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Your search keyword '"Pursell, Zachary F"' showing total 17 results
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17 results on '"Pursell, Zachary F"'

2. RNA-mediated double-strand break repair by end-joining mechanisms.

Author

Jeon, Youngkyu, Lu, Yilin, Ferrari, Margherita Maria, Channagiri, Tejasvi, Xu, Penghao, Meers, Chance, Zhang, Yiqi, Balachander, Sathya, Park, Vivian S., Marsili, Stefania, Pursell, Zachary F., Jonoska, Nataša, and Storici, Francesca

Subjects
HOMOLOGOUS recombination, DNA synthesis, RNA, DNA, GENOMES, DNA repair, DOUBLE-strand DNA breaks
Abstract

Double-strand breaks (DSBs) in DNA are challenging to repair. Cells employ at least three DSB-repair mechanisms, with a preference for non-homologous end joining (NHEJ) over homologous recombination (HR) and microhomology-mediated end joining (MMEJ). While most eukaryotic DNA is transcribed into RNA, providing complementary genetic information, much remains unknown about the direct impact of RNA on DSB-repair outcomes and its role in DSB-repair via end joining. Here, we show that both sense and antisense-transcript RNAs impact DSB repair in a sequence-specific manner in wild-type human and yeast cells. Depending on its sequence complementarity with the broken DNA ends, a transcript RNA can promote repair of a DSB or a double-strand gap in its DNA gene via NHEJ or MMEJ, independently from DNA synthesis. The results demonstrate a role of transcript RNA in directing the way DSBs are repaired in DNA, suggesting that RNA may directly modulate genome stability and evolution. Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequence-specific manner, suggesting a direct role for RNA in modulating genome stability and evolution. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome

Author

Xu, Penghao, primary, Yang, Taehwan, additional, Kundnani, Deepali L, additional, Sun, Mo, additional, Marsili, Stefania, additional, Gombolay, Alli L, additional, Jeon, Youngkyu, additional, Newnam, Gary, additional, Balachander, Sathya, additional, Bazzani, Veronica, additional, Baccarani, Umberto, additional, Park, Vivian S, additional, Tao, Sijia, additional, Lori, Adriana, additional, Schinazi, Raymond F, additional, Kim, Baek, additional, Pursell, Zachary F, additional, Tell, Gianluca, additional, Vascotto, Carlo, additional, and Storici, Francesca, additional

Published
2023
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6. Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.

Author

Xu, Penghao, Yang, Taehwan, Kundnani, Deepali L, Sun, Mo, Marsili, Stefania, Gombolay, Alli L, Jeon, Youngkyu, Newnam, Gary, Balachander, Sathya, Bazzani, Veronica, Baccarani, Umberto, Park, Vivian S, Tao, Sijia, Lori, Adriana, Schinazi, Raymond F, Kim, Baek, Pursell, Zachary F, Tell, Gianluca, Vascotto, Carlo, and Storici, Francesca

Published
2024
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8. Data from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

Author

Galati, Melissa A., primary, Hodel, Karl P., primary, Gams, Miki S., primary, Sudhaman, Sumedha, primary, Bridge, Taylor, primary, Zahurancik, Walter J., primary, Ungerleider, Nathan A., primary, Park, Vivian S., primary, Ercan, Ayse B., primary, Joksimovic, Lazar, primary, Siddiqui, Iram, primary, Siddaway, Robert, primary, Edwards, Melissa, primary, de Borja, Richard, primary, Elshaer, Dana, primary, Chung, Jiil, primary, Forster, Victoria J., primary, Nunes, Nuno M., primary, Aronson, Melyssa, primary, Wang, Xia, primary, Ramdas, Jagadeesh, primary, Seeley, Andrea, primary, Sarosiek, Tomasz, primary, Dunn, Gavin P., primary, Byrd, Jonathan N., primary, Mordechai, Oz, primary, Durno, Carol, primary, Martin, Alberto, primary, Shlien, Adam, primary, Bouffet, Eric, primary, Suo, Zucai, primary, Jackson, James G., primary, Hawkins, Cynthia E., primary, Guidos, Cynthia J., primary, Pursell, Zachary F., primary, and Tabori, Uri, primary

Published
2023
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9. Supplementary Table S3 from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

Author

Galati, Melissa A., primary, Hodel, Karl P., primary, Gams, Miki S., primary, Sudhaman, Sumedha, primary, Bridge, Taylor, primary, Zahurancik, Walter J., primary, Ungerleider, Nathan A., primary, Park, Vivian S., primary, Ercan, Ayse B., primary, Joksimovic, Lazar, primary, Siddiqui, Iram, primary, Siddaway, Robert, primary, Edwards, Melissa, primary, de Borja, Richard, primary, Elshaer, Dana, primary, Chung, Jiil, primary, Forster, Victoria J., primary, Nunes, Nuno M., primary, Aronson, Melyssa, primary, Wang, Xia, primary, Ramdas, Jagadeesh, primary, Seeley, Andrea, primary, Sarosiek, Tomasz, primary, Dunn, Gavin P., primary, Byrd, Jonathan N., primary, Mordechai, Oz, primary, Durno, Carol, primary, Martin, Alberto, primary, Shlien, Adam, primary, Bouffet, Eric, primary, Suo, Zucai, primary, Jackson, James G., primary, Hawkins, Cynthia E., primary, Guidos, Cynthia J., primary, Pursell, Zachary F., primary, and Tabori, Uri, primary

Published
2023
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10. Supplementary Data Figures 1-8 from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

Author

Galati, Melissa A., primary, Hodel, Karl P., primary, Gams, Miki S., primary, Sudhaman, Sumedha, primary, Bridge, Taylor, primary, Zahurancik, Walter J., primary, Ungerleider, Nathan A., primary, Park, Vivian S., primary, Ercan, Ayse B., primary, Joksimovic, Lazar, primary, Siddiqui, Iram, primary, Siddaway, Robert, primary, Edwards, Melissa, primary, de Borja, Richard, primary, Elshaer, Dana, primary, Chung, Jiil, primary, Forster, Victoria J., primary, Nunes, Nuno M., primary, Aronson, Melyssa, primary, Wang, Xia, primary, Ramdas, Jagadeesh, primary, Seeley, Andrea, primary, Sarosiek, Tomasz, primary, Dunn, Gavin P., primary, Byrd, Jonathan N., primary, Mordechai, Oz, primary, Durno, Carol, primary, Martin, Alberto, primary, Shlien, Adam, primary, Bouffet, Eric, primary, Suo, Zucai, primary, Jackson, James G., primary, Hawkins, Cynthia E., primary, Guidos, Cynthia J., primary, Pursell, Zachary F., primary, and Tabori, Uri, primary

Published
2023
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11. Supplementary Data from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

Author

Galati, Melissa A., primary, Hodel, Karl P., primary, Gams, Miki S., primary, Sudhaman, Sumedha, primary, Bridge, Taylor, primary, Zahurancik, Walter J., primary, Ungerleider, Nathan A., primary, Park, Vivian S., primary, Ercan, Ayse B., primary, Joksimovic, Lazar, primary, Siddiqui, Iram, primary, Siddaway, Robert, primary, Edwards, Melissa, primary, de Borja, Richard, primary, Elshaer, Dana, primary, Chung, Jiil, primary, Forster, Victoria J., primary, Nunes, Nuno M., primary, Aronson, Melyssa, primary, Wang, Xia, primary, Ramdas, Jagadeesh, primary, Seeley, Andrea, primary, Sarosiek, Tomasz, primary, Dunn, Gavin P., primary, Byrd, Jonathan N., primary, Mordechai, Oz, primary, Durno, Carol, primary, Martin, Alberto, primary, Shlien, Adam, primary, Bouffet, Eric, primary, Suo, Zucai, primary, Jackson, James G., primary, Hawkins, Cynthia E., primary, Guidos, Cynthia J., primary, Pursell, Zachary F., primary, and Tabori, Uri, primary

Published
2023
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12. RNA-mediated double-strand break repair in human cells

Author

Jeon, Youngkyu, primary, Ferrari, Margherita Maria, additional, Channagiri, Tejasvi, additional, Xu, Penghao, additional, Balachander, Sathya, additional, Park, Vivian S., additional, Marsili, Stefania, additional, Pursell, Zachary F., additional, Jonoska, Nataša, additional, and Storici, Francesca, additional

Published
2022
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