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Palladium‐catalyzed conditions for diazidation or acetoxy/hydroxylation of N‐allyl sulfonamides by using Pd(OAc)2 as the catalyst combined with Mn(OAc)3 ⋅ 2H2O have been developed. The 1,2‐diazidation reaction of the carbon‐carbon double bond occurs in mild conditions (i. e. NaN3 as azide source in THF at room temperature), whereas the 1,2‐acetoxy/hydroxylation requires an excess of Mn(OAc)3 ⋅ 2H2O. The well‐known ability of this reagent to act through single‐electron transfer (SET) makes plausible a radical mechanism involving high valent palladium complexes. [ABSTRACT FROM AUTHOR]

For the needs of music production and multimedia art, sound synthesis algorithms are needed which are versatile, responsive to user's expectations, and having high audio quality. It is useful to organize our intuitive sound abstracts into models. A computational model can be used for representing and generating a whole class of sounds, depending on the internal structure of the model and on the choice of control parameters. We will review some of the most important computational models that are being used for sound synthesis in musical production from the viewpoint of the model structure. Moreover, the Centro di Sonologia Computazionale of Padova University has done research on synthesis models for a long time and the main achievements in both the scientific and musical fields will be presented. [ABSTRACT FROM AUTHOR]

Introduction Methods Results Conclusion This observational study conducted across seven emergency care units compares the efficacy of four D‐dimer detection methods, namely HemosIL D‐dimer HS (HS), HemosIL D‐dimer HS‐500 (HS‐500), VIDAS D‐dimer (VIDAS), and HemosIL AcuStar D‐dimer (ACUSTAR). The primary focus is on patients with a clinical suspicion of deep venous thrombosis (DVT) or pulmonary embolism (PE).A total of 149 samples were collected from patients with suspected DVT or PE. The confirmation of DVT/PE was based on calf ultrasound or computed tomography‐Angiography. Direct comparisons were made between the different detection methods, considering both their analytical performance and clinical utility. Additionally, the impact of an age‐adjusted cut‐off on the diagnostic accuracy of each method was assessed.The results revealed comparable negative predictive value, sensitivity, and specificity across the methods, with a notable exception of increased specificity for HS compared with HS‐500 (50.8% vs. 41.5%, p = 0.03). Further analysis incorporating an age‐adjusted cut‐off demonstrated a significant improvement in specificity for HS. When using the age‐adjusted cut‐off, HS exhibited a substantial increase in specificity compared with HS‐500 (63.1% vs. 49.2%, p = 0.004) and demonstrated significantly higher specificity compared with VIDAS (63.1% vs. 53.8%, p = 0.04).The study emphasizes the nonuniversal effect of an age‐adjusted cut‐off and discusses the potential necessity for different cut‐off values, particularly in the case of HS‐500. These findings contribute to the understanding of D‐dimer detection methods in the context of DVT and PE, providing insights into their relative performances and the potential optimization through age‐adjusted cut‐offs. [ABSTRACT FROM AUTHOR]

Limonene undergoes a regioselective Pd(II)-catalyzed C(sp 2 )-H/C(sp 2 )-H coupling with acrylic acid esters and amides, α,β-unsaturated ketones, styrenes, and allyl acetate, affording novel 1,3-dienes. DFT computations gave results in accord with the experimental results and allowed for the formulation of a plausible mechanism. The postfunctionalization of one of the coupled products was achieved via a large-scale Sonogashira reaction conducted under micellar catalysis.

Type 3 von Willebrand disease (VWD), the most severe form of VWD, is an inherited recessive bleeding disorder caused by the complete deficiency of von Willebrand factor (VWF). The reported prevalence is 1 per million but varies worldwide according to the frequency of consanguineous marriages. The clinical phenotype is characterized not only by mucocutaneous bleedings, but also by hemarthroses and muscle hematoma, as in patients with moderate hemophilia. Long-term prophylaxis with factor (F)VIII/VWF concentrates is recommended in patients with a history of severe and frequent bleeds. A rare complication of replacement therapy is the development of alloantibodies against VWF, with the consequences of an ineffective therapy and risk of anaphylactic reactions upon treatment. Emicizumab is the first bispecific monoclonal antibody that mimics FVIII coagulant activity and is approved for prophylaxis of bleeding in patients with inherited hemophilia A with or without inhibitors and recently also for acquired hemophilia. In this manuscript we report and discuss available data in the literature on the use of emicizumab in type 3 VWD and describe the case of a female patient with type 3 VWD with a history of alloantibodies against VWF and posttransfusion anaphylaxis, recently and successfully put on off-label prophylaxis with emicizumab., Competing Interests: S.M.S. has received honoraria for participating as a speaker in education meetings organized by Pfizer, Novo Nordisk, Bayer, and Roche. F.P. has received honoraria for participating as a speaker in education meetings and symposia organized by Takeda and Spark. She is a consultant/member of the advisory boards for CSL Behring, Biomarin, Roche, Sanofi, and Sobi. The remaining authors declare no conflict of interests., (Thieme. All rights reserved.)