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Simulation of Super Cyclonic Storm (SuCS) Amphan (2020) has been carried out as a case study to analyze the sensitivity of Initial Condition (IC) and Horizontal Resolution (HR) on the intensity, track, and landfall predictions of the Tropical Cyclones (TCs). The results suggest that the IC and HR have a significant impact on TC simulations. Diminishing the HR in simulation results in a comparatively higher severity of the system. The simulation with a reduced lead time and a comparatively smaller HR has forecasted the Minimum Central Pressure (MCP) distribution reasonably well. In comparison to the observations, the reduced lead time model run with higher resolution has forecasted the Maximum Sustained Wind Speed (MSWS) distribution precisely. According to the statistical analysis, the continual reduction of lead time in simulation with the HR of 27 km has simulated better track and landfall positions than other resolutions. Thus, the combination of reduced lead time and higher resolution in simulation may be considered for the proper track and landfall forecasting. Dhaka Univ. J. Sci. 69(3): 202-211, 2022 (June)

Background: The clinical features are nonspecific, vary by community, and can be difficult to distinguish clinically from other febrile illnesses. Objective: The purpose of this study was to present the socio-demographic factors and clinical features of enteric fever in children. Methodology: This hospital-based cross-sectional study was conducted at the Department of Pediatrics in Evercare Hospital, Dhaka, Bangladesh from January 2014 to July 2018. It included 260 hospitalized children aged 2 months to 15 years with either positive blood culture (Salmonella typhi or paratyphi) or fourfold titre in Widal test. Results: Majority were under 5 with Female to male ratio of 1:0.9. About 65% household purified water by both boiling and filter; 32.7% children took outside food. Above 94% children did not receive typhoid vaccine while 90% parents lack knowledge about the vaccination. Highest prevalence of enteric fever recorded in the month of May- October. The commonest symptoms were fever, diarrhea, abdominal pain and anorexia; coated tongue and hepatomegaly were prominent signs. Conclusion: Enteric fever mostly affects under-5 children and lacks specific symptoms and signs with peak prevalence in May to October. Bangladesh Journal of Infectious Diseases December 2021;8(2):75-81

An attempt has been carried out to assess the efficacy of the Weather Research and Forecasting (WRF) model in predicting the genesis and intensification events of Very Severe Cyclonic Storm (VSCS) Fani (26 April – 04 May 2019) over the Bay of Bengal (BoB). WRF model has been conducted on a single domain of 10 km horizontal resolution using the Global Data Assimilation System (GDAS) FNL (final) data (0.250 × 0.250). According to the model simulated outcome analysis, the model is capable of predicting the Minimum Sea Level Pressure (MSLP) and Maximum Sustainable Wind Speed (MSWS) pattern reasonably well, despite some deviations. The model has forecasted the Lowest Central Pressure (LCP) of 919 hPa and the MSWS of 70 ms-1 based on 0000 UTC of 26 April. Except for the model run based on 0000 UTC of 26 April, the simulated values of LCP are relatively higher than the observations. According to the statistical analysis, MSLP and MSWS at 850 hPa level demonstrate a significantly greater influence on Tropical Cyclone (TC) formation and intensification process than any other parameters. The model can predict the intensity features well enough, despite some uncertainty regarding the proper lead time of the model run. Reduced lead time model run, particularly 24 to 48 hr, can be chosen to forecast the genesis and intensification events of TC with minimum uncertainty. Journal of Engineering Science 12(3), 2021, 85-100

Inotropic agents are generally recommended to use in patients with acute decompensated heart failure (HF) with reduced ejection fraction (HFrEF) concurrent to end-organ dysfunction. However, due to certain pharmacological limitations like developing life threatening arrhythmia and tolerance, cannot be employed as much as needed. Meanwhile, Calcium ion (Ca

Objetive: Cardiac ischemia related myocardial damage has been considered as a major reason of heart failure. We aimed to investigate the role of levosimendan (LEVO) in comparison to ramipril and sacubitril/valsartan (Sac/Val) in preventing the damage associated to isoproterenol (ISO) induced myocardial infarction. Method: Myocardial infarction was induced by injecting subcutaneous isoproterenol (5 mg/kg once for 7 consecutive days) to establish experimental heart failure model. Simultaneously, LEVO (1 mg/kg/day), ramipril (3mg/kg/day) and Sac/Val (68 mg/kg/day) suspension were administered orally for four weeks. Results: We observed a significant correlation between ISO induced ischemia with cardiac remodeling and alterations in myocardial architecture. LEVO, ramipril, and Sac/Val significantly prevented lipid peroxidation, damage of antioxidant enzymes like superoxide dismutase, catalase, glutathione and thioredoxin reductase. We also observed their ameliorative effects in cardiac hypertrophy of myocardium evidenced by reduced heart weight to body weight ratio and transforming growth factor β related collagen deposition. LEVO, ramipril, and Sac/Val also maintained cardiac biomarkers like lactate dehydrogenase, creatine kinase-MB, brain natriuretic peptide and cardiac Troponin-I indicating reduced myocardial damage that further demonstrated by histopathological examination. Decreased sarcoplasmic endoplasmic reticulum Ca2+ATPase2a and sodium-calcium exchanger-1 protein depletion after LEVO, ramipril, and Sac/Val adminisreration indicated improved Ca2+ homeostasis during myocardial contractility. Conclusion: Our findings suggest that LEVO have comparable effects to ramipril, and Sac/Val in preventing myocardial damage via balancing oxidant-antioxidant system, decreased collagen deposition, reduced myocardial stress as well as improved Ca2+ homeostasis during myocardial contractility.