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3. Clinical Factors, Treatment Selection, and Outcomes in Postcataract Fungal Endophthalmitis from Contaminated Viscoelastics

Author

Nam, Dong Heun, Lee, Dae Yeong, Park, Young-Hoon, Park, Young-Gun, Kim, Mirinae, Lee, Mee Yon, Choi, Soon-Il, Kim, Min, Lee, Junwon, Moon, Sang Woong, Chung, Hyewon, Lee, Young Hoon, Lee, Min Woo, Shin, Jae Pil, Park, Dong Ho, Park, Han Sang, Kang, Yong Koo, Chung, In Young, Yoo, Woong-Sun, Cho, Yong-Wun, Kim, Yu Cheol, Kang, Kyung Tae, Jang, Ji Hye, Kim, Seong-Woo, Choi, Kwang-Eon, Choi, Mihyun, Nam, Ki Tae, Kim, Young Ho, Ahn, So Min, Lee, Sang Joon, Lim, Jae Wan, Ku, Hee Chan, Yoo, Su Jin, Choi, Moon Jung, Lew, Young Ju, Kim, Jae Hui, Kim, Joo Yeon, Hwang, Jae Hyung, Lee, Seung Woo, Bae, Kunho, Jeong, Woo Jin, Kwon, Yoon Hyung, An, Seoung Hyun, Ahn, Jeeyun, Shin, Joo Young, Byon, Ik Soo, Park, Sung Who, Park, Kyu Hyung, Kang, Se Woong, Ham, Don-Il, Kim, Sang Jin, Park, Un Chul, Oh, Baek Lok, Kim, June-Gone, Lee, Joo Yong, Lee, Jun Yeop, Kim, Yoon Jeon, Chae, Ju Byung, Kim, Dong Yoon, Lee, Christopher Seungkyu, Cho, Kwan Hyuk, Kim, Min Seok, Kim, Seong Wook, Lee, Jung Pil, Kim, Hoon Dong, Cho, In Hwan, Song, Ji Hun, Lee, Ki Hwang, Kwon, Han Jo, Lee, Seung Min, Sagong, Min, Lee, Tae Gon, Han, Jung Il, Chang, Young Suk, Min, Jung Kee, Yang, Yun Sik, Kim, Soo Han, Chin, Hee Seung, Ji, Yong Sok, Lee, Jong Young, Kim, Seong Taeck, Shin, Min Ho, Kim, Jee Taek, Han, Yong Seop, Lee, Woo Hyuk, Jo, Young Joon, Kim, Jung Yeul, Kim, Kyung Tae, Seo, Eoi Jong, Lim, Sun Taek, Lee, Jun Sung, Kim, Chang Ryong, Duck-Jin Hwang, Daniel, Kim, Ha Kyoung, Ma, Dae Joong, Hong, In Hwan, Cho, Bum Joo, Shin, Yong Un, Cho, Heeyoon, and Ahn, Seong Joon

Published
2024
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10. A Case of Lyme Disease Presenting as Bilateral Panuveitis.

Author

Park, Bo Hyun, Kwon, Han Jo, Park, Sung Who, Lee, Jeong Eun, and Byon, Iksoo

Subjects
BLOOD sedimentation, ORAL drug administration, EYE drops, ANTIBODY titer, BLOOD testing, LYME disease
Abstract

Here, we describe a case of Lyme disease presenting as bilateral panuveitis. A 25-year-old woman presented to our clinic with decreased visual acuity of 20/320 and 20/160 in the right and left eye, respectively. An ophthalmic examination revealed the presence of anterior chamber cells 3+, vitreous cells 1+, vitreous haziness 2+/1+, and retinal infiltration in both eyes. She also had fever, headache, and difficulty in breathing. An initial blood analysis did not detect infection; however, high levels of erythrocyte sedimentation rate and C-reactive protein were noted. Pleural and pericardial effusions, and multiple reactive arthritis lesions were observed on chest computed tomography and bone scans, respectively. Oral steroids (30 mg/day) and steroid eye drops were initiated. Ten days later, she was diagnosed with Lyme disease, based on an indirect immunofluorescence antibody test. Ceftriaxone (2 g) was intravenously administered for 2 weeks followed by administration of oral trimethoprim-sulfamethoxazole (400 mg/80 mg/day) for 1 week. Thereafter, she received a 4-week course of doxycycline (100 mg) twice daily. Her symptoms and ocular findings improved; however, a gradually increasing dose of oral steroid was needed to control retinal lesions for some time, since multiple retinitis lesions developed in the peripheral retina after tapering the oral steroid dose to 5 mg/day. In conclusion, panuveitis can occur in patients with Lyme disease and can be treated with systemic antibiotics and steroids [ABSTRACT FROM AUTHOR]

Published
2024
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17. Clinical Factors, Treatment Selection, and Outcomes in Postcataract Fungal Endophthalmitis from Contaminated Viscoelastics

Author

Kim, Jae Hui, primary, Choi, Mihyun, additional, Kim, Seong-Woo, additional, Park, Kyu Hyung, additional, Nam, Dong Heun, additional, Lee, Dae Yeong, additional, Park, Young-Hoon, additional, Park, Young-Gun, additional, Kim, Mirinae, additional, Lee, Mee Yon, additional, Choi, Soon-Il, additional, Kim, Min, additional, Lee, Junwon, additional, Moon, Sang Woong, additional, Chung, Hyewon, additional, Lee, Young Hoon, additional, Lee, Min Woo, additional, Shin, Jae Pil, additional, Park, Dong Ho, additional, Park, Han Sang, additional, Kang, Yong Koo, additional, Chung, In Young, additional, Yoo, Woong-Sun, additional, Cho, Yong-Wun, additional, Kim, Yu Cheol, additional, Kang, Kyung Tae, additional, Jang, Ji Hye, additional, Choi, Kwang-Eon, additional, Nam, Ki Tae, additional, Kim, Young Ho, additional, Ahn, So Min, additional, Lee, Sang Joon, additional, Lim, Jae Wan, additional, Ku, Hee Chan, additional, Yoo, Su Jin, additional, Choi, Moon Jung, additional, Lew, Young Ju, additional, Kim, Jae Hui, additional, Kim, Joo Yeon, additional, Hwang, Jae Hyung, additional, Lee, Seung Woo, additional, Bae, Kunho, additional, Jeong, Woo Jin, additional, Kwon, Yoon Hyung, additional, An, Seoung Hyun, additional, Ahn, Jeeyun, additional, Shin, Joo Young, additional, Byon, Ik Soo, additional, Park, Sung Who, additional, Kang, Se Woong, additional, Ham, Don-Il, additional, Kim, Sang Jin, additional, Park, Un Chul, additional, Oh, Baek Lok, additional, Kim, June-Gone, additional, Lee, Joo Yong, additional, Lee, Jun Yeop, additional, Kim, Yoon Jeon, additional, Chae, Ju Byung, additional, Kim, Dong Yoon, additional, Lee, Christopher Seungkyu, additional, Cho, Kwan Hyuk, additional, Kim, Min Seok, additional, Kim, Seong Wook, additional, Lee, Jung Pil, additional, Kim, Hoon Dong, additional, Cho, In Hwan, additional, Song, Ji Hun, additional, Lee, Ki Hwang, additional, Kwon, Han Jo, additional, Lee, Seung Min, additional, Sagong, Min, additional, Lee, Tae Gon, additional, Han, Jung Il, additional, Chang, Young Suk, additional, Min, Jung Kee, additional, Yang, Yun Sik, additional, Kim, Soo Han, additional, Chin, Hee Seung, additional, Ji, Yong Sok, additional, Lee, Jong Young, additional, Kim, Seong Taeck, additional, Shin, Min Ho, additional, Kim, Jee Taek, additional, Han, Yong Seop, additional, Lee, Woo Hyuk, additional, Jo, Young Joon, additional, Kim, Jung Yeul, additional, Kim, Kyung Tae, additional, Seo, Eoi Jong, additional, Lim, Sun Taek, additional, Lee, Jun Sung, additional, Kim, Chang Ryong, additional, Duck-Jin Hwang, Daniel, additional, Kim, Ha Kyoung, additional, Ma, Dae Joong, additional, Hong, In Hwan, additional, Cho, Bum Joo, additional, Shin, Yong Un, additional, Cho, Heeyoon, additional, and Ahn, Seong Joon, additional

Published
2023
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19. Clinical Factors, Treatment Selection, and Outcomes in Postcataract Fungal Endophthalmitis from Contaminated Viscoelastics

Author

Kim, Jae Hui, Choi, Mihyun, Kim, Seong-Woo, Park, Kyu Hyung, Nam, Dong Heun, Lee, Dae Yeong, Park, Young-Hoon, Park, Young-Gun, Kim, Mirinae, Lee, Mee Yon, Choi, Soon-Il, Kim, Min, Lee, Junwon, Moon, Sang Woong, Chung, Hyewon, Lee, Young Hoon, Lee, Min Woo, Shin, Jae Pil, Park, Dong Ho, Park, Han Sang, Kang, Yong Koo, Chung, In Young, Yoo, Woong-Sun, Cho, Yong-Wun, Kim, Yu Cheol, Kang, Kyung Tae, Jang, Ji Hye, Kim, Seong-Woo, Choi, Kwang-Eon, Choi, Mihyun, Nam, Ki Tae, Kim, Young Ho, Ahn, So Min, Lee, Sang Joon, Lim, Jae Wan, Ku, Hee Chan, Yoo, Su Jin, Choi, Moon Jung, Lew, Young Ju, Kim, Jae Hui, Kim, Joo Yeon, Hwang, Jae Hyung, Lee, Seung Woo, Bae, Kunho, Jeong, Woo Jin, Kwon, Yoon Hyung, An, Seoung Hyun, Ahn, Jeeyun, Shin, Joo Young, Byon, Ik Soo, Park, Sung Who, Park, Kyu Hyung, Kang, Se Woong, Ham, Don-Il, Kim, Sang Jin, Park, Un Chul, Oh, Baek Lok, Kim, June-Gone, Lee, Joo Yong, Lee, Jun Yeop, Kim, Yoon Jeon, Chae, Ju Byung, Kim, Dong Yoon, Lee, Christopher Seungkyu, Cho, Kwan Hyuk, Kim, Min Seok, Kim, Seong Wook, Lee, Jung Pil, Kim, Hoon Dong, Cho, In Hwan, Song, Ji Hun, Lee, Ki Hwang, Kwon, Han Jo, Lee, Seung Min, Sagong, Min, Lee, Tae Gon, Han, Jung Il, Chang, Young Suk, Min, Jung Kee, Yang, Yun Sik, Kim, Soo Han, Chin, Hee Seung, Ji, Yong Sok, Lee, Jong Young, Kim, Seong Taeck, Shin, Min Ho, Kim, Jee Taek, Han, Yong Seop, Lee, Woo Hyuk, Jo, Young Joon, Kim, Jung Yeul, Kim, Kyung Tae, Seo, Eoi Jong, Lim, Sun Taek, Lee, Jun Sung, Kim, Chang Ryong, Duck-Jin Hwang, Daniel, Kim, Ha Kyoung, Ma, Dae Joong, Hong, In Hwan, Cho, Bum Joo, Shin, Yong Un, Cho, Heeyoon, and Ahn, Seong Joon

Abstract

To investigate the factors associated with treatment outcomes of postcataract surgery fungal endophthalmitis outbreaks related to contaminated viscoelastics.

Published
2024
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20. Accuracy of generative deep learning model for macular anatomy prediction from optical coherence tomography images in macular hole surgery.

Author

Kwon, Han Jo, Heo, Jun, Park, Su Hwan, Park, Sung Who, and Byon, Iksoo

Subjects
OPTICAL coherence tomography, DEEP learning, ANATOMY, ARTIFICIAL intelligence
Abstract

This study aims to propose a generative deep learning model (GDLM) based on a variational autoencoder that predicts macular optical coherence tomography (OCT) images following full-thickness macular hole (FTMH) surgery and evaluate its clinical accuracy. Preoperative and 6-month postoperative swept-source OCT data were collected from 150 patients with successfully closed FTMH using 6 × 6 mm2 macular volume scan datasets. Randomly selected and augmented 120,000 training and 5000 validation pairs of OCT images were used to train the GDLM. We assessed the accuracy and F1 score of concordance for neurosensory retinal areas, performed Bland–Altman analysis of foveolar height (FH) and mean foveal thickness (MFT), and predicted postoperative external limiting membrane (ELM) and ellipsoid zone (EZ) restoration accuracy between artificial intelligence (AI)-OCT and ground truth (GT)-OCT images. Accuracy and F1 scores were 94.7% and 0.891, respectively. Average FH (228.2 vs. 233.4 μm, P = 0.587) and MFT (271.4 vs. 273.3 μm, P = 0.819) were similar between AI- and GT-OCT images, within 30.0% differences of 95% limits of agreement. ELM and EZ recovery prediction accuracy was 88.0% and 92.0%, respectively. The proposed GDLM accurately predicted macular OCT images following FTMH surgery, aiding patient and surgeon understanding of postoperative macular features. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Spectral-domain optical coherence tomography morphological characteristics in patients with cone dystrophy

Author

Leung, Loh-Shan, primary, Khojasteh, Hassan, additional, bazvand, fatemeh, additional, Haidari, Mostafa, additional, Mahmoudi, Alireza, additional, Mohammadi, S. Saeed, additional, Riazi-Esfahani, Hamid, additional, Mirghorbani, Masoud, additional, Salmasi, Arefeh Sheikholeslami, additional, Azarkish, Afsaneh, additional, Regenold, Jonathan, additional, Akhavanrezayat, Amir, additional, Karaca, Irmak, additional, Park, Sung Who, additional, Uludag, Gunay, additional, Or, Chris, additional, Ghoraba, Hashem, additional, and Dong, Quan, additional

Published
2023
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25. Intravenous Cyclophosphamide Therapy for Patients with Severe Ocular Inflammatory Diseases Who Failed Other Immunomodulatory Therapies

Author

Karaca, Irmak, primary, Tran, Elaine, additional, Park, Sung Who, additional, Bromeo, Albert John, additional, Khojasteh, Hassan, additional, Tran, Anh, additional, Yavari, Negin, additional, Akhavanrezayat, Amir, additional, Yasar, Cigdem, additional, Uludag, Gunay, additional, Hassan, Muhammad, additional, Or, Chris, additional, Ghoraba, Hashem, additional, Do, Diana, additional, and Dong, Quan, additional

Published
2023
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28. Electroretinographic findings in retinal vasculitis

Author

Ghoraba, Hashem H, primary, Matsumiya, Wataru, additional, Or, Christopher, additional, Khojasteh, Hassan, additional, Patel, Prem, additional, Karaca, Irmak, additional, Regenold, Jonathan, additional, Zaidi, Moosa, additional, Hwang, Jaclyn, additional, Lajevardi, Sherin, additional, Yavari, Negin, additional, Than, Ngoc Trong Tuong, additional, Park, Sung Who, additional, Akhavanrezayat, Amir, additional, Uludag, Gunay, additional, Yasar, Cigdem, additional, Leung, Loh-Shan B, additional, and Nguyen, Quan Dong, additional

Published
2022
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37. Electroretinographic findings in retinal vasculitis

Author

Ghoraba, Hashem H, Matsumiya, Wataru, Or, Christopher, Khojasteh, Hassan, Patel, Prem, Karaca, Irmak, Regenold, Jonathan, Zaidi, Moosa, Hwang, Jaclyn, Lajevardi, Sherin, Yavari, Negin, Than, Ngoc Trong Tuong, Park, Sung Who, Akhavanrezayat, Amir, Uludag, Gunay, Yasar, Cigdem, Leung, Loh-Shan B, and Nguyen, Quan Dong

Abstract

AimTo describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).MethodsMedical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.Results20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08–1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0–6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses.ConclusionIn this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.

Published
2023
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38. Bilateral Hemorrhagic Occlusive Retinal Vasculitis Induced by Osimertinib in a Patient with Non-Small Cell Lung Cancer.

Author

Park, No Hae, Park, Bo Hyun, Kwon, Han Jo, Park, Sung Who, and Byon, Iksoo

Subjects
*NON-small-cell lung carcinoma, *EPIDERMAL growth factor receptors, *PROTEIN-tyrosine kinase inhibitors, *FLUORESCENCE angiography, *OSIMERTINIB
Abstract

PurposeCase ReportConclusionTo report a case of bilateral retinal vasculitis in a patient with non-small cell lung cancer undergoing treatment with osimertinib.A 58-year-old woman with lung adenocarcinoma (T4N3M1a stage IV) presented with blurry vision in both eyes (OU). Eighteen months before symptom onset, the treatment was changed from afatinib (20 mg/day) to osimertinib (80 mg/day) because of tumor progression. The visual acuity was 20/30 and 20/25 in the right and left eyes, respectively. Clinical examination revealed few anterior chamber cells, 2+ vitreous cells, haze, and multiple retinal hemorrhages in the peripheral retinas (OU). Fluorescein angiography revealed retinal vasculitis with a severely non-perfused area in the periphery. These findings indicated hemorrhagic occlusive retinal vasculitis (HORV). Osimertinib was reduced to 40 mg/day, and oral prednisolone was started at 30 mg/day. This improved retinal vasculitis; however, the ischemic area did not improve. Pan-retinal photocoagulation was performed while tapering the oral prednisolone to 10 mg/day. Although macular edema (ME) occasionally occurred (OU), systemic and local treatment with steroid-stabilized HORV and ME helped increase the dose of osimertinib to 80 mg/day without cancer progression for 18 months. Her visual acuity remained 10/20 (OU).Osimertinib, a third-generation tyrosine kinase inhibitor, can be used to treat advanced non-small cell lung cancer with epidermal growth factor receptor mutation-induced bilateral HORV. This adverse effect can be managed with systemic and local steroid treatment and continued osimertinib administration. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Evaluation of the safety of anterior capsule staining with trypan blue under air: a retrospective analysis.

Author

Park YM, Lee JS, Lee JE, Jo YJ, Byon IS, and Park SW

Abstract

Aim: To evaluate the safety of using 0.03% trypan blue under air for anterior capsule staining in cataract surgery., Methods: The current study involved a retrospective analysis of the medical records of 86 patients with vitreous hemorrhage, who underwent pars plana vitrectomy and cataract surgery. The patients were classified into two groups. The trypan blue group ( n =45) comprised patients who underwent anterior capsule staining with 0.03% trypan blue under an air bubble. The control group ( n =41) comprised of patients who underwent intracameral illuminator-assisted capsulorhexis. The status of endothelial cell density (ECD) in both the groups was analyzed., Results: The trypan blue group displayed significant decline in ECD at 1mo (7.91% loss, P <0.001) and 3mo (9.65% loss, P <0.001) after the surgery, whereas no significant changes were observed in the control group. Moreover, the number of patients who did not display a postoperative decline in ECD was significantly higher in the control group (43.9%; 18 patients) than in the trypan blue group (17.1%; 7 patients, P =0.004)., Conclusion: Anterior capsule staining with trypan blue under the air bubble would not be as safe as the intracameral illuminator. The ECD loss might be attributed to the air bubble rather than to the deleterious effects of 0.03% trypan blue. Further studies are required to clarify this., (International Journal of Ophthalmology Press.)

Published
2022
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