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Six Phase Transmission System has the capacity to increase the transmission capacity by 1.732 times the existing Three Phase System. It is possible to convert existing Three Phase Double circuit transmission line into compact Six Phase transmission line within the existing Right-of-way. Forecasting the demand and supply of Electrical energy gives the alternative solution is Six Phase Transmission system in addition to its several advantages like reduced phase voltage, less corona, declined magnetic field etc. This paper presents the study and analysis of design of transformer for six phase system. Comparison by system count per unit use MATLAB and PSCAD/ EMTDC simulation implemented for both system. Analysis of data carried out for parameters as value phase difference, voltage, current and power in transmission line. Apart from that assessment choosing the best transformer design for six phase system also implemented. From the analysis data performed found line system six phase have successfully produced ascendant as many as 73% in the division transmission line over system double three phase circuit. Apart from obtain that the best connection six phase system to acquire stated ascendant is delta Star delta inverted Star connection and diametrical connection

Post-menopausal women are at a higher risk of developing Alzheimer's disease (AD) than males. The higher rates of AD in women are associated with the sharp decline in the estrogen levels after menopause. Estrogen has been shown to downregulate inflammatory cytokines in the central nervous system (CNS), which has a neuroprotective role against neurodegenerative diseases including AD. Sustained neuroinflammation is associated with neurodegeneration and contributes to AD. Nuclear factor kappa-B (NF-κB) is a transcription factor involved with the modulation of inflammation and interacts with estrogen to influence the progression of AD. Application of 17β-estradiol (E2) has been shown to inhibit NF-κB, thereby reducing transcription of NF-κB target genes. Despite accumulating evidence showing that estrogens have beneficial effects in pre-clinical AD studies, there are mixed results with hormone replacement therapy in clinical trials. Furthering our understanding of how NF-κB interacts with estrogen and alters the progression of neurodegenerative disorders including AD, should be beneficial and result in the development of novel therapeutics.

Background: Reconstruction is the gold standard treatment for medial ulnar collateral ligament (MUCL) injuries. However, recent studies show a successful and renewed interest in direct suture repair, particularly in young athletes. Repair augmentation with a suture tape may provide greater stability, enabling healing of the MUCL while protecting the repair at higher valgus loads. Purpose: To perform a systematic review and meta-analysis on whether MUCL repair with augmentation provides a similar biomechanical profile to the traditional MUCL reconstruction. Study Design: Systematic review. Methods: The Cochrane Controlled Register of Trials, PubMed, Medline, and Embase were used to perform a systematic review and meta-analysis using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria with the following search terms: (“ulnar collateral ligament” OR “medial ulnar collateral ligament”) AND (“internal brace” OR “augmentation” OR “suture tape”). Data pertaining to certain biomechanical properties (gap formation, failure to torque [ultimate load to failure], stiffness, degree of valgus opening, and modes of failure) were extracted. The pooled outcome data were analyzed by random- and fixed-effects models. A total of 203 abstracts were identified through the aforementioned databases. Results: After abstract and full-text screening, 6 biomechanical studies were included. All were on cadaveric elbows, with 53 repairs with augmentation and 53 reconstructions compared. There were no differences between the 2 in regard to ultimate load to failure (standard mean difference [SMD], –0.34 N·m; 95% CI, –1.36 to 0.68; P = .51) and rotational stiffness (SMD, 0.26; 95% CI, –1.14 to 1.66; P = .72). Despite a trend in resistance to gapping with augmented repair, this was not significant (SMD, –0.53; 95% CI, –1.08 to 0.01; P = .06). Augmented repairs were more likely to fail by pullout or at the suture-tendon/anchor-suture interface (odds ratio [OR], 12.19; 95% CI, 4.17 to 35.62; P < .00001), while failure by fracture was more common with reconstruction (OR, 5.75; 95% CI, 2.07 to 15.99; P = .0008). Conclusion: MUCL augmented repair establishes the required time-zero structural properties without the need for a tendon graft. However, future clinical studies are necessary to determine its true effectiveness as well as its success at higher levels of professional sport.