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9 results on '"Podder, Sreeparna"'

4. NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis

Author

Biswas, Viplov Kumar, primary, Sen, Kaushik, additional, Ahad, Abdul, additional, Ghosh, Arup, additional, Verma, Surbhi, additional, Pati, Rashmirekha, additional, Prusty, Subhasish, additional, Nayak, Sourya Prakash, additional, Podder, Sreeparna, additional, Kumar, Dhiraj, additional, Gupta, Bhawna, additional, and Raghav, Sunil Kumar, additional

Published
2023
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5. NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

Author

Sen, Kaushik, primary, Pati, Rashmirekha, additional, Jha, Atimukta, additional, Mishra, Gyan Prakash, additional, Prusty, Subhasish, additional, Chaudhary, Shweta, additional, Swetalika, Swati, additional, Podder, Sreeparna, additional, Sen, Aishwarya, additional, Swain, Mamuni, additional, Nanda, Ranjan Kumar, additional, and Raghav, Sunil K., additional

Published
2023
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6. Nuclear Receptor Co-repressor NCoR1 governs immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

Author

Sen, Kaushik, primary, Pati, Rashmirekha, primary, Jha, Atimukta, primary, Mishra, Gyan Prakash, primary, Prusty, Subhasish, primary, Chaudhary, Shweta, primary, Swetalika, Swati, primary, Podder, Sreeparna, primary, Sen, Aishwarya, primary, Swain, Mamuni, primary, Nanda, Ranjan, primary, and Raghav, Sunil K., primary

Published
2023
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7. Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation

Author

Mishra, Gyan Prakash, primary, Jha, Atimukta, additional, Ahad, Abdul, additional, Sen, Kaushik, additional, Sen, Aishwarya, additional, Podder, Sreeparna, additional, Prusty, Subhasish, additional, Biswas, Viplov K, additional, Gupta, Bhawna, additional, and Raghav, Sunil Kumar, additional

Published
2022
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8. Persistence of Antibodies Against Spike Glycoprotein of SARS-CoV-2 in Healthcare Workers Post Double Dose of BBV-152 and AZD1222 Vaccines

Author

Choudhary, Hari Ram, primary, Parai, Debaprasad, additional, Chandra Dash, Girish, additional, Kshatri, Jaya Singh, additional, Mishra, Narayan, additional, Choudhary, Prasanta Kumar, additional, Pattnaik, Dipti, additional, Panigrahi, Kumudini, additional, Behera, Susmita, additional, Ranjan Sahoo, Nihar, additional, Podder, Sreeparna, additional, Mishra, Adyasha, additional, Raghav, Sunil Kumar, additional, Mishra, Sanjeeb Kumar, additional, Pradhan, Subrat Kumar, additional, Sahoo, Subrat Kumar, additional, Pattnaik, Matrujyoti, additional, Rout, Usha Kiran, additional, Nanda, Rashmi Ranjan, additional, Mondal, Nityananda, additional, Kanungo, Srikanta, additional, Palo, Subrata Kumar, additional, Bhattacharya, Debdutta, additional, and Pati, Sanghamitra, additional

Published
2021
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9. NCoR1: a key player regulating mycobacterium tuberculosis pathogenesis.

Author

Sen, Kaushik, Biswas, Viplov Kumar, Ghosh, Arup, Prusty, Subhasish, Nayak, Sourya Prakash, Podder, Sreeparna, Gupta, Bhawna, and Raghav, Sunil Kumar

Subjects
MYCOBACTERIUM tuberculosis, INDUCTION machinery, PATHOGENESIS, MYELOID cells, AUTOPHAGY, TUBERCULOSIS in cattle, AMP-activated protein kinases
Abstract

Mycobacterium tuberculosis (Mtb) employs a multifaceted arsenal to elude host defense mechanisms, including those associated with autophagy and lysosome function. Within the realm of host-pathogen interactions, NCOR1, a well-recognized transcriptional co-repressor, is known to associate with a multitude of protein complexes to effect the repression of a diverse spectrum of genes. However, its role in regulating macroautophagy/autophagy, lysosome biogenesis, and, by extension, Mtb pathogenesis remains unexplored. The depletion of NCOR1 assumes a pivotal role in the control of the AMPK-MTOR-TFEB signaling axis, thereby fine-tuning cellular ATP homeostasis. This finely orchestrated adjustment further alters the profile of proteins involved in autophagy and lysosomal biogenesis through its master regulator, TFEB, culminating in the increased Mtb survival within the host milieu. Furthermore, the treatment of NCOR1-depleted cells with either rapamycin, antimycin A, or metformin demonstrates a capacity to restore the TFEB activity and LC3-II levels, consequently restoring the capacity of host cells to clear Mtb. Additionally, exogenous NCOR1 expression rescues the AMPK-MTOR-TFEB signaling axis and essentially the autophagic induction machinery. Overall, these findings demonstrate a crucial role of NCOR1 in regulating Mtb pathogenesis within myeloid cells and sheds light toward its involvement in the development of novel host-directed therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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