28 results on '"Prendergast N"'
Search Results
2. Biomarkers of Inflammation in Critically Ill Patients According to Data-derived Delirium Subtype Versus Persistent Coma Versus Never Delirious
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Onyemekwu, C.A., primary, Potter, K.M., additional, Prendergast, N., additional, Reznik, M., additional, Kennedy, J.N., additional, Mart, M.F., additional, Pandharipande, P., additional, Ely, E.W., additional, Seymour, C.W., additional, and Girard, T.D., additional
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- 2024
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3. Circulating Glucagon-Like Peptide 1 Predicts Mortality in Critically Ill Patients With Acute Respiratory Failure
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Hansell, C., primary, Kitsios, G.D., additional, Bain, W., additional, Zhao, Y., additional, Suber, T.L., additional, Evankovich, J., additional, Morris, A., additional, Ray, P., additional, Ray, A., additional, Prendergast, N., additional, Hensley, M.K., additional, Petro, N., additional, Patel, J.J., additional, Nouraie, S.M., additional, Dela Cruz, C.S., additional, Mcverry, B.J., additional, Zhang, Y., additional, and Shah, F.A., additional
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- 2024
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4. Distribution of Data-Driven Delirium Subtypes Within Prior Knowledge-based Delirium Phenotypes
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Potter, K., primary, Kennedy, J.N., additional, Onyemekwu, C.A., additional, Prendergast, N., additional, Pandharipande, P., additional, Ely, E.W., additional, Seymour, C.W., additional, and Girard, T.D., additional
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- 2023
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5. Validation of a Predictive Tool for Sedative-associated Delirium During Respiratory Failure
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Prendergast, N., primary, Onyemekwu, C.A., additional, Potter, K.M., additional, Ely, E.W., additional, Pandharipande, P., additional, and Girard, T.D., additional
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- 2023
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6. Associations Between Substance Use Disorders and Sedative Exposure During Acute Respiratory Failure
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Tiberio, P., primary, Kennedy, J.N., additional, Moghbeli, K., additional, Prendergast, N., additional, Onyemekwu, C.A., additional, Potter, K., additional, Roy, P., additional, Mcverry, B.J., additional, and Girard, T.D., additional
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- 2023
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7. Intrapulmonary Administration of Recombinant Activated Factor VII in a Patient With Diffuse Alveolar Hemorrhage and Microscopic Polyangiitis
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Naiditch, H., primary, Allbright, K.O., additional, Prendergast, N., additional, and Maximous, S., additional
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- 2023
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8. Outcomes Among Data-Driven Delirium Subtypes During Critical Illness
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Potter, K., primary, Kennedy, J.N., additional, Onyemekwu, C.A., additional, Prendergast, N., additional, Pandharipande, P.P., additional, Ely, E.W., additional, Seymour, C.W., additional, and Girard, T.D., additional
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- 2023
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9. Novel Sampling Methodology to Identify Metabolites Associated With Delirium in a Sepsis Cohort
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Onyemekwu, C.A., primary, Tan, X., additional, Potter, K., additional, Prendergast, N., additional, Mullet, S., additional, Wendell, S.L., additional, Toney, N., additional, Gu, X., additional, Billings, F., additional, Gamboa, J., additional, Hulgan, T., additional, Samuels, D., additional, Gong, T., additional, and Girard, T.D., additional
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- 2023
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10. 146 Exploring the Impact of Leave and Return to Work Policies on Workplace Lactation for Women in Emergency Medicine
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Prendergast, N., primary, Sebok-Syer, S., additional, and Moulton, K., additional
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- 2022
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11. Specificity and Sensitivity of ICD Codes for Alcohol and Substance Use in ICU Patients
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Tiberio, P., primary, Kennedy, J.N., additional, Holton, J., additional, Prendergast, N., additional, Onyemekwu, C., additional, Potter, K., additional, Roy, P., additional, Mcverry, B.J., additional, and Girard, T.D., additional
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- 2022
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12. Associations Between Plasma Cell-Free Mitochondrial DNA, Delirium and Coma During Sepsis
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Onyemekwu, C.A., primary, Tan, X., additional, Gamboa, J., additional, Moghbeli, K., additional, Potter, K., additional, Prendergast, N., additional, Tiberio, P., additional, Billings, F., additional, Ely, E.W., additional, Hulgan, T., additional, Pandharipande, P., additional, Samuels, D., additional, Tang, G., additional, and Girard, T.D., additional
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- 2022
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13. Multiple Statistical Approaches to a Clinical Prediction Rule for Sedative-Associated Delirium During Acute Respiratory Failure
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Prendergast, N., primary, Tiberio, P.J., additional, Onyemekwu, C.A., additional, Potter, K.M., additional, Nouriae, S.M., additional, Rengel, K.F., additional, Boncyk, C., additional, Ely, E.W., additional, Pandharipande, P.P., additional, and Girard, T.D., additional
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- 2022
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14. Imposter Syndrome: A Reflective Discourse into the Experiences of Canadian Black Nurses through Art.
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Prendergast N and Obewu OAT
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Impostor syndrome is a common phenomenon experienced by individuals when entering new ranks in the workplace. Although women experience greater feelings of imposter syndrome than men, Black individuals report a prolonged experience of imposter syndrome when compared to their white counterparts, which negatively impacts their everyday experiences, health, and overall well-being. With growing studies showing the pervasive nature of anti-Black racism on the health of Black people, there remains a paucity of studies showing the connection between anti-Black racism and imposter syndrome. Within nursing, anti-Black racism can be seen to foster imposter syndrome through discriminatory practices that affect the career development, recruitment, and retention of Black nurses. Anti-Black racism is prevalent, and, in this paper, two Black nurses share insight through their own encounters with imposter syndrome and its relationship with anti-Black racism. Guided by Black feminist thought, they use art to navigate their reflective discourse as a means of reclaiming their identity and positionality as leaders in their rights. Reflective discourse is ideal for transformative learning to occur through dialogue. In addition, it promotes the use of art for deeper discussions when understanding the Black experience. Together, these nurses explicate how adopting Afrocentric knowledge and practices through their reflective discourse can affirm their identity, promote a sense of belonging, and assist in dismantling the effects of anti-Black racism and imposter syndrome within nursing., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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15. 'Ain't I a Nurse', implementing a digital illustration of resistance when challenging anti-Black racism in nursing education.
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Prendergast N
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- Humans, Canada, COVID-19, Students, Nursing psychology, Racism psychology, Education, Nursing methods
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Since the COVID-19 pandemic, ongoing reports have highlighted the urgency of addressing anti-Black racism within Canada's healthcare system. The paucity of research within a Canadian context has created growing concerns among Millennials and Generation Zs for healthcare to address growing health disparities and health inequities that are attributed to institutional and structural racism. Recognizing the paradigm shift that has occurred because of the pandemic and the sleuth of racial killings, the nursing classroom has witnessed a change and a need for nursing education to be relevant for the cohort of nursing students who are seeking answers. The scarcity of nursing literature addressing diverse forms of learning demonstrates the need for nursing education to explore new ways of being diverse, inclusive and innovative when teaching intergenerationally. In this paper, the author challenges nurse educators to revisit the student-educator relationship by introducing critical digital pedagogy to dismantle anti-Black racism and promote student-educator engagement for transformative learning to occur. As an educator, the author implements the use of digital illustration as a tool of resistance for students and educators to assess, engage, act and reflect on creating change within nursing education. Using Black feminist thought and culturally responsive learning, the author introduces an arts-based approach through the innovative design of an illustration, titled, 'Ain't I a Nurse. Combining historical stories with contemporary socio-political experiences, the author demonstrates how students and educators can enter a cognitive learning experience where they can connect mentally and emotionally, and in so doing re-envision and recreate a new world that centralizes equity, diversity and inclusivity through critical discourses. Through the illustration anti-Black racism is challenged and anti-Black racism resistance is discovered as an antidote in dismantling anti-Black racism within nursing education., (© 2024 The Author(s). Nursing Philosophy published by John Wiley & Sons Ltd.)
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- 2024
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16. Challenging anti-racism in nursing education: A moral and professional call to action.
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Boakye PN, Prendergast N, and Bailey A
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- Humans, Students, Nursing psychology, Morals, Antiracism, Racism prevention & control, Curriculum trends, Education, Nursing methods
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The call to implement anti-racism pedagogy in nursing education and practice is reverberating globally. Racist ideologies are foundational to systems of health inequity. An antiracist approach is critical to dismantling systemic racism and promoting optimal health outcomes in the quest for health equity. Therefore, employing an anti-racist pedagogy within nursing education that allows students and teachers to reflect on their roles in dismantling racist structures and transforming equity outcomes in practice and society, is a moral undertaking. However, for nursing education to make significant inroads in health equity, it cannot be guided by the same Eurocentric motives and value systems that continue to shape health inequities. We must transcend the boundaries of Eurocentric knowledge construction to intentionally shift how nurses think and practice within systems of inequities. Alongside the pressing and growing call for radical transformation of students and teachers through anti-racist pedagogy, we also provide directions to teaching strategies that support the uptake of anti-racism in nursing curricula and classroom engagement., Competing Interests: Declaration of competing interest We have no potential conflict of interest to declare related to the publication of this manuscript and I confirm as the corresponding author that this manuscript has been read and approved by all authors., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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17. Alleviating stressfeeding in the emergency department: Elucidating the tensions induced by workplace lactation space issues.
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Moulton KL, Izuno SA, Prendergast N, Battaglioli N, and Sebok-Syer SS
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Objectives: Women remain underrepresented in the emergency medicine (EM) workforce, academic EM, and institutional leadership. In order to support women physicians in EM, we must explore factors that contribute to attrition and workplace satisfaction. For example, tensions between workplace and familial roles are important to consider as women navigate careers in EM. The logistics and stressors of workplace lactation pose a particular challenge during an already stressful time for a new mother returning to work in a busy emergency department (ED), but limited empirical data exist regarding this experience. We aimed to explore the stressors associated with workplace lactation spaces in order to better inform the creation of lactation spaces for individuals working in EDs., Methods: Our team used an exploratory qualitative design to investigate lactation-specific stressors and understand their relationship to individuals' needs when lactating in EM workplace environments. A total of 40 individuals were interviewed, highlighting post-pregnancy return-to-work (RTW) experiences of medical students, residents, advanced practice professionals, nurses, fellows, and faculty. Interviews were coded and analyzed using thematic analysis., Results: We identified both tangible and intangible characteristics of lactation spaces that contribute to stress for lactating individuals. Additionally, we discovered that participants frequently noted a desire to work simultaneously while pumping in order to feel they were self-actualizing in their dual roles of parent and clinician. Among tangible items, access to a computer within lactation space was a key driver of ability to fulfill dual roles. Among intangible characteristics, we identified three distinct, yet interrelated, subthemes, including the need for lactation spaces to be respectful of individuals' time, privacy, and general health and well-being., Conclusions: This study suggests that meeting basic lactation needs with thoughtfully designed lactation spaces can empower individuals in their roles both as a lactating parent and a clinician. EM leadership can evaluate existing lactation spaces to ensure they meet the tangible and intangible needs of lactating physicians, trainees, advanced practice professionals, and nurses., Competing Interests: The authors declare no conflicts of interest., (© 2024 The Author(s). Journal of the American College of Emergency Physicians Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.)
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- 2024
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18. "There is nothing to protect us from dying": Black women's perceived sense of safety accessing pregnancy and intrapartum care.
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Boakye PN and Prendergast N
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- Humans, Female, Pregnancy, Adult, Canada, Black People psychology, Health Services Accessibility standards, Perception, Maternal Health Services standards, Qualitative Research
- Abstract
Pregnancy and childbirth have become a dangerous journey for Black women as harrowing stories of death and near-death experiences resonate within Black communities. While the causes of pregnancy-related morbidity and mortality are well documented, little is known about how Black Canadian women feel protected from undesirable maternal health outcomes when accessing and receiving pregnancy and intrapartum care. This critical qualitative inquiry sheds light on Black women's perceived sense of safety in accessing pregnancy and intrapartum care. Twenty-four in-depth interviews were conducted with Black women who were pregnant or had given birth. Five interconnected themes were generated through thematic analysis: (1) There is a lot of prejudice towards us, (2) We are treated as sick bodies, (3) There is a lot of stereotypes towards us, (4) Our care is lacking in quality, and (5) We feel unsafe in the healthcare system. These themes highlight the perils faced by Black women accessing pregnancy and intrapartum care. The right to safe motherhood and equitable care for Black women should be a national priority in Canada to avert a looming crisis., (© 2024 The Authors. Nursing Inquiry published by John Wiley & Sons Ltd.)
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- 2024
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19. "Treat Me Like a Person": Unveiling Healthcare Narratives of Muslim Women who Wear Islamic Head Coverings Through a Poststructural Narrative Study.
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Rahman R, Lapum J, and Prendergast N
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Background: In Canada, the healthcare experiences and needs of Muslim women who wear Islamic head coverings are conflated with the larger Muslim community who do not wear Islamic head coverings. Understanding their specific and unique preferences and challenges is essential for tailoring care and improving healthcare encounters., Purpose: The study purpose is to explore the healthcare encounters of Muslim women wearing Islamic head coverings in Canada, focusing on how discourse influences their narratives., Methods: A postructuralist narrative methodology was used to understand how power, knowledge, language, and discourse impacted their experiences. Semi-structured interviews were conducted with eight Muslim women. Narrative analysis was used to dissect stories and the way these stories were told., Results: Five themes were identified, including: The Fingerprint: Highlights the importance of recognizing individual identities to provide personalized care.The Membrane: Examines how societal biases and assumptions permeate healthcare professionals and impacts care.The Heartbeat: Reveals the immediate emotional and physical responses that reflect systemic challenges within healthcare encounters.Unseen: Emphasizes the lack of acknowledgement experienced by Muslim women related to their healthcare preferences and/or needs.Heard: Encompasses instances where Muslim women feel recognized by their healthcare provider; contrasts Theme #4., Conclusion: This research emphasizes the diverse experiences of Muslim woman who wear an Islamic head covering and the need for healthcare professionals to move away from a one-size-fits-all approach and instead, provide care that respects the unique preferences amongst this diverse group., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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20. Anti-Racist Approach to Pulse Oximetry: A Nurse Educator's Guide.
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Lapum JL, Prendergast N, and Istanboulian L
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- Humans, Students, Nursing psychology, Education, Nursing methods, Faculty, Nursing psychology, Oximetry, Nursing Education Research, Racism prevention & control
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Competing Interests: The authors declare no conflicts of interest.
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- 2024
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21. Anti-Black Medical Gaslighting in Healthcare: Experiences of Black Women in Canada.
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Boakye PN, Prendergast N, Bailey A, Sharon M, Bandari B, Odutayo AA, and Anane Brown E
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Background: Stereotype about Black people contribute to nurses and healthcare providers gaslighting and dismissing of their health concerns. Despite the popularity of the term medical gaslighting in mainstream literature, few studies have explored the experiences of Black women during pregnancy and childbirth., Purpose: This paper aims to provide an in-depth insight into Black women's experiences of anti-Black medical gaslighting when accessing care during pregnancy and childbirth., Methods: Utilizing qualitative methods, we conducted 24 semi-structured interviews with Black women in the Greater Toronto Area. We used thematic analysis to ground the data analysis and to generate insight into Black women's experiences., Results: Three overarching themes: 1) Not Being Understood: Privileging of Medical Knowledge Contributing to the Downplaying of Health Concerns, 2) Not Being Believed: Stereotypes Contributing to Dismissive Healthcare Encounters and 3) Listen to Us: Turning off the Cycle of Medical Gaslighting. These themes highlight ways anti-Black medical gaslighting manifests in Black women's healthcare encounters to create differential access to treatment and care., Conclusions: Anti-Black medical gaslighting contributes to differential access to treatment and care. Improving equitable access to treatment and care must involve addressing structural and epistemic biases in healthcare and fostering a culture of listening to humanize the experience of illness., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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22. Anti-Black racism: Gaining insight into the experiences of Black nurses in Canada.
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Prendergast N, Boakye P, Bailey A, Igwenagu H, and Burnett-Ffrench T
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- Humans, Black People, Canada, Delivery of Health Care, Feminism, Racism prevention & control
- Abstract
The call to address anti-Black racism in workplaces resonates across several organizations and institutions in Canada. But specifically, the coronavirus disease 2019 pandemic shed further light on how health inequities negatively impact the Black community. After conducting a literature review of the experiences of Black nurses in Canada, a deeper understanding of their plight was gained. In healthcare, the findings from the Black Nurses' Task Force report conclude that anti-Black racist practices are pervasive in nursing, and there remains a paucity of research in this area. This study builds off the report by exploring how Black nurses experience anti-Black racism while working in Canada's healthcare system. Inspired by critical race theory and Black feminist thought, an exploratory qualitative research study was conducted, using semistructured interviews to gather data. The study concludes that Black nurses experience anti-Black racism within the workplace, and it manifests itself through some of the attitudes of colleagues, patients, and nurses in leadership roles. Despite policies and statements that were in place to protect them, anti-Black racism continues to occur systematically. The findings point to the need for change in the overall workplace culture, which includes a fair representation of Black nurses in leadership roles, further research to identify best practices for tackling anti-Black racism within Canada's healthcare system, and mandatory training on anti-Black racism for healthcare leaders, educators, and service providers., (© 2023 The Authors. Nursing Inquiry published by John Wiley & Sons Ltd.)
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- 2024
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23. Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19.
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Al-Yousif N, Komanduri S, Qurashi H, Korzhuk A, Lawal HO, Abourizk N, Schaefer C, Mitchell KJ, Dietz CM, Hughes EK, Brandt CS, Fitzgerald GM, Joyce R, Chaudhry AS, Kotok D, Rivera JD, Kim AI, Shettigar S, Lavina A, Girard CE, Gillenwater SR, Hadeh A, Bain W, Shah FA, Bittner M, Lu M, Prendergast N, Evankovich J, Golubykh K, Ramesh N, Jacobs JJ, Kessinger C, Methe B, Lee JS, Morris A, McVerry BJ, and Kitsios GD
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- Humans, Prognosis, SARS-CoV-2, Inpatients, Reproducibility of Results, RNA, Viral, Respiratory Sounds, Cohort Studies, Lung diagnostic imaging, Edema, Respiration, Artificial, COVID-19 diagnostic imaging, Pulmonary Edema diagnostic imaging
- Abstract
Objectives: To reliably quantify the radiographic severity of COVID-19 pneumonia with the Radiographic Assessment of Lung Edema (RALE) score on clinical chest X-rays among inpatients and examine the prognostic value of baseline RALE scores on COVID-19 clinical outcomes., Setting: Hospitalised patients with COVID-19 in dedicated wards and intensive care units from two different hospital systems., Participants: 425 patients with COVID-19 in a discovery data set and 415 patients in a validation data set., Primary and Secondary Outcomes: We measured inter-rater reliability for RALE score annotations by different reviewers and examined for associations of consensus RALE scores with the level of respiratory support, demographics, physiologic variables, applied therapies, plasma host-response biomarkers, SARS-CoV-2 RNA load and clinical outcomes., Results: Inter-rater agreement for RALE scores improved from fair to excellent following reviewer training and feedback (intraclass correlation coefficient of 0.85 vs 0.93, respectively). In the discovery cohort, the required level of respiratory support at the time of CXR acquisition (supplemental oxygen or non-invasive ventilation (n=178); invasive-mechanical ventilation (n=234), extracorporeal membrane oxygenation (n=13)) was significantly associated with RALE scores (median (IQR): 20.0 (14.1-26.7), 26.0 (20.5-34.0) and 44.5 (34.5-48.0), respectively, p<0.0001). Among invasively ventilated patients, RALE scores were significantly associated with worse respiratory mechanics (plateau and driving pressure) and gas exchange metrics (PaO2/FiO2 and ventilatory ratio), as well as higher plasma levels of IL-6, soluble receptor of advanced glycation end-products and soluble tumour necrosis factor receptor 1 (p<0.05). RALE scores were independently associated with 90-day survival in a multivariate Cox proportional hazards model (adjusted HR 1.04 (1.02-1.07), p=0.002). We replicated the significant associations of RALE scores with baseline disease severity and mortality in the independent validation data set., Conclusions: With a reproducible method to measure radiographic severity in COVID-19, we found significant associations with clinical and physiologic severity, host inflammation and clinical outcomes. The incorporation of radiographic severity assessments in clinical decision-making may provide important guidance for prognostication and treatment allocation in COVID-19., Competing Interests: Competing interests: Dr. Kitsios has received research funding from Karius, Inc. Dr. McVerry receives research funding from Bayer Pharmaceuticals, Inc. All other authors disclosed no conflict of interest, (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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24. Obstetric racism and perceived quality of maternity care in Canada: Voices of Black women.
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Boakye PN, Prendergast N, Bandari B, Anane Brown E, Odutayo AA, and Salami S
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- Pregnancy, Female, Humans, Canada, Delivery, Obstetric, Delivery of Health Care, Maternal Health Services, Racism
- Abstract
Background: Obstetric racism in healthcare encounters impact on access to quality maternal healthcare for Black childbearing women yet remains underexplored in Canada. Understanding the experiences of Black Canadian women is critical to inform policy and create targeted interventions to address obstetric racism and advanced maternal health equity., Objective: The aim of this study was to explore the experiences of obstetric racism and its influence on perceived quality of maternity care among Black women in Toronto, Canada., Design: Qualitative research was conducted using a critical qualitative inquiry approach., Methods: We conducted a semi-structured interviews with 24 Black women who were pregnant and/or have given birth in the last 3 years. The interviews explored their experiences seeking care during pregnancy/childbirth and perceived quality of care., Results: Two themes were generated through the process of thematic analysis: (1) Manifestations and Impacts of Obstetric Racism and (2) Strategies for Addressing Obstetric Racism. Narratives of being dismissed, objectified, dehumanized, trauma and paternalism were reflected in the accounts of the participants. These experiences undermined the quality of care, hindered therapeutic relationships and contributed to mistrust., Conclusion: Black women understood the nature and impact of obstetric racism as it relates to the quality of maternal health care, their safety, and well-being. Participants recommended the need for anti-Black racism training specific to caring of Black childbearing women and increasing Black healthcare provider representation in perinatal settings as strategies to address obstetric racism. Investment in Black maternal health research is urgently needed to generate meaningful evidence to inform policy and interventions to advanced maternal health equity.
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- 2023
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25. Trajectories of host-response biomarkers and inflammatory subphenotypes in COVID-19 patients across the spectrum of respiratory support.
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Lu M, Drohan C, Bain W, Shah FA, Bittner M, Evankovich J, Prendergast N, Hensley M, Suber T, Fitzpatrick M, Ramanan R, Murray H, Schaefer C, Qin S, Wang X, Zhang Y, Nouraie SM, Gentry H, Kessinger C, Patel A, Macatangay BJ, Jacobs J, Mellors J, Lee JS, Ray P, Ray A, Methé B, Morris A, McVerry BJ, and Kitsios GD
- Abstract
Purpose: Enhanced understanding of the dynamic changes in the dysregulated inflammatory response in COVID-19 may help improve patient selection and timing for immunomodulatory therapies., Methods: We enrolled 323 COVID-19 inpatients on different levels of baseline respiratory support: i) Low Flow Oxygen (37%), ii) Non-Invasive Ventilation or High Flow Oxygen (NIV_HFO, 29%), iii) Invasive Mechanical Ventilation (IMV, 27%), and iv) Extracorporeal Membrane Oxygenation (ECMO, 7%). We collected plasma samples upon enrollment and days 5 and 10 to measure host-response biomarkers. We classified subjects into inflammatory subphenotypes using two validated predictive models. We examined clinical, biomarker and subphenotype trajectories and outcomes during hospitalization., Results: IL-6, procalcitonin, and Angiopoietin-2 were persistently elevated in patients at higher levels of respiratory support, whereas sRAGE displayed the inverse pattern. Patients on NIV_HFO at baseline had the most dynamic clinical trajectory, with 26% eventually requiring intubation and exhibiting worse 60-day mortality than IMV patients at baseline (67% vs. 35%, p<0.0001). sRAGE levels predicted NIV failure and worse 60-day mortality for NIV_HFO patients, whereas IL-6 levels were predictive in IMV or ECMO patients. Hyper-inflammatory subjects at baseline (<10% by both models) had worse 60-day survival (p<0.0001) and 50% of them remained classified as hyper-inflammatory on follow-up sampling at 5 days post-enrollment. Receipt of combined immunomodulatory therapies (steroids and anti-IL6 agents) was associated with markedly increased IL-6 and lower Angiopoietin-2 levels (p<0.05)., Conclusions: Longitudinal study of systemic host responses in COVID-19 revealed substantial and predictive inter-individual variability, influenced by baseline levels of respiratory support and concurrent immunomodulatory therapies.
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- 2022
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26. Man With Right Flank Pain.
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Prendergast N and Aliaga L
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- Humans, Male, Flank Pain diagnosis
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- 2022
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27. Evolving Paralysis after Motor Vehicle Collision.
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Prendergast N and Duanmu Y
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Case Presentation: An 85-year-old male who had been prescribed prasugrel presented to the emergency department (ED) after a motor vehicle collision and developed progressive neurological deficits. Computed tomography imaging demonstrated epidural thickening from the second through seventh cervical vertebrae, and magnetic resonance imaging was notable for a cervicothoracic epidural hematoma. The patient underwent emergent decompression with a favorable outcome., Discussion: Cases of traumatic spinal epidural hematomas are rarely seen in the ED. These are part of a small subset of operative neurological emergencies that benefit from urgent surgical intervention.
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- 2022
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28. Radiographic Assessment of Lung Edema (RALE) Scores are Highly Reproducible and Prognostic of Clinical Outcomes for Inpatients with COVID-19.
- Author
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Al-Yousif N, Komanduri S, Qurashi H, Korzhuk A, Lawal HO, Abourizk N, Schaefer C, Mitchell KJ, Dietz CM, Hughes EK, Brandt CS, Fitzgerald GM, Joyce R, Chaudhry AS, Kotok D, Rivera JD, Kim AI, Shettigar S, Lavina A, Girard CE, Gillenwater SR, Hadeh A, Bain W, Shah FA, Bittner M, Lu M, Prendergast N, Evankovich J, Golubykh K, Ramesh N, Jacobs JJ, Kessinger C, Methé B, Lee JS, Morris A, McVerry BJ, and Kitsios GD
- Abstract
Introduction: Chest imaging is necessary for diagnosis of COVID-19 pneumonia, but current risk stratification tools do not consider radiographic severity. We quantified radiographic heterogeneity among inpatients with COVID-19 with the Radiographic Assessment of Lung Edema (RALE) score on Chest X-rays (CXRs)., Methods: We performed independent RALE scoring by ≥2 reviewers on baseline CXRs from 425 inpatients with COVID-19 (discovery dataset), we recorded clinical variables and outcomes, and measured plasma host-response biomarkers and SARS-CoV-2 RNA load from subjects with available biospecimens., Results: We found excellent inter-rater agreement for RALE scores (intraclass correlation co-efficient=0.93). The required level of respiratory support at the time of baseline CXRs (supplemental oxygen or non-invasive ventilation [n=178]; invasive-mechanical ventilation [n=234], extracorporeal membrane oxygenation [n=13]) was significantly associated with RALE scores (median [interquartile range]: 20.0[14.1-26.7], 26.0[20.5-34.0] and 44.5[34.5-48.0], respectively, p<0.0001). Among invasively-ventilated patients, RALE scores were significantly associated with worse respiratory mechanics (plateau and driving pressure) and gas exchange metrics (PaO2/FiO2 and ventilatory ratio), as well as higher plasma levels of IL-6, sRAGE and TNFR1 levels (p<0.05). RALE scores were independently associated with 90-day survival in a multivariate Cox proportional hazards model (adjusted hazard ratio 1.04[1.02-1.07], p=0.002). We validated significant associations of RALE scores with baseline severity and mortality in an independent dataset of 415 COVID-19 inpatients., Conclusion: Reproducible assessment of radiographic severity revealed significant associations with clinical and physiologic severity, host-response biomarkers and clinical outcome in COVID-19 pneumonia. Incorporation of radiographic severity assessments may provide prognostic and treatment allocation guidance in patients hospitalized with COVID-19.
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- 2022
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