Chen, C. and Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Xiao, J. Lu, M. You, Z. Okawa, H. Zhang, Y. and Zhang, L. Lin, Z. Xiao, M. Avila, C. Cabrera, A. and Florez, C. Fraga, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. and Godinovic, N. Lelas, D. Puljak, I Antunovic, Z. Kovac, M. Sculac, T. Brigljevic, V Ferencek, D. Majumder, D. and Roguljic, M. Starodumov, A. Susa, T. Attikis, A. and Christoforou, K. Erodotou, E. Ioannou, A. Kole, G. and Kolosova, M. Konstantinou, S. Mousa, J. Nicolaou, C. and Ptochos, F. Razis, P. A. Rykaczewski, H. Saka, H. and Finger, M. Finger Jr, M. Jr Kveton, A. Ayala, E. Carrera Jarrin, E. Abdalla, H. Assran, Y. Lotfy, A. Mahmoud, M. A. Bhowmik, S. Dewanjee, R. K. Ehataht, K. Kadastik, M. and Nandan, S. Nielsen, C. Pata, J. Raidal, M. Tani, L. and Veelken, C. Eerola, P. Forthomme, L. Kirschenmann, H. and Osterberg, K. Voutilainen, M. Bharthuar, S. Brucken, E. and Garcia, F. Havukainen, J. Kim, M. S. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. and Lotti, M. Martikainen, L. Myllymaki, M. Ott, J. and Siikonen, H. Tuominen, E. Tuominiemi, J. Luukka, P. and Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. and Ganjour, S. Gras, P. de Monchenault, G. Hamel Jarry, P. and Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Sahin, M. O. Savoy-Navarro, A. Titov, M. Yu, G. B. and Mijuskovic, J. Ahuja, S. Beaudette, F. Bonanomi, M. and Perraguin, A. Buchot Busson, P. Cappati, A. Charlot, C. and Davignon, O. Diab, B. Falmagne, G. Ghosh, S. de Cassagnac, R. Granier Hakimi, A. Kucher, I Motta, J. and Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sarkar, U. Sauvan, J. B. Sirois, Y. Tarabini, A. and Zabi, A. Zghiche, A. Agram, J-L Andrea, J. Apparu, D. and Bloch, D. Bourgatte, G. Brom, J-M Chabert, E. C. and Collard, C. Darej, D. Fontaine, J-C Goerlach, U. and Grimault, C. Le Bihan, A-C Nibigira, E. Van Hove, P. and Asilar, E. Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. Fay, J. Gascon, S. Gouzevitch, M. Ille, B. and Laktineh, I. B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. Shchablo, K. Sordini, V and Torterotot, L. Touquet, G. Vander Donckt, M. Viret, S. and Lomidze, I Toriashvili, T. Tsamalaidze, Z. Mestvirishvili, A. Botta, V Feld, L. Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rowert, N. Schulz, J. Teroerde, M. and Dodonova, A. Eliseev, D. Erdmann, M. Fackeldey, P. and Fischer, B. Hebbeker, T. Hoepfner, K. Ivone, F. and Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Mocellin, G. and Mondal, S. Mukherjee, S. Noll, D. Novak, A. Pook, T. and Pozdnyakov, A. Rath, Y. Reithler, H. Roemer, J. Schmidt, A. Schuler, S. C. Sharma, A. Vigilante, L. Wiedenbeck, S. Zaleski, S. Borras, K. Kasem, A. Coubez, X. and Dziwok, C. Flugge, G. Ahmad, W. Haj Hlushchenko, O. and Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. and Stahl, A. Ziemons, T. Zotz, A. Petersen, H. Aarup and Martin, M. Aldaya Asmuss, P. Baxter, S. Bayatmakou, M. and Behnke, O. Martinez, A. Bermudez Bhattacharya, S. Bin Anuar, A. A. Brunner, D. Campbell, A. Cardini, A. Cheng, C. and Colombina, F. Rodriguez, S. Consuegra Silva, G. Correia and Danilov, V De Silva, M. Didukh, L. Eckerlin, G. and Eckstein, D. Banos, L. I. Estevez Filatov, O. Gallo, E. and Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. Jomhari, N. Z. Jung, H. Kasemann, M. Kaveh, H. and Kleinwort, C. Kogler, R. Krucker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Mankel, R. Melzer-Pellmann, I-A and Morentin, M. Mendizabal Metwally, J. Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Adan, D. Perez and Pitzl, D. Raspereza, A. Lopes, B. Ribeiro Rubenach, J. and Saggio, A. Saibel, A. Savitskyi, M. Scham, M. and Scheurer, V Schnake, S. Schutze, P. Schwanenberger, C. and Shchedrolosiev, M. Ricardo, R. E. Sosa Stafford, D. Tonon, N. Van De Klundert, M. Walsh, R. Walter, D. Wang, Q. and Wen, Y. Wichmann, K. Wiens, L. Wissing, C. Wuchterl, S. and Bakhshiansohi, H. Aggleton, R. Albrecht, S. Bein, S. and Benato, L. Connor, P. De Leo, K. Eich, M. Feindt, F. and Frohlich, A. Garbers, C. Garutti, E. Gunnellini, P. and Hajheidari, M. Haller, J. Hinzmann, A. Kasieczka, G. and Klanner, R. Kramer, T. Kutzner, V Lange, J. Lange, T. and Lobanov, A. Malara, A. Nigamova, A. Rodriguez, K. J. Pena Rieger, M. Rieger, O. Schleper, P. Schroder, M. and Schwandt, J. Sonneveld, J. Stadie, H. Steinbruck, G. and Tews, A. Zoi, I Bechtel, J. Brommer, S. Burkart, M. and Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. Faltermann, N. Giffels, M. and Gosewisch, J. O. Gottmann, A. Hartmann, F. Heidecker, C. and Husemann, U. Keicher, P. Koppenhofer, R. Maier, S. and Metzler, M. Mitra, S. Muller, Th Neukum, M. Nurnberg, A. and Quast, G. Rabbertz, K. Rauser, J. Savoiu, D. and Schnepf, M. Seith, D. Shvetsov, I Simonis, H. J. Ulrich, R. Van der Linden, J. Von Cube, R. F. Wassmer, M. Weber, M. Wieland, S. Wolf, R. Wozniewski, S. Wunsch, S. and Anagnostou, G. Daskalakis, G. Geralis, T. Kyriakis, A. and Loukas, D. Stakia, A. Diamantopoulou, M. Karasavvas, D. and Karathanasis, G. Kontaxakis, P. Koraka, C. K. and Manousakis-Katsikakis, A. Panagiotou, A. Papavergou, I and Saoulidou, N. Theofilatos, K. Tziaferi, E. Vellidis, K. and Vourliotis, E. Sphicas, P. Bakas, G. Kousouris, K. and Papakrivopoulos, I Tsipolitis, G. Zacharopoulou, A. and Adamidis, K. Bestintzanos, I Evangelou, I Foudas, C. and Gianneios, P. Katsoulis, P. Kokkas, P. Manthos, N. and Papadopoulos, I Strologas, J. Csanad, M. Farkas, K. and Gadallah, M. M. A. Lokos, S. Major, P. Mandal, K. Mehta, A. Pasztor, G. Radl, A. J. Suranyi, O. Veres, I, G. and Trocsanyi, Z. L. Bartok, M. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Veszpremi, V. Csorgo, T. Nemes, F. Czellar, S. Fasanella, D. Karancsi, J. Molnar, J. and Szillasi, Z. Teyssier, D. Raics, P. Ujvari, B. Novak, T. and Choudhury, S. Komaragiri, J. R. Kumar, D. Panwar, L. and Tiwari, P. C. Bahinipati, S. Kar, C. Mal, P. Mishra, T. and Bindhu, V. K. Muraleedharan Nair Nayak, A. Saha, P. Sur, N. Swain, S. K. Vats, D. Bansal, S. Beri, S. B. and Bhatnagar, V Chaudhary, G. Chauhan, S. Dhingra, N. and Gupta, R. Kaur, A. Kaur, M. Kaur, S. Kumari, P. and Meena, M. Sandeep, K. Singh, J. B. Virdi, A. K. Ahmed, A. Bhardwaj, A. Choudhary, B. C. Gola, M. Keshri, S. and Kumar, A. Naimuddin, M. Priyanka, P. Ranjan, K. Shah, A. and Bharti, M. Bhattacharya, R. Bhowmik, D. Dutta, S. and Gomber, B. Maity, M. Palit, P. Rout, P. K. Saha, G. and Sahu, B. Sarkar, S. Sharan, M. Singh, B. Thakur, S. and Behera, P. K. Behera, S. C. Kalbhor, P. Muhammad, A. and Pradhan, R. Pujahari, P. R. Sikdar, A. K. Dutta, D. Jha, V Kumar, V Mishra, D. K. Naskar, K. Netrakanti, P. K. and Pant, L. M. Shukla, P. Aziz, T. Dugad, S. Kumar, M. and Banerjee, S. Chudasama, R. Guchait, M. Karmakar, S. and Kumar, S. Majumder, G. Mazumdar, K. Alpana, K. Dube, S. and Kansal, B. Laha, A. Pandey, S. Rane, A. Rastogi, A. and Sharma, S. Khazaie, E. Zeinali, M. Chenarani, S. and Etesami, S. M. Khakzad, M. Najafabadi, M. Mohammadi and Grunewald, M. Abbrescia, M. Aly, R. Aruta, C. Colaleo, A. Creanza, D. De Filippis, N. De Palma, M. Di Florio, A. Di Pilato, A. Elmetenawee, W. Fiore, L. Gelmi, A. and Gul, M. Iaselli, G. Ince, M. Lezki, S. Maggi, G. and Maggi, M. Margjeka, I Mastrapasqua, V My, S. Nuzzo, S. and Pellecchia, A. Pompili, A. Pugliese, G. Ramos, D. and Ranieri, A. Selvaggi, G. Silvestris, L. Simone, F. M. and Venditti, R. Verwilligen, P. Abbiendi, G. Battilana, C. and Bonacorsi, D. Borgonovi, L. Brigliadori, L. Campanini, R. and Capiluppi, P. Castro, A. Cavallo, F. R. Cuffiani, M. and Dallavalle, G. M. Diotalevi, T. Fabbri, F. Fanfani, A. and Giacomelli, P. Giommi, L. Grandi, C. Guiducci, L. Lo Meo, S. Lunerti, L. Marcellini, S. Masetti, G. Navarria, F. L. Perrotta, A. Primavera, F. Rossi, A. M. Rovelli, T. Siroli, G. P. Albergo, S. Costa, S. Di Mattia, A. and Potenza, R. Tricomi, A. Tuve, C. Barbagli, G. Cassese, A. Ceccarelli, R. Ciulli, V Civinini, C. D'Alessandro, R. Focardi, E. Latino, G. Lenzi, P. Lizzo, M. and Meschini, M. Paoletti, S. Seidita, R. Sguazzoni, G. and Viliani, L. Benussi, L. Bianco, S. Piccolo, D. Bozzo, M. and Ferro, F. Mulargia, R. Robutti, E. Tosi, S. and Benaglia, A. Brivio, F. Cetorelli, F. De Guio, F. and Dinardo, M. E. Dini, P. Gennai, S. Ghezzi, A. Govoni, P. and Guzzi, L. Lucchini, M. T. Malberti, M. Malvezzi, S. and Massironi, A. Menasce, D. Moroni, L. Paganoni, M. and Pedrini, D. Ragazzi, S. Redaelli, N. de Fatis, T. Tabarelli and Valsecchi, D. Zuolo, D. Buontempo, S. Carnevali, F. and Cavallo, N. De Iorio, A. Fabozzi, F. Iorio, A. O. M. and Lista, L. Meola, S. Paolucci, P. Rossi, B. Sciacca, C. and Azzi, P. Bacchetta, N. Bisello, D. Bortignon, P. and Bragagnolo, A. Carlin, R. Checchia, P. Dorigo, T. and Dosselli, U. Gasparini, F. Gasparini, U. Hoh, S. Y. and Layer, L. Margoni, M. Meneguzzo, A. T. Pazzini, J. and Ronchese, P. Rossin, R. Simonetto, F. Strong, G. Tosi, M. Yarar, H. Zanetti, M. Zotto, P. Zucchetta, A. and Zumerle, G. Aime, C. Braghieri, A. Calzaferri, S. and Fiorina, D. Montagna, P. Ratti, S. P. Re, V Riccardi, C. and Salvini, P. Vai, I Vitulo, P. Fallavollita, F. and Asenov, P. Bilei, G. M. Ciangottini, D. Fano, L. and Mantovani, G. Mariani, V Menichelli, M. Moscatelli, F. and Piccinelli, A. Presilla, M. Rossi, A. Santocchia, A. and Spiga, D. Tedeschi, T. Magherini, M. Azzurri, P. and Bagliesi, G. Bertacchi, V Bianchini, L. Boccali, T. and Bossini, E. Castaldi, R. Ciocci, M. A. D'Amante, V and Dell'Orso, R. Di Domenico, M. R. Donato, S. Giassi, A. and Ligabue, F. Manca, E. Mandorli, G. Messineo, A. Palla, F. Parolia, S. Ramirez-Sanchez, G. Rizzi, A. Rolandi, G. and Chowdhury, S. Roy Scribano, A. Shafiei, N. Spagnolo, P. and Tenchini, R. Tonelli, G. Turini, N. Venturi, A. and Verdini, P. G. Barria, P. Campana, M. Cavallari, F. Del Re, D. Di Marco, E. Diemoz, M. Longo, E. Meridiani, P. and Organtini, G. Pandolfi, F. Paramatti, R. Quaranta, C. and Rahatlou, S. Rovelli, C. Santanastasio, F. Soffi, L. and Tramontano, R. Amapane, N. Arcidiacono, R. Argiro, S. and Arneodo, M. Bartosik, N. Bellan, R. Bellora, A. and Antequera, J. Berenguer Biino, C. Cartiglia, N. Cometti, S. and Costa, M. Covarelli, R. Demaria, N. Kiani, B. and Legger, F. Mariotti, C. Maselli, S. Migliore, E. and Monteil, E. Monteno, M. Obertino, M. M. Ortona, G. and Pacher, L. Pastrone, N. Pelliccioni, M. Angioni, G. L. Pinna and Ruspa, M. Shchelina, K. Siviero, F. Sola, V Solano, A. Soldi, D. Staiano, A. Tornago, M. Trocino, D. and Vagnerini, A. Rumerio, P. Belforte, S. Candelise, V and Casarsa, M. Cossutti, F. Da Rold, A. Della Ricca, G. and Sorrentino, G. Vazzoler, F. Dogra, S. Huh, C. Kim, B. and Kim, D. H. Kim, G. N. Kim, J. Lee, J. Lee, S. W. and Moon, C. S. Oh, Y. D. Pak, I, S. Radburn-Smith, B. C. and Sekmen, S. Yang, Y. C. Kamon, T. Kim, H. Moon, D. H. and Francois, B. Kim, T. J. Park, J. Cho, S. Choi, S. and Go, Y. Hong, B. Lee, K. S. Lim, J. Park, S. K. Yoo, J. Goh, J. Gurtu, A. Kim, H. S. Kim, Y. Almond, J. and Bhyun, J. H. Choi, J. Jeon, S. Kim, J. S. Ko, S. and Kwon, H. Lee, H. Lee, S. Oh, B. H. Oh, M. Oh, S. B. and Seo, H. Yang, U. K. Yoon, I Jang, W. Kang, D. Y. and Kang, Y. Kim, S. Ko, B. Lee, J. S. H. Lee, Y. and Merlin, J. A. Park, I. C. Roh, Y. Ryu, M. S. 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Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Inclusive and differential cross sections of single top quark production in association with a Z boson are measured in proton-proton collisions at a center-of-mass energy of 13 TeV with a data sample corresponding to an integrated luminosity of 138 fb(-1) recorded by the CMS experiment. Events are selected based on the presence of three leptons, electrons or muons, associated with leptonic Z boson and top quark decays. The measurement yields an inclusive cross section of 87.9(-7.3)(+7.5) (stat)(-6.0)(+7.3)(syst) fb for a dilepton invariant mass greater than 30 GeV, in agreement with standard model (SM) calculations and represents the most precise determination to date. The ratio between the cross sections for the top quark and the top antiquark production in association with a Z boson is measured as 2.37(-0.42)(+0.56)(stat)(-0.13)(+0.27) (syst). Differential measurements at parton and particle levels are performed for the first time. Several kinematic observables are considered to study the modeling of the process. Results are compared to theoretical predictions with different assumptions on the source of the initial-state b quark and found to be in agreement, within the uncertainties. Additionally, the spin asymmetry, which is sensitive to the top quark polarization, is determined from the differential distribution of the polarization angle at parton level to be 0.54 +/- 0.16 (stat)+/- 0.06 (syst), in agreement with SM predictions.

Published
2022

38. Measurement and QCD analysis of double-differential inclusive jet cross sections in proton-proton collisions at root s=13 TeV

Author

Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Escalante Del Valle, A. Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Paulitsch, P. Pitters, F. M. and Schieck, J. Schofbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C. -E. Chekhovsky, V. Litomin, A. and Makarenko, V. Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Rejeb Sfar, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. and Kalsi, A. K. Lee, K. Mahdavikhorrami, M. Makarenko, I. and Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. and Vanlaer, P. Cornelis, T. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. Roskas, C. Samalan, A. and Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. and Benecke, A. Bethani, A. Bruno, G. Bury, F. Caputo, C. and David, P. Delaere, C. Donertas, I. S. Giammanco, A. and Jaffel, K. Jain, Sa. Lemaitre, V. Mondal, K. and Prisciandaro, J. Taliercio, A. Teklishyn, M. Tran, T. T. and Vischia, P. Wertz, S. Alves, G. A. Hensel, C. Moraes, A. and Alda Junior, W. L. Alves Gallo Pereira, M. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. and Fonseca De Souza, S. Mora Herrera, C. Mota Amarilo, K. and Mundim, L. Nogima, H. Rebello Teles, P. Santoro, A. and Silva Do Amaral, S. M. Sznajder, A. Thiel, M. Torres Da Silva De Araujo, F. Vilela Pereira, A. Bernardes, C. A. and Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. and Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. and Petrov, A. Cheng, T. Javaid, T. Mittal, M. Yuan, L. and Ahmad, M. Bauer, G. Dozen, C. Hu, Z. Martins, J. and Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. and Chen, M. Iemmi, F. Kapoor, A. Leggat, D. Liao, H. and Liu, Z. -A. Milosevic, V. Monti, F. Sharma, R. Tao, J. and Thomas-Wilsker, J. Wang, J. Zhang, H. Zhao, J. and Agapitos, A. An, Y. Ban, Y. Chen, C. Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Wang, Q. and Xiao, J. Lu, M. You, Z. Gao, X. Okawa, H. Zhang, Y. and Lin, Z. Xiao, M. Avila, C. Cabrera, A. Florez, C. and Fraga, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. Godinovic, N. and Lelas, D. Puljak, I. Antunovic, Z. Kovac, M. Sculac, T. and Brigljevic, V. Ferencek, D. Majumder, D. Roguljic, M. and Starodumov, A. Susa, T. Attikis, A. Christoforou, K. and Erodotou, E. Ioannou, A. Kole, G. Kolosova, M. and Konstantinou, S. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Rykaczewski, H. Saka, H. Finger, M. Finger, Jr., M. Kveton, A. Ayala, E. Carrera Jarrin, E. Assran, Y. Ellithi Kamel, A. Mahmoud, M. A. Mohammed, Y. and Bhowmik, S. Dewanjee, R. K. Ehataht, K. Kadastik, M. and Nandan, S. Nielsen, C. Pata, J. Raidal, M. Tani, L. and Veelken, C. Eerola, P. Forthomme, L. Kirschenmann, H. and Osterberg, K. Voutilainen, M. Bharthuar, S. Brucken, E. and Garcia, F. Havukainen, J. Kim, M. S. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. and Lotti, M. Martikainen, L. Myllymaki, M. Ott, J. and Siikonen, H. Tuominen, E. Tuominiemi, J. Luukka, P. and Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. and Ganjour, S. Gras, P. Hamel de Monchenault, G. Jarry, P. and Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Sahin, M. O. Savoy-Navarro, A. Titov, M. Yu, G. B. and Ahuja, S. Beaudette, F. Bonanomi, M. Buchot Perraguin, A. and Busson, P. Cappati, A. Charlot, C. Davignon, O. and Diab, B. Falmagne, G. Ghosh, S. Granier de Cassagnac, R. and Hakimi, A. Kucher, I. Motta, J. Nguyen, M. Ochando, C. and Paganini, P. Rembser, J. Salerno, R. Sarkar, U. and Sauvan, J. B. Sirois, Y. Tarabini, A. Zabi, A. Zghiche, A. Agram, J. -L. Andrea, J. Apparu, D. Bloch, D. and Bourgatte, G. Brom, J. -M. Chabert, E. C. Collard, C. and Darej, D. Fontaine, J. -C. Goerlach, U. Grimault, C. Le Bihan, A. -C. Nibigira, E. Van Hove, P. Asilar, E. and Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. and Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Gascon, S. Gouzevitch, M. Ille, B. Laktineh, I. B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. Shchablo, K. Sordini, V. Torterotot, L. and Touquet, G. Vander Donckt, M. Viret, S. Lomidze, I. and Toriashvili, T. Tsamalaidze, Z. Botta, V. Feld, L. and Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rowert, N. and Schulz, J. Teroerde, M. Dodonova, A. Eliseev, D. and Erdmann, M. Fackeldey, P. Fischer, B. Ghosh, S. and Hebbeker, T. Hoepfner, K. Ivone, F. Mastrolorenzo, L. and Merschmeyer, M. Meyer, A. Mocellin, G. Mondal, S. and Mukherjee, S. Noll, D. Novak, A. Pook, T. Pozdnyakov, A. and Rath, Y. Reithler, H. Roemer, J. Schmidt, A. and Schuler, S. C. Sharma, A. Vigilante, L. Wiedenbeck, S. and Zaleski, S. Dziwok, C. Flugge, G. Haj Ahmad, W. and Hlushchenko, O. Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. Stahl, A. Ziemons, T. Zotz, A. and Aarup Petersen, H. Aldaya Martin, M. Asmuss, P. Baxter, S. Bayatmakou, M. Behnke, O. Bermudez Martinez, A. and Bhattacharya, S. Bin Anuar, A. A. Borras, K. Brunner, D. and Campbell, A. Cardini, A. Cheng, C. Colombina, F. and Consuegra Rodriguez, S. Correia Silva, G. Danilov, V. De Silva, M. Didukh, L. Eckerlin, G. Eckstein, D. Eren, E. and Estevez Banos, L. I. Filatov, O. Gallo, E. Gao, J. and Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. Kasemann, M. and Kaveh, H. Kleinwort, C. Kruecker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Maekelae, T. Mankel, R. and Melzer-Pellmann, I. -A. Mendizabal Morentin, M. Metwally, J. and Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Perez Adan, D. Pitzl, D. Raspereza, A. Ribeiro Lopes, B. Ruebenach, J. Saggio, A. Saibel, A. Savitskyi, M. and Scham, M. Scheurer, V. Schnake, S. Schuetze, P. and Schwanenberger, C. Shchedrolosiev, M. Sosa Ricardo, R. E. and Stafford, D. Tonon, N. Van De Klundert, M. Walsh, R. and Walter, D. Wen, Y. Wichmann, K. Wiens, L. Wissing, C. and Wuchterl, S. Zlebcik, R. Aggleton, R. Albrecht, S. and Bein, S. Benato, L. Connor, P. De Leo, K. Eich, M. and Feindt, F. Froehlich, A. Garbers, C. Garutti, E. and Gunnellini, P. Hajheidari, M. Haller, J. Hinzmann, A. and Kasieczka, G. Klanner, R. Kogler, R. Kramer, T. Kutzner, V. Lange, J. Lange, T. Lobanov, A. Malara, A. and Nigamova, A. Pena Rodriguez, K. J. Rieger, O. Schleper, P. and Schroeder, M. Schwandt, J. Sonneveld, J. Stadie, H. and Steinbrueck, G. Tews, A. Zoi, I. Bechtel, J. Brommer, S. and Burkart, M. Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. and Faltermann, N. Giffels, M. Gosewisch, J. o. Gottmann, A. and Hartmann, F. Heidecker, C. Husemann, U. Keicher, P. and Koppenhoefer, R. Maier, S. Metzler, M. Mitra, S. and Mueller, Th. Neukum, M. Nuernberg, A. Quast, G. and Rabbertz, K. Rauser, J. Savoiu, D. Schnepf, M. Seith, D. and Shvetsov, I. Simonis, H. J. Ulrich, R. Van Der Linden, J. Von Cube, R. F. Wassmer, M. Weber, M. Wieland, S. and Wolf, R. Wozniewski, S. Wunsch, S. Anagnostou, G. and Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. and Stakia, A. Diamantopoulou, M. Karasavvas, D. Karathanasis, G. Kontaxakis, P. Koraka, C. K. Manousakis-Katsikakis, A. and Panagiotou, A. Papavergou, I. Saoulidou, N. Theofilatos, K. Tziaferi, E. Vellidis, K. Vourliotis, E. Bakas, G. and Kousouris, K. Papakrivopoulos, I. Tsipolitis, G. and Zacharopoulou, A. Adamidis, K. Bestintzanos, I. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. and Manthos, N. Papadopoulos, I. Strologas, J. Csanad, M. and Farkas, K. Gadallah, M. M. A. Lokos, S. Major, P. and Mandal, K. Mehta, A. Pasztor, G. Radl, A. J. Suranyi, O. and Veres, G. I. Bartok, M. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Veszpremi, V. Czellar, S. and Karancsi, J. Molnar, J. Szillasi, Z. Teyssier, D. Raics, P. Trocsanyi, Z. L. Ujvari, B. Csorgo, T. Nemes, F. and Novak, T. Choudhury, S. Komaragiri, J. R. Kumar, D. and Panwar, L. Tiwari, P. C. Bahinipati, S. Kar, C. Mal, P. and Mishra, T. Muraleedharan Nair Bindhu, V. K. Nayak, A. and Saha, P. Sur, N. Swain, S. K. Vats, D. Bansal, S. and Beri, S. B. Bhatnagar, V. Chaudhary, G. Chauhan, S. and Dhingra, N. Gupta, R. Kaur, A. Kaur, M. Kaur, S. and Kumari, P. Meena, M. Sandeep, K. Singh, J. B. Virdi, A. K. Ahmed, A. Bhardwaj, A. Choudhary, B. C. Gola, M. and Keshri, S. Kumar, A. Naimuddin, M. Priyanka, P. Ranjan, K. Shah, A. Bharti, M. Bhattacharya, R. Bhattacharya, S. and Bhowmik, D. Dutta, S. Dutta, S. Gomber, B. Maity, M. and Palit, P. Rout, P. K. Saha, G. Sahu, B. Sarkar, S. and Sharan, M. Singh, B. Thakur, S. Behera, P. K. and Behera, S. C. Kalbhor, P. Muhammad, A. Pradhan, R. and Pujahari, P. R. Sharma, A. Sikdar, A. K. Dutta, D. Jha, V. Kumar, V. Mishra, D. K. Naskar, K. Netrakanti, P. K. and Pant, L. M. Shukla, P. Aziz, T. Dugad, S. Kumar, M. and Banerjee, S. Chudasama, R. Guchait, M. Karmakar, S. and Kumar, S. Majumder, G. Mazumdar, K. Mukherjee, S. and Alpana, K. Dube, S. Kansal, B. Laha, A. Pandey, S. and Rane, A. Rastogi, A. Sharma, S. Bakhshiansohi, H. and Khazaie, E. Zeinali, M. Chenarani, S. Etesami, S. M. and Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. and Abbrescia, M. Aly, R. Aruta, C. Colaleo, A. Creanza, D. and De Filippis, N. De Palma, M. Di Florio, A. Di Pilato, A. and Elmetenawee, W. Fiore, L. Gelmi, A. Gul, M. Iaselli, G. Ince, M. Lezki, S. Maggi, G. Maggi, M. Margjeka, I. Mastrapasqua, V. My, S. Nuzzo, S. Pellecchia, A. and Pompili, A. Pugliese, G. Ramos, D. Ranieri, A. Selvaggi, G. Silvestris, L. Simone, F. M. Venditti, R. and Verwilligen, P. Abbiendi, G. Battilana, C. Bonacorsi, D. and Borgonovi, L. Brigliadori, L. Campanini, R. Capiluppi, P. and Castro, A. Cavallo, F. R. Cuffiani, M. Dallavalle, G. M. and Diotalevi, T. Fabbri, F. Fanfani, A. Giacomelli, P. and Giommi, L. Grandi, C. Guiducci, L. Lo Meo, S. Lunerti, L. Marcellini, S. Masetti, G. Navarria, F. L. Perrotta, A. Primavera, F. Rossi, A. M. Rovelli, T. Siroli, G. P. and Albergo, S. Costa, S. Di Mattia, A. Potenza, R. and Tricomi, A. Tuve, C. Barbagli, G. Cassese, A. and Ceccarelli, R. Ciulli, V. Civinini, C. D'Alessandro, R. and Focardi, E. Latino, G. Lenzi, P. Lizzo, M. Meschini, M. and Paoletti, S. Seidita, R. Sguazzoni, G. Viliani, L. and Benussi, L. Bianco, S. Piccolo, D. Bozzo, M. Ferro, F. and Mulargia, R. Robutti, E. Tosi, S. Benaglia, A. and Boldrini, G. Brivio, F. Cetorelli, F. De Guio, F. and Dinardo, M. E. Dini, P. Gennai, S. Ghezzi, A. Govoni, P. and Guzzi, L. Lucchini, M. T. Malberti, M. Malvezzi, S. and Massironi, A. Menasce, D. Moroni, L. Paganoni, M. and Pedrini, D. Pinolini, B. S. Ragazzi, S. Redaelli, N. and Tabarelli de Fatis, T. Valsecchi, D. Zuolo, D. Buontempo, S. and Carnevali, F. Cavallo, N. De Iorio, A. Fabozzi, F. and Iorio, A. O. M. Lista, L. Meola, S. Paolucci, P. Rossi, B. Sciacca, C. Azzi, P. Bacchetta, N. Bisello, D. and Bortignon, P. Bragagnolo, A. Carlin, R. Checchia, P. and Dorigo, T. Dosselli, U. Gasparini, F. Gasparini, U. and Grosso, G. Hoh, S. Y. Layer, L. Lusiani, E. Margoni, M. and Meneguzzo, A. T. Pazzini, J. Ronchese, P. Rossin, R. and Simonetto, F. Strong, G. Tosi, M. Yarar, H. Zanetti, M. and Zotto, P. Zucchetta, A. Zumerle, G. Aime, C. and Braghieri, A. Calzaferri, S. Fiorina, D. Montagna, P. and Ratti, S. P. Re, V. Riccardi, C. Salvini, P. Vai, I. and Vitulo, P. Asenov, P. Bilei, G. M. Ciangottini, D. Fano, L. Lariccia, P. Magherini, M. Mantovani, G. Mariani, V. and Menichelli, M. Moscatelli, F. Piccinelli, A. Presilla, M. Rossi, A. Santocchia, A. Spiga, D. Tedeschi, T. and Azzurri, P. Bagliesi, G. Bertacchi, V. Bianchini, L. and Boccali, T. Bossini, E. Castaldi, R. Ciocci, M. A. and D'Amante, V. Dell'Orso, R. Di Domenico, M. R. Donato, S. and Giassi, A. Ligabue, F. Manca, E. Mandorli, G. Matos Figueiredo, D. Messineo, A. Palla, F. Parolia, S. and Ramirez-Sanchez, G. Rizzi, A. Rolandi, G. Roy Chowdhury, S. and Scribano, A. Shafiei, N. Spagnolo, P. Tenchini, R. and Tonelli, G. Turini, N. Venturi, A. Verdini, P. G. and Barria, P. Campana, M. Cavallari, F. Del Re, D. Di Marco, E. Diemoz, M. Longo, E. Meridiani, P. Organtini, G. Pandolfi, F. Paramatti, R. Quaranta, C. Rahatlou, S. and Rovelli, C. Santanastasio, F. Soffi, L. Tramontano, R. and Amapane, N. Arcidiacono, R. Argiro, S. Arneodo, M. and Bartosik, N. Bellan, R. Bellora, A. Berenguer Antequera, J. and Biino, C. Cartiglia, N. Cometti, S. Costa, M. and Covarelli, R. Demaria, N. Kiani, B. Legger, F. Mariotti, C. Maselli, S. Migliore, E. Monteil, E. Monteno, M. and Obertino, M. M. Ortona, G. Pacher, L. Pastrone, N. and Pelliccioni, M. Pinna Angioni, G. L. Ruspa, M. Shchelina, K. and Siviero, F. Sola, V. Solano, A. Soldi, D. Staiano, A. Tornago, M. Trocino, D. Vagnerini, A. Belforte, S. and Candelise, V. Casarsa, M. Cossutti, F. Da Rold, A. and Della Ricca, G. Sorrentino, G. Vazzoler, F. Dogra, S. and Huh, C. Kim, B. Kim, D. H. Kim, G. N. Kim, J. Lee, J. Lee, S. W. Moon, C. S. Oh, Y. D. Pak, S. I. and Radburn-Smith, B. C. Sekmen, S. Yang, Y. C. Kim, H. and Moon, D. H. Francois, B. Kim, T. J. Park, J. Cho, S. and Choi, S. Go, Y. Hong, B. Lee, K. Lee, K. S. Lim, J. and Park, J. Park, S. K. Yoo, J. Goh, J. Gurtu, A. and Kim, H. S. Kim, Y. Almond, J. Bhyun, J. H. Choi, J. and Jeon, S. Kim, J. Kim, J. S. Ko, S. Kwon, H. Lee, H. and Lee, S. Oh, B. H. Oh, M. Oh, S. B. Seo, H. Yang, U. K. Yoon, I. Jang, W. Kang, D. Y. Kang, Y. Kim, S. and Ko, B. Lee, J. S. H. Lee, Y. Merlin, J. A. Park, I. C. Roh, Y. Ryu, M. S. Song, D. Watson, I. J. Yang, S. Ha, S. Yoo, H. D. Choi, M. Lee, H. Lee, Y. and Yu, I. Beyrouthy, T. Maghrbi, Y. Dreimanis, K. Veckalns, V. Ambrozas, M. Carvalho Antunes De Oliveira, A. and Juodagalvis, A. Rinkevicius, A. Tamulaitis, G. Bin Norjoharuddeen, N. Wan Abdullah, W. A. T. Yusli, M. N. and Zolkapli, Z. Benitez, J. F. Castaneda Hernandez, A. Leon Coello, M. Murillo Quijada, J. A. Sehrawat, A. Valencia Palomo, L. Ayala, G. Castilla-Valdez, H. De La Cruz-Burelo, E. Heredia-De La Cruz, I. Lopez-Fernandez, R. Mondragon Herrera, C. A. Perez Navarro, D. A. Sanchez Hernandez, A. and Carrillo Moreno, S. Oropeza Barrera, C. Vazquez Valencia, F. and Pedraza, I. Salazar Ibarguen, H. A. Uribe Estrada, C. and Mijuskovic, J. Raicevic, N. Krofcheck, D. Butler, P. H. and Ahmad, A. Asghar, M. I. 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Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

A measurement of the inclusive jet production in proton-proton collisions at the LHC at root s = 13TeV is presented. The double-differential cross sections are measured as a function of the jet transverse momentum p(T) and the absolute jet rapidity vertical bar y vertical bar. The anti- k(T) clustering algorithm is used with distance parameter of 0.4 (0.7) in a phase space region with jet p(T) from 97 GeV up to 3.1TeV and vertical bar y vertical bar < 2.0. Data collected with the CMS detector are used, corresponding to an integrated luminosity of 36.3 fb(-1) (33.5 fb(-1)). The measurement is used in a comprehensive QCD analysis at next-to-next-to-leading order, which results in significant improvement in the accuracy of the parton distributions in the proton. Simultaneously, the value of the strong coupling constant at the Z boson mass is extracted as alpha(S)(m(Z)) = 0.1170 +/- 0.0019. For the first time, these data are used in a standard model effective field theory analysis at next-to-leading order, where parton distributions and the QCD parameters are extracted simultaneously with imposed constraints on the Wilson coefficient c(1) of 4-quark contact interactions.

Published
2022

39. Search for flavor-changing neutral current interactions of the top quark and the Higgs boson decaying to a bottom quark-antiquark pair at root s=13 TeV

Author

Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Escalante Del Valle, A. Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Paulitsch, P. Pitters, F. M. and Schieck, J. Schoefbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C. -E. Chekhovsky, V. Litomin, A. and Makarenko, V. Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Rejeb Sfar, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Mueller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. and Kalsi, A. K. Lee, K. Mahdavikhorrami, M. Makarenko, I. and Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. and Vanlaer, P. Cornelis, T. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. Roskas, C. Samalan, A. and Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. and Benecke, A. Bethani, A. Bruno, G. Bury, F. Caputo, C. and David, P. Delaere, C. Donertas, I. S. Giammanco, A. and Jaffel, K. Jain, Sa. Lemaitre, V. Mondal, K. and Prisciandaro, J. Taliercio, A. Teklishyn, M. Tran, T. T. and Vischia, P. Wertz, S. Alves, G. A. Hensel, C. Moraes, A. and Rebello Teles, P. Alda Junior, W. L. Alves Gallo Pereira, M. and Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Mora Herrera, C. Mota Amarilo, K. Mundim, L. Nogima, H. Santoro, A. Silva Do Amaral, S. M. Sznajder, A. Thiel, M. Torres Da Silva De Araujo, F. Vilela Pereira, A. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. and Mercadante, P. G. Novaes, S. F. Padula, Sandra S. and Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. and Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. and Petrov, A. Cheng, T. Javaid, T. Mittal, M. Yuan, L. and Ahmad, M. Bauer, G. Dozen, C. Hu, Z. Martins, J. and Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. and Chen, M. Iemmi, F. Kapoor, A. Leggat, D. Liao, H. and Liu, Z. -A. Milosevic, V. Monti, F. Sharma, R. Tao, J. and Thomas-Wilsker, J. Wang, J. Zhang, H. Zhao, J. and Agapitos, A. An, Y. Ban, Y. Chen, C. Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Xiao, J. and Lu, M. You, Z. Gao, X. Okawa, H. Zhang, Y. Lin, Z. and Xiao, M. Avila, C. Cabrera, A. Florez, C. Fraga, J. and Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. Godinovic, N. Lelas, D. and Puljak, I. Antunovic, Z. Kovac, M. Sculac, T. and Brigljevic, V. Ferencek, D. Majumder, D. Roguljic, M. and Starodumov, A. Susa, T. Attikis, A. Christoforou, K. and Erodotou, E. Ioannou, A. Kole, G. Kolosova, M. and Konstantinou, S. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Rykaczewski, H. Saka, H. Finger, M. Finger, Jr., M. Kveton, A. Ayala, E. Carrera Jarrin, E. Ellithi Kamel, A. Khalil, S. Lotfy, A. Mahmoud, M. A. Bhowmik, S. Dewanjee, R. K. Ehataht, K. Kadastik, M. Nandan, S. and Nielsen, C. Pata, J. Raidal, M. Tani, L. Veelken, C. and Eerola, P. Forthomme, L. Kirschenmann, H. Osterberg, K. and Voutilainen, M. Bharthuar, S. Bruecken, E. Garcia, F. and Havukainen, J. Kim, M. S. Kinnunen, R. Lampen, T. and Lassila-Perini, K. Lehti, S. Linden, T. Lotti, M. and Martikainen, L. Myllymaki, M. Ott, J. Siikonen, H. and Tuominen, E. Tuominiemi, J. Luukka, P. Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. and Denegri, D. Faure, J. L. Ferri, F. Ganjour, S. Gras, P. Hamel de Monchenault, G. Jarry, P. Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. Sahin, M. O. and Savoy-Navarro, A. Titov, M. Yu, G. B. Ahuja, S. and Beaudette, F. Bonanomi, M. Buchot Perraguin, A. Busson, P. and Cappati, A. Charlot, C. Davignon, O. Diab, B. and Falmagne, G. Ghosh, S. Granier de Cassagnac, R. Hakimi, A. and Kucher, I. Motta, J. Nguyen, M. Ochando, C. and Paganini, P. Rembser, J. Salerno, R. Sarkar, U. Sauvan, J. B. Sirois, Y. Tarabini, A. Zabi, A. Zghiche, A. and Agram, J. -L. Andrea, J. Apparu, D. Bloch, D. Bourgatte, G. Brom, J. -M. Chabert, E. C. Collard, C. Darej, D. and Fontaine, J. -C. Goerlach, U. Grimault, C. Le Bihan, A. -C. and Nibigira, E. Van Hove, P. Asilar, E. Beauceron, S. and Bernet, C. Boudoul, G. Camen, C. Carle, A. Chanon, N. and Contardo, D. Depasse, P. El Mamouni, H. Fay, J. and Gascon, S. Gouzevitch, M. Ille, B. Laktineh, I. B. and Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. and Perries, S. Shchablo, K. Sordini, V. Torterotot, L. and Touquet, G. Vander Donckt, M. Viret, S. Khvedelidze, A. and Lomidze, I. Tsamalaidze, Z. Botta, V. Feld, L. Klein, K. and Lipinski, M. Meuser, D. Pauls, A. Roewrt, N. Schulz, J. Teroerde, M. Dodonova, A. Eliseev, D. Erdmann, M. and Fackeldey, P. Fischer, B. Ghosh, S. Hebbeker, T. and Hoepfner, K. Ivone, F. Mastrolorenzo, L. Merschmeyer, M. and Meyer, A. Mocellin, G. Mondal, S. Mukherjee, S. Noll, D. and Novak, A. Pook, T. Pozdnyakov, A. Rath, Y. Reithler, H. Roemer, J. Schmidt, A. Schuler, S. C. Sharma, A. and Vigilante, L. Wiedenbeck, S. Zaleski, S. Dziwok, C. and Fluegge, G. Haj Ahmad, W. Hlushchenko, O. Kress, T. and Nowack, A. Pistone, C. Pooth, O. Roy, D. Stahl, A. and Ziemons, T. Zotz, A. Aarup Petersen, H. Aldaya Martin, M. and Asmuss, P. Baxter, S. Bayatmakou, M. Behnke, O. and Bermudez Martinez, A. Bhattacharya, S. Bin Anuar, A. A. and Borras, K. Brunner, D. Campbell, A. Cardini, A. Cheng, C. Colombina, F. Consuegra Rodriguez, S. Correia Silva, G. and Danilov, V. De Silva, M. Didukh, L. Eckerlin, G. and Eckstein, D. Estevez Banos, L. I. Filatov, O. Gallo, E. and Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. Kasemann, M. and Kaveh, H. Kleinwort, C. Kogler, R. Kruecker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Mankel, R. and Melzer-Pellmann, I. -a. Mendizabal Morentin, M. Metwally, J. and Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Perez Adan, D. Pitzl, D. Raspereza, A. Ribeiro Lopes, B. Rubenach, J. Saggio, A. Saibel, A. Savitskyi, M. and Scham, M. Scheurer, V. Schnake, S. Schuetze, P. and Schwanenberger, C. Shchedrolosiev, M. Sosa Ricardo, R. E. and Stafford, D. Tonon, N. Van de Klundert, M. Walsh, R. and Walter, D. Wang, Q. Wen, Y. Wichmann, K. Wiens, L. and Wissing, C. Wuchterl, S. Aggleton, R. Albrecht, S. Bein, S. Benato, L. Connor, P. De Leo, K. Eich, M. Feindt, F. Froehlich, A. Garbers, C. Garutti, E. Gunnellini, P. and Hajheidari, M. Haller, J. Hinzmann, A. Kasieczka, G. and Klanner, R. Kramer, T. Kutzner, V. Lange, J. Lange, T. and Lobanov, A. Malara, A. Nigamova, A. Pena Rodriguez, K. J. Rieger, M. Rieger, O. Schleper, P. Schroder, M. and Schwandt, J. Sonneveld, J. Stadie, H. Steinbruck, G. and Tews, A. Zoi, I. Bechtel, J. Brommer, S. Burkart, M. and Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. Faltermann, N. Giffels, M. and Gosewisch, J. O. Gottmann, A. Hartmann, F. Heidecker, C. and Husemann, U. Keicher, P. Koppenhoefer, R. Maier, S. and Metzler, M. Mitra, S. Mueller, Th. Neukum, M. Nuernberg, A. Quast, G. Rabbertz, K. Rauser, J. Savoiu, D. and Schnepf, M. Seith, D. Shvetsov, I. Simonis, H. J. and Ulrich, R. Van der Linden, J. Von Cube, R. F. Wassmer, M. and Weber, M. Wieland, S. Wolf, R. Wozniewski, S. and Wunsch, S. Anagnostou, G. Daskalakis, G. Geralis, T. and Kyriakis, A. Loukas, D. Stakia, A. Diamantopoulou, M. and Karasavvas, D. Karathanasis, G. Kontaxakis, P. Koraka, C. K. and Manousakis-Katsikakis, A. Panagiotou, A. Papavergou, I. and Saoulidou, N. Theofilatos, K. Tziaferi, E. Vellidis, K. and Vourliotis, E. Bakas, G. Kousouris, K. Papakrivopoulos, I. and Tsipolitis, G. Zacharopoulou, A. Adamidis, K. and Bestintzanos, I. Evangelou, I. Foudas, C. Gianneios, P. and Katsoulis, P. Kokkas, P. Manthos, N. Papadopoulos, I. and Strologas, J. Csanad, M. Farkas, K. Gadallah, M. M. A. and Lokos, S. Major, P. Mandal, K. Mehta, A. Pasztor, G. and Radl, A. J. Suranyi, O. Veres, G. I. Bartok, M. Bencze, G. Hajdu, C. Horvath, D. Sikler, F. Veszpremi, V. and Czellar, S. Fasanella, D. Karancsi, J. Molnar, J. and Szillasi, Z. Teyssier, D. Raics, P. Trocsanyi, Z. L. and Ujvari, B. Csorgo, T. Nemes, F. Novak, T. Choudhury, S. and Komaragiri, J. R. Kumar, D. Panwar, L. Tiwari, P. C. and Bahinipati, S. Kar, C. Mal, P. Mishra, T. Muraleedharan Nair Bindhu, V. K. Nayak, A. Saha, P. Sur, N. Swain, S. K. Vats, D. Bansal, S. Beri, S. B. Bhatnagar, V. and Chaudhary, G. Chauhan, S. Dhingra, N. Gupta, R. Kaur, A. and Kaur, M. Kaur, S. Kumari, P. Meena, M. Sandeep, K. and Singh, J. B. Virdi, A. K. Ahmed, A. Bhardwaj, A. and Choudhary, B. C. Gola, M. Keshri, S. Kumar, A. and Naimuddin, M. Priyanka, P. Ranjan, K. Shah, A. Bharti, M. Bhattacharya, R. Bhattacharya, S. Bhowmik, D. Dutta, S. Dutta, S. Gomber, B. Maity, M. Palit, P. Rout, P. K. Saha, G. Sahu, B. Sarkar, S. Sharan, M. Singh, B. and Thakur, S. Behera, P. K. Behera, S. C. Kalbhor, P. and Muhammad, A. Pradhan, R. Pujahari, P. R. Sharma, A. and Sikdar, A. K. Dutta, D. Jha, V. Kumar, V. Mishra, D. K. and Naskar, K. Netrakanti, P. K. Pant, L. M. Shukla, P. and Aziz, T. Dugad, S. Kumar, M. Banerjee, S. Chudasama, R. and Guchait, M. Karmakar, S. Kumar, S. Majumder, G. and Mazumdar, K. Mukherjee, S. Alpana, K. Dube, S. Kansal, B. Laha, A. Pandey, S. Rane, A. Rastogi, A. Sharma, S. Bakhshiansohi, H. Khazaie, E. Zeinali, M. Chenarani, S. Etesami, S. M. Khakzad, M. Mohammadi Najafabadi, M. and Grunewald, M. Abbrescia, M. Aly, R. Aruta, C. Colaleo, A. Creanza, D. De Filippis, N. De Palma, M. Di Florio, A. Di Pilato, A. Elmetenawee, W. Fiore, L. Gelmi, A. and Gul, M. Iaselli, G. Ince, M. Lezki, S. Maggi, G. and Maggi, M. Margjeka, I. Mastrapasqua, V. My, S. Nuzzo, S. and Pellecchia, A. Pompili, A. Pugliese, G. Ramos, D. and Ranieri, A. Selvaggi, G. Silvestris, L. Simone, F. M. and Sozbilir, U. Venditti, R. Verwilligen, P. Abbiendi, G. and Battilana, C. Bonacorsi, D. Borgonovi, L. Brigliadori, L. and Campanini, R. Capiluppi, P. Castro, A. Cavallo, F. R. and Cuffiani, M. Dallavalle, G. M. Diotalevi, T. Fabbri, F. and Fanfani, A. Giacomelli, P. Giommi, L. Grandi, C. and Guiducci, L. Lo Meo, S. Lunerti, L. Marcellini, S. and Masetti, G. Navarria, F. L. Perrotta, A. Primavera, F. and Rossi, A. M. Rovelli, T. Siroli, G. P. Albergo, S. and Costa, S. Di Mattia, A. Potenza, R. Tricomi, A. Tuve, C. and Barbagli, G. Cassese, A. Ceccarelli, R. Ciulli, V. and Civinini, C. D'Alessandro, R. Focardi, E. Latino, G. and Lenzi, P. Lizzo, M. Meschini, M. Paoletti, S. Seidita, R. Sguazzoni, G. Viliani, L. Benussi, L. Bianco, S. and Piccolo, D. Bozzo, M. Ferro, F. Mulargia, R. Robutti, E. and Tosi, S. Benaglia, A. Boldrini, G. Brivio, F. and Cetorelli, F. De Guio, F. Dinardo, M. E. Dini, P. and Gennai, S. Ghezzi, A. Govoni, P. Guzzi, L. Lucchini, M. T. Malberti, M. Malvezzi, S. Massironi, A. Menasce, D. and Moroni, L. Paganoni, M. Pedrini, D. Pinolini, B. S. and Ragazzi, S. Redaelli, N. Tabarelli de Fatis, T. Valsecchi, D. Zuolo, D. Buontempo, S. Carnevali, F. Cavallo, N. and De Iorio, A. Fabozzi, F. Iorio, A. O. M. Lista, L. and Meola, S. Paolucci, P. Rossi, B. Sciacca, C. Azzi, P. and Bacchetta, N. Bisello, D. Bortignon, P. Bragagnolo, A. and Carlin, R. Checchia, P. Dorigo, T. Dosselli, U. and Gasparini, F. Gasparini, U. Grosso, G. Hoh, S. Y. Layer, L. Lusiani, E. Margoni, M. Meneguzzo, A. T. Pazzini, J. and Ronchese, P. Rossin, R. Simonetto, F. Strong, G. and Tosi, M. Yarar, H. Zanetti, M. Zotto, P. Zucchetta, A. and Zumerle, G. Aime', C. Braghieri, A. Calzaferri, S. and Fiorina, D. Montagna, P. Ratti, S. P. Re, V. Riccardi, C. Salvini, P. Vai, I. Vitulo, P. Asenov, P. Bilei, G. M. Ciangottini, D. Fano, L. Magherini, M. Mantovani, G. Mariani, V. Menichelli, M. Moscatelli, F. Piccinelli, A. Presilla, M. Rossi, A. Santocchia, A. Spiga, D. and Tedeschi, T. Azzurri, P. Bagliesi, G. Bertacchi, V. and Bianchini, L. Boccali, T. Bossini, E. Castaldi, R. and Ciocci, M. A. D'Amante, V. Dell'Orso, R. Di Domenico, M. R. and Donato, S. Giassi, A. Ligabue, F. Manca, E. and Mandorli, G. Matos Figueiredo, D. Messineo, A. Palla, F. and Parolia, S. Ramirez-Sanchez, G. Rizzi, A. Rolandi, G. and Roy Chowdhury, S. Scribano, A. Shafiei, N. Spagnolo, P. and Tenchini, R. Tonelli, G. Turini, N. Venturi, A. Verdini, P. G. Barria, P. Campana, M. Cavallari, F. Del Re, D. and Di Marco, E. Diemoz, M. Longo, E. Meridiani, P. and Organtini, G. Pandolfi, F. Paramatti, R. Quaranta, C. and Rahatlou, S. Rovelli, C. Santanastasio, F. Soffi, L. and Tramontano, R. Amapane, N. Arcidiacono, R. Argiro, S. and Arneodo, M. Bartosik, N. Bellan, R. Bellora, A. and Berenguer Antequera, J. Biino, C. Cartiglia, N. Cometti, S. and Costa, M. Covarelli, R. Demaria, N. Kiani, B. and Legger, F. Mariotti, C. Maselli, S. Migliore, E. and Monteil, E. Monteno, M. Obertino, M. M. Ortona, G. and Pacher, L. Pastrone, N. Pelliccioni, M. Pinna Angioni, G. L. and Ruspa, M. Shchelina, K. Siviero, F. Sola, V. Solano, A. Soldi, D. Staiano, A. Tornago, M. Trocino, D. and Vagnerini, A. Belforte, S. Candelise, V. Casarsa, M. and Cossutti, F. Da Rold, A. Della Ricca, G. Sorrentino, G. and Vazzoler, F. Dogra, S. Huh, C. Kim, B. Kim, D. H. and Kim, G. N. Kim, J. Lee, J. Lee, S. W. Moon, C. S. and Oh, Y. D. Pak, S. I. Radburn-Smith, B. C. Sekmen, S. and Yang, Y. C. Kim, H. Moon, D. H. Francois, B. Kim, T. J. and Park, J. Cho, S. Choi, S. Go, Y. Hong, B. Lee, K. Lee, K. S. Lim, J. Park, J. Park, S. K. Yoo, J. and Goh, J. Gurtu, A. Kim, H. S. Kim, Y. Almond, J. and Bhyun, J. H. Choi, J. Jeon, S. Kim, J. Kim, J. S. and Ko, S. Kwon, H. Lee, H. Lee, S. Oh, B. H. Oh, M. and Oh, S. B. Seo, H. Yang, U. K. Yoon, I. Jang, W. and Kang, D. Y. Kang, Y. Kim, S. Ko, B. Lee, J. S. H. and Lee, Y. Merlin, J. A. Park, I. C. Roh, Y. Ryu, M. S. and Song, D. Watson, I. J. Yang, S. Ha, S. Yoo, H. D. and Choi, M. Lee, H. Lee, Y. Yu, I. Beyrouthy, T. and Maghrbi, Y. Dreimanis, K. Veckalns, V. Ambrozas, M. and Carvalho Antunes De Oliveira, A. Juodagalvis, A. Rinkevicius, A. and Tamulaitis, G. Bin Norjoharuddeen, N. Wan Abdullah, W. A. T. and Yusli, M. N. Zolkapli, Z. Benitez, J. F. Castaneda Hernandez, A. Leon Coello, M. Murillo Quijada, J. A. and Sehrawat, A. Valencia Palomo, L. Ayala, G. Castilla-Valdez, H. De la Cruz-Burelo, E. Heredia-De la Cruz, I. and Lopez-Fernandez, R. Mondragon Herrera, C. A. Perez Navarro, D. A. Sanchez Hernandez, A. Carrillo Moreno, S. Oropeza Barrera, C. Vazquez Valencia, F. Pedraza, I. Salazar Ibarguen, H. A. Uribe Estrada, C. Mijuskovic, J. Raicevic, N. Krofcheck, D. Butler, P. H. Ahmad, A. Asghar, M. I. and Awais, A. Awan, M. I. M. Hoorani, H. R. Khan, W. A. and Shah, M. 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Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

A search for flavor-changing neutral current interactions of the top quark (t) and the Higgs boson (H) is presented. The search is based on a data sample corresponding to an integrated luminosity of 137 fb(-1) recorded by the CMS experiment at the LHC in proton-proton collisions at root s = 13TeV. Events containing exactly one lepton (muon or electron) and at least three jets, among which at least two are identified as originating from the hadronization of a bottom quark, are analyzed. A set of deep neural networks is used for kinematic event reconstruction, while boosted decision trees distinguish the signal from the background events. No significant excess over the background predictions is observed, and upper limits on the signal production cross sections are extracted. These limits are interpreted in terms of top quark decay branching fractions (B) to the Higgs boson and an up (u) or a charm quark (c). Assuming one nonvanishing extra coupling at a time, the observed (expected) upper limits at 95% confidence level are B(t -> Hu) < 0.079 (0.11)% and B(t -> Hc) < 0.094 (0.086)%.

Published
2022

40. Search for long-lived particles decaying to leptons with large impact parameter in proton-proton collisions at root s=13 TeV

Author

Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Del Valle, A. Escalante Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I Paulitsch, P. Pitters, F. M. and Schieck, J. Schofbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C-E Chekhovsky, V Litomin, A. and Makarenko, V Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Sfar, H. Rejeb Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. and Kalsi, A. K. Lee, K. Mahdavikhorrami, M. Makarenko, I and Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. and Vanlaer, P. Cornelis, T. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. Roskas, C. Samalan, A. and Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. and Benecke, A. Bethani, A. Bruno, G. Bury, F. Caputo, C. and David, P. Delaere, C. Donertas, I. S. Giammanco, A. and Jaffel, K. Jain, Sa Lemaitre, V Mondal, K. Prisciandaro, J. Taliercio, A. Teklishyn, M. Tran, T. T. Vischia, P. and Wertz, S. Alves, G. A. Hensel, C. Moraes, A. Alda Junior, W. L. Gallo Pereira, M. Alves Ferreira Filho, M. Barroso and Malbouisson, H. Brandao Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. Damiao, D. De Jesus De Souza, S. Fonseca Herrera, C. Mora Amarilo, K. Mota Mundim, L. Nogima, H. Teles, P. Rebello Santoro, A. Silva Do Amaral, S. M. Sznajder, A. Thiel, M. Da Silva De Araujo, F. Torres Pereira, A. Vilela Bernardes, C. A. Calligaris, L. and Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. and Mercadante, P. G. Novaes, S. F. Padula, Sandra S. and Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. and Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. and Petrov, A. Cheng, T. Javaid, T. Mittal, M. Yuan, L. and Ahmad, M. Bauer, G. Dozen, C. Hu, Z. Martins, J. and Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. and Chen, M. Iemmi, F. Kapoor, A. Leggat, D. Liao, H. and Liu, Z-A Milosevic, V Monti, F. Sharma, R. Tao, J. and Thomas-wilsker, J. Wang, J. Zhang, H. Zhao, J. Agapitos, A. An, Y. Ban, Y. Chen, C. Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Xiao, J. Lu, M. and You, Z. Gao, X. Okawa, H. Zhang, Y. Lin, Z. Xiao, M. and Avila, C. Cabrera, A. Florez, C. Fraga, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. Godinovic, N. Lelas, D. Puljak, I and Antunovic, Z. Kovac, M. Sculac, T. Brigljevic, V and Ferencek, D. Majumder, D. Roguljic, M. Starodumov, A. and Susa, T. Attikis, A. Christoforou, K. Erodotou, E. and Ioannou, A. Kole, G. Kolosova, M. Konstantinou, S. and Mousa, J. Nicolaou, C. Ptochos, F. Razis, P. A. and Rykaczewski, H. Saka, H. Finger, M. Finger Jr, M. Jr and Kveton, A. Ayala, E. Carrera Jarrin, E. Abdalla, H. and Assran, Y. Lotfy, A. Mahmoud, M. A. Bhowmik, S. and Dewanjee, R. K. Ehataht, K. Kadastik, M. Nandan, S. and Nielsen, C. Pata, J. Raidal, M. Tani, L. Veelken, C. and Eerola, P. Forthomme, L. Kirschenmann, H. Osterberg, K. and Voutilainen, M. Bharthuar, S. Brucken, E. Garcia, F. and Havukainen, J. Kim, M. S. Kinnunen, R. Lampen, T. and Lassila-Perini, K. Lehti, S. Linden, T. Lotti, M. and Martikainen, L. Myllymaki, M. Ott, J. Siikonen, H. and Tuominen, E. Tuominiemi, J. Luukka, P. Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. and Denegri, D. Faure, J. L. Ferri, F. Ganjour, S. Gras, P. de Monchenault, G. Hamel Jarry, P. Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. Sahin, M. O. and Savoy-Navarro, A. Titov, M. Yu, G. B. Ahuja, S. and Beaudette, F. Bonanomi, M. Perraguin, A. Buchot Busson, P. and Cappati, A. Charlot, C. Davignon, O. Diab, B. and Falmagne, G. Ghosh, S. de Cassagnac, R. Granier Hakimi, A. and Kucher, I Motta, J. Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sarkar, U. Sauvan, J. B. and Sirois, Y. Tarabini, A. Zabi, A. Zghiche, A. Agram, J-L and Andrea, J. Apparu, D. Bloch, D. Bourgatte, G. Brom, J-M Chabert, E. C. Collard, C. Darej, D. Fontaine, J-C and Goerlach, U. Grimault, C. Le Bihan, A-C Nibigira, E. and Van Hove, P. Asilar, E. Beauceron, S. Bernet, C. and Boudoul, G. Camen, C. Carle, A. Chanon, N. Contardo, D. and Depasse, P. El Mamouni, H. Fay, J. Gascon, S. and Gouzevitch, M. Ille, B. Laktineh, I. B. Lattaud, H. and Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. and Shchablo, K. Sordini, V Torterotot, L. Touquet, G. and Vander Donckt, M. Viret, S. Lomidze, I Toriashvili, T. and Tsamalaidze, Z. Botta, V Feld, L. Klein, K. Lipinski, M. and Meuser, D. Pauls, A. Roewert, N. Schulz, J. and Teroerde, M. Dodonova, A. Eliseev, D. Erdmann, M. and Fackeldey, P. Fischer, B. Hebbeker, T. Hoepfner, K. and Ivone, F. Mastrolorenzo, L. Merschmeyer, M. Meyer, A. and Mocellin, G. Mondal, S. Mukherjee, S. Noll, D. Novak, A. and Pook, T. Pozdnyakov, A. Rath, Y. Reithler, H. and Roemer, J. Schmidt, A. Schuler, S. C. Sharma, A. and Vigilante, L. Wiedenbeck, S. Zaleski, S. Dziwok, C. and Fluegge, G. Ahmad, W. Haj Hlushchenko, O. Kress, T. and Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. and Stahl, A. Ziemons, T. Zotz, A. Petersen, H. Aarup and Martin, M. Aldaya Asmuss, P. Baxter, S. Bayatmakou, M. and Behnke, O. Martinez, A. Bermudez Bhattacharya, S. Bin Anuar, A. A. Borras, K. Brunner, D. Campbell, A. Cardini, A. and Cheng, C. Colombina, F. Rodriguez, S. Consuegra Silva, G. Correia Danilov, V De Silva, M. Didukh, L. Eckerlin, G. Eckstein, D. Banos, L. I. Estevez Filatov, O. Gallo, E. Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. and Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. Kasemann, M. Kaveh, H. Kleinwort, C. Kogler, R. Kruecker, D. and Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Mankel, R. and Melzer-Pellmann, I-A Morentin, M. Mendizabal Metwally, J. and Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. and Otarid, Y. Adan, D. Perez Pitzl, D. Raspereza, A. Lopes, B. Ribeiro Ruebenach, J. Saggio, A. Saibel, A. and Savitskyi, M. Scham, M. Scheurer, V Schnake, S. and Schuetze, P. Schwanenberger, C. Shchedrolosiev, M. Ricardo, R. E. Sosa Stafford, D. Tonon, N. Van de Klundert, M. and Walsh, R. Walter, D. Wang, Q. Wen, Y. Wichmann, K. and Wiens, L. Wissing, C. Wuchterl, S. Aggleton, R. and Albrecht, S. Bein, S. Benato, L. Connor, P. De Leo, K. and Eich, M. Feindt, F. Froehlich, A. Garbers, C. and Garutti, E. Gunnellini, P. Hajheidari, M. Haller, J. and Hinzmann, A. Kasieczka, G. Klanner, R. Kramer, T. and Kutzner, V Lange, J. Lange, T. Lobanov, A. Malara, A. and Nigamova, A. Rodriguez, K. J. Pena Rieger, O. Schleper, P. Schroder, M. Schwandt, J. Sonneveld, J. Stadie, H. and Steinbrueck, G. Tews, A. Zoi, I Bechtel, J. Brommer, S. Burkart, M. Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. and Faltermann, N. Giffels, M. Gosewisch, J. O. Gottmann, A. and Hartmann, F. Heidecker, C. Husemann, U. Keicher, P. and Koppenhofer, R. Maier, S. Metzler, M. Mitra, S. Mueller, Th Neukum, M. Nuernberg, A. Quast, G. Rabbertz, K. and Rauser, J. Savoiu, D. Schnepf, M. Seith, D. Shvetsov, I and Simonis, H. J. Ulrich, R. Van der Linden, J. Von Cube, R. F. Wassmer, M. Weber, M. Wieland, S. Wolf, R. and Wozniewski, S. Wunsch, S. Anagnostou, G. Daskalakis, G. and Geralis, T. Kyriakis, A. Loukas, D. Stakia, A. and Diamantopoulou, M. Karasavvas, D. Karathanasis, G. and Kontaxakis, P. Koraka, C. K. Manousakis-Katsikakis, A. and Panagiotou, A. Papavergou, I Saoulidou, N. Theofilatos, K. and Tziaferi, E. Vellidis, K. Vourliotis, E. Bakas, G. and Kousouris, K. Papakrivopoulos, I Tsipolitis, G. and Zacharopoulou, A. Adamidis, K. Bestintzanos, I Evangelou, I and Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. and Manthos, N. Papadopoulos, I Strologas, J. Csanad, M. and Farkas, K. Gadallah, M. M. A. Lokos, S. Major, P. and Mandal, K. Mehta, A. Pasztor, G. Radl, A. J. Suranyi, O. and Veres, I, G. Bartok, M. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Veszpremi, V. Czellar, S. and Fasanella, D. Karancsi, J. Molnar, J. Szillasi, Z. and Teyssier, D. Raics, P. Trocsanyi, Z. L. Ujvari, B. and Csorgo, T. Nemes, F. Novak, T. Choudhury, S. Komaragiri, J. R. Kumar, D. Panwar, L. Tiwari, P. C. Bahinipati, S. and Kar, C. Mal, P. Mishra, T. Bindhu, V. K. Muraleedharan Nair Nayak, A. Saha, P. Sur, N. Swain, S. K. Vats, D. Bansal, S. Beri, S. B. Bhatnagar, V Chaudhary, G. and Chauhan, S. Dhingra, N. Gupta, R. Kaur, A. Kaur, M. and Kaur, S. Kumari, P. Meena, M. Sandeep, K. Singh, J. B. and Virdi, A. K. Ahmed, A. Bhardwaj, A. Choudhary, B. C. and Gola, M. Keshri, S. Kumar, A. Naimuddin, M. Priyanka, P. and Ranjan, K. Shah, A. Bharti, M. Bhattacharya, R. and Bhowmik, D. Dutta, S. Gomber, B. Maity, M. Palit, P. and Rout, P. K. Saha, G. Sahu, B. Sarkar, S. Sharan, M. and Singh, B. Thakur, S. Behera, P. K. Behera, S. C. and Kalbhor, P. Muhammad, A. Pradhan, R. Pujahari, P. R. and Sikdar, A. K. Dutta, D. Jha, V Kumar, V Mishra, D. K. and Naskar, K. Netrakanti, P. K. Pant, L. M. Shukla, P. and Aziz, T. Dugad, S. Kumar, M. Banerjee, S. Chudasama, R. and Guchait, M. Karmakar, S. Kumar, S. Majumder, G. and Mazumdar, K. Alpana, K. Dube, S. Kansal, B. Laha, A. and Pandey, S. Rane, A. Rastogi, A. Sharma, S. and Bakhshiansohi, H. Khazaie, E. Zeinali, M. Chenarani, S. and Etesami, S. M. Khakzad, M. Najafabadi, M. Mohammadi and Grunewald, M. Abbrescia, M. Aly, R. Aruta, C. Colaleo, A. Creanza, D. De Filippis, N. De Palma, M. Di Florio, A. Di Pilato, A. Elmetenawee, W. Fiore, L. Gelmi, A. and Gul, M. Iaselli, G. Ince, M. Lezki, S. Maggi, G. and Maggi, M. Margjeka, I Mastrapasqua, V My, S. Nuzzo, S. and Pellecchia, A. Pompili, A. Pugliese, G. Ramos, D. and Ranieri, A. Selvaggi, G. Silvestris, L. Simone, F. M. and Venditti, R. Verwilligen, P. Abbiendi, G. Battilana, C. and Bonacorsi, D. Borgonovi, L. Brigliadori, L. Campanini, R. and Capiluppi, P. Castro, A. Cavallo, F. R. Cuffiani, M. and Dallavalle, G. M. Diotalevi, T. Fabbri, F. Fanfani, A. and Giacomelli, P. Giommi, L. Grandi, C. Guiducci, L. Lo Meo, S. Lunerti, L. Marcellini, S. Masetti, G. Navarria, F. L. Perrotta, A. Primavera, F. Rossi, A. M. Rovelli, T. Siroli, G. P. Albergo, S. Costa, S. Di Mattia, A. and Potenza, R. Tricomi, A. Tuve, C. Barbagli, G. Cassese, A. Ceccarelli, R. Ciulli, V Civinini, C. D'Alessandro, R. Focardi, E. Latino, G. Lenzi, P. Lizzo, M. and Meschini, M. Paoletti, S. Seidita, R. Sguazzoni, G. and Viliani, L. Benussi, L. Bianco, S. Piccolo, D. Bozzo, M. and Ferro, F. Mulargia, R. Robutti, E. Tosi, S. and Benaglia, A. Boldrini, G. Brivio, F. Cetorelli, F. De Guio, F. Dinardo, M. E. Dini, P. Gennai, S. Ghezzi, A. and Govoni, P. Guzzi, L. Lucchini, M. T. Malberti, M. and Malvezzi, S. Massironi, A. Menasce, D. Moroni, L. and Paganoni, M. Pedrini, D. Pinolini, B. S. Ragazzi, S. and Redaelli, N. de Fatis, T. Tabarelli Valsecchi, D. Zuolo, D. and Buontempo, S. Carnevali, F. Cavallo, N. De Iorio, A. and Fabozzi, F. Iorio, A. O. M. Lista, L. Meola, S. and Paolucci, P. Rossi, B. Sciacca, C. Azzi, P. Bacchetta, N. Bisello, D. Bortignon, P. Bragagnolo, A. Carlin, R. and Checchia, P. Dorigo, T. Dosselli, U. Gasparini, F. and Gasparini, U. Grosso, G. Hoh, S. Y. Layer, L. Lusiani, E. Margoni, M. Meneguzzo, A. T. Pazzini, J. Ronchese, P. and Rossin, R. Simonetto, F. Strong, G. Tosi, M. Yarar, H. Zanetti, M. Zotto, P. Zucchetta, A. Zumerle, G. and Aime, C. Braghieri, A. Calzaferri, S. Fiorina, D. and Montagna, P. Ratti, S. P. Re, V Riccardi, C. Salvini, P. and Vai, I Vitulo, P. Asenov, P. Bilei, G. M. and Ciangottini, D. Fano, L. Lariccia, P. Magherini, M. and Mantovani, G. Mariani, V Menichelli, M. Moscatelli, F. and Piccinelli, A. Presilla, M. Rossi, A. Santocchia, A. and Spiga, D. Tedeschi, T. Azzurri, P. Bagliesi, G. and Bertacchi, V Bianchini, L. Boccali, T. Bossini, E. and Castaldi, R. Ciocci, M. A. D'Amante, V Dell'Orso, R. Di Domenico, M. R. Donato, S. Giassi, A. Ligabue, F. Manca, E. Mandorli, G. Figueiredo, D. Matos Messineo, A. Palla, F. Parolia, S. Ramirez-Sanchez, G. Rizzi, A. Rolandi, G. and Chowdhury, S. Roy Scribano, A. Shafiei, N. Spagnolo, P. and Tenchini, R. Tonelli, G. Turini, N. Venturi, A. and Verdini, P. G. Barria, P. Campana, M. Cavallari, F. Del Re, D. Di Marco, E. Diemoz, M. Longo, E. Meridiani, P. and Organtini, G. Pandolfi, F. Paramatti, R. Quaranta, C. and Rahatlou, S. Rovelli, C. Santanastasio, F. Soffi, L. and Tramontano, R. Amapane, N. Arcidiacono, R. Argiro, S. and Arneodo, M. Bartosik, N. Bellan, R. Bellora, A. and Antequera, J. Berenguer Biino, C. Cartiglia, N. Cometti, S. and Costa, M. Covarelli, R. Demaria, N. Kiani, B. and Legger, F. Mariotti, C. Maselli, S. Migliore, E. and Monteil, E. Monteno, M. Obertino, M. M. Ortona, G. and Pacher, L. Pastrone, N. Pelliccioni, M. Angioni, G. L. Pinna and Ruspa, M. Shchelina, K. Siviero, F. Sola, V Solano, A. Soldi, D. Staiano, A. Tornago, M. Trocino, D. and Vagnerini, A. Belforte, S. Candelise, V Casarsa, M. and Cossutti, F. Da Rold, A. Della Ricca, G. Sorrentino, G. and Vazzoler, F. Dogra, S. Huh, C. Kim, B. Kim, D. H. and Kim, G. N. Kim, J. Lee, J. Lee, S. W. Moon, C. S. and Oh, Y. D. Pak, I, S. Radburn-Smith, B. C. Sekmen, S. and Yang, Y. C. Kim, H. Moon, D. H. Francois, B. Kim, T. J. and Park, J. Cho, S. Choi, S. Go, Y. Hong, B. Lee, K. S. Lim, J. Park, S. K. Yoo, J. Goh, J. Gurtu, A. and Kim, H. S. Kim, Y. Almond, J. Bhyun, J. H. Choi, J. and Jeon, S. Kim, J. S. Ko, S. Kwon, H. Lee, H. Lee, S. Oh, B. H. Oh, M. Oh, S. B. Seo, H. Yang, U. K. and Yoon, I Jang, W. Kang, D. Y. Kang, Y. Kim, S. and Ko, B. Lee, J. S. H. Lee, Y. Merlin, J. A. Park, I. C. and Roh, Y. Ryu, M. S. Song, D. Watson, I. J. Yang, S. and Ha, S. Yoo, H. D. Choi, M. Yu, I Beyrouthy, T. and Maghrbi, Y. Dreimanis, K. Veckalns, V. Ambrozas, M. De Oliveira, A. Carvalho Antunes Juodagalvis, A. Rinkevicius, A. and Tamulaitis, G. Bin Norjoharuddeen, N. Abdullah, W. A. T. Wan and Yusli, M. N. Zolkapli, Z. Benitez, J. F. Castaneda Hernandez, A. Leon Coello, M. Murillo Quijada, J. A. and Sehrawat, A. Valencia Palomo, L. Ayala, G. Castilla-Valdez, H. De la Cruz-Burelo, E. Heredia-De la Cruz, I and Lopez-Fernandez, R. Mondragon Herrera, C. A. Perez Navarro, D. A. Sanchez-Hernandez, A. Carrillo Moreno, S. Oropeza Barrera, C. Vazquez Valencia, F. Pedraza, I Salazar Ibarguen, H. A. Uribe Estrada, C. Mijuskovic, J. Raicevic, N. Krofcheck, D. Butler, P. H. Ahmad, A. Asghar, I, M. and Awais, A. Awan, M. I. M. Hoorani, H. R. Khan, W. A. and Shah, M. A. Shoaib, M. Waqas, M. Avati, V Grzanka, L. and Malawski, M. Bialkowska, H. Bluj, M. Boimska, B. and Gorski, M. Kazana, M. Szleper, M. Zalewski, P. and Bunkowski, K. Doroba, K. Kalinowski, A. Konecki, M. and Krolikowski, J. Araujo, M. Bargassa, P. Bastos, D. and Boletti, A. Faccioli, P. Gallinaro, M. Hollar, J. and Leonardo, N. Niknejad, T. Pisano, M. Seixas, J. and Toldaiev, O. Varela, J. Afanasiev, S. Budkouski, D. and Golutvin, I Gorbunov, I Karjavine, V Korenkov, V Lanev, A. Malakhov, A. Matveev, V Palichik, V Perelygin, V and Savina, M. Seitova, D. Shalaev, V Shmatov, S. Shulha, S. and Smirnov, V Teryaev, O. Voytishin, N. Yuldashev, B. S. and Zarubin, A. Zhizhin, I Gavrilov, G. Golovtcov, V and Ivanov, Y. Kim, V Kuznetsova, E. Murzin, V Oreshkin, V and Smirnov, I Sosnov, D. Sulimov, V Uvarov, L. Volkov, S. Vorobyev, A. Andreev, Yu Dermenev, A. Gninenko, S. and Golubev, N. Karneyeu, A. Kirpichnikov, D. Kirsanov, M. and Krasnikov, N. Pashenkov, A. Pivovarov, G. Toropin, A. and Epshteyn, V Gavrilov, V Lychkovskaya, N. Nikitenko, A. and Popov, V Stepennov, A. Toms, M. Vlasov, E. Zhokin, A. Aushev, T. Bychkova, O. Chistov, R. Danilov, M. and Oskin, A. Parygin, P. 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A. and Bloom, K. Bryson, M. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. Joo, C. Kravchenko, I Musich, M. Reed, I and Siado, J. E. Snow, G. R. Tabb, W. Yan, F. and Zecchinelli, A. G. Agarwal, G. Bandyopadhyay, H. Hay, L. and Iashvili, I. Kharchilava, A. McLean, C. Nguyen, D. and Pekkanen, J. Rappoccio, S. Williams, A. Alverson, G. and Barberis, E. Haddad, Y. Hortiangtham, A. Li, J. Madigan, G. Marzocchi, B. Morse, D. M. Nguyen, V Orimoto, T. and Parker, A. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. and Wang, B. Wisecarver, A. Wood, D. Bueghly, J. Chen, Z. Gilbert, A. Gunter, T. Hahn, K. A. Liu, Y. Odell, N. Schmitt, M. H. Velasco, M. Band, R. Bucci, R. and Cremonesi, M. Das, A. Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Hurtado Jessop, C. Lannon, K. Lawrence, J. and Loukas, N. Lutton, D. Marinelli, N. Mcalister, I and McCauley, T. Mcgrady, C. Mohrman, K. Moore, C. Musienko, Y. Ruchti, R. Siddireddy, P. Townsend, A. Wayne, M. and Wightman, A. Zarucki, M. Zygala, L. Bylsma, B. 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Chiarito, B. and Chou, J. P. Gandrakota, A. Gershtein, Y. Halkiadakis, E. and Hart, A. Heindl, M. Karacheban, O. Laflotte, I Lath, A. and Montalvo, R. Nash, K. Osherson, M. Salur, S. and Schnetzer, S. Somalwar, S. Stone, R. Thayil, S. A. and Thomas, S. Wang, H. Acharya, H. Delannoy, A. G. and Fiorendi, S. Spanier, S. Bouhali, O. Dalchenko, M. and Delgado, A. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. and Luo, S. Malhotra, S. Mueller, R. Overton, D. and Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. Hegde, V Kunori, S. Lamichhane, K. Mengke, T. Muthumuni, S. and Peltola, T. Volobouev, I Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. and Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Arenton, M. W. Cox, B. Cummings, G. Hakala, J. Hirosky, R. and Joyce, M. Ledovskoy, A. Li, A. Neu, C. Lara, C. E. Perez and Tannenwald, B. White, S. Wolfe, E. Poudyal, N. and Black, K. Bose, T. Caillol, C. Dasu, S. De Bruyn, I and Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. and Herve, A. Hussain, U. Lanaro, A. Loeliger, A. and Loveless, R. Sreekala, J. Madhusudanan Mallampalli, A. and Mohammadi, A. Pinna, D. Savin, A. Shang, V Smith, W. H. and Teague, D. Trembath-Reichert, S. Vetens, W. CMS Collaboration

Subjects
High Energy Physics::Experiment
Abstract

A search for new long-lived particles decaying to leptons using proton-proton collision data produced by the CERN LHC at root s = 13 TeV is presented. Events are selected with two leptons (an electron and a muon, two electrons, or two muons) that both have transverse impact parameter values between 0.01 and 10 cm and are not required to form a common vertex. Data used for the analysis were collected with the CMS detector in 2016, 2017, and 2018, and correspond to an integrated luminosity of 118 (113) fb(-1) in the ee channel (e mu and mu mu channels). The search is designed to be sensitive to a wide range of models with displaced e mu ee, and mu mu final states. The results constrain several well-motivated models involving new long-lived particles that decay to displaced leptons. For some areas of the available phase space, these are the most stringent constraints to date.

Published
2022

42. Origin of theater-headed valleys in the Valles Marineris region, Mars

Author

P. Singh, R. Sarkar, and Alok Porwal

Subjects
Canyon, geography, geography.geographical_feature_category, Plateau, Fluvial, Astronomy and Astrophysics, Mass wasting, Pit crater, Graben, Space and Planetary Science, Ejecta, Geomorphology, Geology, Tharsis
Abstract

This paper reports high-resolution observations of theater-headed valleys in the Valles Marineris region and proposes an integrated model of their formation and localization across the walls of the canyons of Valles Marineris. These theater-headed valleys have formed over a long period of time from Middle-Hesperian to Early-Amazonian. The valleys show several common features, namely, proximity to areas of high ejecta mobility on the Tharsis plateau; alignment along the major tectonic features such as wrinkle ridges, grabens, pit crater chains; association with fluvial channels and layered deposits on the plateau adjacent to the valley heads; and occurrences of mass wasting features at the valley mouths. Elevation profiles of the walls of Valles Marineris display ramp and cliff topography indicating mechanical stratification in the wall rocks. These observations reveal multiple controls over the formation and localization of theater-headed valleys in Valles Marineris. However, the major controls appear to be strong-over-weak stratigraphy in the canyon walls and the pre-existing zones of structural weakness in the Valles Marineris region. The source of water could likely be groundwater; however, snowmelt accumulated on the upper parts of the wallrock would additionally facilitate the process. Based on the above observations, we propose a sequence of events for the evolution of theater-headed valleys in the Valles Marineris region.

Published
2021
Full Text
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43. A Rare Incidence of Sweating Sickness-Like Symptoms in a Crossbred Holstein Friesian Cow in Chattogram, Bangladesh

Author

Faruq, Omar, R. Sarkar, Eti, and Sikder, Suchandan

Abstract

In this report, an incidence of sweating sickness-like symptoms in a crossbred Holstein Friesian cow was diagnosed. The cow was suffering from vaporization of the skin, dehydration, wet hair coat, and matting of hair due to excessive sweating. There were several ticks, flies, and mosquitoes in tail switch and other parts of the body. Blood and urine parameters were tested. We treated the patient successfully with ivermectin as ectoparasite control, ceftiofur sodium antibiotic to treat bacterial infections, ketoprofen as analgesics and antipyretics, chlorpheniramine maleate as H2-blocker, and trichlorfon and povidone-iodine skin spray to prevent fly invasion and prevent opportunistic bacterial infection, respectively. Acyclovir and oil of turpentine were suggested to be sprayed on the floor and wall of the shed for viral and ectoparasitic control. Our treatment regime successfully recovered the cow with no recurrence.

Published
2023
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44. Analysing the impact of legal and procedural frameworks on the socio-cultural and political dynamics of extrajudicial killings and forced disappearances.

Author

Dempsey N, Sarkar R, and Bassed R

Abstract

The remains of unlawfully killed individuals can provide evidence concerning human rights violations. The intricate challenges of extrajudicial killings and forced disappearances can complicate legal and procedural processes. These cases often present indicators of suspicious circumstances, necessitating specialised investigative approaches to ascertain the circumstance and cause of death as well as potential human rights violations. This review explores the legal and procedural dimensions of handling the remains of individuals who have been unlawfully killed, critically examining the implementation of legal instruments and their impact on the socio-cultural and political landscape regarding cases of extrajudicial killings and forced disappearances. This study utilised a Python-based web scraper, with an HTML parsing library to aggregate articles on three themes of 1) International law, humanitarian law and laws protecting human remains 2), protection of human remains in cases of extrajudicial killings and forced disappearances and 3), Considerations of socio-cultural, psychosocial factors in the protection of human remains and institutional failures. The programming-based method for locating articles is innovative, and the search covered both English and Spanish languages. This review establishes the tension between psychosocial/cultural requirements and legal practice, and describes community mechanisms such as social services, mental health support for affected families, and citizen initiatives. By emphasising the gap between legal standards and practical execution, the study highlights the need to refine legal guidance and strengthen procedural compliance to uphold the dignity of the deceased and ensure accountability for violations of the right to life., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article., (Copyright © 2024. Published by Elsevier B.V.)

Published
2024
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45. A simple method to overcome paraproteinemic interferences in chemistry and immunoassays.

Author

Sarkar R

Subjects
Humans, Immunoassay methods, Multiple Myeloma diagnosis, Multiple Myeloma blood, Paraproteins analysis, Male, Bilirubin blood, Blood Chemical Analysis methods, Thyroxine blood, Middle Aged, Female, Paraproteinemias diagnosis, Paraproteinemias blood
Abstract

Background: Interferences on chemistry and immunoassay results due to paraproteinemia may lead to erroneous diagnoses and treatment. Such interferences are difficult to recognize and even more difficult to deal with. This report describes 1 such case where multiple measurands were affected and how the interferant was overcome., Case Report: Paraproteins present in an immunoglobulin (Ig)G-lambda multiple myeloma specimen interfered with results of total bilirubin, direct bilirubin, inorganic phosphate, iron, ferritin, and total thyroxine measured on 3 platforms: AU5800, Alinity ci, and cobas pure. Repeat testing upon dilution with normal saline or deproteinization by polyethylene glycol precipitation gave unsatisfactory results on some or all the affected measurands. Repeat testing after dilution of the interferant serum with a healthy serum corrected the anomalous results for all the affected measurands., Conclusion: Dilution of paraproteinemic serum with a healthy serum of known concentrations appears to be the most suitable method to negate the effects of paraproteinemic interferences., (© The Author(s) 2024. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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46. Regulation of macrophage fibrinolysis during venous thrombus resolution.

Author

Johnson TA, Mukhopadhyay S, Buzza MS, Brooks JA, Sarkar R, and Antalis TM

Subjects
Animals, Mice, Plasminogen Activator Inhibitor 1 metabolism, Urokinase-Type Plasminogen Activator metabolism, Mice, Inbred C57BL, Male, Mice, Knockout, Humans, Fibrinolysis, Venous Thrombosis pathology, Venous Thrombosis metabolism, Macrophages metabolism, Plasminogen Activator Inhibitor 2 metabolism
Abstract

Background: Venous thromboembolism (VTE), which includes pulmonary embolism (PE) and deep vein thrombosis (DVT), is a serious cardiovascular disease with significant mortality and morbidity. Clinically, patients with faster resolution of a venous thrombi have improved prognosis. Urokinase-plasminogen activator (uPA), produced by macrophages, is a key mediator of fibrinolysis required for resolving venous thrombi and restoring vascular integrity. The major macrophage protein, plasminogen activator inhibitor type-2 (PAI-2), was originally identified as an inhibitor of uPA and is implicated in the modulation of pathways affecting fibrinolytic uPA activity, however its direct role in blocking uPA-mediated clot lysis is not known., Objective: To determine the contribution of macrophage PAI-2 in inhibiting uPA-mediated fibrinolysis during resolution of DVT., Methods: Using a murine model of venous thrombosis and resolution, we determined histological changes and molecular features of fibrin degradation in venous thrombi from WT mice and mice genetically deficient in PAI-2 and PAI-1, and determined the fibrinolytic activities of macrophages from these genotypes ex vivo., Results: Acceleration of venous thrombus resolution by PAI-2 -/- mice increases fibrin degradation in venous thrombi showing a pattern similar to genetic deficiency of PAI-1, the major attenuator of fibrinolysis. PAI-2 deficiency was not associated with increased macrophage infiltration into thrombi or changes in macrophage PAI-1 expression. uPA-initiated fibrinolysis by macrophages in vitro could be accelerated by PAI-1 deficiency, but not PAI-2 deficiency., Conclusion: PAI-2 has an alternate anti-fibrinolytic activity that is macrophage uPA independent, where PAI-1 is the dominant uPA inhibitor during DVT resolution., Competing Interests: Declaration of competing interest There are no competing interests to disclose., (Published by Elsevier Ltd.)

Published
2024
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47. Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy.

Author

Bercz A, Park BK, Pappou E, Nemirovsky D, Sarkar R, Yamner M, Omer D, Verheij FS, Alvarez J, Atri P, Reyngold M, Yaeger R, Wei IH, Wu A, Raj N, Widmar M, Hajj C, Kim MJ, Rao D, Nash GM, Williams V, Shia J, Segal NH, Diaz L, Ganesh K, Weiser MR, Gollub MJ, Paty PB, Horvat N, Zinovoy M, Roth O'Brien D, Sanchez-Vega F, Saltz LB, Crane CH, Cercek A, Gonen M, Garcia-Aguilar J, Smith JJ, and Romesser PB

Subjects
Humans, Female, Male, Middle Aged, Aged, Adult, COVID-19, Adenocarcinoma therapy, Adenocarcinoma pathology, Organ Sparing Treatments methods, Disease-Free Survival, Retrospective Studies, Neoplasm Recurrence, Local pathology, Watchful Waiting, Neoadjuvant Therapy methods, Rectal Neoplasms therapy, Rectal Neoplasms pathology, Rectal Neoplasms radiotherapy, Rectal Neoplasms mortality, Chemoradiotherapy methods
Abstract

Background: Potential differences in organ preservation between total neoadjuvant therapy (TNT) regimens integrating long-course chemoradiotherapy (LCCRT) and short-course radiotherapy (SCRT) in rectal cancer remain undefined., Patients and Methods: This natural experiment arose from a policy change in response to the COVID-19 pandemic during which our institution switched from uniformly treating patients with LCCRT to mandating that all patients be treated with SCRT. Our study includes 323 locally advanced rectal adenocarcinoma patients treated with LCCRT-based or SCRT-based TNT from January 2018 to January 2021. Patients who achieved clinical complete response were offered organ preservation with watch-and-wait (WW) management. The primary outcome was 2-year organ preservation. Additional outcomes included local regrowth, distant recurrence, disease-free survival (DFS), and overall survival (OS)., Results: Patient and tumor characteristics were similar between LCCRT (n = 247) and SCRT (n = 76) cohorts. Median follow-up was 31 months. Similar clinical complete response rates were observed following LCCRT and SCRT (44.5% versus 43.4%). Two-year organ preservation was 40% [95% confidence interval (CI) 34% to 46%] and 31% (95% CI 22% to 44%) among all patients treated with LCCRT and SCRT, respectively. In patients managed with WW, LCCRT resulted in higher 2-year organ preservation (89% LCCRT, 95% CI 83% to 95% versus 70% SCRT, 95% CI 55% to 90%; P = 0.005) and lower 2-year local regrowth (19% LCCRT, 95% CI 11% to 26% versus 36% SCRT, 95% CI 16% to 52%; P = 0.072) compared with SCRT. The 2-year distant recurrence (10% versus 6%), DFS (90% versus 90%), and OS (99% versus 100%) were similar between WW patients treated with LCCRT and SCRT, respectively., Conclusions: While WW eligibility was similar between cohorts, WW patients treated with LCCRT had higher 2-year organ preservation and lower local regrowth than those treated with SCRT, yet similar DFS and OS. These data support induction LCCRT followed by consolidation chemotherapy as the preferred TNT regimen for patients with locally advanced rectal cancer pursuing organ preservation., (Copyright © 2024 European Society for Medical Oncology. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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49. Multiscale Materials Engineering via Self-Assembly of Pentapeptide Derivatives from SARS CoV E Protein.

Author

Sarkar D, Khan AH, Polepalli S, Sarkar R, Das PK, Dutta S, Sahoo N, and Bhunia A

Subjects
Oligopeptides chemistry, Coronavirus Envelope Proteins chemistry, Amino Acid Sequence, Protein Structure, Secondary, Hydrogels chemistry
Abstract

Short peptide-based supramolecular hydrogels hold enormous potential for a wide range of applications. However, the gelation of these systems is very challenging to control. Minor changes in the peptide sequence can significantly influence the self-assembly mechanism and thereby the gelation propensity. The involvement of SARS CoV E protein in the assembly and release of the virus suggests that it may have inherent self-assembling properties that can contribute to the development of hydrogels. Here, three pentapeptide sequences derived from C-terminal of SARS CoV E protein are explored with same amino acid residues but different sequence distributions and discovered a drastic difference in the gelation propensity. By combining spectroscopic and microscopic techniques, the relationship between peptide sequence arrangement and molecular assembly structure are demonstrated, and how these influence the mechanical properties of the hydrogel. The present study expands the variety of secondary structures for generating supramolecular hydrogels by introducing the 3 10 -helix as the primary building block for gelation, facilitated by a water-mediated structural transition into β-sheet conformation. Moreover, these Fmoc-modified pentapeptide hydrogels/supramolecular assemblies with tunable morphology and mechanical properties are suitable for tissue engineering, injectable delivery, and 3D bio-printing applications., (© 2024 Wiley‐VCH GmbH.)

Published
2024
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50. Real-World Evidence of Crizanlizumab Showing Reductions in Vaso-Occlusive Crises and Opioid Usage in Sickle Cell Disease.

Author

DeBonnett L, Joshi V, Silva-Pinto AC, Colombatti R, Pasanisi A, Arcioni F, Cançado RD, Sarp S, Sarkar R, and Soliman W

Abstract

Objective: Access to crizanlizumab, a disease-modifying therapy for sickle cell disease (SCD), was provided through a managed access program (MAP, NCT03720626). The present analysis evaluated the impact of 12 months of crizanlizumab treatment on vaso-occlusive crises (VOCs), and on the use of opioids for VOC-related pain relief, in patients with SCD from the MAP., Methods: From June 2018 to January 2023, 112 patients with a history of recurrent VOCs completed 12 months of crizanlizumab (5 mg/kg) treatment and were monitored for adverse events (AEs)., Results: Crizanlizumab led to reductions of 18.0% and 36.2% in the proportions of patients having ≥ 1 home- and ≥ 1 healthcare-managed VOCs. Median absolute changes (interquartile range) from baseline in the rates of home- and healthcare-managed VOCs were -3.0 (-6.0, -1.0) and -2.0 (-4.0, 0), respectively. Data stratified by genotype and prior hydroxyurea use showed similar reductions in VOC rates. A 35.5% reduction in the proportion of patients requiring opioids was noted. AEs were consistent with earlier reports, and no new safety concerns were identified., Conclusions: Crizanlizumab demonstrated potential benefits in attenuating VOC episodes, irrespective of SCD genotype and prior hydroxyurea use, and in lowering opioid usage. The safety of crizanlizumab was consistent with earlier reports., Trial Registration: The MAP has been registered at ClinicalTrials.gov with the ID, NCT03720626., (© 2024 Novartis and The Author(s). European Journal of Haematology published by John Wiley & Sons Ltd.)

Published
2024
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