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152 results on '"Patrono, Damiano"'

1. The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives

Author

Gringeri, Enrico, Furlanetto, Alessandro, Billato, Ilaria, Cescon, Matteo, De Carlis, Luciano, Mazzaferro, Vincenzo, Romagnoli, Renato, De Simone, Paolo, Vivarelli, Marco, Di Benedetto, Fabrizio, Ravaioli, Matteo, Lauterio, Andrea, Sposito, Carlo, Patrono, Damiano, Ghinolfi, Davide, Moccheggiani, Federico, Di Sandro, Stefano, D’Amico, Francesco Enrico, Lanari, Jacopo, Gambato, Martina, Trapani, Silvia, Bergamo, Francesca, Cardillo, Massimo, Burra, Patrizia, and Cillo, Umberto

Published
2024
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2. Combined transarterial chemoembolization and thermal ablation in candidates to liver transplantation with hepatocellular carcinoma: pathological findings and post-transplant outcome

Author

Fronda, Marco, Susanna, Eleonora, Doriguzzi Breatta, Andrea, Gazzera, Carlo, Patrono, Damiano, Piccione, Federica, Bertero, Luca, Ciferri, Fernanda, Carucci, Patrizia, Gaia, Silvia, Rolle, Emanuela, Vocino Trucco, Giulia, Bergamasco, Laura, Tandoi, Francesco, Cassoni, Paola, Romagnoli, Renato, Fonio, Paolo, and Calandri, Marco

Published
2024
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6. Combined hepatocellular-cholangiocarcinoma compared to hepatocellular carcinoma and intrahepatic cholangiocarcinoma: Different survival, similar recurrence: Report of a large study on repurposed databases with propensity score matching

Author

Abba, Julio, Adam, René, Adham, Mustapha, Addeo, Pietro, Allard, Marc-Antoine, Amaddeo, Giuliana, Ayav, Ahmet, Azoulay, Daniel, Bachellier, Philippe, Balladur, Pierre, Barbieux, Julien, Boleslawski, Emmanuel, Boudjema, Karim, Bougard, M., Buc, Emmanuel, Bucur, Petru, Carmelo, Antoine, Cauchy, François, Chatelain, Denis, Chauvat, Jean, Cherkaoui, Zineb, Chirica, Mircea, Ciacio, Oriana, Codjia, Tatiana, Colli, Fabio, De Carlis, Luciano, Delpero, Jean-Robert, Demartines, Nicolas, Detry, Olivier, Sanches, Marcelo Dias, Diouf, Momar, Doussot, Alexandre, Ducerf, Christian, El Amrani, Mehdi, Ewald, Jacques, Fabre, Jean-Marc, Fagot, Hervé, Famularo, Simone, Ferre, Léo, Fleres, Francesco, Fonseca, Gilton Marques, Quintana, Álvaro Gancedo, Gayet, Brice, Giacomoni, Alessandro, Gigot, Jean-Francois, Golse, Nicolas, Gregoire, Emilie, Hardwigsen, Jean, Herman, Paulo, Hor, Thevi, Jehaes, François, Kianmanesh, Ali-Reza, Komatsu, Shohei, Laroche, Sophie, Laurent, Christophe, Le Treut, Yves-Patrice, Leourier, Philippe, Lermite, Emilie, Lesurtel, Mikael, Letoublon, Christian, Leyman, Paul, Lesurtel, Mickael, Lubrano, Jean, Mabrut, Jean-Yves, Mantion, Georges, Marchese, Ugo, Martín-Pérez, Elena, Menahem, Benjamin, Meunier, Maxime, Millet, Guillaume, Mohkam, Kayvan, Mulliri, André, Muscari, Fabrice, Navarro, Francis, Nolasco, Francisco, Nomi, Takeo, Nunoz, Jean, Nuzzo, Gennaro, Okumura, Shinya, Oudafal, Nassima, Pascal, Gerard, Passot, Guillaume, Patrono, Damiano, Paye, François, Perdigao, Fabiano, Petrucciani, Niccolo, Pittau, Gabriella, Pruvot, François-René, Raventos, Artigas, Regnault, Hélène, Rivoire, Michel, Romagnoli, Renato, Roulin, Didier, Sa-Cunha, Antonio, Scotte, Michel, Souche, François-Regis, Suc, Bertrand, Thobie, Alexandre, Trechot, Boris, Truant, Stéphanie, Turini, Olivier, Uemoto, Shinji, Unterteiner, Xavier, Vanbrugghe, Charles, Zemour, Jean, Amory, Boris, Goumard, Claire, Laurent, Alexis, Langella, Serena, Cherqui, Daniel, Salame, Ephrem, Barbier, Louise, Soubrane, Olivier, Farges, Olivier, Hobeika, Christian, Kawai, Takayuki, Regimbeau, Jean-Marc, Faitot, François, Pessaux, Patrick, Herrero, Astrid, Chiche, Laurence, Di Martino, Marcello, Rhaiem, Rami, Schwarz, Lilian, Resende, Vivian, Calderaro, Julien, Augustin, Jérémy, Caruso, Stefano, Sommacale, Daniele, Hofmeyr, Stefan, Ferrero, Alessandro, Fuks, David, Vibert, Eric, Torzilli, Guido, Scatton, Olivier, and Brustia, Raffaele

Published
2024
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7. Long-term outcomes after hypothermic oxygenated machine perfusion and transplantation of 1,202 donor livers in a real-world setting (HOPE-REAL study)

Author

Eden, Janina, Brüggenwirth, Isabel M.A., Berlakovich, Gabriela, Buchholz, Bettina M., Botea, Florin, Camagni, Stefania, Cescon, Matteo, Cillo, Umberto, Colli, Fabio, Compagnon, Philippe, De Carlis, Luciano G., De Carlis, Riccardo, Di Benedetto, Fabrizio, Dingfelder, Jule, Diogo, Dulce, Dondossola, Daniele, Drefs, Moritz, Fronek, Jiri, Germinario, Giuliana, Gringeri, Enrico, Györi, Georg, Kocik, Matej, Küçükerbil, Efrayim H., Koliogiannis, Dionysios, Lam, Hwai-Ding, Lurje, Georg, Magistri, Paolo, Monbaliu, Diethard, Moumni, Mostafa el, Patrono, Damiano, Polak, Wojciech G., Ravaioli, Matteo, Rayar, Michel, Romagnoli, Renato, Sörensen, Gustaf, Uluk, Deniz, Schlegel, Andrea, Porte, Robert J., Dutkowski, Philipp, and de Meijer, Vincent E.

Published
2024
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8. Improving outcomes of in situ split liver transplantation in Italy over the last 25 years

Author

Lauterio, Andrea, Cillo, Umberto, Spada, Marco, Trapani, Silvia, De Carlis, Riccardo, Bottino, Giuliano, Bernasconi, Davide, Scalamogna, Chiara, Pinelli, Domenico, Cintorino, Davide, D’Amico, Francesco Enrico, Spagnoletti, Gionata, Miggino, Marco, Romagnoli, Renato, Centonze, Leonardo, Caccamo, Lucio, Baccarani, Umberto, Carraro, Amedeo, Cescon, Matteo, Vivarelli, Marco, Mazaferro, Vincenzo, Ettorre, Giuseppe Maria, Rossi, Massimo, Vennarecci, Giovanni, De Simone, Paolo, Angelico, Roberta, Agnes, Salvatore, Di Benedetto, Fabrizio, Lupo, Luigi Giovanni, Zamboni, Fausto, Zefelippo, Arianna, Patrono, Damiano, Diviacco, Pietro, Laureiro, Zoe Larghi, Gringeri, Enrico, Di Francesco, Fabrizio, Lucianetti, Alessandro, Valsecchi, Maria Grazia, Gruttadauria, Salvatore, De Feo, Tullia, Cardillo, Massimo, De Carlis, Luciano, Colledan, Michele, and Andorno, Enzo

Published
2023
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9. Alternative forms of portal vein revascularization in liver transplant recipients with complex portal vein thrombosis

Author

Fundora, Yiliam, Hessheimer, Amelia J., Del Prete, Luca, Maroni, Lorenzo, Lanari, Jacopo, Barrios, Oriana, Clarysse, Mathias, Gastaca, Mikel, Barrera Gómez, Manuel, Bonadona, Agnès, Janek, Julius, Boscà, Andrea, Álamo Martínez, Jose María, Zozaya, Gabriel, López Garnica, Dolores, Magistri, Paolo, León, Francisco, Magini, Giulia, Patrono, Damiano, Ničovský, Jiří, Hakeem, Abdul Rahman, Nadalin, Silvio, McCormack, Lucas, Palacios, Pilar, Zieniewicz, Krzysztof, Blanco, Gerardo, Nuño, Javier, Pérez Saborido, Baltasar, Echeverri, Juan, Bynon, J. Steve, Martins, Paulo N., López López, Víctor, Dayangac, Murat, Lodge, J. Peter A., Romagnoli, Renato, Toso, Christian, Santoyo, Julio, Di Benedetto, Fabrizio, Gómez-Gavara, Concepción, Rotellar, Fernando, Gómez-Bravo, Miguel Ángel, López Andújar, Rafael, Girard, Edouard, Valdivieso, Andrés, Pirenne, Jacques, Lladó, Laura, Germani, Giacomo, Cescon, Matteo, Hashimoto, Koji, Quintini, Cristiano, Cillo, Umberto, Polak, Wojciech G., and Fondevila, Constantino

Published
2023
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11. Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study

Author

Brüggenwirth, Isabel M.A., Mueller, Matteo, Lantinga, Veerle A., Camagni, Stefania, De Carlis, Riccardo, De Carlis, Luciano, Colledan, Michele, Dondossola, Daniele, Drefs, Moritz, Eden, Janina, Ghinolfi, Davide, Koliogiannis, Dionysios, Lurje, Georg, Manzia, Tommaso M., Monbaliu, Diethard, Muiesan, Paolo, Patrono, Damiano, Pratschke, Johann, Romagnoli, Renato, Rayar, Michel, Roma, Federico, Schlegel, Andrea, Dutkowski, Philipp, Porte, Robert J., and de Meijer, Vincent E.

Published
2022
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12. Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors

Author

Patrono, Damiano, Cussa, Davide, Sciannameo, Veronica, Montanari, Elena, Panconesi, Rebecca, Berchialla, Paola, Lepore, Mirella, Gambella, Alessandro, Rizza, Giorgia, Catalano, Giorgia, Mirabella, Stefano, Tandoi, Francesco, Lupo, Francesco, Balagna, Roberto, Salizzoni, Mauro, and Romagnoli, Renato

Published
2022
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13. Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching

Author

Abba, Julio, Adam, René, Adham, Mustapha, Allard, Marc-Antoine, Ayav, Ahmet, Azoulay, Daniel, Bachellier, Philippe, Balladur, Pierre, Barbier, Louise, Barbieux, Julien, Boleslawski, Emmanuel, Boudjema, Karim, Bougard, M., Buc, Emmanuel, Bucur, Petru, Carmelo, Antoine, Chatelain, Denis, Chauvat, Jean, Cherkaoui, Zineb, Chiche, Laurence, Chirica, Mircea, Ciacio, Oriana, Codjia, Tatiana, Colli, Fabio, De Carlis, Luciano, Delpero, Jean-Robert, Demartines, Nicolas, Detry, Olivier, Sanches, Marcelo Dias, Diouf, Momar, Doussot, Alexandre, Ducerf, Christian, El Amrani, Mehdi, Ewald, Jacques, Fabre, Jean-Marc, Fagot, Hervé, Famularo, Simone, Ferre, Léo, Fleres, Francesco, Fonseca, Gilton Marques, Gayet, Brice, Giacomoni, Alessandro, Gigot, Jean-Francois, Girard, E., Golse, Nicolas, Gregoire, Emilie, Hardwigsen, Jean, Herman, Paulo, Hor, Thevi, Jehaes, François, Kianmanesh, Ali-Reza, Komatsu, Shohei, Laroche, Sophie, Laurent, Christophe, Le Treut, Yves-Patrice, Lecolle, K., Leourier, Philippe, Lermite, Emilie, Lesurtel, Mikael, Letoublon, Christian, Leyman, Paul, Lubrano, Jean, Mabrut, Jean-Yves, Mantion, Georges, Marchese, Ugo, Memeo, Riccardo, Millet, Guillaume, Mohkam, Kayvan, Mulliri, André, Muscari, Fabrice, Navarro, Francis, Nolasco, Francisco, Nomi, Takeo, Nunoz, Jean, Nuzzo, Gennaro, Oudafal, Nassima, Pascal, Gerard, Passot, Guillaume, Patrice, D., Patrono, Damiano, Paye, François, Perdigao, Fabiano, Pessaux, Patrick, Petrucciani, Niccolo, Pittau, Gabriella, Ratajczak, C., Raventos, Artigas, Rebibo, Lionel, Resende, Vivian, Rivoire, Michel, Romagnoli, Renato, Roulin, Didier, Sa-Cunha, Antonio, Salame, Ephrem, Schielke, Astrid, Schwarz, Lilian, Scotte, Michel, Souche, François-Regis, Suc, Bertrand, Tedeschi, Michele, Thobie, Alexandre, Trechot, Boris, Truant, Stéphanie, Turini, Olivier, Uemoto, Shinji, Unterteiner, Xavier, Vanbrugghe, Charles, Zemour, Jean, Brustia, Raffaele, Laurent, Alexis, Goumard, Claire, Langella, Serena, Cherqui, Daniel, Kawai, Takayuki, Soubrane, Olivier, Cauchy, Francois, Farges, Olivier, Menahem, Benjamin, Hobeika, Christian, Rhaiem, Rami, Sommacale, Daniele, Okumura, Shinya, Hofmeyr, Stefan, Ferrero, Alessandro, Pruvot, François-René, Regimbeau, Jean-Marc, Fuks, David, Vibert, Eric, and Scatton, Olivier

Published
2022
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14. Recipient hepatectomy technique may affect oncological outcomes of Liver Transplantation for hepatocellular carcinoma

Author

Pravisani, Riccardo, primary, De Martino, Maria, additional, Mocchegiani, Federico, additional, Melandro, Fabio, additional, Patrono, Damiano, additional, Lauterio, Andrea, additional, Di Francesco, Fabrizio, additional, Ravaioli, Matteo, additional, Zambelli, Marco Fabrizio, additional, Bosio, Claudio, additional, Dondossola, Daniele, additional, Lai, Quirino, additional, Zanchetta, Matteo, additional, Dingfelder, Jule, additional, Toti, Luca, additional, Iacomino, Alessandro, additional, Nicolae, Sermed, additional, Ghinolfi, Davide, additional, Romagnoli, Renato, additional, De Carlis, Luciano, additional, Gruttadauria, Salvatore, additional, Cescon, Matteo, additional, Colledan, Michele, additional, Carraro, Amedeo, additional, Caccamo, Lucio, additional, Vivarelli, Marco, additional, Rossi, Massimo, additional, Nadalin, Silvio, additional, Gyori, Georg, additional, Tisone, Giuseppe, additional, Vennarecci, Giovanni, additional, Rostved, Andreas, additional, De Simone, Paolo, additional, Isola, Miriam, additional, and Baccarani, Umberto, additional

Published
2024
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15. Liver Transplantation for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors.

Author

De Stefano, Nicola, Patrono, Damiano, Colli, Fabio, Rizza, Giorgia, Paraluppi, Gianluca, and Romagnoli, Renato

Subjects
*LEGAL evidence, *RISK assessment, *CANCER relapse, *IMMUNOTHERAPY, *CELLULAR signal transduction, *IMMUNE checkpoint inhibitors, *GRAFT rejection, *LIVER transplantation, *HEPATOCELLULAR carcinoma, *PHARMACODYNAMICS
Abstract

Simple Summary: Immune checkpoint inhibitors (ICIs) have witnessed significant success in systemic therapy of hepatocellular carcinoma, stimulating the transplant community to consider their use in the liver transplantation (LT) setting. This review provides an updated overview of the current evidence on ICI therapy before and after LT, discussing the associated pitfalls and remaining challenges. A particular focus is placed on the interactions between ICIs and immunosuppressive drugs, in order to identify predictive factors of good response, as well as critical aspects that should guide future research on the topic. Hepatocellular carcinoma (HCC) remains the leading oncological indication for liver transplantation (LT), with evolving and broadened inclusion criteria. Immune checkpoint inhibitors (ICIs) gained a central role in systemic HCC treatment and showed potential in the peri-transplant setting as downstaging/bridging therapy before LT or as a treatment for HCC recurrence following LT. However, the antagonistic mechanisms of action between ICIs and immunosuppressive drugs pose significant challenges, particularly regarding the risk of acute rejection (AR). This review analyzes the main signaling pathways targeted by ICI therapies and summarizes current studies on ICI therapy before and after LT. The literature on this topic is limited and highly heterogeneous, precluding definitive evidence-based conclusions. The use of ICIs before LT appears promising, provided that a sufficient wash-out period is implemented. In contrast, the results of post-LT ICI therapy do not support its wide clinical application due to high AR rates and overall poor response to treatment. In the future, modern graft preservation techniques might support the selection of good ICI responders, but data from high-level studies are urgently needed. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Guidelines for Perioperative Care for Liver Transplantation: Enhanced Recovery After Surgery (ERAS) Recommendations

Author

Brustia, Raffaele, Monsel, Antoine, Skurzak, Stefano, Schiffer, Eduardo, Carrier, François Martin, Patrono, Damiano, Kaba, Abdourahamane, Detry, Olivier, Malbouisson, Luiz, Andraus, Wellington, Vandenbroucke-Menu, Franck, Biancofiore, Gianni, Kaido, Toshimi, Compagnon, Philippe, Uemoto, Shinji, Rodriguez Laiz, Gonzalo, De Boer, Marieke, Orloff, Susan, Melgar, Paola, Buis, Carlijn, Zeillemaker-Hoekstra, Miriam, Usher, Helen, Reyntjens, Koen, Baird, Emily, Demartines, Nicolas, Wigmore, Stephen, and Scatton, Olivier

Published
2022
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21. Viability assessment of livers donated after circulatory determination of death during normothermic regional perfusion

Author

Steinberg, Irene, primary, Patrono, Damiano, additional, De Cesaris, Enrico, additional, Lucà, Michele, additional, Catalano, Giorgia, additional, Marro, Matteo, additional, Rizza, Giorgia, additional, Simonato, Erika, additional, Brazzi, Luca, additional, Romagnoli, Renato, additional, and Zanierato, Marinella, additional

Published
2023
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22. Location and allocation

Author

Artzner, Thierry, Bernal, William, Belli, Luca S, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie‐Caroline, Pageaux, George‐Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinowich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Besch, Camille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Fondevila, Constantino, Duvoux, Christophe, Jalan, Rajiv, Viganò, Raffaella, Mazzarelli, Chiara, Lauterio, Andrea, Giacomoni, Alessandro, Donato, Francesca, Lampertico, Pietro, Pasulo, Luisa, Fagiuoli, Stefano, Colledan, Michele, Cristina Morelli, Maria, Vitale, Giovanni, Ottobrelli, Antonio, Patrono, Damiano, Romagnoli, Renato, Petridis, Ioannis, Cillo, Umberto, Germani, Giacomo, Burra, Patrizia, Bachellier, Philippe, Schneider, Francis, Castelain, Vincent, Addeo, Pietro, Deridder, Mathilde, Caroline Sacleux Audrey Coilly, Sophie, Faouzi, Saliba, Adam, Rene, Samuel, Didier, Guichon, Celine, Faure, Stéfanie, Ursic‐Bedoya, Josè, Fondevila, Costantino, Colmenero, Jorde, Toapanta, David, Hernández‐Tejero, María, Vinaixa, Carmen, Polak, Wojciech G., den Hoed, Caroline, Haan, Jubi E., Della Penna, Andrea, Erhard Uschner, Frank, Welker, Martin, Zeuzem, Stefan, Bechstein, Wolf, Goossens, Nicolas, Raszeja‐Wyszomirska, Joanna, Rabinovich, Liane, Katarey, Dev, Agarwal, Banwari, Surgery, Gastroenterology & Hepatology, Intensive Care, Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), the ELITA/EF-CLIF Working Group, Artzner, T, Bernal, W, Belli, L, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinowich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Besch, C, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Fondevila, C, Duvoux, C, Jalan, R, Viganò, R, Mazzarelli, C, Lauterio, A, Giacomoni, A, Donato, F, Lampertico, P, Pasulo, L, Fagiuoli, S, Colledan, M, Cristina Morelli, M, Vitale, G, Ottobrelli, A, Patrono, D, Romagnoli, R, Petridis, I, Cillo, U, Germani, G, Burra, P, Bachellier, P, Schneider, F, Castelain, V, Addeo, P, Deridder, M, Caroline Sacleux Audrey Coilly, S, Faouzi, S, Samuel, D, Guichon, C, Faure, S, Ursic‐bedoya, J, Colmenero, J, Toapanta, D, Hernández‐tejero, M, Vinaixa, C, den Hoed, C, Haan, J, Della Penna, A, Erhard Uschner, F, Welker, M, Zeuzem, S, Bechstein, W, Goossens, N, Raszeja‐wyszomirska, J, Rabinovich, L, Katarey, D, and Agarwal, B

Subjects
Transplantation, ILL CIRRHOTIC-PATIENTS, Liver transplantation, Hepatology, Intensive care, Waiting list, Surgery, Acute-on-Chronic Liver Failure, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

There is growing evidence that liver transplantation (LT) is the most effective treatment for acute-on-chronic liver failure grade-3 (ACLF-3). This study examines whether and how this evidence translates into practice by analyzing the variability in intensive care unit (ICU) admissions, listing strategies, and LT activity for patients with ACLF-3 across transplantation centers in Europe. Consecutive patients who were admitted to the ICU with ACLF-3, whether or not they were listed and/or transplanted with ACLF-3, between 2018 and 2019 were included across 20 transplantation centers. A total of 351 patients with ACLF-3 were included: 33 had been listed prior to developing ACLF-3 and 318 had not been listed at the time of admission to the ICU. There was no correlation between the number of unlisted patients with ACLF-3 admitted to the ICU and the number listed or transplanted while in ACLF-3 across centers. By contrast, there was a correlation between the number of patients listed and the number transplanted while in ACLF-3. About 21% of patients who were listed while in ACLF-3 died on the waiting list or were delisted. The percentage of LT for patients with ACLF-3 varied from 0% to 29% for those transplanted with decompensated cirrhosis across centers (average = 8%), with an I(2) index of 68% (95% confidence interval, 49%-80%), showing substantial heterogeneity among centers. The 1-year survival for all patients with ACLF-3 was significantly higher in centers that listed and transplanted more patients with ACLF-3 (>10 patients) than in centers that listed and transplanted fewer: 36% versus 20%, respectively (p = 0.012). Patients with ACLF-3 face inequity of access to LT across Europe. Waitlisting strategies for patients with ACLF-3 influence their access to LT and, ultimately, their survival.

Published
2022

24. Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation

Author

Rigo, Federica, primary, De Stefano, Nicola, additional, Patrono, Damiano, additional, De Donato, Victor, additional, Campi, Ludovico, additional, Turturica, Diana, additional, Doria, Teresa, additional, Sciannameo, Veronica, additional, Berchialla, Paola, additional, Tandoi, Francesco, additional, and Romagnoli, Renato, additional

Published
2023
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28. Organ reconditioning and machine perfusion in transplantation

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Bellini, Maria Irene, Bonaccorsi Riani, Eliano, Giorgakis, Emmanouil, Kaisar, Maria E., Patrono, Damiano, Weissenbacher, Annemarie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Bellini, Maria Irene, Bonaccorsi Riani, Eliano, Giorgakis, Emmanouil, Kaisar, Maria E., Patrono, Damiano, and Weissenbacher, Annemarie

Abstract

Society’s self-sufficiency in terms of organ replacement is still far away from being achieved, given the large disparity between transplant demand and donor organ availability. In the attempt to reduce this discrepancy and expand the donor pool, the transplant community has progressively increased the utilisation of extended-criteria donors (ECD) such as older donors, donors with comorbidities and donation after circulatory death (DCD). The main challenge preventing a wider utilisation of ECD and DCD allografts is the higher susceptibility to the ischemia-reperfusion injury (IRI) (1), an unavoidable part of the transplantation process. For this reason, in the last decades, there has been an exponential development on organ reconditioning strategies, in order to enable graft resuscitation and viability assessment prior to implantation (2).

Published
2023

32. Splenic Vessels as a Rescue for Pediatric Kidney Retransplantation in Children With Iliac-caval Agenesis or Thrombosis

Author

Tandoi, Francesco, primary, Peruzzi, Licia, additional, Lonardi, Pietro, additional, Cussa, Davide, additional, Catalano, Silvia, additional, Verri, Aldo, additional, Merlo, Maurizio, additional, Sedigh, Omidreza, additional, Gerocarni Nappo, Simona, additional, Melloni, Claudia, additional, Patrono, Damiano, additional, Gianoglio, Bruno, additional, and Romagnoli, Renato, additional

Published
2022
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34. How to Preserve Steatotic Liver Grafts for Transplantation.

Author

Patrono, Damiano, De Stefano, Nicola, Vissio, Elena, Apostu, Ana Lavinia, Petronio, Nicoletta, Vitelli, Giovanni, Catalano, Giorgia, Rizza, Giorgia, Catalano, Silvia, Colli, Fabio, Chiusa, Luigi, and Romagnoli, Renato

Subjects
*LIVER transplantation, *FATTY liver, *PREOPERATIVE risk factors, *LIVER histology, *REPERFUSION injury, *HOMOGRAFTS, *GRAFT survival, *FATTY degeneration
Abstract

Liver allograft steatosis is a significant risk factor for postoperative graft dysfunction and has been associated with inferior patient and graft survival, particularly in the case of moderate or severe macrovesicular steatosis. In recent years, the increasing incidence of obesity and fatty liver disease in the population has led to a higher proportion of steatotic liver grafts being used for transplantation, making the optimization of their preservation an urgent necessity. This review discusses the mechanisms behind the increased susceptibility of fatty livers to ischemia-reperfusion injury and provides an overview of the available strategies to improve their utilization for transplantation, with a focus on preclinical and clinical evidence supporting donor interventions, novel preservation solutions, and machine perfusion techniques. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Viability testing during liver preservation

Author

Patrono, Damiano, Lonati, Caterina, and Romagnoli, Renato

Subjects
Transplantation, ischemia-reperfusion injury, machine perfusion, Organ Preservation, Tissue Donors, flavin mononucleotide, Liver Transplantation, Perfusion, Liver, Immunology and Allergy, Animals, Humans, liver transplantation, prognostic scores
Abstract

Viability assessment is one of the main indications for machine perfusion (MP) in liver transplantation. This review summarizes the rationale, evolution and limitations of proposed viability criteria and suggests a framework for future studies.Liver viability is most frequently assessed during normothermic MP by combining parameters relative to perfusate and bile composition, vascular flows and macroscopic aspect. Assessment protocols are largely heterogeneous and have significantly evolved over time, also within the same group, reflecting the ongoing evolution of the subject. Several recent preclinical studies using discarded human livers or animal models have explored other approaches to viability assessment. During hypothermic MP, perfusate flavin mononucleotide has emerged as a promising biomarker of mitochondrial injury and function. Most studies on the subject suffer from limitations, including low numbers, lack of multicenter validation, and subjective interpretation of some viability parameters.MP adds a further element of complexity in the process of assessing the quality of a liver graft. Understanding the physiology of the parameters included in the different assessment protocols is necessary for their correct interpretation. Despite the possibility of assessing liver viability during MP, the importance of donor-recipient matching and operational variables should not be disregarded.

Published
2022

38. Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching

Author

Brustia, Raffaele, primary, Laurent, Alexis, additional, Goumard, Claire, additional, Langella, Serena, additional, Cherqui, Daniel, additional, Kawai, Takayuki, additional, Soubrane, Olivier, additional, Cauchy, Francois, additional, Farges, Olivier, additional, Menahem, Benjamin, additional, Hobeika, Christian, additional, Rhaiem, Rami, additional, Sommacale, Daniele, additional, Okumura, Shinya, additional, Hofmeyr, Stefan, additional, Ferrero, Alessandro, additional, Pruvot, François-René, additional, Regimbeau, Jean-Marc, additional, Fuks, David, additional, Vibert, Eric, additional, Scatton, Olivier, additional, Abba, Julio, additional, Adam, René, additional, Adham, Mustapha, additional, Allard, Marc-Antoine, additional, Ayav, Ahmet, additional, Azoulay, Daniel, additional, Bachellier, Philippe, additional, Balladur, Pierre, additional, Barbier, Louise, additional, Barbieux, Julien, additional, Boleslawski, Emmanuel, additional, Boudjema, Karim, additional, Bougard, M., additional, Buc, Emmanuel, additional, Bucur, Petru, additional, Carmelo, Antoine, additional, Chatelain, Denis, additional, Chauvat, Jean, additional, Cherkaoui, Zineb, additional, Chiche, Laurence, additional, Chirica, Mircea, additional, Ciacio, Oriana, additional, Codjia, Tatiana, additional, Colli, Fabio, additional, De Carlis, Luciano, additional, Delpero, Jean-Robert, additional, Demartines, Nicolas, additional, Detry, Olivier, additional, Sanches, Marcelo Dias, additional, Diouf, Momar, additional, Doussot, Alexandre, additional, Ducerf, Christian, additional, El Amrani, Mehdi, additional, Ewald, Jacques, additional, Fabre, Jean-Marc, additional, Fagot, Hervé, additional, Famularo, Simone, additional, Ferre, Léo, additional, Fleres, Francesco, additional, Fonseca, Gilton Marques, additional, Gayet, Brice, additional, Giacomoni, Alessandro, additional, Gigot, Jean-Francois, additional, Girard, E., additional, Golse, Nicolas, additional, Gregoire, Emilie, additional, Hardwigsen, Jean, additional, Herman, Paulo, additional, Hor, Thevi, additional, Jehaes, François, additional, Kianmanesh, Ali-Reza, additional, Komatsu, Shohei, additional, Laroche, Sophie, additional, Laurent, Christophe, additional, Le Treut, Yves-Patrice, additional, Lecolle, K., additional, Leourier, Philippe, additional, Lermite, Emilie, additional, Lesurtel, Mikael, additional, Letoublon, Christian, additional, Leyman, Paul, additional, Lubrano, Jean, additional, Mabrut, Jean-Yves, additional, Mantion, Georges, additional, Marchese, Ugo, additional, Memeo, Riccardo, additional, Millet, Guillaume, additional, Mohkam, Kayvan, additional, Mulliri, André, additional, Muscari, Fabrice, additional, Navarro, Francis, additional, Nolasco, Francisco, additional, Nomi, Takeo, additional, Nunoz, Jean, additional, Nuzzo, Gennaro, additional, Oudafal, Nassima, additional, Pascal, Gerard, additional, Passot, Guillaume, additional, Patrice, D., additional, Patrono, Damiano, additional, Paye, François, additional, Perdigao, Fabiano, additional, Pessaux, Patrick, additional, Petrucciani, Niccolo, additional, Pittau, Gabriella, additional, Ratajczak, C., additional, Raventos, Artigas, additional, Rebibo, Lionel, additional, Resende, Vivian, additional, Rivoire, Michel, additional, Romagnoli, Renato, additional, Roulin, Didier, additional, Sa-Cunha, Antonio, additional, Salame, Ephrem, additional, Schielke, Astrid, additional, Schwarz, Lilian, additional, Scotte, Michel, additional, Souche, François-Regis, additional, Suc, Bertrand, additional, Tedeschi, Michele, additional, Thobie, Alexandre, additional, Trechot, Boris, additional, Truant, Stéphanie, additional, Turini, Olivier, additional, Uemoto, Shinji, additional, Unterteiner, Xavier, additional, Vanbrugghe, Charles, additional, and Zemour, Jean, additional

Published
2022
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39. A Multicentre Outcome Analysis to Define Global Benchmarks for Donation after Circulatory Death Liver Transplantation

Author

Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B, Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Carvalho, Mauricio Flores, et al, and University of Zurich

Subjects
Hepatology, 610 Medicine & health, 2721 Hepatology, 10217 Clinic for Visceral and Transplantation Surgery
Published
2022

40. Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: a European observational cohort study

Author

Brüggenwirth, I, Mueller, M, Lantinga, V, Camagni, S, De Carlis, R, De Carlis, L, Colledan, M, Dondossola, D, Drefs, M, Eden, J, Ghinolfi, D, Koliogiannis, D, Lurje, G, Manzia, T, Monbaliu, D, Muiesan, P, Patrono, D, Pratschke, J, Romagnoli, R, Rayar, M, Roma, F, Schlegel, A, Dutkowski, P, Porte, R, de Meijer, V, Brüggenwirth, Isabel M A, Mueller, Matteo, Lantinga, Veerle A, Camagni, Stefania, De Carlis, Riccardo, De Carlis, Luciano, Colledan, Michele, Dondossola, Daniele, Drefs, Moritz, Eden, Janina, Ghinolfi, Davide, Koliogiannis, Dionysios, Lurje, Georg, Manzia, Tommaso M, Monbaliu, Diethard, Muiesan, Paolo, Patrono, Damiano, Pratschke, Johann, Romagnoli, Renato, Rayar, Michel, Roma, Federico, Schlegel, Andrea, Dutkowski, Philipp, Porte, Robert J, de Meijer, Vincent E, Brüggenwirth, I, Mueller, M, Lantinga, V, Camagni, S, De Carlis, R, De Carlis, L, Colledan, M, Dondossola, D, Drefs, M, Eden, J, Ghinolfi, D, Koliogiannis, D, Lurje, G, Manzia, T, Monbaliu, D, Muiesan, P, Patrono, D, Pratschke, J, Romagnoli, R, Rayar, M, Roma, F, Schlegel, A, Dutkowski, P, Porte, R, de Meijer, V, Brüggenwirth, Isabel M A, Mueller, Matteo, Lantinga, Veerle A, Camagni, Stefania, De Carlis, Riccardo, De Carlis, Luciano, Colledan, Michele, Dondossola, Daniele, Drefs, Moritz, Eden, Janina, Ghinolfi, Davide, Koliogiannis, Dionysios, Lurje, Georg, Manzia, Tommaso M, Monbaliu, Diethard, Muiesan, Paolo, Patrono, Damiano, Pratschke, Johann, Romagnoli, Renato, Rayar, Michel, Roma, Federico, Schlegel, Andrea, Dutkowski, Philipp, Porte, Robert J, and de Meijer, Vincent E

Abstract

A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver transplantation. Machine perfusion time is occasionally prolonged for logistical reasons, but it is unknown if prolonged HOPE is safe and compromises outcomes. We conducted a multicenter, observational cohort study of patients transplanted with a liver preserved by prolonged (≥4 h) HOPE. Postoperative biochemistry, complications, and survival were evaluated. The cohort included 93 recipients from 12 European transplant centers between 2014–2021. The most common reason to prolong HOPE was the lack of an available operating room to start the transplant procedure. Grafts underwent HOPE for a median (range) of 4:42 h (4:00–8:35 h) with a total preservation time of 10:50 h (5:50–20:50 h). Postoperative peak ALT was 675 IU/L (interquartile range 419–1378 IU/L). The incidence of postoperative complications was low, and 1-year graft and patient survival were 94% and 88%, respectively. To conclude, good outcomes are achieved after transplantation of donor livers preserved with prolonged (median 4:42 h) HOPE, leading to a total preservation time of almost 21 h. These results suggest that simple, end-ischemic HOPE may be utilized for safe extension of the preservation time to ease transplantation logistics.

Published
2022

41. Impact of MELD 30-allocation policy on liver transplant outcomes in Italy

Author

Ravaioli, Matteo, Lai, Quirino, Sessa, Maurizio, Ghinolfi, Davide, Fallani, Guido, Patrono, Damiano, Di Sandro, Stefano, Avolio, Alfonso, Odaldi, Federica, Bronzoni, Jessica, Tandoi, Francesco, De Carlis, Riccardo, Pascale, Marco Maria, Mennini, Gianluca, Germinario, Giuliana, Rossi, Massimo, Agnes, Salvatore, De Carlis, Luciano, Cescon, Matteo, Romagnoli, Renato, De Simone, Paolo, Ravaioli, Matteo, Lai, Quirino, Sessa, Maurizio, Ghinolfi, Davide, Fallani, Guido, Patrono, Damiano, Di Sandro, Stefano, Avolio, Alfonso, Odaldi, Federica, Bronzoni, Jessica, Tandoi, Francesco, De Carlis, Riccardo, Pascale, Marco Maria, Mennini, Gianluca, Germinario, Giuliana, Rossi, Massimo, Agnes, Salvatore, De Carlis, Luciano, Cescon, Matteo, Romagnoli, Renato, and De Simone, Paolo

Abstract

BACKGROUND & AIMS: In Italy, since August 2014, LT candidates with MELD≥30 receive a national allocation priority. This multi-center cohort study aims to evaluate waiting time in the list, dropout rate, and graft survival before and after introducing the macroarea sharing policy.METHODS: 4,238 patients registered from 2010 to 2018 have been enrolled and categorized in an ERA-1 Group (n=2,013; before August 2014) and an ERA-2 Group (n=2,225; during and after August 2014). Cox proportional hazard model was used to estimate the HR of receiving LT or death between the two ERAs. The Fine-Gray model was used to estimate the HR for dropout from the waiting list and graft loss, considering death as a competing risk event. A Fine-Gray model was also used to estimate risk factors of graft loss.RESULTS: MELD≥30 patients had a lower median waiting time in the list for LT (4vs.12 days, p<0.001) and a higher probability to be transplanted (HR=2.27, 95%CI 1.78-2.90; p=0.001) in the ERA-2 when compared to ERA-1. The subgroup analysis on 3,515 LTs confirmed ERA-2 (odds ratio=0.56, 95%CI=0.46-0.68; p=0.001) as a protective factor for better graft survival rate. The protective variables for lower dropouts on the waiting list were: ERA-2, high volume centers, no competition centers, male recipients, and hepatocellular carcinoma. The protective variables for graft loss were high volume center and ERA-2, while MELD≥30 remained related to a higher risk of graft loss.CONCLUSIONS: The national MELD≥30 priority allocation was associated with improved patient outcomes, although MELD≥30 had a higher risk of graft loss. The transplant centers volume and competition among centers may have a role in the recipient prioritization and outcome.CLINICAL TRIAL NUMBER: NCT04530240 LAY SUMMARY: After introducing the Italian national MELD≥30 priority, more LT, fewer dropouts, and shorter waiting times were observed in patients with MELD≥30. However, a higher risk of g

Published
2022

42. Location and allocation: inequity of access to liver transplantation for patients with severe acute‐on‐chronic liver failure in Europe

Author

Artzner, T, Bernal, W, Belli, L, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinowich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Besch, C, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Fondevila, C, Duvoux, C, Jalan, R, Viganò, R, Mazzarelli, C, Lauterio, A, Giacomoni, A, Donato, F, Lampertico, P, Pasulo, L, Fagiuoli, S, Colledan, M, Cristina Morelli, M, Vitale, G, Ottobrelli, A, Patrono, D, Romagnoli, R, Petridis, I, Cillo, U, Germani, G, Burra, P, Bachellier, P, Schneider, F, Castelain, V, Addeo, P, Deridder, M, Caroline Sacleux Audrey Coilly, S, Faouzi, S, Samuel, D, Guichon, C, Faure, S, Ursic‐bedoya, J, Colmenero, J, Toapanta, D, Hernández‐tejero, M, Vinaixa, C, den Hoed, C, Haan, J, Della Penna, A, Erhard Uschner, F, Welker, M, Zeuzem, S, Bechstein, W, Goossens, N, Raszeja‐wyszomirska, J, Rabinovich, L, Katarey, D, Agarwal, B, Artzner, Thierry, Bernal, William, Belli, Luca S, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie‐Caroline, Pageaux, George‐Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinowich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Besch, Camille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Fondevila, Constantino, Duvoux, Christophe, Jalan, Rajiv, Viganò, Raffaella, Mazzarelli, Chiara, Lauterio, Andrea, Giacomoni, Alessandro, Donato, Francesca, Lampertico, Pietro, Pasulo, Luisa, Fagiuoli, Stefano, Colledan, Michele, Cristina Morelli, Maria, Vitale, Giovanni, Ottobrelli, Antonio, Patrono, Damiano, Romagnoli, Renato, Petridis, Ioannis, Cillo, Umberto, Germani, Giacomo, Burra, Patrizia, Bachellier, Philippe, Schneider, Francis, Castelain, Vincent, Addeo, Pietro, Deridder, Mathilde, Caroline Sacleux Audrey Coilly, Sophie, Faouzi, Saliba, Adam, Rene, Samuel, Didier, Guichon, Celine, Faure, Stéfanie, Ursic‐Bedoya, Josè, Fondevila, Costantino, Colmenero, Jorde, Toapanta, David, Hernández‐Tejero, María, Vinaixa, Carmen, Polak, Wojciech G., den Hoed, Caroline, Haan, Jubi E., Della Penna, Andrea, Erhard Uschner, Frank, Welker, Martin, Zeuzem, Stefan, Bechstein, Wolf, Goossens, Nicolas, Raszeja‐Wyszomirska, Joanna, Rabinovich, Liane, Katarey, Dev, Agarwal, Banwari, Artzner, T, Bernal, W, Belli, L, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinowich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Besch, C, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Fondevila, C, Duvoux, C, Jalan, R, Viganò, R, Mazzarelli, C, Lauterio, A, Giacomoni, A, Donato, F, Lampertico, P, Pasulo, L, Fagiuoli, S, Colledan, M, Cristina Morelli, M, Vitale, G, Ottobrelli, A, Patrono, D, Romagnoli, R, Petridis, I, Cillo, U, Germani, G, Burra, P, Bachellier, P, Schneider, F, Castelain, V, Addeo, P, Deridder, M, Caroline Sacleux Audrey Coilly, S, Faouzi, S, Samuel, D, Guichon, C, Faure, S, Ursic‐bedoya, J, Colmenero, J, Toapanta, D, Hernández‐tejero, M, Vinaixa, C, den Hoed, C, Haan, J, Della Penna, A, Erhard Uschner, F, Welker, M, Zeuzem, S, Bechstein, W, Goossens, N, Raszeja‐wyszomirska, J, Rabinovich, L, Katarey, D, Agarwal, B, Artzner, Thierry, Bernal, William, Belli, Luca S, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie‐Caroline, Pageaux, George‐Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinowich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Besch, Camille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Fondevila, Constantino, Duvoux, Christophe, Jalan, Rajiv, Viganò, Raffaella, Mazzarelli, Chiara, Lauterio, Andrea, Giacomoni, Alessandro, Donato, Francesca, Lampertico, Pietro, Pasulo, Luisa, Fagiuoli, Stefano, Colledan, Michele, Cristina Morelli, Maria, Vitale, Giovanni, Ottobrelli, Antonio, Patrono, Damiano, Romagnoli, Renato, Petridis, Ioannis, Cillo, Umberto, Germani, Giacomo, Burra, Patrizia, Bachellier, Philippe, Schneider, Francis, Castelain, Vincent, Addeo, Pietro, Deridder, Mathilde, Caroline Sacleux Audrey Coilly, Sophie, Faouzi, Saliba, Adam, Rene, Samuel, Didier, Guichon, Celine, Faure, Stéfanie, Ursic‐Bedoya, Josè, Fondevila, Costantino, Colmenero, Jorde, Toapanta, David, Hernández‐Tejero, María, Vinaixa, Carmen, Polak, Wojciech G., den Hoed, Caroline, Haan, Jubi E., Della Penna, Andrea, Erhard Uschner, Frank, Welker, Martin, Zeuzem, Stefan, Bechstein, Wolf, Goossens, Nicolas, Raszeja‐Wyszomirska, Joanna, Rabinovich, Liane, Katarey, Dev, and Agarwal, Banwari

Abstract

Background: There is growing evidence that liver transplantation (LT) is the most effective treatment for acute-on-chronic liver failure grade-3 (ACLF-3). This study examines whether and how this evidence translates into practice by analyzing the variability in intensive care unit (ICU) admissions, listing strategies and LT activity for ACLF-3 patients across transplant centers in Europe. Methods: Consecutive patients who were admitted to the ICU with ACLF-3, whether or not they were listed and/or transplanted with ACLF-3 between 2018 and 2019 were included across 20 transplantation centers. Results: 351 patients with ACLF-3 were included: 33 had been listed prior to developing ACLF-3 and 318 had not been listed at the time of admission to the ICU. There was no correlation between the number of unlisted ACLF-3 patients admitted to the ICU and the number listed or transplanted whilst in ACLF-3 across centers. In contrast, there was a correlation between the number of patients listed and the number transplanted whilst in ACLF-3. 21% of patients who were listed whilst in ACLF-3 died on the waiting list or were delisted. The percentage of LT for ACLF-3 patients varied from 0%-29% of patients transplanted with decompensated cirrhosis across centers (average = 8%), with an I2 index of 68% (95% CI: 49%-80%), showing substantial heterogeneity among centers. The one-year survival for all patients with ACLF-3 was significantly higher in centers that listed and transplanted more ACLF-3 patients (>10 patients) than in centers that listed and transplanted fewer: respectively 36% vs. 20%, p = 0.012. Conclusion: Patients with ACLF-3 face inequity of access to LT across Europe. Wait-listing strategies for ACLF-3 patients influence their access to LT and, ultimately, their survival.

Published
2022

43. A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

Author

Schlegel, A, van Reeven, M, Croome, K, Parente, A, Dolcet, A, Widmer, J, Meurisse, N, De Carlis, R, Hessheimer, A, Jochmans, I, Mueller, M, van Leeuwen, O, Nair, A, Tomiyama, K, Sherif, A, Elsharif, M, Kron, P, van der Helm, D, Borja-Cacho, D, Bohorquez, H, Germanova, D, Dondossola, D, Olivieri, T, Camagni, S, Gorgen, A, Patrono, D, Cescon, M, Croome, S, Panconesi, R, Flores Carvalho, M, Ravaioli, M, Caicedo, J, Loss, G, Lucidi, V, Sapisochin, G, Romagnoli, R, Jassem, W, Colledan, M, De Carlis, L, Rossi, G, Di Benedetto, F, Miller, C, van Hoek, B, Attia, M, Lodge, P, Hernandez-Alejandro, R, Detry, O, Quintini, C, Oniscu, G, Fondevila, C, Malagó, M, Pirenne, J, Ijzermans, J, Porte, R, Dutkowski, P, Taner, C, Heaton, N, Clavien, P, Polak, W, Muiesan, P, Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B, Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Flores Carvalho, Mauricio, Ravaioli, Matteo, Caicedo, Juan Carlos, Loss, George, Lucidi, Valerio, Sapisochin, Gonzalo, Romagnoli, Renato, Jassem, Wayel, Colledan, Michele, De Carlis, Luciano, Rossi, Giorgio, Di Benedetto, Fabrizio, Miller, Charles M, van Hoek, Bart, Attia, Magdy, Lodge, Peter, Hernandez-Alejandro, Roberto, Detry, Olivier, Quintini, Cristiano, Oniscu, Gabriel C, Fondevila, Constantino, Malagó, Massimo, Pirenne, Jacques, IJzermans, Jan Nm, Porte, Robert J, Dutkowski, Philipp, Taner, C Burcin, Heaton, Nigel, Clavien, Pierre-Alain, Polak, Wojciech G, Muiesan, Paolo, Schlegel, A, van Reeven, M, Croome, K, Parente, A, Dolcet, A, Widmer, J, Meurisse, N, De Carlis, R, Hessheimer, A, Jochmans, I, Mueller, M, van Leeuwen, O, Nair, A, Tomiyama, K, Sherif, A, Elsharif, M, Kron, P, van der Helm, D, Borja-Cacho, D, Bohorquez, H, Germanova, D, Dondossola, D, Olivieri, T, Camagni, S, Gorgen, A, Patrono, D, Cescon, M, Croome, S, Panconesi, R, Flores Carvalho, M, Ravaioli, M, Caicedo, J, Loss, G, Lucidi, V, Sapisochin, G, Romagnoli, R, Jassem, W, Colledan, M, De Carlis, L, Rossi, G, Di Benedetto, F, Miller, C, van Hoek, B, Attia, M, Lodge, P, Hernandez-Alejandro, R, Detry, O, Quintini, C, Oniscu, G, Fondevila, C, Malagó, M, Pirenne, J, Ijzermans, J, Porte, R, Dutkowski, P, Taner, C, Heaton, N, Clavien, P, Polak, W, Muiesan, P, Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B, Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Flores Carvalho, Mauricio, Ravaioli, Matteo, Caicedo, Juan Carlos, Loss, George, Lucidi, Valerio, Sapisochin, Gonzalo, Romagnoli, Renato, Jassem, Wayel, Colledan, Michele, De Carlis, Luciano, Rossi, Giorgio, Di Benedetto, Fabrizio, Miller, Charles M, van Hoek, Bart, Attia, Magdy, Lodge, Peter, Hernandez-Alejandro, Roberto, Detry, Olivier, Quintini, Cristiano, Oniscu, Gabriel C, Fondevila, Constantino, Malagó, Massimo, Pirenne, Jacques, IJzermans, Jan Nm, Porte, Robert J, Dutkowski, Philipp, Taner, C Burcin, Heaton, Nigel, Clavien, Pierre-Alain, Polak, Wojciech G, and Muiesan, Paolo

Abstract

Background & Aims: The concept of benchmarking is established in the field of transplant surgery; however, benchmark values for donation after circulatory death (DCD) liver transplantation are not available. Thus, we aimed to identify the best possible outcomes in DCD liver transplantation and to propose outcome reference values. Methods: Based on 2,219 controlled DCD liver transplantations, collected from 17 centres in North America and Europe, we identified 1,012 low-risk, primary, adult liver transplantations with a laboratory MELD score of ≤20 points, receiving a DCD liver with a total donor warm ischemia time of ≤30 minutes and asystolic donor warm ischemia time of ≤15 minutes. Clinically relevant outcomes were selected and complications were reported according to the Clavien-Dindo-Grading and the comprehensive complication index (CCI). Corresponding benchmark cut-offs were based on median values of each centre, where the 75th-percentile was considered. Results: Benchmark cases represented between 19.7% and 75% of DCD transplantations in participating centres. The 1-year retransplant and mortality rates were 4.5% and 8.4% in the benchmark group, respectively. Within the first year of follow-up, 51.1% of recipients developed at least 1 major complication (≥Clavien-Dindo-Grade III). Benchmark cut-offs were ≤3 days and ≤16 days for ICU and hospital stay, ≤66% for severe recipient complications (≥Grade III), ≤16.8% for ischemic cholangiopathy, and ≤38.9 CCI points 1 year after transplant. Comparisons with higher risk groups showed more complications and impaired graft survival outside the benchmark cut-offs. Organ perfusion techniques reduced the complications to values below benchmark cut-offs, despite higher graft risk. Conclusions: Despite excellent 1-year survival, morbidity in benchmark cases remains high. Benchmark cut-offs targeting morbidity parameters offer a valid tool to assess the protective value of new preservation technologies in higher risk grou

Published
2022

44. Normothermic Regional Perfusion and Hypothermic Oxygenated Machine Perfusion for Livers Donated After Controlled Circulatory Death With Prolonged Warm Ischemia Time: A Matched Comparison With Livers From Brain-Dead Donors

Author

Patrono, Damiano, primary, Zanierato, Marinella, additional, Vergano, Marco, additional, Magaton, Chiara, additional, Diale, Enrico, additional, Rizza, Giorgia, additional, Catalano, Silvia, additional, Mirabella, Stefano, additional, Cocchis, Donatella, additional, Potenza, Raffaele, additional, Livigni, Sergio, additional, Balagna, Roberto, additional, and Romagnoli, Renato, additional

Published
2022
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45. Impact of MELD 30-allocation policy on liver transplant outcomes in Italy

Author

Ravaioli, Matteo, primary, Lai, Quirino, additional, Sessa, Maurizio, additional, Ghinolfi, Davide, additional, Fallani, Guido, additional, Patrono, Damiano, additional, Di Sandro, Stefano, additional, Avolio, Alfonso, additional, Odaldi, Federica, additional, Bronzoni, Jessica, additional, Tandoi, Francesco, additional, De Carlis, Riccardo, additional, Pascale, Marco Maria, additional, Mennini, Gianluca, additional, Germinario, Giuliana, additional, Rossi, Massimo, additional, Agnes, Salvatore, additional, De Carlis, Luciano, additional, Cescon, Matteo, additional, Romagnoli, Renato, additional, and De Simone, Paolo, additional

Published
2022
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46. A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

Author

Schlegel, Andrea, primary, van Reeven, Marjolein, additional, Croome, Kristopher, additional, Parente, Alessandro, additional, Dolcet, Annalisa, additional, Widmer, Jeannette, additional, Meurisse, Nicolas, additional, De Carlis, Riccardo, additional, Hessheimer, Amelia, additional, Jochmans, Ina, additional, Mueller, Matteo, additional, van Leeuwen, Otto B., additional, Nair, Amit, additional, Tomiyama, Koji, additional, Sherif, Ahmed, additional, Elsharif, Mohamed, additional, Kron, Philipp, additional, van der Helm, Danny, additional, Borja-Cacho, Daniel, additional, Bohorquez, Humberto, additional, Germanova, Desislava, additional, Dondossola, Daniele, additional, Olivieri, Tiziana, additional, Camagni, Stefania, additional, Gorgen, Andre, additional, Patrono, Damiano, additional, Cescon, Matteo, additional, Croome, Sarah, additional, Panconesi, Rebecca, additional, Carvalho, Mauricio Flores, additional, Ravaioli, Matteo, additional, Caicedo, Juan Carlos, additional, Loss, George, additional, Lucidi, Valerio, additional, Sapisochin, Gonzalo, additional, Romagnoli, Renato, additional, Jassem, Wayel, additional, Colledan, Michele, additional, De Carlis, Luciano, additional, Rossi, Giorgio, additional, Di Benedetto, Fabrizio, additional, Miller, Charles M., additional, van Hoek, Bart, additional, Attia, Magdy, additional, Lodge, Peter, additional, Hernandez-Alejandro, Roberto, additional, Detry, Olivier, additional, Quintini, Cristiano, additional, Oniscu, Gabriel C., additional, Fondevila, Constantino, additional, Malagó, Massimo, additional, Pirenne, Jacques, additional, IJzermans, Jan N.M., additional, Porte, Robert J., additional, Dutkowski, Philipp, additional, Taner, C. Burcin, additional, Heaton, Nigel, additional, Clavien, Pierre-Alain, additional, Polak, Wojciech G., additional, Muiesan, Paolo, additional, Alwayn, Ian P.J., additional, van der Berg, Aad P., additional, Carbonaro, Margherita, additional, Claasen, Marco, additional, Daud, Amna, additional, de Meijer, Vincent E., additional, Metselaar, Herold J., additional, Monbaliu, Diethard, additional, Paolucci, Maite, additional, Vets, Sofie, additional, and Winter, Erin, additional

Published
2022
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47. Normothermic Regional Perfusion and Hypothermic Oxygenated Machine Perfusion for Livers Donated After Controlled Circulatory Death With Prolonged Warm Ischemia Time: A Matched Comparison With Livers From Brain-Dead Donors

Author

Patrono, Damiano, Zanierato, Marinella, Vergano, Marco, Magaton, Chiara, Diale, Enrico, Rizza, Giorgia, Catalano, Silvia, Mirabella, Stefano, Cocchis, Donatella, Potenza, Raffaele, Livigni, Sergio, Balagna, Roberto, and Romagnoli, Renato

Subjects
Transplantation, Brain Death, abdominal normothermic regional perfusion, Graft Survival, Brain, ischemic cholangiopathy, donation after circulatory death, Organ Preservation, warm ischemia time, Tissue Donors, Death, Perfusion, Liver, hypothermic oxygenated machine perfusion, Humans, Warm Ischemia, liver transplantation outcome, Retrospective Studies
Abstract

Prolonged warm ischemia time (WIT) has a negative prognostic value in liver transplantation (LT) using grafts procured after circulatory death (DCD). To assess the value of abdominal normothermic regional perfusion (A-NRP) associated with dual hypothermic oxygenated machine perfusion (D-HOPE) in controlled DCD LT, prospectively collected data on LTs performed between January 2016 and July 2021 were analyzed. Outcome of controlled DCD LTs performed using A-NRP + D-HOPE (

Published
2022

48. Heterogeneous Indications and the Need for Viability Assessment: An International Survey on the Use of Machine Perfusion in Liver Transplantation

Author

Patrono, Damiano, Cussa, Davide, Rigo, Federica, Romagnoli, Renato, et al, and University of Zurich

Subjects
Biomaterials, 1502 Bioengineering, 2502 Biomaterials, Biomedical Engineering, 2204 Biomedical Engineering, Medicine (miscellaneous), 610 Medicine & health, 2701 Medicine (miscellaneous), Bioengineering, General Medicine, 10217 Clinic for Visceral and Transplantation Surgery
Published
2022
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49. Highlights from the Turin international workshop on liver machine perfusion.

Author

Patrono, Damiano, De Stefano, Nicola, Martins, Paulo N., and Romagnoli, Renato

Subjects
*PERFUSION, *TREND setters, *CLINICAL indications, *LIVER transplantation, *MACHINERY
Abstract

The 1st Turin international workshop on liver machine perfusion, which was held in Turin (Italy) on June 10th–11th, 2022, gathered more than 50 key opinion leaders and more than 220 delegates from 11 countries. The purpose of the meeting was discussing several aspects of liver machine perfusion in liver transplantation, including the state of the art, real‐world clinical indications, and potential developments of this technology. We herein provide a brief summary of the evidence, perspectives and controversies presented during the meeting. [ABSTRACT FROM AUTHOR]

Published
2022
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50. How to Preserve Liver Grafts From Circulatory Death With Long Warm Ischemia? A Retrospective Italian Cohort Study With Normothermic Regional Perfusion and Hypothermic Oxygenated Perfusion

Author

De Carlis, Riccardo, primary, Schlegel, Andrea, additional, Frassoni, Samuele, additional, Olivieri, Tiziana, additional, Ravaioli, Matteo, additional, Camagni, Stefania, additional, Patrono, Damiano, additional, Bassi, Domenico, additional, Pagano, Duilio, additional, Di Sandro, Stefano, additional, Lauterio, Andrea, additional, Bagnardi, Vincenzo, additional, Gruttadauria, Salvatore, additional, Cillo, Umberto, additional, Romagnoli, Renato, additional, Colledan, Michele, additional, Cescon, Matteo, additional, Di Benedetto, Fabrizio, additional, Muiesan, Paolo, additional, and De Carlis, Luciano, additional

Published
2021
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