Search

Your search keyword '"Paulina Barasińska"' showing total 2 results
Start Over Author "Paulina Barasińska" Publication Year Range Last 3 years
2 results on '"Paulina Barasińska"'

1. The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis

Author

Anna Kisielnicka, Marta Sobalska-Kwapis, Dorota Purzycka-Bohdan, Bogusław Nedoszytko, Monika Zabłotna, Michał Seweryn, Dominik Strapagiel, Roman J. Nowicki, Adam Reich, Dominik Samotij, Justyna Szczęch, Dorota Krasowska, Joanna Bartosińska, Joanna Narbutt, Aleksandra Lesiak, Paulina Barasińska, Agnieszka Owczarczyk-Saczonek, Joanna Czerwińska, Jacek C. Szepietowski, Aleksandra Batycka-Baran, Rafał Czajkowski, Magdalena Górecka-Sokołowska, Lidia Rudnicka, Joanna Czuwara, and Aneta Szczerkowska-Dobosz

Subjects
psoriasis, obesity, BMI, GWAS, gene polymorphisms, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

There is evidence that the concomitance of psoriasis and obesity may originate from the interplay between multiple genetic pathways and involve gene–gene interactions. The aim of this study was to compare the genetic background related to obesity among psoriatic patients versus healthy controls by means of a Genome-Wide Association Study (GWAS). A total of 972 psoriatic patients and a total of 5878 healthy donors were enrolled in this study. DNA samples were genotyped for over 500,000 single nucleotide polymorphisms (SNPs) using Infinium CoreExome BeadChips (Illumina, San Diego, CA, USA). Statistical analysis identified eleven signals (p < 1 × 10−5) associated with BMI across the study groups and revealed a varying effect size in each sub-cohort. Seven of the alternative alleles (rs1558902 in the FTO gene, rs696574 in the CALCRL gene, as well as rs10968110, rs4551082, rs4609724, rs9320269, and rs2338833,) are associated with increased BMI among all psoriatic patients and four (rs1556519 in the ITLN2 gene, rs12972098 in the AC003006.7 gene, rs12676670 in the PAG1 gene, and rs1321529) are associated with lower BMI. The results of our study may lead to further insights into the understanding of the pathogenesis of obesity among psoriatic patients.

Published
2022
Full Text
View/download PDF

2. Chronic Plaque Psoriasis in Poland: Disease Severity, Prevalence of Comorbidities, and Quality of Life

Author

Dorota Purzycka-Bohdan, Anna Kisielnicka, Monika Zabłotna, Bogusław Nedoszytko, Roman J. Nowicki, Adam Reich, Dominik Samotij, Justyna Szczęch, Dorota Krasowska, Joanna Bartosińska, Joanna Narbutt, Aleksandra Lesiak, Paulina Barasińska, Agnieszka Owczarczyk-Saczonek, Joanna Czerwińska, Jacek C. Szepietowski, Aleksandra Batycka-Baran, Rafał Czajkowski, Magdalena Górecka-Sokołowska, Lidia Rudnicka, Joanna Czuwara, Marta Sobalska-Kwapis, Dominik Strapagiel, and Aneta Szczerkowska-Dobosz

Subjects
psoriasis, epidemiology, comorbidities, environmental factors, quality of life, General Medicine
Abstract

The epidemiology of psoriasis has not been widely assessed in Polish population so far. This study aimed to investigate psoriasis epidemiological situation by evaluating disease course and severity, management, comorbidities, environmental factors, and knowledge about this disorder among psoriatic patients in Poland. A cross-sectional cohort population-based study enrolled 1080 psoriatic patients and 1200 controls. The mean age of psoriasis onset was 27.6 years; 78.24% had type I psoriasis. Positive family history of psoriasis was reported in 44.81% of patients, whereas itch was reported in vast majority of patients (83.33%). Based on PASI score moderate psoriasis was the most common in studied group (mean 12.63 ± 9.33, range 0–67.2). The DLQI score (12.01 ± 7.41, range 0–30.0) indicated a very large effect of psoriasis on the quality of life. Hypertension was the most prevalent comorbidity (33.80%), followed by obesity (16.85%) and dyslipidemia (11.85%). Stress was the foremost cause of disease exacerbation (66.20%); however, infections (44.07%) and seasonal changes (45.09%) had also an impact on the course of psoriasis. Psoriatic patients were more often smokers (37.59%) vs. general population (27.50%; p < 0.0001). In conclusion, epidemiological studies help clinicians in better disease and patient understanding, which may translate into better management and patient compliance.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results