139 results on '"Popov, Todor"'
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2. Perceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts
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Asllani, Julijana, Douagui, Habib, Asayag, Estrella, Elizabeth, Castro Maria, Crisci, Carlos D., Gomez, René Maximiliano, Ivancevich, Juan Carlos, Jares, Edgardo, Máspero, Jorge Fernando, Moreno, Pablo, Neffen, Hugo Eduardo, Zernotti, Mario Emilio, Bosnic-Anticevich, Sinthia, Chahhoud Carson, Kristin, Cvetkovski, Biljana, Davies, Janet M., Kritikos, Vicky, O'Hehir, Robyn, Oliver, Brian, Tan, House Rachel, Tattersall, Jessica, Zubrinich, Celia, Aberer, Werner, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Doyen, Virginie, Ebo, Didier, Louis, Renaud, Rombaux, Philippe, Scheire, Sophie, Bennoor, Kazi, Barreto, Bruno A., Camargos, Paulo, Chong-Neto, Herberto Jose, Cruz, Alvaro A., da Silva, Jane, Marta, Guidacci, Rizzo, José Angelo, Rosario Filho, Nelson, Faradiba, Sarquis Serpa, Solé, Dirceu, Urrutia-Pereira, Marilyn, Christoff, George, Mariana, Mandazhieva-Pepelanova, Cvetanka, Odjakova, Popov, Todor A., Vicheva, Dilyana, Teixeira Maria, do Ceu, Bouchard, Jacques, Brozek, Jan, Chu, Derek K., Denburg, Judah, Eiwegger, Thomas, Keith, Paul K., To, Teresa, Waserman, Susan, Abusada, Nancy, Alvarez Cuesta, Emilio, Calvo-Gil, Mario A., Guzmán, Maria Antonieta, Pérez Gomez, Tamara, Wong Gary, Wing Kin, Zhang, Luo, Caraballo, Luis, Cepeda Sarabia, Alfonso, Nyembue, Dieudonné, Soto-Martinez, Manuel, Miculinic, Neven, Plavec, Davor, Pitsios, Constantinos, Yiallouros, Panayiotis, Panzner, Petr, Sova, Milan, Vachova, Martina, Bindslev-Jensen, Carsten, Dahl, Ronald, Malling, Hans-Jorgen, Münter, Lars, Poulsen, Lars K., Charlotte, Suppli Ulrik, Tannert, Line Kring, Mahboub, Bassam, Salameh, Laila, Cherrez-Ojeda, Ivan, Robles, de Guevara Karla, El-Owaidy, Rasha Hassan, El-Sayed, Zeinab A., El-Sayed, Shereen Saad, Hossny, Elham, Mostafa, Badr Eldin, Julge, Kaja, Billo, Nils Eric, Eklund, Patrik, Erhola, Marina, Haahtela, Tari, Karjalainen, Jussi, Makela, Mika, Toppila-Salmi, Sanna, Valovirta, Erkka, Vasankari, Tuula, Annesi-Maesano, Isabella, Bossé, Isabelle, Bourgoin-Heck, Melisande, Charpin, Denis, Coste, André, de Blay, Frédéric, Devillier, Philippe, Didier, Alain, Dinh-Xuan, Anh Tuan, Fontaine, Jean-François, Just, Jocelyne, Nadif, Rachel, Pham-Thi, Nhân, Pigearias, Bernard, Roche, Nicolas, Ganse Eric, Van, Chkhartishvili, Ekaterine, Gamkrelidze, Amiran, Gotua, Maia, Becker, Sven, Bergmann, Karl-Christian, Bieber, Thomas, Brehler, Randolf, Buhl, Roland, Chaker, Adam M., Darsow, Ulf, Hamelmann, Eckard, Heinrich, Joachim, Keil, Thomas, Klimek, Ludger, Kolkhir, Pavel, Lau, Susanne, Maurer, Marcus, Mösges, Ralph, Neou, Angelos, Pfaar, Oliver, Ring, Johannes, Wagenmann, Martin, Zuberbier, Torsten, Ramanauskaite, Aiste, Lingnau, Anja, Christou, Demetrios, Neisinger, Sophia, Aggelidis, Xenophon, Constantinidis, Jannis, Dimou, Maria, Grigoreas, Christos, Kapsali, Trisevgeni, Katotomichelakis, Michael, Loukides, Stelios, Makris, Michael, Manousakis, Emmanouil, Mikos, Nikolaos, Pagkalos, Aris, Papadopoulos, Nikolaos G., Papanikolaou, Vasileios, Paraskevopoulos, Giannis, Piskou, Konstantina, Prokopakis, Emmanuel, Psarros, Fotios, Samitas, Konstantinos, Stamataki, Sofia, Stefanaki Lina, Evangelia, Syrigou, Ekaterini, Tsiligianni, Ioanna, Vallianatou, Mina, Vourdas, Dimitrios, Xepapadaki, Paraskevi, Karavelia, Aspasia, Wai San Ko, Fanny, Wong, Gary, Hirschberg, Andor, Kraxner, Helga, Nekam, Kristof, Lane, Stephen, Rottem, Menachem, Artesani Maria, Cristina, Barbaglia, Simona, Beghé, Bianca, Bilo Maria, Beatrice, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Braido, Fulvio, Brussino, Luisa, Canonica, G Walter, Cecchi, Lorenzo, Ciprandi, Giorgio, Compalati, Enrico, D'Amato, Gennaro, De Feo, Giulia, Del Giacco, Stefano, Fiocchi, Alessandro, Heffler, Enrico, Lombardi, Carlo, Monti, Riccardo, Muraro, Antonella, Nettis, Eustachio, Nicola, Stefania, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Rolla, Giovanni, Romano, Antonino, Scichilone, Nicola, Triggiani, Massimo, Ventura Maria, Teresa, Viegi, Giovanni, Boccabella, Cristina, Giovannini, Mattia, Mahesh Padukudru, Anand, Iinuma, Tomohisa, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Pawankar, Ruby, Sakurai, Daiju, Suzukawa, Maho, Yamaguchi, Masao, Ispayeva, Zhanat, Chang, Yoon-Seok, Park, Hae-Sim, Al-Ahmad, Mona, Cirule, Ieva, Grisle, Ineta, Irani, Carla, Rouadi, Philip, Zaitoun, Fares, Dubakiene, Ruta, Emuzyte, Regina, Kvedariene, Violeta, Gradauskiene, Brigita, Valiulis, Arunas, Ollert, Markus, Hannachi, Farah, Dokic, Dejan, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Palaniappan, S.P., Woo, Kent, Montefort, Stephen, Bedolla Barajas, Martín, Costa Domínguez, María del Carmen, Espinoza Contreras, Jesús Guillermo, Fuentes Pèrez, Jose Miguel, Gálvez Romero, José Luis, García Cruz, María de la Luz Hortensia, González Diaz, Sandra, Huerta Villalobos, Yunuen Rocío, Larenas-Linnemann, Désiree E., Luna-Pech, Jorge Agustin, Matta Campos, Juan José, Rivero Yeverino, Daniela, Rodríguez González, Mónica, Rodríguez Zagal, Eréndira, Lkhagvaa, Battur, Mavale-Manuel, Sandra, Nunes Elizabete, Abrantes, Chavannes, Niels, Fokkens, Wytske J., Koppelman, Gerard, Maitland-van der Zee, Anke-Hilse, Reitsma, Sietze, Chandrasekharan, Ramanathan, Yusuf, Osman, Repka-Ramirez, Maria Susana, Sisul, Juan Carlos, Gereda, José E., Recto, Marysia T., Bialek, Slawomir, Bialoszewski, Artur, Chelminska, Marta, Gawlik, Radoslaw, Jassem, Ewa, Jutel, Marek, Kuna, Piotr, Kupczyk, Maciej, Moniuszko, Marcin, Niedoszytko, Marek, Raciborski, Filip, Romantowski, Jan, Samolinski, Boleslaw, Specjalski, Krzysztof, Carreiro Martins, Pedro, Correia de Sousa, Jaime, Costa, Elisio, Fonseca, Joao A., Lourenço, Olga, Morais-Almeida, Mario, Pereira Ana, Margarida, Regateiro, Frederico, Robalo Cordeiro, Carlos, Rosado Pinto, Jose, Sousa-Pinto, Bernardo, Taborda Barata, Luis, Todo-Bom, Ana Maria, Vieira Rafael, José, Carvalho, Daniela, Al-Nesf, Maryam Ali, Agache, Ioana, Berghea Elena, Camelia, Bumbacea, Roxana, Deleanu, Diana, Mihaltan, Florin, Panaitescu Bunu, Carmen, Khaitov, Musa, Namazova-Baranova, Leyla, Vishneva, Elena, Alshaikh Nada, Ali, Dimic-Janjic, Sanja, Milenkovic, Branislava, Wang, De Yun, Hrubiško, Martin, Edelbaher, Natalija, Jošt, Maja, Kopac, Peter, Košnik, Mitja, Lalek, Nika, Poplas Susic, Antonija, Rozman Sinur, Irma, Soklic Košak, Tanja, Triller, Nadja, Triller, Katja, Urbancic, Jure, Zidarn, Mihaela, Levin, Michael, Potter, Paul, Zar, Heather, Alobid, Isam, Anto, Aram, Bartra, Joan, Bobolea, Irina, Campo, Paloma, Cardona, Vicky, Carriazo Ana, Maria, Castillo Vizuete, José Antonio, Chivato, Tomas, Davila Gonzalez, Ignacio Jesus, Mullol, Joaquim, Nieto Garcia, Antonio, Picado, César, Quirce, Santiago, Sastre, Joaquin, de las Vecillas, Leticia, Benson, Mikael, Kull, Inger, van Hage, Marianne, Wickman, Magnus, Khaltaev, Nikolai, Mohammad, Yousser, Tantilipikorn, Pongsakorn, Vichyanond, Pakit, Cingi, Cemal, Gemicioglu, Bilun, Goksel, Ozlem, Kalayci, Omer, Kalyoncu, Ali Fuat, Meço, Cem, Vardaloglu, Koyuncu Ilgim, Yorgancioglu, Arzu, Karabacak, Deniz Eyice, Kirenga, Bruce, Adcock, Ian Michael, Arshad, Hasan S., Bewick, Mike, Bond, Christine, Brightling, Christopher, Bush, Andrew, Calderon, Moïses, Chung, Kian Fan, Custovic, Adnan, Djukanovic, Ratko, Durham, Stephen, Farrell, John, Halpin, David, Hyland, Michael, Johnston, Sebastian, Lipworth, Brian, Nakonechna, Alla, Price, David, Roberts, Graham, Ryan, Dermot, Schwarze, Jürgen, Sheikh, Aziz, Shields, Mike, Walker, Samantha, Williams, Sian, Kaidashev, Igor, Kurchenko, Andrii Igorevich, Tsaryk, Vladyslav, Bernstein, David, Bernstein, Jonathan A., Casale, Thomas B., Chinthrajah, Sharon, Dykewicz, Mark, Marshall, Gailen D., Meltzer, Eli O., Naclerio, Robert M., Togias, Alkis, Toskala, Elina, Wallace, Dana, Williams, Dennis M., Yawn, Barbara, Caballero-Fonseca, Fernan, Le Thi Tuyet, Lan, Vu, Tran Thien Quan, Gil-Mata, Sara, Teixeira, Tatiana, Bedbrook, Anna, Bousquet, Jean, and Vieira, Rafael José more...
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- 2024
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3. Concepts for the Development of Person-Centered, Digitally Enabled, Artificial Intelligence–Assisted ARIA Care Pathways (ARIA 2024)
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Bousquet, Jean, Schünemann, Holger J., Sousa-Pinto, Bernardo, Zuberbier, Torsten, Togias, Alkis, Samolinski, Boleslaw, Bedbrook, Anna, Czarlewski, Wienczyslawa, Hofmann-Apitius, Martin, Litynska, Justyna, Vieira, Rafael José, Anto, Josep M., Fonseca, Joao A., Brozek, Jan, Bognanni, Antonio, Brussino, Luisa, Canonica, G. Walter, Cherrez-Ojeda, Ivan, Cruz, Alvaro A., Vecillas, Leticia de las, Dykewicz, Mark, Gemicioglu, Bilun, Giovannini, Mattia, Haahtela, Tari, Jacobs, Marc, Jacomelli, Cristina, Klimek, Ludger, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Louis, Gilles, Lourenço, Olga, Leemann, Lucas, Morais-Almeida, Mario, Neves, Ana Luisa, Nadeau, Kari C., Nowak, Artur, Palamarchuk, Yuliia, Palkonen, Susanna, Papadopoulos, Nikolaos G., Parmelli, Elena, Pereira, Ana Margarida, Pfaar, Oliver, Regateiro, Frederico S., Savouré, Marine, Taborda-Barata, Luis, Toppila-Salmi, Sanna K., Torres, Maria J., Valiulis, Arunas, Ventura, Maria Teresa, Williams, Sian, Yepes-Nuñez, Juan J., Yorgancioglu, Arzu, Zhang, Luo, Zuberbier, Jaron, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Agache, Ioana, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Al Shaikh, Nada A., Amaral, Rita, Ansotegui, Ignacio J., Asllani, Julijana, Balotro-Torres, Maria Cristina, Bergmann, Karl-Christian, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Blaiss, Michael S., Bonaglia, Cristina, Bonini, Matteo, Bossé, Isabelle, Braido, Fulvio, Caballero-Fonseca, Fernan, Camargos, Paulo, Carreiro-Martins, Pedro, Casale, Thomas, Castillo-Vizuete, José-Antonio, Cecchi, Lorenzo, Teixeira, Maria do Ceu, Chang, Yoon-Seok, Loureiro, Claudia Chaves, Christoff, George, Ciprandi, Giorgio, Cirule, Ieva, Correia-de-Sousa, Jaime, Costa, Elisio M., Cvetkovski, Biljana, de Vries, Govert, Del Giacco, Stefano, Devillier, Philippe, Dokic, Dejan, Douagui, Habib, Durham, Stephen R., Enecilla, Maria Lourdes, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean-François, Gawlik, Radoslaw, Gereda, Jose E., Gil-Mata, Sara, Giuliano, Antonio F.M., Gotua, Maia, Gradauskiene, Brigita, Guzman, Maria Antonieta, Hossny, Elham, Hrubiško, Martin, Iinuma, Tomohisa, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Jartti, Tuomas, Jeseňák, Miloš, Julge, Kaja, Jutel, Marek, Kaidashev, Igor, Bennoor, Kazi S., Khaltaev, Nicolai, Kirenga, Bruce, Kraxner, Helga, Kull, Inger, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Kurchenko, Andriy, La Grutta, Stefania, Lane, Stephen, Miculinic, Neven, Lee, Sang Min, Le Thi Tuyet, Lan, Lkhagvaa, Battur, Louis, Renaud, Mahboub, Bassam, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Eric, Milenkovic, Branislava, Mohammad, Yousser, Moniuszko, Marcin, Montefort, Stephen, Moreira, Andre, Moreno, Pablo, Mullol, Joaquim, Nadif, Rachel, Nakonechna, Alla, Navarro-Locsin, Cecilia Gretchen, Neffen, Hugo E., Nekam, Kristof, Niedoszytko, Marek, Nunes, Elizabete, Nyembue, Dieudonné, O’Hehir, Robyn, Ollert, Markus, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Olze, Heidi, Padukudru, Mahesh Anand, Palomares, Oscar, Pali-Schöll, Isabella, Panzner, Petr, Palosuo, Kati, Park, Hae S., Passalacqua, Giovanni, Patella, Vincenzo, Pawankar, Ruby, Pétré, Benoît, Pitsios, Constantinos, Plavec, Davor, Popov, Todor A., Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Ramonaité, Agné, Recto, Marysia, Repka-Ramirez, Susana, Roberts, Graham, Robles-Velasco, Karla, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romualdez, Joel A., Rottem, Menachem, Rouadi, Philip W., Salapatas, Marianella, Sastre, Joaquin, Serpa, Faradiba S., Sayah, Zineb, Scichilone, Nicola, Senna, Gianenrico, Sisul, Juan Carlos, Solé, Dirceu, Soto-Martinez, Manuel E., Sova, Milan, Sozinova, Olga, Stevanovic, Katarina, Ulrik, Charlotte Suppli, Szylling, Anna, Tan, Frances M., Tantilipikorn, Pongsakorn, Todo-Bom, Ana, Tomic-Spiric, Vesna, Tsaryk, Vladyslav, Tsiligianni, Ioanna, Urrutia-Pereira, Marilyn, Rostan, Marylin Valentin, Sofiev, Mikhail, Valovirta, Erkka, Van Eerd, Michiel, Van Ganse, Eric, Vasankari, Tuula, Vichyanond, Pakit, Viegi, Giovanni, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wong, Gary, Worm, Margitta, Yusuf, Osman M., Zaitoun, Fares, and Zidarn, Mihaela more...
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- 2024
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4. Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
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Scelo, Ghislaine, Tran, Trung N., Le, Tham T., Fagerås, Malin, Dorscheid, Delbert, Busby, John, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Beastall, Aaron, Bergeron, Celine, Bjermer, Leif, Bjerrum, Anne S., Cano-Rosales, Diana Jimena, Canonica, Giorgio Walter, Carter, Victoria, Charriot, Jeremy, Christoff, George C., Cosio, Borja G., Denton, Eve, Fernandez-Sanchez, Maria Jose, Fonseca, João A., Gibson, Peter G., Goh, Celine, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Katial, Rohit, Koh, Mariko S., Kuna, Piotr, Larenas-Linnemann, Désirée, Lehtimäki, Lauri, Mahboub, Bassam, Martin, Neil, Matsumoto, Hisako, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Patel, Pujan, Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin K., Sadatsafavi, Mohsen, Taillé, Camille, Torres-Duque, Carlos A., Tsai, Ming-Ju, Ulrik, Charlotte S., Upham, John W., von Bülow, Anna, Wang, Eileen, Wechsler, Michael E., and Price, David B. more...
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- 2024
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5. Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus
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Reshef, Avner, Buttgereit, Thomas, Betschel, Stephen D., Caballero, Teresa, Farkas, Henriette, Grumach, Anete S., Hide, Michihiro, Jindal, Ankur K., Longhurst, Hilary, Peter, Jonathan, Riedl, Marc A., Zhi, Yuxiang, Aberer, Werner, Abuzakouk, Mohamed, Al Farsi, Tariq, Al Sukaiti, Nashat, Al-Ahmad, Mona, Altrichter, Sabine, Aygören-Pürsün, Emel, Baeza, Maria Luisa, Bara, Noemi Anna, Bauer, Andrea, Bernstein, Jonathan A., Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Bygum, Anette, Calderon, Oscar, de Albuquerque Campos, Regis, Campos Romero, Freya Helena, Cancian, Mauro, Chong-Neto, Herberto Jose, Christoff, George, Cimbollek, Stefan, Cohn, Danny M., Craig, Timothy, Danilycheva, Inna, Darlenski, Razvigor, Du-Thanh, Aurélie, Ensina, Luis Felipe, Fomina, Daria, Fonacier, Luz, Fukunaga, Atsushi, Gelincik, Asli, Giavina-Bianchi, Pedro, Godse, Kiran, Gompels, Mark, Goncalo, Margarida, Gotua, Maia, Guidos-Fogelbach, Guillermo, Guilarte, Mar, Kasperska-Zajac, Alicja, Katelaris, Constance H., Kinaciyan, Tamar, Kolkhir, Pavel, Kulthanan, Kanokvalai, Kurowski, Marcin, Latysheva, Elena, Lauerma, Antti, Launay, David, Lleonart, Ramon, Lumry, William, Malbran, Alejandro, Ali, Ramzy Mohammed, Nasr, Iman, Nieto-Martinez, Sandra, Parisi, Claudio, Pawankar, Ruby, Piñero-Saavedra, Macarena, Popov, Todor A., Porebski, Grzegorz, Prieto Garcia, Alicia, Pyatilova, Polina, Rudenko, Michael, Sekerel, Bulent Enis, Serpa, Faradiba Sarquis, Sheikh, Farrukh, Siebenhaar, Frank, Soria, Angèle, Staevska, Maria, Staubach, Petra, Stobiecki, Marcin, Thomsen, Simon Francis, Triggiani, Massimo, Valerieva, Anna, Valle, Solange, Van Dinh, Nguyen, Vera Ayala, Carolina Elisa, Zalewska-Janowska, Anna, Zanichelli, Andrea, Magerl, Markus, and Maurer, Marcus more...
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- 2024
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6. International Variation in Severe Exacerbation Rates in Patients With Severe Asthma
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Lee, Tae Yoon, Price, David, Yadav, Chandra Prakash, Roy, Rupsa, Lim, Laura Huey Mien, Wang, Eileen, Wechsler, Michael E., Jackson, David J., Busby, John, Heaney, Liam G., Pfeffer, Paul E., Mahboub, Bassam, Perng (Steve), Diahn-Warng, Cosio, Borja G., Perez-de-Llano, Luis, Al-Lehebi, Riyad, Larenas-Linnemann, Désirée, Al-Ahmad, Mona, Rhee, Chin Kook, Iwanaga, Takashi, Heffler, Enrico, Canonica, Giorgio Walter, Costello, Richard, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Porsbjerg, Celeste M., Torres-Duque, Carlos A., Christoff, George C., Popov, Todor A., Hew, Mark, Peters, Matthew, Gibson, Peter G., Maspero, Jorge, Bergeron, Celine, Cerda, Saraid, Contreras-Contreras, Elvia Angelica, Chen, Wenjia, and Sadatsafavi, Mohsen more...
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- 2024
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7. Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma
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Perez-de-Llano, Luis, Scelo, Ghislaine, Canonica, G. Walter, Chen, Wenjia, Henley, William, Larenas-Linnemann, Désirée, Peters, Matthew J., Pfeffer, Paul E., Tran, Trung N., Ulrik, Charlotte Suppli, Popov, Todor A., Sadatsafavi, Mohsen, Hew, Mark, Máspero, Jorge, Gibson, Peter G., Christoff, George C., Fitzgerald, J. Mark, Torres-Duque, Carlos A., Porsbjerg, Celeste M., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Kuna, Piotr, Fonseca, João A., Al-Lehebi, Riyad, Rhee, Chin Kook, Koh, Mariko Siyue, Cosio, Borja G., Perng (Steve), Diahn-Warng, Mahboub, Bassam, Menzies-Gow, Andrew N., Jackson, David J., Busby, John, Heaney, Liam G., Patel, Pujan H., Wang, Eileen, Wechsler, Michael E., Altraja, Alan, Lehtimäki, Lauri, Bourdin, Arnaud, Bjermer, Leif, Bulathsinhala, Lakmini, Carter, Victoria, Murray, Ruth, Beastall, Aaron, Denton, Eve, and Price, David B. more...
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- 2024
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8. Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry
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Scelo, Ghislaine, Torres-Duque, Carlos A., Maspero, Jorge, Tran, Trung N., Murray, Ruth, Martin, Neil, Menzies-Gow, Andrew N., Hew, Mark, Peters, Matthew J., Gibson, Peter G., Christoff, George C., Popov, Todor A., Côté, Andréanne, Bergeron, Celine, Dorscheid, Delbert, FitzGerald, J. Mark, Chapman, Kenneth R., Boulet, Louis Philippe, Bhutani, Mohit, Sadatsafavi, Mohsen, Jiménez-Maldonado, Libardo, Duran-Silva, Mauricio, Rodriguez, Bellanid, Celis-Preciado, Carlos Andres, Cano-Rosales, Diana Jimena, Solarte, Ivan, Fernandez-Sanchez, Maria Jose, Parada-Tovar, Patricia, von Bülow, Anna, Bjerrum, Anne Sofie, Ulrik, Charlotte S., Assing, Karin Dahl, Rasmussen, Linda Makowska, Hansen, Susanne, Altraja, Alan, Bourdin, Arnaud, Taille, Camille, Charriot, Jeremy, Roche, Nicolas, Papaioannou, Andriana I., Kostikas, Konstantinos, Papadopoulos, Nikolaos G., Salvi, Sundeep, Long, Deirdre, Mitchell, Patrick D., Costello, Richard, Sirena, Concetta, Cardini, Cristina, Heffler, Enrico, Puggioni, Francesca, Canonica, Giorgio Walter, Guida, Giuseppe, Iwanaga, Takashi, Al-Ahmad, Mona, Linnemann, Désirée Larenas, Garcia, Ulises, Kuna, Piotr, Fonseca, João A., Al-Lehebi, Riyad, Koh, Mariko Siyue, Rhee, Chin Kook, Cosio, Borja G., de Llano, Luis Perez, Perng (Steve), Diahn-Warng, Huang, Erick Wan-Chun, Wang, Hao-Chien, Tsai, Ming-Ju, Mahboub, Bassam, Salameh, Laila Ibraheem Jaber, Jackson, David, Busby, John, Heaney, Liam G., Pfeffer, Paul, Goddard, Amanda Grippen, Wang, Eileen, Hoyte, Flavia, Wechsler, Michael E., Chapman, Nicholas, Katial, Rohit, Carter, Victoria, Bulathsinhala, Lakmini, Eleangovan, Neva, Ariti, Con, Lyu, Juntao, Price, David B., and Porsbjerg, Celeste more...
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- 2024
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9. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination: Results of the UCARE COVAC-CU study
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Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al-Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael, Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Meshkova, Raisa Y., Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young-Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus more...
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- 2023
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10. Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry
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Chen, Wenjia, Tran, Trung N., Sadatsafavi, Mohsen, Murray, Ruth, Wong, Nigel Chong Boon, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Gil, Esther Garcia, FitzGerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne-Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fonseca, João A., Gibson, Peter G., Yoo, Kwang-Ha, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng (Steve), Diahn-Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Ra, Seung-Won, Wang, Eileen, Wechsler, Michael E., and Price, David B. more...
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- 2023
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11. The Conformal-Symmetry–Color-Neutrality Connection in Strong Interaction
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Kirchbach, Mariana, Popov, Todor, Vallejo, Jose Antonio, and Dobrev, Vladimir, editor
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- 2022
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12. Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma
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Porsbjerg, Celeste M., Menzies-Gow, Andrew N., Tran, Trung N., Murray, Ruth B., Unni, Bindhu, Audrey Ang, Shi Ling, Alacqua, Marianna, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Belevskiy, Andrey S., Björnsdóttir, Unnur S., Bourdin, Arnaud, Busby, John, Canonica, G. Walter, Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Fonseca, João A., Hansen, Susanne, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jackson, David J., Kocks, Janwillem W.H., Kallieri, Maria, Bruce Ko, Hsin-Kuo, Koh, Mariko Siyue, Larenas-Linnemann, Désirée, Lehtimäki, Lauri A., Loukides, Stelios, Lugogo, Njira, Maspero, Jorge, Papaioannou, Andriana I., Perez-de-Llano, Luis, Pitrez, Paulo Márcio, Popov, Todor A., Rasmussen, Linda M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Schmid, Johannes, Siddiqui, Salman, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Upham, John W., Wang, Eileen, Wechsler, Michael E., Bulathsinhala, Lakmini, Carter, Victoria, Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Rowlands, Mari-Anne, Price, David B., and van Boven, Job F.M. more...
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- 2022
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13. A Critical Review on microRNAs as Prognostic Biomarkers in Laryngeal Carcinoma.
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Komitova, Kristina S., Dimitrov, Lyuben D., Stancheva, Gergana S., Kyurkchiyan, Silva G., Petkova, Veronika, Dimitrov, Stoyan I., Skelina, Silviya P., Kaneva, Radka P., and Popov, Todor M.
- Abstract
During the past decade, a vast number of studies were dedicated to unravelling the obscurities of non-coding RNAs in all fields of the medical sciences. A great amount of data has been accumulated, and consequently a natural need for organization and classification in all subfields arises. The aim of this review is to summarize all reports on microRNAs that were delineated as prognostic biomarkers in laryngeal carcinoma. Additionally, we attempt to allocate and organize these molecules according to their association with key pathways and oncogenes affected in laryngeal carcinoma. Finally, we critically analyze the common shortcomings and biases of the methodologies in some of the published papers in this area of research. A literature search was performed using the PubMed and MEDLINE databases with the keywords "laryngeal carcinoma" OR "laryngeal cancer" AND "microRNA" OR "miRNA" AND "prognostic marker" OR "prognosis". Only research articles written in English were included, without any specific restrictions on study type. We have found 43 articles that report 39 microRNAs with prognostic value associated with laryngeal carcinoma, and all of them are summarized along with the major characteristics and methodology of the respective studies. A second layer of the review is structural analysis of the outlined microRNAs and their association with oncogenes and pathways connected with the cell cycle (p53, CCND1, CDKN2A/p16, E2F1), RTK/RAS/PI3K cascades (EGFR, PI3K, PTEN), cell differentiation (NOTCH, p63, FAT1), and cell death (FADD, TRAF3). Finally, we critically review common shortcomings in the methodology of the papers and their possible effect on their results. [ABSTRACT FROM AUTHOR] more...
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- 2024
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14. Global microRNA expression profile in laryngeal carcinoma unveils new prognostic biomarkers and novel insights into field cancerization
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Popov, Todor M., Stancheva, Gergana, Kyurkchiyan, Silva G., Petkova, Veronika, Panova, Stiliana, Kaneva, Radka P., and Popova, Diana P.
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- 2022
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15. Exploration of the association between HIF3α mRNA and lncRNA MALAT1 in laryngeal squamous cell carcinoma by correlation analysis
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Kyurkchiyan, Silva, primary, Stancheva, Gergana, additional, Petkova, Veronika, additional, Hadzhiev, Yuliyan, additional, Dobriyanova, Venera, additional, Popova, Diana, additional, Kaneva, Radka, additional, and Popov, Todor, additional more...
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- 2024
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16. Smartphone Exophthalmometry and Eyeball Protrusion Measurement—In Reply
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Popov, Todor, primary, Fierz, Fabienne C., additional, and Weber, Konrad P., additional
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- 2024
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17. Protective Role of Intranasal Methylcellulose Powder Against Nasal Inflammatory Episodes in Children Attending Daycare Facilities
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Popov, Todor, primary, Josling, Peter, additional, and Dubuske, Lawrence, additional
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- 2024
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18. Reply to “Exploring the long-term effects of biologic initiation in severe asthma: Insights from the International Severe Asthma Registry”
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Chen, Wenjia, primary, Tran, Trung N., additional, Sadatsafavi, Mohsen, additional, Murray, Ruth B., additional, Boon Wong, Nigel Chong, additional, Ali, Nasloon, additional, Ariti, Con, additional, Bulathsinhala, Lakmini, additional, Garcia Gil, Esther, additional, FitzGerald, J. Mark, additional, Alacqua, Marianna, additional, Al-Ahmad, Mona, additional, Altraja, Alan, additional, Al-Lehebi, Riyad, additional, Bhutani, Mohit, additional, Bjermer, Leif, additional, Bjerrum, Anne-Sofie, additional, Bourdin, Arnaud, additional, von Bülow, Anna, additional, Busby, John, additional, Canonica, Giorgio Walter, additional, Carter, Victoria, additional, Christoff, George C., additional, Cosio, Borja G., additional, Costello, Richard W., additional, Fonseca, João A., additional, Gibson, Peter G., additional, Yoo, Kwang Ha, additional, Heaney, Liam G., additional, Heffler, Enrico, additional, Hew, Mark, additional, Hilberg, Ole, additional, Hoyte, Flavia, additional, Iwanaga, Takashi, additional, Jackson, David J., additional, Jones, Rupert C., additional, Koh, Mariko Siyue, additional, Kuna, Piotr, additional, Larenas-Linnemann, Désirée, additional, Lehmann, Sverre, additional, Lehtimäki, Lauri, additional, Lyu, Juntao, additional, Mahboub, Bassam, additional, Maspero, Jorge, additional, Menzies-Gow, Andrew N., additional, Newell, Anthony, additional, Sirena, Concetta, additional, Papadopoulos, Nikolaos G., additional, Papaioannou, Andriana I., additional, Perez-de-Llano, Luis, additional, Perng (Steve), Diahn-Warng, additional, Peters, Matthew J., additional, Pfeffer, Paul E., additional, Porsbjerg, Celeste M., additional, Popov, Todor A., additional, Rhee, Chin Kook, additional, Salvi, Sundeep, additional, Taillé, Camille, additional, Taube, Christian, additional, Torres-Duque, Carlos A., additional, Ulrik, Charlotte, additional, Ra, Seung Won, additional, Wang, Eileen, additional, Wechsler, Michael E., additional, and Price, David B., additional more...
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- 2024
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19. Real-world biologics response and super-response in the International Severe Asthma Registry cohort
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Denton, Eve, Hew, Mark, Peters, Matthew J., Upham, John W., Bulathsinhala, Lakmini, Tran, Trung N., Martin, Neil, Bergeron, Celine, Al-Ahmad, Mona, Altraja, Alan, Larenas-Linnemann, Desiree, Murray, Ruth, Celis-Preciado, Carlos Andres, Al-Lehebi, Riyad, Belhassen, Manon, Bhutani, Mohit, Bosnic-Anticevich, Sinthia Z., Bourdin, Arnaud, Brusselle, Guy G., Busby, John, Canonica, Giorgio Walter, Heffler, Enrico, Chapman, Kenneth R., Charriot, Jeremy, Christoff, George C., Chung, Li Ping, Cosio, Borja G., Cote, Andreanne, Costello, Richard W., Cushen, Breda, Fingleton, James, Fonseca, Joao A., Gibson, Peter G., Heaney, Liam G., Huang, Erick Wan-Chun, Iwanaga, Takashi, Jackson, David J., Koh, Mariko Siyue, Lehtimaki, Lauri, Maspero, Jorge, Mahboub, Bassam, Menzies-Gow, Andrew N., Mitchell, Patrick D., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng, Diahn-Warng, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Denton, Eve, Hew, Mark, Peters, Matthew J., Upham, John W., Bulathsinhala, Lakmini, Tran, Trung N., Martin, Neil, Bergeron, Celine, Al-Ahmad, Mona, Altraja, Alan, Larenas-Linnemann, Desiree, Murray, Ruth, Celis-Preciado, Carlos Andres, Al-Lehebi, Riyad, Belhassen, Manon, Bhutani, Mohit, Bosnic-Anticevich, Sinthia Z., Bourdin, Arnaud, Brusselle, Guy G., Busby, John, Canonica, Giorgio Walter, Heffler, Enrico, Chapman, Kenneth R., Charriot, Jeremy, Christoff, George C., Chung, Li Ping, Cosio, Borja G., Cote, Andreanne, Costello, Richard W., Cushen, Breda, Fingleton, James, Fonseca, Joao A., Gibson, Peter G., Heaney, Liam G., Huang, Erick Wan-Chun, Iwanaga, Takashi, Jackson, David J., Koh, Mariko Siyue, Lehtimaki, Lauri, Maspero, Jorge, Mahboub, Bassam, Menzies-Gow, Andrew N., Mitchell, Patrick D., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng, Diahn-Warng, Pfeffer, Paul E., Popov, Todor A., and Porsbjerg, Celeste M. more...
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Background: Biologic asthma therapies reduce exacerbations and long-term oral corticosteroids (LTOCS) use in randomized controlled trials (RCTs); however, there are limited data on outcomes among patients ineligible for RCTs. Hence, we investigated responsiveness to biologics in a real-world population of adults with severe asthma. Methods: Adults in the International Severe Asthma Registry (ISAR) with ≥24 weeks of follow-up were grouped into those who did, or did not, initiate biologics (anti-IgE, anti-IL5/IL5R, anti-IL4/13). Treatment responses were examined across four domains: forced expiratory volume in 1 second (FEV 1) increase by ≥100 mL, improved asthma control, annualized exacerbation rate (AER) reduction ≥50%, and any LTOCS dose reduction. Super-response criteria were: FEV 1 increase by ≥500 mL, new well-controlled asthma, no exacerbations, and LTOCS cessation or tapering to ≤5 mg/day. Results: 5.3% of ISAR patients met basic RCT inclusion criteria; 2116/8451 started biologics. Biologic initiators had worse baseline impairment than non-initiators, despite having similar biomarker levels. Half or more of initiators had treatment responses: 59% AER reduction, 54% FEV 1 increase, 49% improved control, 49% reduced LTOCS, of which 32%, 19%, 30%, and 39%, respectively, were super-responses. Responses/super-responses were more frequent in biologic initiators than in non-initiators; nevertheless, ~40–50% of initiators did not meet response criteria. Conclusions: Most patients with severe asthma are ineligible for RCTs of biologic therapies. Biologics are initiated in patients who have worse baseline impairments than non-initiators despite similar biomarker levels. Although biologic initiators exhibited clinical responses and super-responses in all outcome domains, 40–50% did not meet the response criteria. more...
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- 2024
20. Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma
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Porsbjerg, Celeste M., Townend, John, Bergeron, Celine, Christoff, George C., Katsoulotos, Gregory P., Larenas-Linnemann, Desiree, Tran, Trung N., Al-Lehebi, Riyad, Bosnic-Anticevich, Sinthia Z., Busby, John, Hew, Mark, Kostikas, Konstantinos, Papadopoulos, Nikolaos G., Pfeffer, Paul E., Popov, Todor A., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tsai, Ming-Ju, Ulrik, Charlotte Suppli, Al-Ahmad, Mona, Altraja, Alan, Beastall, Aaron, Bulathsinhala, Lakmini, Carter, Victoria, Cosio, Borja G., Fletton, Kirsty, Hansen, Susanne, Heaney, Liam G., Hubbard, Richard B., Kuna, Piotr, Murray, Ruth B., Nagano, Tatsuya, Pini, Laura, Rosales, Diana Jimena Cano, Schleich, Florence, Wechsler, Michael E., Amaral, Rita, Bourdin, Arnaud, Brusselle, Guy G., Chen, Wenjia, Chung, Li Ping, Denton, Eve, Fonseca, Joao A., Hoyte, Flavia, Jackson, David J., Katial, Rohit, Kirenga, Bruce J., Koh, Mariko Siyue, Lawkiedraj, Agnieszka, Lehtimaki, Lauri, Liew, Mei Fong, Mahboub, Bassam, Martin, Neil, Menzies-Gow, Andrew N., Pang, Pee Hwee, Papaioannou, Andriana I., Patel, Pujan H., Perez-De-Llano, Luis, Peters, Matthew J., Ricciardi, Luisa, Rodriguez-Caceres, Bellanid, Solarte, Ivan, Tay, Tunn Ren, Torres-Duque, Carlos A., Wang, Eileen, Zappa, Martina, Abisheganaden, John, Assing, Karin Dahl, Costello, Richard W., Gibson, Peter G., Heffler, Enrico, Maspero, Jorge, Nicola, Stefania, Steve, Diahn-Warng Perng, Puggioni, Francesca, Salvi, Sundeep, Sheu, Chau-Chyun, Sirena, Concetta, Taille, Camille, Tan, Tze Lee, Bjermer, Leif, Canonica, Giorgio Walter, Iwanaga, Takashi, Jimenez-Maldonado, Libardo, Taube, Christian, Brussino, Luisa, Price, David B., Porsbjerg, Celeste M., Townend, John, Bergeron, Celine, Christoff, George C., Katsoulotos, Gregory P., Larenas-Linnemann, Desiree, Tran, Trung N., Al-Lehebi, Riyad, Bosnic-Anticevich, Sinthia Z., Busby, John, Hew, Mark, Kostikas, Konstantinos, Papadopoulos, Nikolaos G., Pfeffer, Paul E., Popov, Todor A., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tsai, Ming-Ju, Ulrik, Charlotte Suppli, Al-Ahmad, Mona, Altraja, Alan, Beastall, Aaron, Bulathsinhala, Lakmini, Carter, Victoria, Cosio, Borja G., Fletton, Kirsty, Hansen, Susanne, Heaney, Liam G., Hubbard, Richard B., Kuna, Piotr, Murray, Ruth B., Nagano, Tatsuya, Pini, Laura, Rosales, Diana Jimena Cano, Schleich, Florence, Wechsler, Michael E., Amaral, Rita, Bourdin, Arnaud, Brusselle, Guy G., Chen, Wenjia, Chung, Li Ping, Denton, Eve, Fonseca, Joao A., Hoyte, Flavia, Jackson, David J., Katial, Rohit, Kirenga, Bruce J., Koh, Mariko Siyue, Lawkiedraj, Agnieszka, Lehtimaki, Lauri, Liew, Mei Fong, Mahboub, Bassam, Martin, Neil, Menzies-Gow, Andrew N., Pang, Pee Hwee, Papaioannou, Andriana I., Patel, Pujan H., Perez-De-Llano, Luis, Peters, Matthew J., Ricciardi, Luisa, Rodriguez-Caceres, Bellanid, Solarte, Ivan, Tay, Tunn Ren, Torres-Duque, Carlos A., Wang, Eileen, Zappa, Martina, Abisheganaden, John, Assing, Karin Dahl, Costello, Richard W., Gibson, Peter G., Heffler, Enrico, Maspero, Jorge, Nicola, Stefania, Steve, Diahn-Warng Perng, Puggioni, Francesca, Salvi, Sundeep, Sheu, Chau-Chyun, Sirena, Concetta, Taille, Camille, Tan, Tze Lee, Bjermer, Leif, Canonica, Giorgio Walter, Iwanaga, Takashi, Jimenez-Maldonado, Libardo, Taube, Christian, Brussino, Luisa, and Price, David B. more...
- Abstract
Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials. Aim: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life. Methods: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change for each of three asthma outcome domains (i.e. exacerbation rate, symptom control and lung function), and the association of this change with pre-biologic biomarkers was investigated for individual and combined biomarkers. Results: Overall, 3751 patients initiated biologics and were included in the analysis. No association was found between pre-biologic BEC and pre-to-post biologic change in exacerbation rate for any biologic class. However, higher pre-biologic BEC and FeNO were both associated with greater post-biologic improvement in FEV1 for both anti-IgE and anti-IL5/5R, with a trend for antiI-IL4R alpha. Mean FEV1 improved by 27-178 mL post-anti-IgE as pre-biologic BEC increased (250 to 1000 cells/mu L), and by 43-216 mL and 129-250 mL post-anti-IL5/5R and - anti- IL4R alpha, respectively along the same BEC gradient. Corresponding improvements along a FeNO gradient (25-100 ppb) were 41-274 mL, 69-207 mL and 148-224 mL for anti-IgE, anti-IL5/5R, and anti-IL4R alpha, respectively. Higher baseline BEC was also associated with lower probability of uncontrolled asthma (OR 0.392; p=0.001) post-biologic for anti-IL5/5R. Pre-biologic IgE was a poor predictor of subsequent pre-to-post-biologic change for more...
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- 2024
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21. Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma
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Perez-de-Llano, Luis, primary, Scelo, Ghislaine, additional, Canonica, G. Walter, additional, Chen, Wenjia, additional, Henley, William, additional, Larenas-Linnemann, Désirée, additional, Peters, Matthesadatw J, additional, Pfeffer, Paul E., additional, Tran, Trung N., additional, Ulrik, Charlotte Suppli, additional, Popov, Todor A., additional, Sadatsafavi, Mohsen, additional, Hew, Mark, additional, Maspero, Jorge, additional, Gibson, Peter G., additional, Christoff, George C., additional, Fitzgerald, J. Mark, additional, Torres-Duque, Carlos A., additional, Porsbjerg, Celeste M., additional, Papadopoulos, Nikolaos G., additional, Papaioannou, Andriana I., additional, Heffler, Enrico, additional, Iwanaga, Takashi, additional, Al-Ahmad, Mona, additional, Kuna, Piotr, additional, Fonseca, João A, additional, Al-Lehebi, Riyad, additional, Rhee, Chin Kook, additional, Koh, Mariko Siyue, additional, Cosio, Borja G., additional, Perng (Steve), Diahn-Warng, additional, Mahboub, Bassam, additional, Menzies-Gow, Andrew N., additional, Jackson, David J., additional, Busby, John, additional, Heaney, Liam G., additional, Patel, Pujan H, additional, Wang, Eileen, additional, Wechsler, Michael E., additional, Altraja, Alan, additional, Lehtimäki, Lauri, additional, Bourdin, Arnaud, additional, Bjermer, Leif, additional, Bulathsinhala, Lakmini, additional, Carter, Victoria, additional, Murray, Ruth, additional, Beastall, Aaron, additional, Denton, Eve, additional, and Price, David B., additional more...
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- 2023
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22. Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma
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Wechsler, Michael E, primary, Scelo, Ghislaine, additional, Larenas-Linnemann, Désirée E. S., additional, Torres-Duque, Carlos A., additional, Maspero, Jorge, additional, Tran, Trung N., additional, Murray, Ruth B., additional, Martin, Neil, additional, Menzies-Gow, Andrew N., additional, Hew, Mark, additional, Peters, Matthew J, additional, Gibson, Peter G, additional, Christoff, George C., additional, Popov, Todor A., additional, Côté, Andréanne, additional, Bergeron, Celine, additional, Dorscheid, Delbert, additional, FitzGerald, J Mark, additional, Chapman, Kenneth R, additional, Boulet, Louis Philippe, additional, Bhutani, Mohit, additional, Sadatsafavi, Mohsen, additional, Jiménez-Maldonado, Libardo, additional, Duran-Silva, Mauricio, additional, Rodriguez, Bellanid, additional, Celis-Preciado, Carlos Andres, additional, Cano-Rosales, Diana Jimena, additional, Solarte, Ivan, additional, Fernandez- Sanchez, Maria Jose, additional, Parada-Tovar, Patricia, additional, von Bülow, Anna, additional, Bjerrum, Anne Sofie, additional, Ulrik, Charlotte S, additional, Assing, Karin Dahl, additional, Rasmussen, Linda Makowska, additional, Hansen, Susanne, additional, Altraja, Alan, additional, Bourdin, Arnaud, additional, Taille, Camille, additional, Charriot, Jeremy, additional, Roche, Nicolas, additional, Papaioannou, Andriana I, additional, Kostikas, Konstantinos, additional, Papadopoulos, Nikolaos G., additional, Salvi, Sundeep, additional, Long, Deirdre, additional, Mitchell, Patrick D, additional, Costello, Richard, additional, Sirena, Concetta, additional, Cardini, Cristina, additional, Heffler, Enrico, additional, Puggioni, Francesca, additional, Canonica, Giorgio Walter, additional, Guida, Giuseppe, additional, Iwanaga, Takashi, additional, Al-Ahmad, Mona, additional, García, Ulises, additional, Kuna, Piotr, additional, Fonseca, João A., additional, Al-Lehebi, Riyad, additional, Koh, Mariko S., additional, Rhee, Chin Kook, additional, Cosio, Borja G, additional, Perez de Llano, Luis, additional, Perng, Diahn-Warng, additional, Huang, Erick Wan-Chun, additional, Wang, Hao-Chien, additional, Tsai, Ming-Ju, additional, Mahboub, Bassam, additional, Salameh, Laila Ibraheem Jaber, additional, Jackson, David J., additional, Busby, John, additional, Heaney, Liam G, additional, Pfeffer, Paul E., additional, Goddard, Amanda Grippen, additional, Wang, Eileen, additional, Hoyte, Flavia C. L., additional, Chapman, Nicholas M, additional, Katial, Rohit, additional, Carter, Victoria, additional, Bulathsinhala, Lakmini, additional, Eleangovan, Neva, additional, Ariti, Con, additional, Lyu, Juntao, additional, Porsbjerg, Celeste, additional, and Price, David B., additional more...
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- 2023
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23. Using Smartphone Exophthalmometry to Measure Eyeball Protrusion
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Popov, Todor, primary, Fierz, Fabienne C., additional, Bockisch, Christopher J., additional, and Weber, Konrad P., additional
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- 2023
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24. Clinical remission following biologic initiation in severe asthma: results of the International Severe Asthma Registry (ISAR)
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Scelo, Ghislaine, primary, Tran, Trung N., additional, Le, Tham T., additional, Faregås, Malin, additional, Martin, Neil, additional, Menzies-Gow, Andrew N., additional, Eileen, Wang, additional, Wechsler, Michael, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Heaney, Liam G., additional, Jackson, David J., additional, Pfeffer, Paul E, additional, Busby, John, additional, Porsbjerg, Celeste M., additional, Hew, Mark, additional, Peters, Matthew, additional, Gibson, Peter G., additional, Al-Ahmad, Mona, additional, Bergeron, Celine, additional, Sadatsafavi, Mohsen, additional, Perez-De-Llano, Luis, additional, Cosio, Borja G, additional, Kuna, Piotr, additional, Perng, Diahn-Warng, additional, Iwanaga, Takashi, additional, Torres-Duque, Carlos A., additional, Larenas-Linnemann, Désirée, additional, Mahboub, Bassam, additional, Al-Lehebi, Riyad, additional, Fonseca, João A., additional, Rhee, Chin Kook, additional, Máspero, Jorge, additional, Siyue, Mariko Koh, additional, Christoff, George C, additional, Popov, Todor A., additional, Kwiatek, Justin, additional, Carter, Victoria, additional, Goh, Celine, additional, Bulathsinhala, Lakmini, additional, Beastall, Aaron, additional, and Price, David, additional more...
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- 2023
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25. Real-world associations between outcomes and biomarkers in severe asthma patients treated with biologics
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Townend, John, primary, Tran, Trung N, additional, Martin, Neil, additional, Menzies-Gow, Andrew N., additional, Wang, Eileen, additional, Wechsler, Michael E., additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Perez-De-Llano, Luis, additional, Cosio, Borja G., additional, Hew, Mark, additional, Peters, Matthew, additional, Gibson, Peter G., additional, Bosnic-Anticevich, Sinthia, additional, Heaney, Liam G., additional, Jackson, David J., additional, Pfeffer, Paul E., additional, Busby, John, additional, Salvi, Sundeep, additional, Christoff, George C., additional, Popov, Todor A., additional, Porsbjerg, Celeste M., additional, Torres-Duque, Carlos A., additional, Al-Lehebi, Riyad, additional, Al-Ahmad, Mona, additional, Perng, Diahn-Warng, additional, Bergeron, Celine, additional, Sadatsafavi, Mohsen, additional, Mahboub, Bassam, additional, Iwanaga, Takashi, additional, Maspero, Jorge, additional, Kuna, Piotr, additional, Chin, Kook Rhee, additional, Larenas-Linnemann, Désirée, additional, Papadopoulos, Nikolaos G., additional, Papaioannou, Andriana I., additional, Fonseca, João A., additional, Siyue Koh, Mariko, additional, Costello, Richard W., additional, and Price, David, additional more...
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- 2023
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26. Real world biologic treatment response in severe asthma: an analysis of the International Severe Asthma Registry (ISAR)
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Le, Tham T., primary, Scelo, Ghislaine, additional, Tran, Trung N.., additional, Faregås, Malin, additional, Martin, Neil, additional, Menzies-Gow, Andrew N., additional, Eileen, Wang, additional, Wechsler, Michael, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Heaney, Liam G., additional, Jackson, David J., additional, Pfeffer, Paul E., additional, Busby, John, additional, Porsbjerg, Celeste M., additional, Hew, Mark, additional, Peters, Matthew, additional, Gibson, Peter G., additional, Al-Ahmad, Mona, additional, Bergeron, Celine, additional, Sadatsafavi, Mohsen, additional, Perez-De-Llano, Luis, additional, Cosio, Borja G., additional, Kuna, Piotr, additional, Perng, Diahn-Warng, additional, Iwanaga, Takashi, additional, Torres-Duque, Carlos A., additional, Larenas-Linnemann, Désirée, additional, Mahboub, Bassam, additional, Papadopoulos, Nikolaos G., additional, Al-Lehebi, Riyad, additional, Fonseca, João A., additional, Rhee, Chin Kook, additional, Máspero, Jorge, additional, Siyue, Mariko Koh, additional, Christoff, George C., additional, Popov, Todor A., additional, Kwiatek, Justin, additional, Carter, Victoria, additional, Goh, Celine, additional, Bulathsinhala, Lakmini, additional, Beastall, Aaron, additional, and Price, David, additional more...
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- 2023
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27. Characteristics associated with clinical remission in patients with severe asthma who initiate biologics
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Pérez De Llano, Luis, primary, Scelo, Ghislaine, additional, Tran, Trung N, additional, T. Le, Tham, additional, Martin, Neil, additional, Fagerås, Malin, additional, Menzies-Gow, Andrew N., additional, Wang, Eileen, additional, E. Wechsler, Michael, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Heaney, Liam G., additional, Jackson, David J., additional, Pfeffer, Paul E., additional, Busby, John, additional, Porsbjerg, Celeste M., additional, Hew, Mark, additional, Peters, Matthew, additional, Gibson, Peter G., additional, Al-Ahmad, Mona, additional, Bergeron, Celine, additional, Sadatsafavi, Mohsen, additional, Cosio, Borja G., additional, Kuna, Piotr, additional, Perng, Diahn-Warng, additional, Iwanaga, Takashi, additional, Torres-Duque, Carlos A., additional, Larenas-Linnemann, Désirée, additional, Mahboub, Bassam, additional, Papadopoulos, Nikolaos G., additional, Al-Lehebi, Riyad, additional, Fonseca, João A., additional, Kook Rhee, Chin, additional, Máspero, Jorge, additional, Koh, Mariko Siyue, additional, Christoff, George C., additional, Popov, Todor A., additional, Kwiatek, Justin, additional, Carter, Victoria, additional, Goh, Celine, additional, Bulathsinhala, Lakmini, additional, Beastall, Aaron, additional, and Price, David, additional more...
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- 2023
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28. Peritumor Mucosa in Advanced Laryngeal Carcinoma Exhibits an Aberrant Proangiogenic Signature Distinctive from the Expression Pattern in Adjacent Tumor Tissue.
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Kyurkchiyan, Silva G., Stancheva, Gergana, Petkova, Veronika, Panova, Stiliana, Dobriyanova, Venera, Stancheva, Iglika, Marinov, Venelin, Zahariev, Zahari, Kaneva, Radka P., and Popov, Todor M.
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MUCOUS membranes ,CARCINOMA ,TUMORS ,TISSUES ,TREATMENT effectiveness - Abstract
The field cancerization theory is an important paradigm in head and neck carcinoma as its oncological repercussions affect treatment outcomes in diverse ways. The aim of this study is to assess the possible interconnection between peritumor mucosa and the process of tumor neoangiogenesis. Sixty patients with advanced laryngeal carcinoma were enrolled in this study. The majority of patients express a canonical HIF-upregulated proangiogenic signature with almost complete predominancy of HIF-1α overexpression and normal expression levels of the HIF-2α isoform. Remarkably, more than 60% of the whole cohort also exhibited an HIF-upregulated proangiogenic signature in the peritumoral benign mucosa. Additionally, the latter subgroup had a distinctly shifted phenotype towards HIF-2α upregulation compared to the one in tumor tissue, i.e., a tendency towards an HIF switch is observed in contrast to the dominated by HIF-1α tumor phenotype. ETS-1 displays stable and identical significant overexpression in both the proangiogenic phenotypes present in tumor and peritumoral mucosa. In the current study, we report for the first time the existence of an abnormal proangiogenic expression profile present in the peritumoral mucosa in advanced laryngeal carcinoma when compared to paired distant laryngeal mucosa. Moreover, we describe a specific phenotype of this proangiogenic signature that is significantly different from the one present in tumor tissue as we delineate both phenotypes, quantitively and qualitatively. This finding is cancer heterogeneity, per se, which extends beyond the "classical" borders of the malignancy, and it is proof of a strong interconnection between field cancerization and one of the classical hallmarks of cancer—the process of tumor neoangiogenesis. [ABSTRACT FROM AUTHOR] more...
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- 2024
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29. Landau Levels versus Hydrogen Atom.
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Dereli, Tekin, Nounahon, Philippe, and Popov, Todor
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LANDAU levels ,HARMONIC oscillators ,HILBERT space ,ANGULAR momentum (Mechanics) ,KEPLER problem ,SYMMETRY breaking ,HYDROGEN atom - Abstract
The Landau problem and harmonic oscillator in the plane share a Hilbert space that carries the structure of Dirac's remarkable s o (2 , 3) representation. We show that the orthosymplectic algebra o s p (1 | 4) is the spectrum generating algebra for the Landau problem and, hence, for the 2D isotropic harmonic oscillator. The 2D harmonic oscillator is in duality with the 2D quantum Coulomb–Kepler systems, with the o s p (1 | 4) symmetry broken down to the conformal symmetry s o (2 , 3) . The even s o (2 , 3) submodule (coined Rac) generated from the ground state of zero angular momentum is identified with the Hilbert space of a 2D hydrogen atom. An odd element of the superalgebra o s p (1 | 4) creates a pseudo-vacuum with intrinsic angular momentum 1/2 from the vacuum. The odd s o (2 , 3) -submodule (coined Di) built upon the pseudo-vacuum is the Hilbert space of a magnetized 2D hydrogen atom: a quantum system of a dyon and an electron. Thus, the Hilbert space of the Landau problem is a direct sum of two massless unitary s o (2 , 3) representations, namely, the Di and Rac singletons introduced by Flato and Fronsdal. [ABSTRACT FROM AUTHOR] more...
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- 2024
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30. Solutions with exponential singularity for (3 + 1)-D Protter problems
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Popivanov, Nedyu, primary, Popov, Todor, additional, and Witt, Ingo, additional
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- 2023
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31. Impact of Inititing Biologics in Patients With Severe Asthma on Long-term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER):Data From the International Severe Asthma Registry
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Chen, Wenjia, Tran, Trung N., Sadatsafavi, Mohsen, Murray, Ruth, Wong, Nigel Chong Boon, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Gil, Esther Garcia, FitzGerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fonseca, João A., Gibson, Peter G., Yoo, Kwang Ha, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng (Steve), Diahn Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Ra, Seung Won, Wang, Eileen, Wechsler, Michael E., Price, David B., Chen, Wenjia, Tran, Trung N., Sadatsafavi, Mohsen, Murray, Ruth, Wong, Nigel Chong Boon, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Gil, Esther Garcia, FitzGerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fonseca, João A., Gibson, Peter G., Yoo, Kwang Ha, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng (Steve), Diahn Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Ra, Seung Won, Wang, Eileen, Wechsler, Michael E., and Price, David B. more...
- Abstract
Background Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective To examine the effectiveness of initiating biologics in a large, real-world cohort of adult patients with severe asthma and HOCS. Methods This was a propensity score–matched, prospective cohort study using data from the International Severe Asthma Registry. Between January 2015 and February 2021, patients with severe asthma and HOCS (long-term OCSs for ≥1 year or ≥4 courses of rescue OCSs within a 12-month period) were identified. Biologic initiators were identified and, using propensity scores, matched 1:1 with noninitiators. The impact of biologic initiation on asthma outcomes was assessed using generalized linear models. Results We identified 996 matched pairs of patients. Both groups improved over the 12-month follow-up period, but improvement was greater for biologic initiators. Biologic initiation was associated with a 72.9% reduction in the average number of exacerbations per year versus noninitiators (0.64 vs 2.06; rate ratio, 0.27 [95% CI, 0.10-0.71]). Biologic initiators were 2.2 times more likely than noninitiators to take a daily long-term OCS dose of less than 5 mg (risk probability, 49.6% vs 22.5%; P = .002) and had a lower risk of asthma-related emergency department visits (relative risk, 0.35 [95% CI, 0.21-0.58]; rate ratio, 0.26 [0.14-0.48]) and hospitalizations (relative risk, 0.31 [95% CI, 0.18-0.52]; rate ratio, 0.25 [0.13-0.48]). Conclusions In a real-world setting, including patients with severe asthma and HOCS from 19 countries, and within an environment of clinical improvement, initiation of biologics was associated with further improvements across multiple asthma outcomes, including exacerbation rate, OCS exposure, and health care resource utilization., Background: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective: To examine the effectiveness of initiating biologics in a large, real-world cohort of adult patients with severe asthma and HOCS. Methods: This was a propensity score–matched, prospective cohort study using data from the International Severe Asthma Registry. Between January 2015 and February 2021, patients with severe asthma and HOCS (long-term OCSs for ≥1 year or ≥4 courses of rescue OCSs within a 12-month period) were identified. Biologic initiators were identified and, using propensity scores, matched 1:1 with noninitiators. The impact of biologic initiation on asthma outcomes was assessed using generalized linear models. Results: We identified 996 matched pairs of patients. Both groups improved over the 12-month follow-up period, but improvement was greater for biologic initiators. Biologic initiation was associated with a 72.9% reduction in the average number of exacerbations per year versus noninitiators (0.64 vs 2.06; rate ratio, 0.27 [95% CI, 0.10-0.71]). Biologic initiators were 2.2 times more likely than noninitiators to take a daily long-term OCS dose of less than 5 mg (risk probability, 49.6% vs 22.5%; P = .002) and had a lower risk of asthma-related emergency department visits (relative risk, 0.35 [95% CI, 0.21-0.58]; rate ratio, 0.26 [0.14-0.48]) and hospitalizations (relative risk, 0.31 [95% CI, 0.18-0.52]; rate ratio, 0.25 [0.13-0.48]). Conclusions: In a real-world setting, including patients with severe asthma and HOCS from 19 countries, and within an environment of clinical improvement, initiation of biologics was associated with further improvements across multiple asthma outcomes, including exacerbation rate, OCS exposure, and health care resource utilization. more...
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- 2023
32. Comparative effectiveness of anti-IL5 and anti-IgE biologic classes in patients with severe asthma eligible for both
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Pfeffer, Paul E., Ali, Nasloon, Murray, Ruth, Ulrik, Charlotte, Tran, Trung N., Maspero, Jorge, Peters, Matthew, Christoff, George C., Sadatsafavi, Mohsen, Torres-Duque, Carlos A., Altraja, Alan, Lehtimäki, Lauri, Papadopoulos, Nikolaos G, Salvi, Sundeep, Costello, Richard W., Cushen, Breda, Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Larenas-Linnemann, Désirée, Kuna, Piotr, Fonseca, João A., Al-Lehebi, Riyad, Rhee, Chin Kook, Perez-de-Llano, Luis, Perng Steve, Diahn Warng, Mahboub, Bassam, Wang, Eileen, Goh, Celine, Lyu, Juntao, Newell, Anthony, Alacqua, Marianna, Belevskiy, Andrey S., Bhutani, Mohit, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Bulow, Anna von, Busby, John, Canonica, Giorgio Walter, Cosio, Borja G., Dorscheid, Delbert R., Muñoz-Esquerre, Mariana, FitzGerald, J. Mark, Gil, Esther Garcia, Gibson, Peter G., Heaney, Liam G., Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Jackson, David J., Koh, Mariko Siyue, Ko, Hsin Kuo Bruce, Lee, Jae Ha, Lehmann, Sverre, Chaves Loureiro, Cláudia, Lúðvíksdóttir, Dóra, Menzies-Gow, Andrew N., Mitchell, Patrick, Papaioannou, Andriana I., Popov, Todor A., Porsbjerg, Celeste M., Salameh, Laila, Sirena, Concetta, Taillé, Camille, Taube, Christian, Tohda, Yuji, Wechsler, Michael E., Price, David B., Pfeffer, Paul E., Ali, Nasloon, Murray, Ruth, Ulrik, Charlotte, Tran, Trung N., Maspero, Jorge, Peters, Matthew, Christoff, George C., Sadatsafavi, Mohsen, Torres-Duque, Carlos A., Altraja, Alan, Lehtimäki, Lauri, Papadopoulos, Nikolaos G, Salvi, Sundeep, Costello, Richard W., Cushen, Breda, Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Larenas-Linnemann, Désirée, Kuna, Piotr, Fonseca, João A., Al-Lehebi, Riyad, Rhee, Chin Kook, Perez-de-Llano, Luis, Perng Steve, Diahn Warng, Mahboub, Bassam, Wang, Eileen, Goh, Celine, Lyu, Juntao, Newell, Anthony, Alacqua, Marianna, Belevskiy, Andrey S., Bhutani, Mohit, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Bulow, Anna von, Busby, John, Canonica, Giorgio Walter, Cosio, Borja G., Dorscheid, Delbert R., Muñoz-Esquerre, Mariana, FitzGerald, J. Mark, Gil, Esther Garcia, Gibson, Peter G., Heaney, Liam G., Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Jackson, David J., Koh, Mariko Siyue, Ko, Hsin Kuo Bruce, Lee, Jae Ha, Lehmann, Sverre, Chaves Loureiro, Cláudia, Lúðvíksdóttir, Dóra, Menzies-Gow, Andrew N., Mitchell, Patrick, Papaioannou, Andriana I., Popov, Todor A., Porsbjerg, Celeste M., Salameh, Laila, Sirena, Concetta, Taillé, Camille, Taube, Christian, Tohda, Yuji, Wechsler, Michael E., and Price, David B. more...
- Abstract
Background Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible for both anti-IgE and anti-IL5/5R and to compare the effectiveness of both classes of treatment in real life. Methods This was a prospective cohort study that included adult patients with severe asthma from 22 countries enrolled into the International Severe Asthma registry (ISAR) who were eligible for both anti-IgE and anti-IL5/5R. The effectiveness of anti-IgE and anti-IL5/5R was compared in a 1:1 matched cohort. Exacerbation rate was the primary effectiveness endpoint. Secondary endpoints included long-term-oral corticosteroid (LTOCS) use, asthma-related emergency room (ER) attendance, and hospital admissions. Results In the matched analysis (n = 350/group), the mean annualized exacerbation rate decreased by 47.1% in the anti-IL5/5R group and 38.7% in the anti-IgE group. Patients treated with anti-IL5/5R were less likely to experience a future exacerbation (adjusted IRR 0.76; 95% CI 0.64, 0.89; p < 0.001) and experienced a greater reduction in mean LTOCS dose than those treated with anti-IgE (37.44% vs. 20.55% reduction; p = 0.023). There was some evidence to suggest that patients treated with anti-IL5/5R experienced fewer asthma-related hospitalizations (IRR 0.64; 95% CI 0.38, 1.08), but not ER visits (IRR 0.94, 95% CI 0.61, 1.43). Conclusions In real life, both anti-IgE and anti-IL5/5R improve asthma outcomes in patients eligible for both biologic classes; however, anti-IL5/5R was superior in terms of reducing asthma exacerbations and LTOCS use., Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible for both anti-IgE and anti-IL5/5R and to compare the effectiveness of both classes of treatment in real life. Methods: This was a prospective cohort study that included adult patients with severe asthma from 22 countries enrolled into the International Severe Asthma registry (ISAR) who were eligible for both anti-IgE and anti-IL5/5R. The effectiveness of anti-IgE and anti-IL5/5R was compared in a 1:1 matched cohort. Exacerbation rate was the primary effectiveness endpoint. Secondary endpoints included long-term-oral corticosteroid (LTOCS) use, asthma-related emergency room (ER) attendance, and hospital admissions. Results: In the matched analysis (n = 350/group), the mean annualized exacerbation rate decreased by 47.1% in the anti-IL5/5R group and 38.7% in the anti-IgE group. Patients treated with anti-IL5/5R were less likely to experience a future exacerbation (adjusted IRR 0.76; 95% CI 0.64, 0.89; p < 0.001) and experienced a greater reduction in mean LTOCS dose than those treated with anti-IgE (37.44% vs. 20.55% reduction; p = 0.023). There was some evidence to suggest that patients treated with anti-IL5/5R experienced fewer asthma-related hospitalizations (IRR 0.64; 95% CI 0.38, 1.08), but not ER visits (IRR 0.94, 95% CI 0.61, 1.43). Conclusions: In real life, both anti-IgE and anti-IL5/5R improve asthma outcomes in patients eligible for both biologic classes; however, anti-IL5/5R was superior in terms of reducing asthma exacerbations and LTOCS use. more...
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- 2023
33. Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report
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Koch, Christian, Fleischer, Juliane, Popov, Todor, Frontzek, Karl, Schreiner, Bettina, Roth, Patrick, Manz, Markus G, Unseld, Simone, Müller, Antonia M S; https://orcid.org/0000-0003-4420-9466, Russkamp, Norman F; https://orcid.org/0000-0002-3090-7186, Koch, Christian, Fleischer, Juliane, Popov, Todor, Frontzek, Karl, Schreiner, Bettina, Roth, Patrick, Manz, Markus G, Unseld, Simone, Müller, Antonia M S; https://orcid.org/0000-0003-4420-9466, and Russkamp, Norman F; https://orcid.org/0000-0002-3090-7186 more...
- Abstract
Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and studied. Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited. Main body: We here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement. Both complications were refractory to standard treatment of ICANS. Weakness of respiratory muscles required mechanical ventilation and tracheostomy while cDI was treated with desmopressin substitution for several weeks. Muscle-nerve biopsy and nerve conduction studies confirmed an axonal pattern of nerve damage. T cell-rich infiltrates and detection of the CAR transgene in muscle-nerve sections imply a direct or indirect role of CAR-T cell-mediated inflammation. In line with current treatment guidelines for GBS, intravenous immunoglobulin was administered and gradual but incomplete recovery was observed over the course of several months. Conclusions: This case report highlights the risk of rare but severe neurological adverse events, such as acute GBS or cDI, in patients treated with CAR-T cells. It further underlines the importance of appropriate patient surveillance and systematic reporting of rare complications to eventually improve treatment. more...
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- 2023
34. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination:Results of the UCARE COVAC-CU study
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Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, Maurer, Marcus, Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus more...
- Abstract
Background: Concern about disease exacerbations and fear of reactions after coronavirus disease 2019 (COVID-19) vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy. Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19 vaccination. Methods: COVAC-CU is an international multicenter study of Urticaria Centers of Reference and Excellence (UCAREs) that retrospectively evaluated the effects of COVID-19 vaccination in CU patients aged ≥18 years and vaccinated with ≥1 dose of any COVID-19 vaccine. We evaluated CU exacerbations and severe allergic reactions as well as other adverse events associated with COVID-19 vaccinations and their association with various CU parameters. Results: Across 2769 COVID-19–vaccinated CU patients, most (90%) received at least 2 COVID-19 vaccine doses, and most patients received CU treatment and had well-controlled disease. The rate of COVID-19 vaccination–induced CU exacerbation was 9%. Of 223 patients with CU exacerbation after the first dose, 53.4% experienced recurrence of CU exacerbation after the second dose. CU exacerbation most often started <48 hours after vaccination (59.2%), lasted for a few weeks or less (70%), and was treated mainly with antihistamines (70.3%). Factors that increased the risk for COVID-19 vaccination–induced CU exacerbation included female sex, disease duration shorter than 24 months, having chronic spontaneous versus inducible urticaria, receipt of adenovirus viral vector vaccine, having nonsteroidal anti-inflammatory drug/aspirin intolerance, and having concerns about getting vaccinated; receiving omalizumab treatment and Latino/Hispanic ethnicity lowered the risk. First-dose vaccine–related adverse effects, most commonly local reactions, fever, fatigue, and muscle pain, were reported by 43.5% of CU patients. Seven patients reported severe allergic reactions. Conclusions: COVID-19 vaccination lead more...
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- 2023
35. Comparative effectiveness of anti‐IL5 and anti‐IgE biologic classes in patients with severe asthma eligible for both
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Pfeffer, Paul E., primary, Ali, Nasloon, additional, Murray, Ruth, additional, Ulrik, Charlotte, additional, Tran, Trung N., additional, Maspero, Jorge, additional, Peters, Matthew, additional, Christoff, George C., additional, Sadatsafavi, Mohsen, additional, Torres‐Duque, Carlos A., additional, Altraja, Alan, additional, Lehtimäki, Lauri, additional, Papadopoulos, Nikolaos G., additional, Salvi, Sundeep, additional, Costello, Richard W., additional, Cushen, Breda, additional, Heffler, Enrico, additional, Iwanaga, Takashi, additional, Al‐Ahmad, Mona, additional, Larenas‐Linnemann, Désirée, additional, Kuna, Piotr, additional, Fonseca, João A., additional, Al‐Lehebi, Riyad, additional, Rhee, Chin Kook, additional, Perez‐de‐Llano, Luis, additional, Perng Steve, Diahn‐Warng, additional, Mahboub, Bassam, additional, Wang, Eileen, additional, Goh, Celine, additional, Lyu, Juntao, additional, Newell, Anthony, additional, Alacqua, Marianna, additional, Belevskiy, Andrey S., additional, Bhutani, Mohit, additional, Bjermer, Leif, additional, Bjornsdottir, Unnur, additional, Bourdin, Arnaud, additional, Bulow, Anna von, additional, Busby, John, additional, Canonica, Giorgio Walter, additional, Cosio, Borja G., additional, Dorscheid, Delbert R., additional, Muñoz‐Esquerre, Mariana, additional, FitzGerald, J. Mark, additional, Gil, Esther Garcia, additional, Gibson, Peter G., additional, Heaney, Liam G., additional, Hew, Mark, additional, Hilberg, Ole, additional, Hoyte, Flavia, additional, Jackson, David J., additional, Koh, Mariko Siyue, additional, Ko, Hsin‐Kuo Bruce, additional, Lee, Jae Ha, additional, Lehmann, Sverre, additional, Chaves Loureiro, Cláudia, additional, Lúðvíksdóttir, Dóra, additional, Menzies‐Gow, Andrew N., additional, Mitchell, Patrick, additional, Papaioannou, Andriana I., additional, Popov, Todor A., additional, Porsbjerg, Celeste M., additional, Salameh, Laila, additional, Sirena, Concetta, additional, Taillé, Camille, additional, Taube, Christian, additional, Tohda, Yuji, additional, Wechsler, Michael E., additional, and Price, David B., additional more...
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- 2023
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36. Parallel Assessment of Seasonal Allergic Rhinitis Subjects Using 4 and 6-point Symptom Score Assessments
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Popov, Todor, primary, Josling, Peter, additional, and DuBuske, Lawrence, additional
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- 2023
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37. Delayed respiratory distress after thyroidectomy—another challenge for us: a case report
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Belitova, Maya, primary, Popov, Todor, additional, and Marinov, Tsvetomir, additional
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- 2023
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38. Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report
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Koch, Christian, primary, Fleischer, Juliane, additional, Popov, Todor, additional, Frontzek, Karl, additional, Schreiner, Bettina, additional, Roth, Patrick, additional, Manz, Markus G., additional, Unseld, Simone, additional, Müller, Antonia M. S., additional, and Russkamp, Norman F., additional more...
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- 2023
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39. Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in severe asthma patients eligible for both
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Price, David, primary, pfeffer, paul, additional, Ali, Nasloon, additional, Murray, Ruth, additional, Ulrik, Charlotte, additional, Tran, Trung, additional, Maspero, Jorge, additional, Peters, Matthew, additional, Christoff, George, additional, Sadatsafavi, Mohsen, additional, Torres-Duque, Carlos A., additional, Altraja, Alan, additional, Lehtimäki, Lauri, additional, Papadopoulos, Nikolaos, additional, Salvi, Sundeep, additional, Costello, Richard W., additional, Cushen, Breda, additional, Heffler, Enrico, additional, Iwanaga, Takashi, additional, Al-Ahmad, Mona, additional, Larenas-Linnemann, Désirée, additional, Kuna, Piotr, additional, Fonseca, João, additional, Al-Lehebi, Riyad, additional, Rhee, Chin Kook, additional, Llano, Luis Perez de, additional, Perng, Diahn-Wang, additional, Mahboub, Bassam, additional, Wang, Eileen, additional, Goh, Yun Yi Celine, additional, Lyu, Juntao, additional, Newell, Anthony, additional, Alacqua, Marianna, additional, Bhutani, Mohit, additional, Bjermer, Leif, additional, Björnsdóttir, Unnur Steina, additional, Bourdin, Arnaud, additional, Bülow, Anna Von, additional, Busby, John, additional, Canonica, Walter, additional, Cosio, Borja G, additional, Dorscheid, Delbert, additional, Esquerre, Mariana Muñoz, additional, FitzGerald, Mark, additional, Gil, Esther Garcia, additional, Gibson, Peter Gerard, additional, Heaney, Liam, additional, Hew, Mark, additional, Hilberg, Ole, additional, Hoyte, Flavia, additional, Jackson, David, additional, Koh, Mariko, additional, Ko, Hsin-Kuo, additional, Lee, Jae Ha, additional, Lehmann, Sverre, additional, Loureiro, Claudia Chaves, additional, Ludviksdottir, Dora, additional, Menzies-Gow, Andrew, additional, Mitchell, Patrick, additional, Papaioannou, Andriana, additional, Popov, Todor, additional, Porsbjerg, Celeste, additional, Salameh, Laila, additional, Sirena, Concetta, additional, Taillé, Camille, additional, Taube, Christian, additional, Tohda, Yuji, additional, and Wechsler, M. E., additional more...
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- 2022
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40. Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy
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Chen, Wenjia, primary, Sadatsafavi, Mohsen, additional, Tran, Trung N, additional, Murray, Ruth B, additional, Wong, Chong Boon Nigel, additional, Ali, Nasloon, additional, Ariti, Cono, additional, Garcia Gil, Esther, additional, Newell, Anthony, additional, Alacqua, Marianna, additional, Al-Ahmad, Mona, additional, Altraja, Alan, additional, Al-Lehebi, Riyad, additional, Bhutani, Mohit, additional, Bjermer, Leif, additional, Bjerrum, Anne Sofie, additional, Bourdin, Arnaud, additional, Bulathsinhala, Lakmini, additional, von Bülow, Anna, additional, Busby, John, additional, Canonica, Giorgio Walter, additional, Carter, Victoria, additional, Christoff, George C, additional, Cosio, Borja G, additional, Costello, Richard W, additional, FitzGerald, J Mark, additional, Fonseca, João A, additional, Yoo, Kwang Ha, additional, Heaney, Liam G, additional, Heffler, Enrico, additional, Hew, Mark, additional, Hilberg, Ole, additional, Hoyte, Flavia, additional, Iwanaga, Takashi, additional, Jackson, David J, additional, Jones, Rupert C, additional, Koh, Mariko Siyue, additional, Kuna, Piotr, additional, Larenas-Linnemann, Désirée, additional, Lehmann, Sverre, additional, Lehtimäki, Lauri A, additional, Lyu, Juntao, additional, Mahboub, Bassam, additional, Maspero, Jorge, additional, Menzies-Gow, Andrew N, additional, Sirena, Concetta, additional, Papadopoulos, Nikolaos, additional, Papaioannou, Andriana I, additional, Pérez de Llano, Luis, additional, Perng, Diahn-Warng, additional, Peters, Matthew, additional, Pfeffer, Paul E, additional, Porsbjerg, Celeste M, additional, Popov, Todor A, additional, Rhee, Chin Kook, additional, Salvi, Sundeep, additional, Taillé, Camille, additional, Taube, Christian, additional, Torres-Duque, Carlos A, additional, Ulrik, Charlotte S, additional, Ra, Seung Won, additional, Wang, Eileen, additional, Wechsler, Michael E, additional, and Price, David B, additional more...
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- 2022
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41. Solutions with exponential singularity for (3+1)-D Protter problems.
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Popivanov, Nedyu, Popov, Todor, and Witt, Ingo
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FLUID flow , *TRANSONIC flow , *LIGHT cones , *BOUNDARY value problems , *MODEL airplanes , *HYPERBOLIC differential equations - Abstract
In the 1950s, Protter proposed multi-dimensional analogues of the classical Guderley–Morawetz problem for mixed-type hyperbolic-elliptic equations on the plane that models transonic flows in fluid dynamics. The multi-dimensional variants turn out to be different from the two-dimensional case and the situation there is still not clear. Here, we study Protter problems in the hyperbolic part of the domain. Unlike the planar analogues, the four-dimensional variant is not well-posed for classical solutions. The problem is not Fredholm — there is an infinite number of necessary conditions for classical solvability. Alternatively, the notion of a generalized solution that may have singularities was introduced. It is known that for smooth right-hand sides, the uniquely determined generalized solution may have a power-type growth at one boundary point. The singularity is isolated at the vertex of the boundary characteristic light cone and does not propagate along the cone. Here, we construct a new singular solution with an exponential growth at the point where the singularity appears. [ABSTRACT FROM AUTHOR] more...
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- 2023
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42. The Allergen Immunotherapy Adverse Events Registry: Setup & methodology of a European Academy of Allergy and Clinical Immunology taskforce project.
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Asllani, Julijana, Mitsias, Dimitrios, Konstantinou, George, Priftanji, Alfred, Hoxha, Mehmet, Sinani, Gerta, Christoff, George, Zlatko, Dimitrov, Makris, Michael, Aggelidis, Xenofon, Stipic, Asja, Popovic‐Grle, Sanja, Deleanu, Diana, Tomic‐Spiric, Vesna, Plavsic, Aleksandra, Mungan, Dilsad, Kosnik, Mitja, Popov, Todor A., Papadopoulos, Nikolaos G., and Calderon, Moises more...
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CLINICAL immunology ,ALLERGENS ,ITCHING ,ALLERGIES ,DEGLUTITION ,VENOM hypersensitivity ,MEDICAL terminology - Abstract
To the Editor, Over the last decades, systematic reviews and meta analyses of multiple double-blind randomized placebo-controlled trials have demonstrated the efficacy and safety of both subcutaneous (SCIT) and sublingual (SLIT) allergen immunotherapy (AIT) for respiratory and insect venom allergy.[1] However, there is a wide range of AIT preparations used around the globe, and AEs are not always uniformly recorded, limiting the capability to draw safe conclusions or compare reports. Though various clinical development programs[2] have generated substantial knowledge on different AIT preparations, they have been conducted in pre-defined clinical conditions, not reflecting real-life and therefore the results may not have generalized applicability.[3] Very few pragmatic trials and observational studies have evaluated AIT safety in real-life. Adverse Events Registry is the first AIT Registry for AE piloted in different countries in Europe that uses the harmonized MedDRA terminology[9] (Table 1). [Extracted from the article] more...
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- 2023
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43. Adverse events in children and adolescents undergoing allergen immunotherapy for respiratory allergies—Report from the Allergen Immunotherapy Adverse Events Registry (ADER), a European Academy of Allergy and Clinical Immunology taskforce.
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Asllani, Julijana, Mitsias, Dimitrios, Konstantinou, George, Mesonjesi, Eris, Xhixha, Fatmira, Shehu, Esmeralda, Christoff, George, Noleva, Katia, Makris, Michael, Aggelidis, Xenofon, Turkalj, Mirjana, Damir, Erceg, Agache, Ioana, Tomic‐Spiric, Vesna, Stosovic, Rajica, Misirligil, Zeynep, Kosnik, Mitja, Popov, Todor A., Calderon, Moises, and Papadopoulos, Nikolaos G. more...
- Subjects
RESPIRATORY allergy ,CLINICAL immunology ,ALLERGENS ,IMMUNOTHERAPY ,ALLERGIES - Abstract
Background: Although it has been shown that allergen immunotherapy (AIT) is well‐tolerated in children, systematic and prospective surveillance of AIT safety in real life settings is needed. Methods: The multinational Allergen Immunotherapy Adverse Events Registry (ADER) was designed to address AIT safety in real life clinical practice. Data on children ≤18 years old with respiratory allergies undergoing AIT were retrieved. Patient‐ and AIT‐related features were collected and analyzed. The characteristics of adverse events (AE) and risk factors were evaluated. Results: A total of 851 patients, 11.3 ± 3.4 years old, with rhinitis only (47.6%); asthma and rhinitis (44.5%); asthma (7.9%), receiving 998 AIT courses were analyzed. Sublingual immunotherapy (SLIT) accounted for 51% of the courses. In 84.5% of patients only one AIT treatment was prescribed. Pollen was the most frequent sensitizer (57.1%), followed by mites (53.4%), molds (18.2%) and epithelia (16.7%). Local and systemic AEs were reported in 85 patients (9.9%). Most AEs (83.1%) were mild and occurred in <30 min (87%). Respiratory and cutaneous symptoms were more frequent. Only 4 patients (0.47%) had severe AE (none after 6 weeks of maintenance). The risk of AE was higher in patients undergoing SCIT. Conclusions: AIT is safe and well tolerated in children and adolescents with respiratory allergies in real‐life clinical practice. Though SCIT is more prone to AE compared to SLIT, overall severe reactions are rare and occur during build‐up and early maintenance. [ABSTRACT FROM AUTHOR] more...
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- 2023
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44. Narrow band imaging (NBI) technology and its possibilities for "optical biopsy" in early laryngeal cancer
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Nizamova, Nezi, additional and Popov, Todor, additional
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- 2022
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45. Cutaneous Squamous Cell Carcinoma of Head and Neck – A Case Series
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Kasaboglu, Julide, additional, Terziev, Ivan, additional, Popov, Todor Miroslavov, additional, and Rangachev, Julian, additional
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- 2022
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46. Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy
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Chen, Wenjia, Sadatsafavi, Mohsen, Tran, Trung N., Murray, Ruth B., Wong, Chong Boon Nigel, Ali, Nasloon, Ariti, Cono, Gil, Esther Garcia, Newell, Anthony, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne Sofie, Bourdin, Arnaud, Bulathsinhala, Lakmini, Von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fitzgerald, J. Mark, Fonseca, João A., Ha Yoo, Kwang, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri A., Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Sirena, Concetta, Papadopoulos, Nikolaos, Papaioannou, Andriana I., De Llano, Luis Pérez, Perng, Diahn Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte S., Won Ra, Seung, Wang, Eileen, Wechsler, Michael E., Price, David B., Chen, Wenjia, Sadatsafavi, Mohsen, Tran, Trung N., Murray, Ruth B., Wong, Chong Boon Nigel, Ali, Nasloon, Ariti, Cono, Gil, Esther Garcia, Newell, Anthony, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne Sofie, Bourdin, Arnaud, Bulathsinhala, Lakmini, Von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fitzgerald, J. Mark, Fonseca, João A., Ha Yoo, Kwang, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri A., Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Sirena, Concetta, Papadopoulos, Nikolaos, Papaioannou, Andriana I., De Llano, Luis Pérez, Perng, Diahn Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte S., Won Ra, Seung, Wang, Eileen, Wechsler, Michael E., and Price, David B. more...
- Abstract
Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. Methods: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of steroid bursts in a year) from the International Severe Asthma Registry (ISAR; https://isaregistries.org/), who initiated or did not initiate biologics (anti-lgE, anti-IL5/5R or anti-IL4R), were described at the time of biologic initiation or registry enrolment. Statistical relationships were tested using Pearson's chi-squared tests for categorical variables, and t-tests for continuous variables, adjusting for potential errors in multiple comparisons. Results: Between January 2015 and February 2021, we identified 1412 adult patients with severe asthma from 19 countries that met our inclusion criteria of HOCS, of whom 996 (70.5%) initiated a biologic and 416 (29.5%) did not. The frequency of biologic initiation varied across geographical regions. Those who initiated a biologic were more likely to have higher blood eosinophil count (483 vs 399 cells/µL, p=0.003), serious infections (49.0% vs 13.3%, p<0.001), nasal polyps (35.2% vs 23.6%, p<0.001), airflow limitation (56.8% vs 51.8%, p=0.013), and uncontrolled asthma (80.8% vs 73.2%, p=0.004) despite greater conventional treatment adherence than those who did not start a biologic. Both groups had similar annual asthma exacerbation rates in the previous 12 months (5.7 vs 5.3, p=0.147). Conclusion: Around one third of severe HOCS asthma patients did not receive biologics despite a similar high burden of asthma exacerbations as those who initiated a biologic therapy. Other disease characteristics such as eosinophilic phenotype, serious infectious events, nasal polyps, airflow limitation and lack of asthma control appear to di more...
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- 2022
47. Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy
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Chen,Wenjia, Sadatsafavi,Mohsen, Tran,Trung N, Murray,Ruth B, Wong,Chong Boon Nigel, Ali,Nasloon, Ariti,Cono, Garcia Gil,Esther, Newell,Anthony, Alacqua,Marianna, Al-Ahmad,Mona, Altraja,Alan, Al-Lehebi,Riyad, Bhutani,Mohit, Bjermer,Leif, Bjerrum,Anne Sofie, Bourdin,Arnaud, Bulathsinhala,Lakmini, von Bülow,Anna, Busby,John, Canonica,Giorgio Walter, Carter,Victoria, Christoff,George C, Cosio,Borja G, Costello,Richard W, FitzGerald,J Mark, Fonseca,João A, Yoo,Kwang Ha, Heaney,Liam G, Heffler,Enrico, Hew,Mark, Hilberg,Ole, Hoyte,Flavia, Iwanaga,Takashi, Jackson,David J, Jones,Rupert C, Koh,Mariko Siyue, Kuna,Piotr, Larenas-Linnemann,Désirée, Lehmann,Sverre, Lehtimäki,Lauri A, Lyu,Juntao, Mahboub,Bassam, Maspero,Jorge, Menzies-Gow,Andrew N, Sirena,Concetta, Papadopoulos,Nikolaos, Papaioannou,Andriana I, Pérez de Llano,Luis, Perng,Diahn-Warng, Peters,Matthew, Pfeffer,Paul E, Porsbjerg,Celeste M, Popov,Todor A, Rhee,Chin Kook, Salvi,Sundeep, Taillé,Camille, Taube,Christian, Torres-Duque,Carlos A, Ulrik,Charlotte S, Ra,Seung Won, Wang,Eileen, Wechsler,Michael E, Price,David B, Chen,Wenjia, Sadatsafavi,Mohsen, Tran,Trung N, Murray,Ruth B, Wong,Chong Boon Nigel, Ali,Nasloon, Ariti,Cono, Garcia Gil,Esther, Newell,Anthony, Alacqua,Marianna, Al-Ahmad,Mona, Altraja,Alan, Al-Lehebi,Riyad, Bhutani,Mohit, Bjermer,Leif, Bjerrum,Anne Sofie, Bourdin,Arnaud, Bulathsinhala,Lakmini, von Bülow,Anna, Busby,John, Canonica,Giorgio Walter, Carter,Victoria, Christoff,George C, Cosio,Borja G, Costello,Richard W, FitzGerald,J Mark, Fonseca,João A, Yoo,Kwang Ha, Heaney,Liam G, Heffler,Enrico, Hew,Mark, Hilberg,Ole, Hoyte,Flavia, Iwanaga,Takashi, Jackson,David J, Jones,Rupert C, Koh,Mariko Siyue, Kuna,Piotr, Larenas-Linnemann,Désirée, Lehmann,Sverre, Lehtimäki,Lauri A, Lyu,Juntao, Mahboub,Bassam, Maspero,Jorge, Menzies-Gow,Andrew N, Sirena,Concetta, Papadopoulos,Nikolaos, Papaioannou,Andriana I, Pérez de Llano,Luis, Perng,Diahn-Warng, Peters,Matthew, Pfeffer,Paul E, Porsbjerg,Celeste M, Popov,Todor A, Rhee,Chin Kook, Salvi,Sundeep, Taillé,Camille, Taube,Christian, Torres-Duque,Carlos A, Ulrik,Charlotte S, Ra,Seung Won, Wang,Eileen, Wechsler,Michael E, and Price,David B more...
- Abstract
Wenjia Chen,1 Mohsen Sadatsafavi,2 Trung N Tran,3 Ruth B Murray,4 Chong Boon Nigel Wong,1 Nasloon Ali,4,5 Cono Ariti,4,5 Esther Garcia Gil,6 Anthony Newell,5,7 Marianna Alacqua,8 Mona Al-Ahmad,9 Alan Altraja,10 Riyad Al-Lehebi,11,12 Mohit Bhutani,13 Leif Bjermer,14 Anne Sofie Bjerrum,15 Arnaud Bourdin,16 Lakmini Bulathsinhala,4,5 Anna von Bülow,17 John Busby,18 Giorgio Walter Canonica,19,20 Victoria Carter,4,5 George C Christoff,21 Borja G Cosio,22 Richard W Costello,23 J Mark FitzGerald,24 João A Fonseca,25 Kwang Ha Yoo,26 Liam G Heaney,27 Enrico Heffler,19,20 Mark Hew,28,29 Ole Hilberg,30 Flavia Hoyte,31,32 Takashi Iwanaga,33 David J Jackson,34,35 Rupert C Jones,36 Mariko Siyue Koh,37,38 Piotr Kuna,39 Désirée Larenas-Linnemann,40 Sverre Lehmann,41 Lauri A Lehtimäki,42,43 Juntao Lyu,5,7 Bassam Mahboub,44,45 Jorge Maspero,46,47 Andrew N Menzies-Gow,48 Concetta Sirena,49 Nikolaos Papadopoulos,50,51 Andriana I Papaioannou,52 Luis Pérez de Llano,53,54 Diahn-Warng Perng,55,56 Matthew Peters,57 Paul E Pfeffer,58,59 Celeste M Porsbjerg,17 Todor A Popov,60 Chin Kook Rhee,61 Sundeep Salvi,62 Camille Taillé,63 Christian Taube,64 Carlos A Torres-Duque,65 Charlotte S Ulrik,66 Seung Won Ra,67 Eileen Wang,31,32 Michael E Wechsler,68 David B Price4,5,69 1Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; 2Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; 3AstraZeneca, Gaithersburg, MD, USA; 4Optimum Patient Care, Cambridge, UK; 5Observational and Pragmatic Research Institute, Singapore, Singapore; 6AstraZeneca, Barcelona, Spain; 7Optimum Patient Care, Queensland, VIC, Australia; 8AstraZeneca, Cambridge, UK; 9Microbiology Department, Faculty of Medicine, Kuwait University, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait; 10Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia; 11De more...
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- 2022
48. Development and validation of the Food Allergy Severity Score
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Fernández-Rivas, Montserrat, Gómez García, Ismael, Gonzalo-Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle-Bierke, Sabine, Marco-Martín, Guadalupe, Ballmer-Weber, Barbara K, Asero, Riccardo, Belohlavkova, Simona, Beyer, Kirsten, de Blay, Frédéric, Clausen, Michael, Datema, Mareen R, Dubakiene, Ruta, Grimshaw, Kate E C, Hoffmann-Sommergruber, Karin, Hourihane, Jonathan O'B, Jedrzejczak-Czechowicz, Monika, Knulst, André C, Kralimarkova, Tanya, Le, Thuy-My, Papadopoulos, Nikolaos G, Popov, Todor A, Poulsen, Lars K, Purohit, Ashok, Seneviratne, Suranjith L, Simpson, Angela, Sinaniotis, Atanasios, Turkalji, Mirjana, Vázquez-Cortés, Sonia, Vera-Berrios, Rosialzira N, Muraro, Antonella, Worm, Margitta, Roberts, Graham, van Ree, Ronald, Fernández-Pérez, Cristina, Turner, Paul J, Mills, Elizabeth N Clare, Fernández-Rivas, Montserrat, Gómez García, Ismael, Gonzalo-Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle-Bierke, Sabine, Marco-Martín, Guadalupe, Ballmer-Weber, Barbara K, Asero, Riccardo, Belohlavkova, Simona, Beyer, Kirsten, de Blay, Frédéric, Clausen, Michael, Datema, Mareen R, Dubakiene, Ruta, Grimshaw, Kate E C, Hoffmann-Sommergruber, Karin, Hourihane, Jonathan O'B, Jedrzejczak-Czechowicz, Monika, Knulst, André C, Kralimarkova, Tanya, Le, Thuy-My, Papadopoulos, Nikolaos G, Popov, Todor A, Poulsen, Lars K, Purohit, Ashok, Seneviratne, Suranjith L, Simpson, Angela, Sinaniotis, Atanasios, Turkalji, Mirjana, Vázquez-Cortés, Sonia, Vera-Berrios, Rosialzira N, Muraro, Antonella, Worm, Margitta, Roberts, Graham, van Ree, Ronald, Fernández-Pérez, Cristina, Turner, Paul J, and Mills, Elizabeth N Clare more...
- Abstract
BACKGROUND: The heterogeneity and lack of validation of existing severity scores for food allergic reactions limit standardization of case management and research advances. We aimed to develop and validate a severity score for food allergic reactions.METHODS: Following a multidisciplinary experts consensus, it was decided to develop a food allergy severity score (FASS) with ordinal (oFASS) and numerical (nFASS) formats. oFASS with 3 and 5 grades were generated through expert consensus, and nFASS by mathematical modeling. Evaluation was performed in the EuroPrevall outpatient clinic cohort (8232 food reactions) by logistic regression with request of emergency care and medications used as outcomes. Discrimination, classification, and calibration were calculated. Bootstrapping internal validation was followed by external validation (logistic regression) in 5 cohorts (3622 food reactions). Correlation of nFASS with the severity classification done by expert allergy clinicians by Best-Worst Scaling of 32 food reactions was calculated.RESULTS: oFASS and nFASS map consistently, with nFASS having greater granularity. With the outcomes emergency care, adrenaline and critical medical treatment, oFASS and nFASS had a good discrimination (receiver operating characteristic area under the curve [ROC-AUC]>0.80), classification (sensitivity 0.87-0.92, specificity 0.73-0.78), and calibration. Bootstrapping over ROC-AUC showed negligible biases (1.0 × 10-6 -1.23 × 10-3 ). In external validation, nFASS performed best with higher ROC-AUC. nFASS was strongly correlated (R 0.89) to best-worst scoring of 334 expert clinicians.CONCLUSION: FASS is a validated and reliable method to measure severity of food allergic reactions. The ordinal and numerical versions that map onto each other are suitable for use by different stakeholders in different settings. more...
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- 2022
49. Development and validation of the Food Allergy Severity Score
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MS Dermatologie/Allergologie, Infection & Immunity, Fernández-Rivas, Montserrat, Gómez García, Ismael, Gonzalo-Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle-Bierke, Sabine, Marco-Martín, Guadalupe, Ballmer-Weber, Barbara K., Asero, Riccardo, Belohlavkova, Simona, Beyer, Kirsten, de Blay, Frédéric, Clausen, Michael, Datema, Mareen R., Dubakiene, Ruta, Grimshaw, Kate E.C., Hoffmann-Sommergruber, Karin, Hourihane, Jonathan O.B., Jedrzejczak-Czechowicz, Monika, Knulst, André C., Kralimarkova, Tanya, Le, Thuy My, Papadopoulos, Nikolaos G., Popov, Todor A., Poulsen, Lars K., Purohit, Ashok, Seneviratne, Suranjith L., Simpson, Angela, Sinaniotis, Atanasios, Turkalji, Mirjana, Vázquez-Cortés, Sonia, Vera-Berrios, Rosialzira N., Muraro, Antonella, Worm, Margitta, Roberts, Graham, van Ree, Ronald, Fernández-Pérez, Cristina, Turner, Paul J., Mills, Elizabeth N.Clare, MS Dermatologie/Allergologie, Infection & Immunity, Fernández-Rivas, Montserrat, Gómez García, Ismael, Gonzalo-Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle-Bierke, Sabine, Marco-Martín, Guadalupe, Ballmer-Weber, Barbara K., Asero, Riccardo, Belohlavkova, Simona, Beyer, Kirsten, de Blay, Frédéric, Clausen, Michael, Datema, Mareen R., Dubakiene, Ruta, Grimshaw, Kate E.C., Hoffmann-Sommergruber, Karin, Hourihane, Jonathan O.B., Jedrzejczak-Czechowicz, Monika, Knulst, André C., Kralimarkova, Tanya, Le, Thuy My, Papadopoulos, Nikolaos G., Popov, Todor A., Poulsen, Lars K., Purohit, Ashok, Seneviratne, Suranjith L., Simpson, Angela, Sinaniotis, Atanasios, Turkalji, Mirjana, Vázquez-Cortés, Sonia, Vera-Berrios, Rosialzira N., Muraro, Antonella, Worm, Margitta, Roberts, Graham, van Ree, Ronald, Fernández-Pérez, Cristina, Turner, Paul J., and Mills, Elizabeth N.Clare more...
- Published
- 2022
50. Time course of disease characteristics in patients with severe allergic asthma starting treatment with omalizumab
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Popov, Todor A., primary, Hristova, Diana, additional, Kralimarkova, Tanya Z., additional, Mustakov, Tihomir B., additional, and Christoff, George H., additional
- Published
- 2022
- Full Text
- View/download PDF
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