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3. Multicenter comparison of transcatheter aortic valve implantation with the self-expanding ACURATE neo2 versus Evolut PRO transcatheter heart valves

Author

Rheude, Tobias, Pellegrini, Costanza, Landt, Martin, Bleiziffer, Sabine, Wolf, Alexander, Renker, Matthias, Neuser, Jonas, Dörr, Oliver, Allali, Abdelhakim, Rudolph, Tanja K., Wambach, Jan Martin, Widder, Julian D., Singh, Parminder, Berliner, Dominik, Alvarez-Covarrubias, Hector A., Richardt, Gert, Xhepa, Erion, Kim, Won-Keun, and Joner, Michael

Published
2024
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4. Invasive Assessment of Right Ventricular to Pulmonary Artery Coupling Improves 1-year Mortality Prediction After Transcatheter Aortic Valve Replacement and Anticipates the Persistence of Extra-Aortic Valve Cardiac Damage

Author

Lachmann, Mark, Hesse, Amelie, Trenkwalder, Teresa, Xhepa, Erion, Rheude, Tobias, von Scheidt, Moritz, Covarrubias, Héctor Alfonso Alvarez, Rippen, Elena, Hramiak, Oksana, Pellegrini, Costanza, Schuster, Tibor, Yuasa, Shinsuke, Schunkert, Heribert, Kastrati, Adnan, Kupatt, Christian, Laugwitz, Karl-Ludwig, and Joner, Michael

Published
2024
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6. ACURATE neo2 Transcatheter aortic valve implantation without balloon aortic valvuloplasty - direct ACURATE neo2

Author

Elkoumy, Ahmed, Rück, Andreas, Abdel-Wahab, Mohamed, Thiele, Holger, Rudolph, Tanja K., Wolf, Alexander, Wambach, Jan Martin, De Backer, Ole, Sondergaard, Lars, Hengstenberg, Christian, Abdelshafy, Mahmoud, Arsang-Jang, Shahram, Elzomor, Hesham, Laine, Mika, Bjursten, Henrik, Götberg, Matthias, Wykrzykowska, Joanna J., Mohamed, Sameh K., Pellegrini, Costanza, Rheude, Tobias, Toggweiler, Stefan, Saleh, Nawzad, Meduri, Christopher U., Kim, Won-Keun, and Soliman, Osama

Published
2024
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7. Near-infrared spectroscopy-intravascular ultrasound to improve assessment of coronary artery disease severity in patients referred for transcatheter aortic valve implantation (The IMPACTavi registry): Design and rationale

Author

Seguchi, Masaru, Aytekin, Alp, Steiger, Lena, Nicol, Philipp, Pellegrini, Costanza, Rheude, Tobias, Engel, Leif-Christopher, Alvarez‐Covarrubias, Hector A., Xhepa, Erion, Mayr, N. Patrick, Hadamitzky, Martin, Kastrati, Adnan, Schunkert, Heribert, Joner, Michael, and Lenz, Tobias

Published
2023
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9. Very early infective endocarditis after transcatheter aortic valve replacement

Author

Panagides, Vassili, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Scislo, Piotr, Huczek, Zenon, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won-Keun, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Gervais, Philippe, del Val, David, Linke, Axel, Crusius, Lisa, Thiele, Holger, Holzhey, David, and Rodés-Cabau, Josep

Published
2022
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10. Prognostic implications of impaired longitudinal left ventricular systolic function assessed by tissue Doppler imaging prior to transcatheter aortic valve implantation for severe aortic stenosis

Author

Gallone, Guglielmo, Bruno, Francesco, Trenkwalder, Teresa, D’Ascenzo, Fabrizio, Islas, Fabian, Leone, Pier Pasquale, Nicol, Philipp, Pellegrini, Costanza, Incaminato, Enrico, Jimenez-Quevedo, Pilar, Alvarez-Covarrubias, Hector Alfonso, Bragato, Renato, Andreis, Alessandro, Salizzoni, Stefano, Rinaldi, Mauro, Kastrati, Adnan, Conrotto, Federico, Joner, Michael, Stefanini, Giulio, Nombela-Franco, Luis, Xhepa, Erion, Escaned, Javier, and De Ferrari, Gaetano M.

Published
2022
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11. Sex Differences in Infective Endocarditis After Transcatheter Aortic Valve Replacement

Author

Panagides, Vassili, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Scislo, Piotr, Huczek, Zenon, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won-Keun, Eltchaninoff, Helene, Sondergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, le Breton, Hervé, Servoz, Clement, Gervais, Philippe, del Val, David, Linke, Axel, Crusius, Lisa, Thiele, Holger, Holzhey, David, and Rodés-Cabau, Josep

Published
2022
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13. Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation

Author

Mangner, Norman, del Val, David, Abdel-Wahab, Mohamed, Crusius, Lisa, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L., Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C., Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B., Mangione, Jose Armando, Sandoli de Brito, Fabio, Jr., Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria-Cristina, Correia de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R., Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G., Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S., Boukhris, Marouane, Gervais, Philippe, Côté, Mélanie, Holzhey, David, Linke, Axel, and Rodés-Cabau, Josep

Published
2022
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14. Infective Endocarditis Caused by Staphylococcus aureus After Transcatheter Aortic Valve Replacement

Author

del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Won-Keun, Kim, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L., Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C., Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Vendramin, Igor, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B., Mangione, Jose Armando, Sandoli de Brito, Fabio, Jr., Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria-Cristina, Corriea de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R., Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G., Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S., Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, and Rodés-Cabau, Josep

Published
2022
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16. Safety and efficacy of minimalist transcatheter aortic valve implantation using a new-generation balloon-expandable transcatheter heart valve in bicuspid and tricuspid aortic valves

Author

Michel, Jonathan M., Frangieh, Antonio H., Giacoppo, Daniele, Alvarez-Covarrubias, Hector A., Pellegrini, Costanza, Rheude, Tobias, Deutsch, Oliver, Mayr, N. Patrick, Rumpf, P. Moritz, Stähli, Barbara E., Kastrati, Adnan, Schunkert, Heribert, Xhepa, Erion, Joner, Michael, and Kasel, A. Markus

Published
2021
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19. Incidence of systemic inflammatory response syndrome and patient outcome following transcatheter edge-to-edge mitral valve repair

Author

Syryca, Finn, primary, Pellegrini, Costanza, additional, Gollreiter, Marie, additional, Nicol, Philipp, additional, Mayr, N. Patrick, additional, Alvarez-Covarrubias, Hector A., additional, Altaner, Niklas, additional, Rheude, Tobias, additional, Holdenrieder, Stefan, additional, Schunkert, Heribert, additional, Kastrati, Adnan, additional, Joner, Michael, additional, Xhepa, Erion, additional, and Trenkwalder, Teresa, additional

Published
2023
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20. Infective Endocarditis After Transcatheter versus Surgical Aortic Valve Replacement

Author

Panagides, Vassili, primary, Cuervo, Guillermo, additional, Llopis, Jaume, additional, Abdel-Wahab, Mohamed, additional, Mangner, Norman, additional, Habib, Gilbert, additional, Regueiro, Ander, additional, Mestres, Carlos, additional, Tornos, Pilar, additional, Durand, Eric, additional, Selton-Suty, Christine, additional, Ihlemann, Nikolaj, additional, Bruun, Niels, additional, Urena, Marina, additional, Cecchi, Enrico, additional, Thiele, Holger, additional, Durante-Mangoni, Emanuele, additional, Pellegrini, Costanza, additional, Eltchaninoff, Helene, additional, Athan, Eugene, additional, Søndergaard, Lars, additional, Linke, Axel, additional, Tattevin, Pierre, additional, del Val, David, additional, Quintana, Eduard, additional, Chu, Vivian, additional, Rodés-Cabau, Josep, additional, and Miro, Jose M, additional

Published
2023
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21. The Early neo2 Registry: Transcatheter Aortic Valve Implantation With ACURATE neo2 in a European Population

Author

Rück, Andreas, primary, Kim, Won‐Keun, additional, Abdel‐Wahab, Mohamed, additional, Thiele, Holger, additional, Rudolph, Tanja K., additional, Wolf, Alexander, additional, Wambach, Jan Martin, additional, De Backer, Ole, additional, Sondergaard, Lars, additional, Hengstenberg, Christian, additional, Laine, Mika, additional, Miyashita, Hirokazu, additional, Bjursten, Henrik, additional, Götberg, Matthias, additional, Pellegrini, Costanza, additional, Toggweiler, Stefan, additional, Wykrzykowska, Joanna J., additional, Soliman, Osama, additional, Saleh, Nawzad, additional, and Meduri, Christopher U., additional

Published
2023
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22. Infective Endocarditis After Transcatheter Versus Surgical Aortic Valve Replacement.

Author

Panagides, Vassili, Cuervo, Guillermo, Llopis, Jaume, Abdel-Wahab, Mohamed, Mangner, Norman, Habib, Gilbert, Regueiro, Ander, Mestres, Carlos A, Tornos, Pilar, Durand, Eric, Selton-Suty, Christine, Ihlemann, Nikolaj, Bruun, Niels, Urena, Marina, Cecchi, Enrico, Thiele, Holger, Durante-Mangoni, Emanuele, Pellegrini, Costanza, Eltchaninoff, Helene, and Athan, Eugene

Subjects
REPORTING of diseases, HEART valve prosthesis implantation, INFECTIVE endocarditis, TREATMENT effectiveness, COMPARATIVE studies, BIOPROSTHETIC heart valves, PROSTHETIC heart valves, RESEARCH funding, AORTIC valve insufficiency, SYMPTOMS
Abstract

Background Scarce data are available comparing infective endocarditis (IE) following surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). This study aimed to compare the clinical presentation, microbiological profile, management, and outcomes of IE after SAVR versus TAVR. Methods Data were collected from the "Infectious Endocarditis after TAVR International" (enrollment from 2005 to 2020) and the "International Collaboration on Endocarditis" (enrollment from 2000 to 2012) registries. Only patients with an IE affecting the aortic valve prosthesis were included. A 1:1 paired matching approach was used to compare patients with TAVR and SAVR. Results A total of 1688 patients were included. Of them, 602 (35.7%) had a surgical bioprosthesis (SB), 666 (39.5%) a mechanical prosthesis, 70 (4.2%) a homograft, and 350 (20.7%) a transcatheter heart valve. In the SAVR versus TAVR matched population, the rate of new moderate or severe aortic regurgitation was higher in the SB group (43.4% vs 13.5%; P <.001), and fewer vegetations were diagnosed in the SB group (62.5% vs 82%; P <.001). Patients with an SB had a higher rate of perivalvular extension (47.9% vs 27%; P <.001) and Staphylococcus aureus was less common in this group (13.4% vs 22%; P =.033). Despite a higher rate of surgery in patients with SB (44.4% vs 27.3%; P <.001), 1-year mortality was similar (SB: 46.5%; TAVR: 44.8%; log-rank P =.697). Conclusions Clinical presentation, type of causative microorganism, and treatment differed between patients with an IE located on SB compared with TAVR. Despite these differences, both groups exhibited high and similar mortality at 1-year follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Permanent pacemaker implantation and left bundle branch block with self-expanding valves &ndash; a SCOPE 2 subanalysis

Author

Pellegrini, Costanza, primary, Garot, Philippe, additional, Morice, Marie-Claude, additional, Tamburino, Corrado, additional, Bleiziffer, Sabine, additional, Thiele, Holger, additional, Scholtz, Smita, additional, Schramm, Rene, additional, Cockburn, James, additional, Cunnington, Michael, additional, Wolf, Alexander, additional, Barbanti, Marco, additional, Tchétché, Didier, additional, Pagnotta, Paolo, additional, Gilard, Martine, additional, Bedogni, Francesco, additional, Van Belle, Eric, additional, Vasa-Nicotera, Mariuca, additional, Chieffo, Alaide, additional, Bogaerts, Kris, additional, Hengstenberg, Christian, additional, Capodanno, Davide, additional, and Joner, Michael, additional

Published
2023
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25. Correlación fluoroscópica y tomográfica para medir el anillo aórtico en implante percutáneo de válvula aórtica: regla de cúspide coronaria derecha

Author

Álvarez Covarrubias, Héctor A., Kasel, Albert Markus, Michel, Jonathan M., Cassese, Salvatore, Kufner, Sebastian, Duesmann, Charlotte, Pellegrini, Costanza, Rheude, Tobias, Mayr, Nicola Patrick, Schunkert, Heribert, Kastrati, Adnan, Xhepa, Erion, Borrayo Sánchez, Gabriela, Joner, Michael, Álvarez Covarrubias, Héctor A., Kasel, Albert Markus, Michel, Jonathan M., Cassese, Salvatore, Kufner, Sebastian, Duesmann, Charlotte, Pellegrini, Costanza, Rheude, Tobias, Mayr, Nicola Patrick, Schunkert, Heribert, Kastrati, Adnan, Xhepa, Erion, Borrayo Sánchez, Gabriela, and Joner, Michael

Abstract

Introduction and objectives: Coronary computed tomography angiography (CCTA) has become the gold standard to measure the size of the aortic annulus and better select the size of transcatheter heart valves (THV) in patients undergoing transcatheter aortic valve implantation (TAVI). However, in selected cases, CCTA may not be feasible. Angiographic aortic annulus (AAA) measurements during TAVI may be an alternative and should be evaluated for precision regarding the proper selection of THV sizes. We sought to investigate the correlation between AAA and CCTA measurements for the proper selection of balloon-expandable valve (BEV) sizes in patients undergoing TAVI. Methods: Patients undergoing TAVI with BEV and high-quality CCTA were included. AAA measurements were obtained in the standard 3-cusp view after aortic root aortography. Angiographic distance between non- and left coronary cusps were compared to CCTA annulus measurements. Endpoints were diagnostic tests and correlations between angiographic and CCTA measurements, and the composite endpoint of the VARC-3-defined efficacy (technical success, correct position, and intended performance), and safety profile (multiple valves, valve embolization, pacemaker implantation, and more than moderate valvular regurgitation). Results: Regarding the Sapien family of THV, aortography-based distance measurements showed a correlation of 0.528 (P < .01), 0.451 (P < .01), and 0.579 (P < .01) for 23 mm, 26 mm, and 29 mm valves with CCTA-based distance measurements. No difference was seen regarding the VARC-3-defined efficacy (94.2% vs 96.0%; P = .60) and safety profile (90.9% vs 91.9%; P = .84) among cases showing discordant and concordant pairs of measurements. Conclusions: AAA measurement showed a moderate diagnostic test and Spearman’s correlation coefficient compared to CCTA-based annulus assessment for perioperative THV size selection. This strategy could potentially enable TAVI in patients in whom access to preoperative CCTA i, Introducción y objetivos: La angiografía por tomografía computarizada (angio-TC) es el estándar para medir el anillo aórtico en pacientes tratados mediante implante percutáneo de válvula aórtica (TAVI), aunque en algunos casos podría no ser factible. Debería evaluarse la precisión de las medición del anillo aórtico angiográfica (AAA) durante el TAVI como alternativa para elegir el tamaño correcto de la válvula cardiaca percutánea. Por ello, investigamos la correlación entre las mediciones angiográficas y por angio-TC para elegir el tamaño adecuado de la válvula en pacientes que reciben un TAVI. Métodos: Se incluyeron pacientes de TAVI con prótesis de balón expandible y angio-TC de alta calidad. Las mediciones del AAA se obtuvieron de la angiografía de la raíz aórtica en proyección de 3 cúspides. Se comparó la distancia angiográfica entre la cúspide izquierda y no coronariana con las mediciones de angio-TC. Se evaluaron la prueba diagnóstica y la correlación entre las medidas angiográficas y de angio-TC, así como la eficacia (éxito técnico, posición correcta y desempeño intencionado) y la seguridad (múltiples válvulas, embolización, implante de marcapasos e insuficiencia valvular moderada o mayor) definida por VARC-3. Resultados: Para válvulas con balón expandible de 23 mm, la distancia en la aortografía tuvo una correlación de 0,528 (p < 0,01) comparada con las mediciones de angio-TC; para las de 26 mm, la correlación fue de 0,451 (< 0,01), y para las de 29 mm fue de 0,579 (< 0,01). No hubo diferencia en cuanto a eficacia (94,2 frente a 96,0%; p = 0,60) y seguridad (90,9 frente a 91,9%; p = 0,84) entre casos con medidas concordantes y discordantes. Conclusiones: Las mediciones del AAA mostraron un moderado valor de prueba diagnóstica y de correlación Spearman en comparación con la angio-TC para elegir el tamaño de la válvula cardiaca percutánea. Esta estrategia podría permitir un TAVI en situaciones en que la angio-TC no esté disponible.

Published
2023

26. Incidence, Clinical Characteristics, and Impact of Absent Echocardiographic Signs in Patients with Infective Endocarditis after Transcatheter Aortic Valve Implantation

Author

Mangner, Norman, Panagides, Vassili, del Val, David, Abdel-Wahab, Mohamed, Crusius, Lisa, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won Keun, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Gervais, Philippe, Côté, Mélanie, Thiele, Holger, Holzhey, David, Linke, Axel, Rodés-Cabau, Josep, Mangner, Norman, Panagides, Vassili, del Val, David, Abdel-Wahab, Mohamed, Crusius, Lisa, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won Keun, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Gervais, Philippe, Côté, Mélanie, Thiele, Holger, Holzhey, David, Linke, Axel, and Rodés-Cabau, Josep

Abstract

Background Echocardiography is the primary imaging modality for diagnosis of infective endocarditis (IE) in prosthetic valve endocarditis (PVE) including IE after transcatheter aortic valve implantation (TAVI). This study aimed to evaluate the characteristics and clinical outcomes of patients with absent compared with evident echocardiographic signs of TAVI-IE. Methods Patients with definite TAVI-IE derived from the Infectious Endocarditis after TAVI International Registry were investigated comparing those with absent and evident echocardiographic signs of IE defined as vegetation, abscess, pseudo-aneurysm, intracardiac fistula, or valvular perforation or aneurysm. Results Among 578 patients, 87 (15.1%) and 491 (84.9%) had absent (IE-neg) and evident (IE-pos) echocardiographic signs of IE, respectively. IE-neg were more often treated via a transfemoral access with a self-expanding device and had higher rates of peri-interventional complications (eg, stroke, major vascular complications) during the TAVI procedure (P < .05 for all). IE-neg had higher rates of IE caused by Staphylococcus aureus (33.7% vs 23.2%; P = .038) and enterococci (37.2% vs 23.8%; P = .009) but lower rates of coagulase-negative staphylococci (4.7% vs 20.0%, P = .001). IE-neg was associated with the same dismal prognosis for in-hospital mortality in a multivariate binary regression analysis (odds ratio: 1.51; 95% confidence interval [CI]: .55–4.12) as well as a for 1-year mortality in Cox regression analysis (hazard ratio: 1.10; 95% CI: .67–1.80). Conclusions Even with negative echocardiographic imaging, patients who have undergone TAVI and presenting with positive blood cultures and symptoms of infection are a high-risk patient group having a reasonable suspicion of IE and the need for an early treatment initiation., Background. Echocardiography is the primary imaging modality for diagnosis of infective endocarditis (IE) in prosthetic valve endocarditis (PVE) including IE after transcatheter aortic valve implantation (TAVI). This study aimed to evaluate the characteristics and clinical outcomes of patients with absent compared with evident echocardiographic signs of TAVI-IE. Methods. Patients with definite TAVI-IE derived from the Infectious Endocarditis after TAVI International Registry were investigated comparing those with absent and evident echocardiographic signs of IE defined as vegetation, abscess, pseudo-aneurysm, intracardiac fistula, or valvular perforation or aneurysm. Results. Among 578 patients, 87 (15.1%) and 491 (84.9%) had absent (IE-neg) and evident (IE-pos) echocardiographic signs of IE, respectively. IE-neg were more often treated via a transfemoral access with a self-expanding device and had higher rates of peri-interventional complications (eg, stroke, major vascular complications) during the TAVI procedure (P < .05 for all). IE-neg had higher rates of IE caused by Staphylococcus aureus (33.7% vs 23.2%; P = .038) and enterococci (37.2% vs 23.8%; P = .009) but lower rates of coagulase-negative staphylococci (4.7% vs 20.0%, P = .001). IE-neg was associated with the same dismal prognosis for in-hospital mortality in a multivariate binary regression analysis (odds ratio: 1.51; 95% confidence interval [CI]: .55–4.12) as well as a for 1-year mortality in Cox regression analysis (hazard ratio: 1.10; 95% CI: .67–1.80). Conclusions. Even with negative echocardiographic imaging, patients who have undergone TAVI and presenting with positive blood cultures and symptoms of infection are a high-risk patient group having a reasonable suspicion of IE and the need for an early treatment initiation.

Published
2023

27. ACURATE neo2 versus SAPIEN 3 Ultra for transcatheter aortic valve implantation

Author

Pellegrini, Costanza, primary, Rheude, Tobias, additional, Renker, Matthias, additional, Wolf, Alexander, additional, Wambach, Jan Martin, additional, Alvarez-Covarrubias, Hector A., additional, Dörr, Oliver, additional, Singh, Parminder, additional, Charitos, Efstratios, additional, Xhepa, Erion, additional, Joner, Michael, additional, and Kim, Won-Keun, additional

Published
2023
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28. The impact of extra-valvular cardiac damage on mid-term clinical outcome following transcatheter aortic valve replacement in patients with severe aortic stenosis

Author

Pellegrini, Costanza, primary, Duesmann, Charlotte, additional, Rheude, Tobias, additional, Berg, Amelie, additional, Alvarez-Covarrubias, Hector A., additional, Trenkwalder, Teresa, additional, Mayr, N. Patrick, additional, Schürmann, Friederike, additional, Nicol, Philipp, additional, Xhepa, Erion, additional, and Joner, Michael, additional

Published
2022
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29. Incidence, Clinical Characteristics, and Impact of Absent Echocardiographic Signs in Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation

Author

Mangner, Norman, primary, Panagides, Vassili, additional, del Val, David, additional, Abdel-Wahab, Mohamed, additional, Crusius, Lisa, additional, Durand, Eric, additional, Ihlemann, Nikolaj, additional, Urena, Marina, additional, Pellegrini, Costanza, additional, Giannini, Francesco, additional, Gasior, Tomasz, additional, Wojakowski, Wojtek, additional, Landt, Martin, additional, Auffret, Vincent, additional, Sinning, Jan-Malte, additional, Cheema, Asim N, additional, Nombela-Franco, Luis, additional, Chamandi, Chekrallah, additional, Campelo-Parada, Francisco, additional, Munoz-Garcia, Erika, additional, Herrmann, Howard C, additional, Testa, Luca, additional, Kim, Won-Keun, additional, Eltchaninoff, Helene, additional, Søndergaard, Lars, additional, Himbert, Dominique, additional, Husser, Oliver, additional, Latib, Azeem, additional, Le Breton, Hervé, additional, Servoz, Clement, additional, Gervais, Philippe, additional, Côté, Mélanie, additional, Thiele, Holger, additional, Holzhey, David, additional, Linke, Axel, additional, and Rodés-Cabau, Josep, additional

Published
2022
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30. Artificial intelligence-enabled phenotyping of patients with severe aortic stenosis: on the recovery of extra-aortic valve cardiac damage after transcatheter aortic valve replacement

Author

Lachmann, Mark, primary, Rippen, Elena, additional, Schuster, Tibor, additional, Xhepa, Erion, additional, von Scheidt, Moritz, additional, Trenkwalder, Teresa, additional, Pellegrini, Costanza, additional, Rheude, Tobias, additional, Hesse, Amelie, additional, Stundl, Anja, additional, Harmsen, Gerhard, additional, Yuasa, Shinsuke, additional, Schunkert, Heribert, additional, Kastrati, Adnan, additional, Laugwitz, Karl-Ludwig, additional, Joner, Michael, additional, and Kupatt, Christian, additional

Published
2022
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31. One-Year Ischemic and Bleeding Events According to Renal Function in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Treated With Percutaneous Coronary Intervention and Third-Generation Antiplatelet Drugs

Author

Ndrepepa, Gjin, primary, Lahu, Shqipdona, additional, Aytekin, Alp, additional, Scalamogna, Maria, additional, Coughlan, John Joseph, additional, Gewalt, Senta, additional, Pellegrini, Costanza, additional, Mayer, Katharina, additional, and Kastrati, Adnan, additional

Published
2022
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32. Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation

Author

Panagides, Vassili, primary, del Val, David, additional, Abdel-Wahab, Mohamed, additional, Mangner, Norman, additional, Durand, Eric, additional, Ihlemann, Nikolaj, additional, Urena, Marina, additional, Pellegrini, Costanza, additional, Giannini, Francesco, additional, Scislo, Piotr, additional, Huczek, Zenon, additional, Landt, Martin, additional, Auffret, Vincent, additional, Sinning, Jan Malte, additional, Cheema, Asim N., additional, Nombela-Franco, Luis, additional, Chamandi, Chekrallah, additional, Campelo-Parada, Francisco, additional, Munoz-Garcia, Erika, additional, Herrmann, Howard C, additional, Testa, Luca, additional, Kim, Won-Keun, additional, Castillo, Juan Carlos, additional, Alperi, Alberto, additional, Tchetche, Didier, additional, Bartorelli, Antonio L., additional, Kapadia, Samir, additional, Stortecky, Stefan, additional, Amat-Santos, Ignacio, additional, Wijeysundera, Harindra C., additional, Lisko, John, additional, Gutiérrez-Ibanes, Enrique, additional, Serra, Vicenç, additional, Salido, Luisa, additional, Alkhodair, Abdullah, additional, Livi, Ugolino, additional, Chakravarty, Tarun, additional, Lerakis, Stamatios, additional, Vilalta, Victoria, additional, Regueiro, Ander, additional, Romaguera, Rafael, additional, Kappert, Utz, additional, Barbanti, Marco, additional, Masson, Jean-Bernard, additional, Maes, Frédéric, additional, Fiorina, Claudia, additional, Miceli, Antonio, additional, Kodali, Susheel, additional, Ribeiro, Henrique B., additional, Mangione, Jose Armando, additional, Brito, Fabio Sandoli de, additional, Dato, Guglielmo Mario Actis, additional, Rosato, Francesco, additional, Ferreira, Maria-Cristina, additional, de Lima, Valter Correia, additional, Colafranceschi, Alexandre Siciliano, additional, Abizaid, Alexandre, additional, Marino, Marcos Antonio, additional, Esteves, Vinicius, additional, Andrea, Julio, additional, Godinho, Roger R., additional, Alfonso, Fernando, additional, Eltchaninoff, Helene, additional, Søndergaard, Lars, additional, Himbert, Dominique, additional, Husser, Oliver, additional, Latib, Azeem, additional, Breton, Hervé Le, additional, Servoz, Clement, additional, Pascual, Isaac, additional, Siddiqui, Saif, additional, Olivares, Paolo, additional, Hernandez-Antolin, Rosana, additional, Webb, John G., additional, Sponga, Sandro, additional, Makkar, Raj, additional, Kini, Annapoorna S., additional, Boukhris, Marouane, additional, Gervais, Philippe, additional, Linke, Axel, additional, Crusius, Lisa, additional, Holzhey, David, additional, and Rodés-Cabau, Josep, additional

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2022
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33. Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial

Author

Gewalt, Senta, primary, Lahu, Shqipdona, additional, Ndrepepa, Gjin, additional, Pellegrini, Costanza, additional, Bernlochner, Isabell, additional, Neumann, Franz-Josef, additional, Menichelli, Maurizio, additional, Morath, Tanja, additional, Witzenbichler, Bernhard, additional, Wöhrle, Jochen, additional, Hoppe, Katharina, additional, Richardt, Gert, additional, Laugwitz, Karl-Ludwig, additional, Schunkert, Heribert, additional, Kastrati, Adnan, additional, Schüpke, Stefanie, additional, and Mayer, Katharina, additional

Published
2022
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34. Infective Endocarditis Caused by Staphylococcus aureus After Transcatheter Aortic Valve Replacement.

Author

UCL - (SLuc) Département cardiovasculaire, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Won-Keun, Kim, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Vendramin, Igor, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, Sandoli de Brito, Fabio, Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria-Cristina, Corriea de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R, Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S, Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, Rodés-Cabau, Josep, UCL - (SLuc) Département cardiovasculaire, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Won-Keun, Kim, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Vendramin, Igor, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, Sandoli de Brito, Fabio, Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria-Cristina, Corriea de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R, Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S, Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, and Rodés-Cabau, Josep

Abstract

Staphylococcus aureus (SA) has been extensively studied as causative microorganism of surgical prosthetic-valve infective endocarditis (IE). However, scarce evidence exists on SA IE after transcatheter aortic valve replacement (TAVR). Data were obtained from the Infectious Endocarditis After TAVR International Registry, including patients with definite IE after TAVR from 59 centres in 11 countries. Patients were divided into 2 groups according to microbiologic etiology: non-SA IE vs SA IE. SA IE was identified in 141 patients out of 573 (24.6%), methicillin-sensitive SA in most cases (115/141, 81.6%). Self-expanding valves were more common than balloon-expandable valves in patients presenting with early SA IE. Major bleeding and sepsis complicating TAVR, neurologic symptoms or systemic embolism at admission, and IE with cardiac device involvement (other than the TAVR prosthesis) were associated with SA IE (P < 0.05 for all). Among patients with IE after TAVR, the likelihood of SA IE increased from 19% in the absence of those risk factors to 84.6% if ≥ 3 risk factors were present. In-hospital (47.8% vs 26.9%; P < 0.001) and 2-year (71.5% vs 49.6%; P < 0.001) mortality rates were higher among patients with SA IE vs non-SA IE. Surgery at the time of index SA IE episode was associated with lower mortality at follow-up compared with medical therapy alone (adjusted hazard ratio 0.46, 95% CI 0.22-0.96; P = 0.038). SA IE represented approximately 25% of IE cases after TAVR and was associated with very high in-hospital and late mortality. The presence of some features determined a higher likelihood of SA IE and could help to orientate early antibiotic regimen selection. Surgery at index SA IE was associated with improved outcomes, and its role should be evaluated in future studies.

Published
2022

35. Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département cardiovasculaire, Panagides, Vassili, Del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Scislo, Piotr, Huczek, Zenon, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, Brito, Fabio Sandoli de, Dato, Guglielmo Mario Actis, Rosato, Francesco, Ferreira, Maria-Cristina, de Lima, Valter Correia, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R, Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Breton, Hervé Le, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S, Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, Rodés-Cabau, Josep, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département cardiovasculaire, Panagides, Vassili, Del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Scislo, Piotr, Huczek, Zenon, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, Brito, Fabio Sandoli de, Dato, Guglielmo Mario Actis, Rosato, Francesco, Ferreira, Maria-Cristina, de Lima, Valter Correia, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R, Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Breton, Hervé Le, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S, Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, and Rodés-Cabau, Josep

Abstract

Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation ≥2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p <0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p <0.001) and septic shock (adjusted p <0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation ≥2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up.

Published
2022

36. Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département cardiovasculaire, Mangner, Norman, del Val, David, Abdel-Wahab, Mohamed, Crusius, Lisa, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, Sandoli de Brito, Fabio, Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria-Cristina, Correia de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R, Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S, Boukhris, Marouane, Gervais, Philippe, Côté, Mélanie, Holzhey, David, Linke, Axel, Rodés-Cabau, Josep, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département cardiovasculaire, Mangner, Norman, del Val, David, Abdel-Wahab, Mohamed, Crusius, Lisa, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, Sandoli de Brito, Fabio, Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria-Cristina, Correia de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R, Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S, Boukhris, Marouane, Gervais, Philippe, Côté, Mélanie, Holzhey, David, Linke, Axel, and Rodés-Cabau, Josep

Abstract

The optimal treatment of patients developing infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is uncertain. The goal of this study was to investigate the clinical characteristics and outcomes of patients with TAVI-IE treated with cardiac surgery and antibiotics (IE-CS) compared with patients treated with antibiotics alone (IE-AB). Crude and inverse probability of treatment weighting analyses were applied for the treatment effect of cardiac surgery vs medical therapy on 1-year all-cause mortality in patients with definite TAVI-IE. The study used data from the Infectious Endocarditis after TAVI International Registry. Among 584 patients, 111 patients (19%) were treated with IE-CS and 473 patients (81%) with IE-AB. Compared with IE-AB, IE-CS was not associated with a lower in-hospital mortality (HR: 0.85; 95% CI: 0.58-1.25) and 1-year all-cause mortality (HR: 0.88; 95% CI: 0.64-1.22) in the crude cohort. After adjusting for selection and immortal time bias, IE-CS compared with IE-AB was also not associated with lower mortality rates for in-hospital mortality (HR: 0.92; 95% CI: 0.80-1.05) and 1-year all-cause mortality (HR: 0.95; 95% CI: 0.84-1.07). Results remained similar when patients with and without TAVI prosthesis involvement were analyzed separately. Predictors for in-hospital and 1-year all-cause mortality included logistic EuroSCORE I, Staphylococcus aureus, acute renal failure, persistent bacteremia, and septic shock. In this registry, the majority of patients with TAVI-IE were treated with antibiotics alone. Cardiac surgery was not associated with an improved all-cause in-hospital or 1-year mortality. The high mortality of patients with TAVI-IE was strongly linked to patients' characteristics, pathogen, and IE-related complications.

Published
2022

37. Perivalvular Extension of Infective Endocarditis After Transcatheter Aortic Valve Replacement

Author

Panagides, Vassili, Del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L., Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C., Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B., Mangione, Jose Armando, Sandoli de Brito, Fabio, Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria Cristina, Correia de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R., Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G., Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S., Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, Rodés-Cabau, Josep, Panagides, Vassili, Del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Gasior, Tomasz, Wojakowski, Wojtek, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N., Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C., Testa, Luca, Kim, Won Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L., Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C., Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B., Mangione, Jose Armando, Sandoli de Brito, Fabio, Actis Dato, Guglielmo Mario, Rosato, Francesco, Ferreira, Maria Cristina, Correia de Lima, Valter, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R., Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Le Breton, Hervé, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G., Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S., Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, and Rodés-Cabau, Josep

Abstract

BACKGROUND: Infective endocarditis (IE) following transcatheter aortic valve replacement (TAVR) has been associated with a dismal prognosis. However, scarce data exist on IE perivalvular extension (PEE) in such patients. METHODS: This multicenter study included 579 patients who had the diagnosis of definite IE at a median of 171 (53-421) days following TAVR. PEE was defined as the presence of an intracardiac abscess, pseudoaneurysm, or fistula. RESULTS: A total of 105 patients (18.1%) were diagnosed with PEE (perivalvular abscess, pseudoaneurysm, fistula, or a combination in 87, 7, 7, and 4 patients, respectively). A history of chronic kidney disease (adjusted odds ratio [ORadj], 2.08; 95% confidence interval [CI]: 1.27-3.41; P = .003) and IE secondary to coagulase-negative staphylococci (ORadj, 2.71; 95% CI: 1.57-4.69; P < .001) were associated with an increased risk of PEE. Surgery was performed at index IE episode in 34 patients (32.4%) with PEE (vs 15.2% in patients without PEE, P < .001). In-hospital and 2-year mortality rates among PEE-IE patients were 36.5% and 69.4%, respectively. Factors independently associated with an increased mortality were the occurrence of other complications (stroke post-TAVR, acute renal failure, septic shock) and the lack of surgery at index IE hospitalization (padj < 0.05 for all). CONCLUSIONS: PEE occurred in about one-fifth of IE post-TAVR patients, with the presence of coagulase-negative staphylococci and chronic kidney disease determining an increased risk. Patients with PEE-IE exhibited high early and late mortality rates, and surgery during IE hospitalization seemed to be associated with better outcomes.

Published
2022

38. Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation

Author

Panagides, Vassili, del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Scislo, Piotr, Huczek, Zenon, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, de Brito, Fabio Sandoli, Dato, Guglielmo Mario Actis, Rosato, Francesco, Ferreira, Maria-Cristina, de Lima, Valter Correia, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R., Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Breton, Hervé Le, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S., Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, Rodés-Cabau, Josep, Panagides, Vassili, del Val, David, Abdel-Wahab, Mohamed, Mangner, Norman, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Scislo, Piotr, Huczek, Zenon, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim N, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Erika, Herrmann, Howard C, Testa, Luca, Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John, Gutiérrez-Ibanes, Enrique, Serra, Vicenç, Salido, Luisa, Alkhodair, Abdullah, Livi, Ugolino, Chakravarty, Tarun, Lerakis, Stamatios, Vilalta, Victoria, Regueiro, Ander, Romaguera, Rafael, Kappert, Utz, Barbanti, Marco, Masson, Jean-Bernard, Maes, Frédéric, Fiorina, Claudia, Miceli, Antonio, Kodali, Susheel, Ribeiro, Henrique B, Mangione, Jose Armando, de Brito, Fabio Sandoli, Dato, Guglielmo Mario Actis, Rosato, Francesco, Ferreira, Maria-Cristina, de Lima, Valter Correia, Colafranceschi, Alexandre Siciliano, Abizaid, Alexandre, Marino, Marcos Antonio, Esteves, Vinicius, Andrea, Julio, Godinho, Roger R., Alfonso, Fernando, Eltchaninoff, Helene, Søndergaard, Lars, Himbert, Dominique, Husser, Oliver, Latib, Azeem, Breton, Hervé Le, Servoz, Clement, Pascual, Isaac, Siddiqui, Saif, Olivares, Paolo, Hernandez-Antolin, Rosana, Webb, John G, Sponga, Sandro, Makkar, Raj, Kini, Annapoorna S., Boukhris, Marouane, Gervais, Philippe, Linke, Axel, Crusius, Lisa, Holzhey, David, and Rodés-Cabau, Josep

Abstract

Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation ≥2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p <0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p <0.001) and septic shock (adjusted p <0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation ≥2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up.

Published
2022

39. Harnessing feature extraction capacities from a pre-trained convolutional neural network (VGG-16) for the unsupervised distinction of aortic outflow velocity profiles in patients with severe aortic stenosis

Author

Lachmann, Mark, primary, Rippen, Elena, additional, Rueckert, Daniel, additional, Schuster, Tibor, additional, Xhepa, Erion, additional, von Scheidt, Moritz, additional, Pellegrini, Costanza, additional, Trenkwalder, Teresa, additional, Rheude, Tobias, additional, Stundl, Anja, additional, Thalmann, Ruth, additional, Harmsen, Gerhard, additional, Yuasa, Shinsuke, additional, Schunkert, Heribert, additional, Kastrati, Adnan, additional, Joner, Michael, additional, Kupatt, Christian, additional, and Laugwitz, Karl Ludwig, additional

Published
2022
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41. Safety and efficacy of minimalist transcatheter aortic valve implantation using a new-generation balloon-expandable transcatheter heart valve in bicuspid and tricuspid aortic valves

Author

Michel, Jonathan M, Frangieh, Antonio H, Giacoppo, Daniele, Alvarez-Covarrubias, Hector A, Pellegrini, Costanza, Rheude, Tobias, Deutsch, Oliver, Mayr, N Patrick, Rumpf, P Moritz, Stähli, Barbara E, Kastrati, Adnan, Schunkert, Heribert, Xhepa, Erion, Joner, Michael, Kasel, A Markus, University of Zurich, and Kasel, A Markus

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2021

43. Perivalvular Extension of Infective Endocarditis After Transcatheter Aortic Valve Replacement

Author

Panagides, Vassili, primary, del Val, David, additional, Abdel-Wahab, Mohamed, additional, Mangner, Norman, additional, Durand, Eric, additional, Ihlemann, Nikolaj, additional, Urena, Marina, additional, Pellegrini, Costanza, additional, Giannini, Francesco, additional, Gasior, Tomasz, additional, Wojakowski, Wojtek, additional, Landt, Martin, additional, Auffret, Vincent, additional, Sinning, Jan Malte, additional, Cheema, Asim N, additional, Nombela-Franco, Luis, additional, Chamandi, Chekrallah, additional, Campelo-Parada, Francisco, additional, Munoz-Garcia, Erika, additional, Herrmann, Howard C, additional, Testa, Luca, additional, Kim, Won Keun, additional, Castillo, Juan Carlos, additional, Alperi, Alberto, additional, Tchetche, Didier, additional, Bartorelli, Antonio L, additional, Kapadia, Samir, additional, Stortecky, Stefan, additional, Amat-Santos, Ignacio, additional, Wijeysundera, Harindra C, additional, Lisko, John, additional, Gutiérrez-Ibanes, Enrique, additional, Serra, Vicenç, additional, Salido, Luisa, additional, Alkhodair, Abdullah, additional, Livi, Ugolino, additional, Chakravarty, Tarun, additional, Lerakis, Stamatios, additional, Vilalta, Victoria, additional, Regueiro, Ander, additional, Romaguera, Rafael, additional, Kappert, Utz, additional, Barbanti, Marco, additional, Masson, Jean Bernard, additional, Maes, Frédéric, additional, Fiorina, Claudia, additional, Miceli, Antonio, additional, Kodali, Susheel, additional, Ribeiro, Henrique B, additional, Mangione, Jose Armando, additional, Sandoli de Brito, Fabio, additional, Actis Dato, Guglielmo Mario, additional, Rosato, Francesco, additional, Ferreira, Maria Cristina, additional, Correia de Lima, Valter, additional, Colafranceschi, Alexandre Siciliano, additional, Abizaid, Alexandre, additional, Marino, Marcos Antonio, additional, Esteves, Vinicius, additional, Andrea, Julio, additional, Godinho, Roger R, additional, Alfonso, Fernando, additional, Eltchaninoff, Helene, additional, Søndergaard, Lars, additional, Himbert, Dominique, additional, Husser, Oliver, additional, Latib, Azeem, additional, Le Breton, Hervé, additional, Servoz, Clement, additional, Pascual, Isaac, additional, Siddiqui, Saif, additional, Olivares, Paolo, additional, Hernandez-Antolin, Rosana, additional, Webb, John G, additional, Sponga, Sandro, additional, Makkar, Raj, additional, Kini, Annapoorna S, additional, Boukhris, Marouane, additional, Gervais, Philippe, additional, Linke, Axel, additional, Crusius, Lisa, additional, Holzhey, David, additional, and Rodés-Cabau, Josep, additional

Published
2021
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46. TCT-230 One-Year Results After Transcatheter Aortic Valve Replacement With Balloon-Expandable Valves: Comparison of SAPIEN 3 Ultra and SAPIEN 3

Author

Rheude, Tobias, primary, Kornhuber, Katharina, additional, Pellegrini, Costanza, additional, Freißmuth, Markus, additional, Syryca, Finn, additional, Mayr, Patrick, additional, Covarrubias, Hector Alvarez, additional, Kasel, Markus, additional, Joner, Michael, additional, and Xhepa, Erion, additional

Published
2021
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47. Prognostic Implications of Impaired Longitudinal Left Ventricular Systolic Function Assessed by Tissue Doppler Imaging Prior to Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis

Author

gallone, guglielmo, primary, Bruno, Francesco, additional, Trenkwalder, Teresa, additional, D'Ascenzo, Fabrizio, additional, Islas, Fabian, additional, Leone, Pier Pasquale, additional, Nicol, Phillip, additional, Pellegrini, Costanza, additional, Incaminato, Enrico, additional, Jimenez-Quevedo, Pilar, additional, Covarrubias, Hector Alfonso Alvarez, additional, Bragato, Renato, additional, Andreis, Alessandro, additional, Salizzoni, Stefano, additional, Rinaldi, Mauro, additional, Kastrati, Adnan, additional, Conrotto, Federico, additional, Joner, Michael, additional, Stefanini, Giulio, additional, Nombela-Franco, Luis, additional, Xhepa, Erion, additional, Escaned, Javier, additional, and De Ferrari, Gaetano Maria, additional

Published
2021
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49. Subphenotyping of Patients With Aortic Stenosis by Unsupervised Agglomerative Clustering of Echocardiographic and Hemodynamic Data

Author

Lachmann, Mark, primary, Rippen, Elena, additional, Schuster, Tibor, additional, Xhepa, Erion, additional, von Scheidt, Moritz, additional, Pellegrini, Costanza, additional, Trenkwalder, Teresa, additional, Rheude, Tobias, additional, Stundl, Anja, additional, Thalmann, Ruth, additional, Harmsen, Gerhard, additional, Yuasa, Shinsuke, additional, Schunkert, Heribert, additional, Kastrati, Adnan, additional, Laugwitz, Karl-Ludwig, additional, Kupatt, Christian, additional, and Joner, Michael, additional

Published
2021
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50. Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement.

Author

Val, David del, Abdel-Wahab, Mohamed, Linke, Axel, Durand, Eric, Ihlemann, Nikolaj, Urena, Marina, Pellegrini, Costanza, Giannini, Francesco, Landt, Martin, Auffret, Vincent, Sinning, Jan Malte, Cheema, Asim, Nombela-Franco, Luis, Chamandi, Chekrallah, Campelo-Parada, Francisco, Munoz-Garcia, Antonio, Herrmann, Howard C, Testa, Luca, Won-Keun, Kim, and Castillo, Juan Carlos

Subjects
HEART valve prosthesis implantation, SCIENTIFIC observation, MULTIVARIATE analysis, ENDOCARDITIS, TREATMENT effectiveness, HOSPITAL mortality, DISEASE complications
Abstract

Background Procedural improvements combined with the contemporary clinical profile of patients undergoing transcatheter aortic valve replacement (TAVR) may have influenced the incidence and outcomes of infective endocarditis (IE) following TAVR. We aimed to determine the temporal trends, characteristics, and outcomes of IE post-TAVR. Methods Observational study including 552 patients presenting definite IE post-TAVR. Patients were divided in 2 groups according to the timing of TAVR (historical cohort [HC]: before 2014; contemporary cohort [CC]: after 2014). Results Overall incidence rates of IE were similar in both cohorts (CC vs HC: 5.45 vs 6.52 per 1000 person-years; P  = .12), but the rate of early IE was lower in the CC (2.29‰ vs 4.89‰, P  < .001). Enterococci were the most frequent microorganism. Most patients presented complicated IE (CC: 67.7%; HC: 69.6%; P  = .66), but the rate of surgical treatment remained low (CC: 20.7%; HC: 17.3%; P  = .32). The CC exhibited lower rates of in-hospital acute kidney injury (35.1% vs 44.6%; P  = .036) and in-hospital (26.6% vs 36.4%; P  = .016) and 1-year (37.8% vs 53.5%; P  < .001) mortality. Higher logistic EuroScore, Staphylococcus aureus etiology, and complications (stroke, heart failure, and acute renal failure) were associated with in-hospital mortality in multivariable analyses (P  < .05 for all). Conclusions Although overall IE incidence has remained stable, the incidence of early IE has declined in recent years. The microorganism, high rate of complications, and very low rate of surgical treatment remained similar. In-hospital and 1-year mortality rates were high but progressively decreased over time. [ABSTRACT FROM AUTHOR]

Published
2021
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