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205 results on '"Pardo, L."'

2. Robust parameter estimation of the log-logistic distribution based on density power divergence estimators

Author

Felipe, A., Jaenada, M., Miranda, P., and Pardo, L.

Subjects
Mathematics - Statistics Theory, 62F35 (Primary), 62F03, 62F05 (Secondary), G.3
Abstract

Robust inferential methods based on divergences measures have shown an appealing trade-off between efficiency and robustness in many different statistical models. In this paper, minimum density power divergence estimators (MDPDEs) for the scale and shape parameters of the log-logistic distribution are considered. The log-logistic is a versatile distribution modeling lifetime data which is commonly adopted in survival analysis and reliability engineering studies when the hazard rate is initially increasing but then it decreases after some point. Further, it is shown that the classical estimators based on maximum likelihood (MLE) are included as a particular case of the MDPDE family. Moreover, the corresponding influence function of the MDPDE is obtained, and its boundlessness is proved, thus leading to robust estimators. A simulation study is carried out to illustrate the slight loss in efficiency of MDPDE with respect to MLE and, at besides, the considerable gain in robustness.

Published
2023

3. Effect of regular thicknesses on the microstructural and quantitative analysis for a hypo-eutectic ductile iron alloyed with Ni and V

Author

Colin-García E., Sánchez-Alvarado R.G., Cruz-Ramírez A., Suarez-Rosales M.A., Portuguez-Pardo L., and Jiménez-Lugos J.C.

Subjects
ductile iron, thickness, microstructure, cooling rate, quantitative analysis, nodular characteristics, Mining engineering. Metallurgy, TN1-997
Abstract

Ductile iron contains free graphite nodules within the metallic matrix, which generally consists of ferrite and pearlite in the as-cast condition. The casting thicknesses have a great influence on the size, shape, and quantity of the microconstituents of the metallic matrix and the graphite nodules and thus on the mechanical properties. In this study the cooling rate (caused by the casting thicknesses) on the metallic matrix and the nodular characteristics of a low alloyed ductile iron with 0.8 %Ni and 0.15 %V was investigated. The ductile iron was produced in a sandwich process with ladle inoculation. Six plates of different thicknesses, from 4.3 mm to 25.4 mm, were produced in a green sand mold. The microstructural characterization was performed by optical microscopy (OM), scanning electron microscopy (SEM), and the image J software using different quantification methods. The area method to determine the average nodule size and nodular structure provided more reliable results than the perimeter and total particle count methods. The hardness test on the Rockwell C scale was used for the mechanical characterization. The low content of vanadium added to the ductile cast iron had a negligible effect on the solidification pattern, which was mainly due to the graphitizing impact of the nickel and silicon addition. The results of the microstructural characteristics are therefore primarily due to the cooling rate, which is determined by the casting thickness. The thinnest casting section significantly improved the number of nodules (414 Nod/mm2), sphericity (0.96), and nodularity (96.21 %). In contrast, the thickest casting plate obtained the highest volume fraction of graphite (10.85 %) and the lowest volume fraction of unwanted particles (0.36 %). The high cooling rate in the thinnest casting plate resulted in the highest hardness of 31.56 HRC due to the higher volume fraction of the pearlite (33.7 %) and carbides (4.5 %).

Published
2024
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4. Empirical phi-divergence test statistics in the logistic regression model

Author

Felipe, A., Garcia-Segador, P., Martin, N., Miranda, P., and Pardo, L.

Subjects
Mathematics - Statistics Theory
Abstract

In this paper we apply divergence measures to empirical likelihood applied to logistic regression models. We define a family of empirical test statistics based on divergence measures, called empirical phi-divergence test statistics, extending the empirical likelihood ratio test. We study the asymptotic distribution of these empirical test statistics, showing that it is the same for all the test statistics in this family, and the same as the classical empirical likelihood ratio test. Next, we study the power function for the members in this family, showing that the empirical phi-divergence tests introduced in the paper are consistent in the Fraser sense. In order to compare the differences in behavior among the empirical phi-divergence test statistics in this new family, considered for the first time in this paper, we carry out a simulation study.

Published
2021

5. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., de Queiroz, J.P., Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, and Hill, Michael D

Published
2024
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6. Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer

Author

Harvey-Jones, E., Raghunandan, M., Robbez-Masson, L., Magraner-Pardo, L., Alaguthurai, T., Yablonovitch, A., Yen, J., Xiao, H., Brough, R., Frankum, J., Song, F., Yeung, J., Savy, T., Gulati, A., Alexander, J., Kemp, H., Starling, C., Konde, A., Marlow, R., Cheang, M., Proszek, P., Hubank, M., Cai, M., Trendell, J., Lu, R., Liccardo, R., Ravindran, N., Llop-Guevara, A., Rodriguez, O., Balmana, J., Lukashchuk, N., Dorschner, M., Drusbosky, L., Roxanis, I., Serra, V., Haider, S., Pettitt, S.J., Lord, C.J., and Tutt, A.N.J.

Published
2024
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7. Prevention of Recurrent Attacks of Hereditary Angioedema (HAE): Berotralstat and Its Oral Bioavailability

Author

Diaz-Menindez M, Morgenstern-Kaplan D, Cuervo-Pardo L, Alvarez-Arango S, and Gonzalez-Estrada A

Subjects
hereditary angioedema, berotralstat, Therapeutics. Pharmacology, RM1-950
Abstract

Maximiliano Diaz-Menindez,1 Dan Morgenstern-Kaplan,2 Lyda Cuervo-Pardo,3 Santiago Alvarez-Arango,4,5 Alexei Gonzalez-Estrada6 1Division of Pulmonary, Allergy, and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA; 2Department of Internal Medicine, University of Miami/Jackson Health System, Miami, FL, USA; 3Division of Rheumatology, Allergy and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, USA; 4Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 6Division of Allergy, Asthma and Clinical Immunology, Department of Medicine, Mayo Clinic, Phoenix, AZ, USACorrespondence: Alexei Gonzalez-Estrada, Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, 5777 E. Mayo Blvd, Phoenix, AZ, 85054, USA, Tel +1 480-301-4284, Fax +1 480-301-4041, Email gonzalez.alexei@mayo.eduAbstract: Hereditary angioedema (HAE) is a condition characterized by episodes of cutaneous and submucosal edema. Angioedema of the extremities and abdominal attacks are the most common manifestations of the disease. It can also affect the upper airways with the potential of becoming life-threatening. The two most common causes of HAE are a deficiency of C1 inhibitor (classified as type 1 HAE) or a dysfunction of C1 inhibitor (type 2 HAE). A malfunction or deficiency of C1 inhibitor leads to an overactivated plasma kallikrein (an inflammatory vasoactive peptide), that increases bradykinin, mediating the angioedema episodes in patients with HAE. To minimize the difficulties of this pathology and to improve patients’ quality of life, prevention of this condition is essential. Berotralstat is a unique option for oral administration for routine prophylaxis. This drug acts by binding to kallikrein and reducing its plasma activity, lowering bradykinin levels. Open-label studies have demonstrated the effectiveness of a single daily dose of berotralstat 150 mg in preventing HAE attacks. This review aims to examine studies performed to elucidate the efficacy, safety, and tolerability of berotralstat.Keywords: hereditary angioedema, berotralstat

Published
2023

9. Contributors

Author

Alippi, A., primary, Andrés, R.R., additional, Ashokkumar, M., additional, Baillon, F., additional, Barthe, L., additional, Benatar, A., additional, Bhat, A.P., additional, Carcel, J.A., additional, Cardoni, A., additional, Chemat, F., additional, Cleary, R., additional, Cleveland, R.O., additional, Cogné, C., additional, Cravotto, G., additional, Croënne, Ch., additional, Delmas, H., additional, Dubus, B., additional, Ellens, N.P.K., additional, Eskin, D.G., additional, Espitalier, F., additional, Friel, R.J., additional, Fuchs, F.J., additional, Gaete-Garretón, L.F., additional, Gallego-Juárez, J.A., additional, García-Pérez, J.V., additional, Gedanken, A., additional, Gogate, P.R., additional, González-Gómez, I., additional, Graff, K.F., additional, Harkness, P., additional, Hodnett, M., additional, Hynynen, K., additional, Khaire, R.A., additional, Kramlick, J.D., additional, Labouret, S., additional, Lauterborn, W., additional, Li, Xi., additional, Li, Xu., additional, Lindamood, L.R., additional, Liu, X., additional, Louisnard, O., additional, Lucas, M., additional, Marcus, M., additional, Mason, T.J., additional, Matheny, M.P., additional, Mathieson, A., additional, Mettin, R., additional, Mishra, A., additional, Moghaddas, A., additional, Mosbah, P., additional, Mulet, A., additional, Nakamura, K., additional, Neis, U., additional, Norfolk, M., additional, Pandit, A.B., additional, Pardo, L., additional, Peczalski, R., additional, Perelshtein, I., additional, Perkas, N., additional, Pétrier, C., additional, Prentice, P., additional, Riera, E., additional, Rodríguez, G., additional, Sapozhnikov, O.A., additional, Schafer, M.E., additional, Sheehan, J.F., additional, Tiwari, B.K., additional, Tzanakis, I., additional, Vargas-Hernández, Y.P., additional, Videla, A.R., additional, Virkutyte, J., additional, Walmsley, A.D., additional, Wei, Z., additional, Wu, Z., additional, Zhao, Ch., additional, and Zhu, X., additional

Published
2023
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13. Local and Remote Atmosphere‐Ocean Coupling During Extreme Warming Events Impacting Subsurface Ocean Temperature in an Antarctic Embayment.

Author

Piñones, A., Aziares‐Aguayo, N., Amador‐Véliz, P., Mercado‐Peña, O., González‐Reyes, A., Valdivia, N., Garcés‐Vargas, J., Garrido, I., Pardo, L. M., and Höfer, J.

Subjects
MARINE heatwaves, ANTARCTIC oscillation, OCEAN temperature, WESTERLIES, WEATHER
Abstract

Coastal ocean temperatures can respond to different atmospheric and oceanic processes at local spatial scales or through remote teleconnections. This study focused on subsurface ocean temperatures (subT) at 10 m depth in Maxwell Bay, northern Antarctic Peninsula from February 2017 and January 2022. It investigated extreme warming events during austral summers and their interaction with atmospheric and oceanic conditions regionally and locally. The analysis identified active and extreme Marine Heat Waves (MHWs) in March 2017 and January‐February 2020 associated with a significantly negative Southern Annular Mode index observed 3–4 months before the temperature increase. In March 2017, temperatures exceeded the climatological mean by over 1°C. This anomaly was linked to a strengthened Amundsen Sea Low and a blocking anticyclone moving between the Scotia Sea and the South‐West Atlantic Ocean that deflected westerly winds and facilitated the anomalous transport of warmer northern air masses to the AP. In January‐February 2020, the highest recorded subT was observed (2.97°C), although air‐sea heat fluxes did not show a similar pattern. In February 2020, one of the most intense atmospheric heatwaves ever recorded in West Antarctica was observed. This heatwave corresponded with maximum subT and positive sea surface temperature anomalies extending throughout the western region of the Southern Ocean, related to an extremely negative Southern Annular Mode. This study provides valuable insights into the impact of strong MHWs, a phenomenon that has been less documented in Antarctic coastal regions. Plain Language Summary: Understanding how ocean temperature varies and responds to different local and remote forcings is crucial for quantifying the potential impact of temperature fluctuations on the coastal Antarctic environment. Between 2017 and 2022 in Maxwell Bay, Antarctic Peninsula, the response of subsurface ocean temperatures (subT, temperature at 10 m depth) to extreme warming events was recorded and analyzed in relation to atmospheric and oceanic conditions. Extreme warming events in the ocean, identified as Marine Heat Waves, occurred in March 2017 and in January and February 2020. In March 2017 subT exceeded the historical averaged temperature by over 1°C. The increase in subT was associated with the deflection of the typically dominant westerly winds to the south, which transported warmer northern air to the Peninsula. In January 2020, the highest recorded subT was observed (2.97°C). Observations suggested this warming was related to the negative Southern Annular Mode in 2019. This study provides valuable insights into the environmental variability and temperature ranges that affect Antarctic marine communities. Key Points: Subsurface ocean temperature (subT, temperature at 10 m depth) in a coastal Antarctic embayment responded to extreme warming eventsSubT recorded Marine Heat Waves in summers 2017 and 2020, identified as years of extreme negative Southern Annular Mode prior to extremely high subTThe main dominant modes of subT variability were related to the Amundsen Sea Low and the Southern Annular Mode [ABSTRACT FROM AUTHOR]

Published
2024
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16. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kenney, Carol, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, Hill, Michael D, Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Chen, S., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Cooley, R., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Irons, R., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Biswas, V., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Kerr, E., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Patel, V., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Aissa, M., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., Ismail, M., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., and de Queiroz, J.P.

Abstract

Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.

Published
2024
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19. Conductas autolesivas en niños y adolescentes en Urgencias Pediátricas durante la Pandemia de COVID-19: relación con las medidas de restricción social y otros factores de riesgo conocidos

Author

Ferrer, M., primary, Calvo, N., additional, Rué, À., additional, Andión, Ó., additional, Soriano Dia, A., additional, González Domínguez, M., additional, Gallego Pardo, L., additional, Castillo Martínez, M., additional, Sancosmed-Ron, M., additional, González Peris, S., additional, and Ramos Quiroga, J. A., additional

Published
2023
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20. Obscure digestive bleeding

Author

Hurtado-Pardo, L, primary, Bruna Esteban, M, additional, González López, J.C., additional, Mingol-Navarro, F, additional, and Vaqué Urbaneja, J, additional

Published
2023
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21. Tunnel geometries and the relation with the in-situ stresses in the Stockholm region. Case study of the special tunnel geometries in the Stockholm metro - Blue line extension.

Author

Ceballos, F., Cantarero, A., and Pardo, L.

Subjects
TUNNEL design & construction, GEOMETRIC analysis, EXCAVATION, IGNEOUS rocks, METAMORPHIC rocks
Abstract

The new Blue line extension is one of the key parts of Stockholm's metro extension project. The existing blue line will be extended southwards from Kungsträdgården to Nacka and the southern suburbs. The new tunnels are going to be excavated through igneous and metamorphic rock masses using the Drill and Blast method and SCL (Sprayed concrete lining). It is well known that the Stockholm basin can carry high residual tectonic stresses as a consequence of its Glacial past. The influence of the in-situ 3D stresses tensor in the tunnel design is explicitly stated in the design requirements for tunnels in rock and the challenge is how to transfer the general assessment into a specific localization: the size and the geometry of the tunnel in relation to the stress field presented in the rock mass will govern this stress redistribution, having a key importance in the stability of the excavation. Along the alignment of the new Stockholm metro project, two areas of special interest in terms of nonconventional tunnel geometries and in-situ rock stresses can be identified: the required geometry modifications of the tunnels in the connection with the existing Kungsträdgården station to be adapted to the new alignment, where narrow tunnels with wall heights up to 14m are required, and the large caverns for station platforms and operational switch gear systems, with spans up to 31m in several rock conditions. A summary of these and the design approaches followed in the detailed design is included in this paper. [ABSTRACT FROM AUTHOR]

Published
2023

24. Nuevos modelos multicelulares para la predicción de la hepatotoxicidad idiosincrática

Author

Pons Andrés, N., Villanueva Bádenas, E., Gallego Ferrer, G., Tolosa Pardo, L., Pons Andrés, N., Villanueva Bádenas, E., Gallego Ferrer, G., and Tolosa Pardo, L.

Abstract

La hepatotoxicidad inducida por fármacos (DILI) se refiere al daño hepático resultante de la exposición del organismo a un medicamento o xenobiótico. Concretamente la de tipo idiosincrático (iDILI) es la principal causa de retirada de fármacos tanto en fases de desarrollo como ya comercializados. Los estudios preclínicos con animales de experimentación presentan una baja predictividad, por ello, ha sido necesaria la búsqueda de nuevos modelos in vitro que permitan una mejor comprensión de los mecanismos que subyacen al iDILI para reducir su impacto. La mayoría de los modelos clásicos propuestos están basados en el cultivo de hepatocitos, pero no permiten modelar sus interacciones con las células no parenquimáticas como las células de Kupffer, que han demostrado estar implicadas en la hepatotoxicidad mediada por el sistema inmunitario. En el presente trabajo se ha optimizado y caracterizado un modelo de co-cultivo de hepatocitos y macrófagos proinflamatorios, derivados de líneas celulares inmortalizadas (HepG2 y THP-1, respectivamente) para el estudio de la hepatotoxicidad idiosincrática. El modelo ha mostrado un adecuado mantenimiento de la viabilidad celular, expresión génica y funcionalidad hepática. Asimismo, la idoneidad del co-cultivo como plataforma de detección de fármacos que inducen iDILI ha sido evaluada a través de su exposición a dos medicamentos asociados con este, el trovafloxacino y la troglitazona. Los resultados obtenidos han probado su mayor sensibilidad y activación de las rutas metabólicas que conducen al iDILI, frente a los sistemas de monocultivo utilizados tradicionalmente.

Published
2023

25. Robust Wald-type tests based on minimum Rényi pseudodistance estimators for the multiple linear regression model

Author

Castilla, E., Martín, N., Muñoz, S., Pardo, L., Castilla, E., Martín, N., Muñoz, S., and Pardo, L.

Abstract

We introduce a new family of Wald-type tests, based on minimum Rényi pseudodistance estimators, for testing general linear hypotheses and the variance of the residuals in the multiple regression model. The classical Wald test, based on the maximum likelihood estimator, can be seen as a particular case inside our family. Theoretical results, supported by an extensive simulation study, point out how some tests included in this family have a better behaviour, in the sense of robustness, than the Wald test. Finally, we provide a data-driven procedure for the choice of the optimal test given any data set., Depto. de Economía Financiera y Actuarial y Estadística, Depto. de Estadística e Investigación Operativa, Fac. de Ciencias Económicas y Empresariales, Fac. de Ciencias Matemáticas, FALSE, pub

Published
2023

26. Immunosuppressive effects of new thiophene-based KV1.3 inhibitors

Author

Gubič, Š, Montalbano, A, Sala, C, Becchetti, A, Hendrickx, L, Van Theemsche, K, Pinheiro-Junior, E, Altadonna, G, Peigneur, S, Ilaš, J, Labro, A, Pardo, L, Tytgat, J, Tomašič, T, Arcangeli, A, Peterlin Mašič, L, Gubič, Špela, Montalbano, Alberto, Sala, Cesare, Becchetti, Andrea, Hendrickx, Louise Antonia, Van Theemsche, Kenny M, Pinheiro-Junior, Ernesto Lopes, Altadonna, Ginevra Chioccioli, Peigneur, Steve, Ilaš, Janez, Labro, Alain J, Pardo, Luis A, Tytgat, Jan, Tomašič, Tihomir, Arcangeli, Annarosa, Peterlin Mašič, Lucija, Gubič, Š, Montalbano, A, Sala, C, Becchetti, A, Hendrickx, L, Van Theemsche, K, Pinheiro-Junior, E, Altadonna, G, Peigneur, S, Ilaš, J, Labro, A, Pardo, L, Tytgat, J, Tomašič, T, Arcangeli, A, Peterlin Mašič, L, Gubič, Špela, Montalbano, Alberto, Sala, Cesare, Becchetti, Andrea, Hendrickx, Louise Antonia, Van Theemsche, Kenny M, Pinheiro-Junior, Ernesto Lopes, Altadonna, Ginevra Chioccioli, Peigneur, Steve, Ilaš, Janez, Labro, Alain J, Pardo, Luis A, Tytgat, Jan, Tomašič, Tihomir, Arcangeli, Annarosa, and Peterlin Mašič, Lucija

Abstract

Voltage-gated potassium channel KV1.3 inhibitors have been shown to be effective in preventing T-cell proliferation and activation by affecting intracellular Ca2+ homeostasis. Here, we present the structure-activity relationship, KV1.3 inhibition, and immunosuppressive effects of new thiophene-based KV1.3 inhibitors with nanomolar potency on K+ current in T-lymphocytes and KV1.3 inhibition on Ltk− cells. The new KV1.3 inhibitor trans-18 inhibited KV1.3 -mediated current in phytohemagglutinin (PHA)-activated T-lymphocytes with an IC50 value of 26.1 nM and in mammalian Ltk− cells with an IC50 value of 230 nM. The KV1.3 inhibitor trans-18 also had nanomolar potency against KV1.3 in Xenopus laevis oocytes (IC50 = 136 nM). The novel thiophene-based KV1.3 inhibitors impaired intracellular Ca2+ signaling as well as T-cell activation, proliferation, and colony formation.

Published
2023

27. The Gi and Gs protein-coupled μ-opioid-galanin Gal1 receptor heterotetramer

Author

Guillén, E. Moreno, primary, De Oliveira, P.A., additional, Casajuana-Martin, N., additional, Casadó-Anguera, V., additional, Ning-Sheng, C., additional, Camacho-Hernandez, G.A., additional, Zhu, H., additional, Bonifazi, A., additional, Hall, M.D., additional, Weinshenker, D., additional, Newman, A.H., additional, Logothetis, D.E., additional, Casado, V., additional, Plant, L.D., additional, Pardo, L., additional, and Ferré, S., additional

Published
2023
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29. Tendencias y retos de la formación docente en Iberoamérica

Author

Pirela Morillo, J., Pérez, L. E., and Pardo, L. E.

Abstract

La formación docente se enfrenta, en estos momentos, con retos y desafíos que implican de parte de las instituciones formadoras, esfuerzos para garantizar que los futuros maestros y maestras puedan hacer frente a las complejidades y el dinamismo de las sociedades actuales, caracterizadas por incertidumbres y turbulencias. En este sentido, el objetivo de este artículo es analizar las tendencias de la formación docente en Iberoamérica y cómo éstas podrían permitir evaluar hasta qué punto tienen vigencia los conceptos que la fundamentan. La metodología se basó en el análisis documental de contenido de documentos académicos y directrices trazadas desde organismos internacionales. Los resultados revelan la urgencia de construir sistemas para la formación de docentes, considerando singularidades históricas, sociales, políticas y culturales como horizontes de sentido que ayudan a potenciar la formación de los formadores requeridos para incrementar el desarrollo humano, integral y sustentable, enfatizando en las complejidades, interactividades y diversidades de hoy. Las conclusiones resaltan la evidente formulación de concepciones sobre la educación y la formación docente; sin embargo, aún hace falta trabajar mucho más en los procesos de construcción de sistemas integrales para la formación del magisterio, estableciendo su naturaleza, alcance y estructura para el desarrollo de los países.

Published
2022

39. Enzymatic determination of trimethylamine in fish

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Diputación General de Aragón, European Commission, Cebrián, Pablo, Pardo, L., Sanz Vicente, Isabel, Marcos, Susana de, Galbán, Javier, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Diputación General de Aragón, European Commission, Cebrián, Pablo, Pardo, L., Sanz Vicente, Isabel, Marcos, Susana de, and Galbán, Javier

Abstract

Trimethylamine (TMA) is the substance responsible for the fishy odour and it is produced by the reduction of trimethylamine N-oxide (TMAO) by microorganism. Fresh seafood contains low levels TMA but higher of TMAO and its concentration rapidly increases after death. This is because, its concentration is used as an indicator of the freshness of fish. On the other hand, in humans, TMA is metabolized to TMAO (odourless) catalyzed by flavin-containing monooxygenase (FMO). Trimethylaminuria or "fish odour syndrome" is a human disorder characterized by the difficulty of converting foul-smelling TMA to its odourless N-oxide. In this case, the intake of excess TMA is a serious problem so it is necessary to control the concentration of TMA in food. The most frequent methods of analysis of TMA in foods involve GC, HPLC and EC. These methods are not appropriate for in-situ determination so it is necessary to develop rapid methods for determination of TMA. In this work, a rapid and “in-situ” method for the determination of TMA based on its enzymatic reaction with FMO3 is presented. FMO3: TMA + NADPH + H+ +O2 → TMAO + NADP + H2O. It has been found that the slope of the variation of absorbance at 340 nm due to the disappearance of NADPH (Figure 1a: [NADPH]=3.45.10-4 M, pH= 7.74 , Tª=38 ºC, [FMO3]=500 U.) can be related to the concentration of TMA and used as analytical signal of the proposed method. FMO3 concentration, pH, NADPH concentration and Tª have been optimized. In the optimal conditions ([NADPH] = 8·10-4 M, pH= 9, Tª=38ºC,FMO3=2000 U), the method shows a linear response to TMA between 2·10-5 and 1.5·10-4 M, with a RSD of 9.67% (n=3). An exhaustive interference study (putrescine, cadaverine, histamine, tyramine, monomethylamine and dimethylamine (DMA) were considered) show that only DMA is an interference but if the ratio DMA: TMA is 10:1. The method was applied to the determination of TMA in codfish by the addition standard method with good results.

Published
2022

41. Different profiles of advanced heart failure among patients with and without diabetes mellitus. Findings from the EPICTER study

Author

Lorido J, Gomez J, Correa M, Iglesias J, Fernandez T, Camajuncosa R, Izquierdo M, Guardiola C, Pardo L, Ruiz E, Formiga F, and Bautista P

Subjects
Diabetes complications, Advanced heart failure, Diabetes Mellitus, Palliative care
Abstract

Aim: This work aims to compare the characteristics of advanced heart failure (HF) in patients with and without type 2 diabetes mellitus (DM) and to determine the relevance of variables used to define advanced HF.Patients and methods: This cross-sectional, multicenter study included patients hospitalized for HF. They were classified into four groups according to presence/absence of advanced HF, determined based on general and cardiac criteria, and presence/absence of DM. To analyze the importance of variables, we grew a random forest algorithm (RF) based on mortality at six months.Results: A total of 3153 patients were included. The prevalence of advanced HF among patients with DM was 24% compared to 23% among those without DM (p=0.53). Patients with advanced HF and DM had more comorbidity related to cardiovascular and renal diseases; their prognosis was the poorest (log-rank

Published
2022

42. Enzymatic determination of trimethylamine in fish

Author

Cebrián, P., Pardo, L., Sanz Vicente, Isabel, Marcos, Susana de, Galbán, Javier, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Diputación General de Aragón, and European Commission

Abstract

Resumen del póster presentado a la XXXVIII Reunión Bienal de la Real Sociedad Española de Química, celebrada en el Palacio de Congresos de Granada, del 27 de junio al 30 de junio de 2022., Trimethylamine (TMA) is the substance responsible for the fishy odour and it is produced by the reduction of trimethylamine N-oxide (TMAO) by microorganism. Fresh seafood contains low levels TMA but higher of TMAO and its concentration rapidly increases after death. This is because, its concentration is used as an indicator of the freshness of fish. On the other hand, in humans, TMA is metabolized to TMAO (odourless) catalyzed by flavin-containing monooxygenase (FMO). Trimethylaminuria or "fish odour syndrome" is a human disorder characterized by the difficulty of converting foul-smelling TMA to its odourless N-oxide. In this case, the intake of excess TMA is a serious problem so it is necessary to control the concentration of TMA in food. The most frequent methods of analysis of TMA in foods involve GC, HPLC and EC. These methods are not appropriate for in-situ determination so it is necessary to develop rapid methods for determination of TMA. In this work, a rapid and “in-situ” method for the determination of TMA based on its enzymatic reaction with FMO3 is presented. FMO3: TMA + NADPH + H+ +O2 → TMAO + NADP + H2O. It has been found that the slope of the variation of absorbance at 340 nm due to the disappearance of NADPH (Figure 1a: [NADPH]=3.45.10-4 M, pH= 7.74 , Tª=38 ºC, [FMO3]=500 U.) can be related to the concentration of TMA and used as analytical signal of the proposed method. FMO3 concentration, pH, NADPH concentration and Tª have been optimized. In the optimal conditions ([NADPH] = 8·10-4 M, pH= 9, Tª=38ºC,FMO3=2000 U), the method shows a linear response to TMA between 2·10-5 and 1.5·10-4 M, with a RSD of 9.67% (n=3). An exhaustive interference study (putrescine, cadaverine, histamine, tyramine, monomethylamine and dimethylamine (DMA) were considered) show that only DMA is an interference but if the ratio DMA: TMA is 10:1. The method was applied to the determination of TMA in codfish by the addition standard method with good results., This work has been supported by the Agencia Estatal de Investigación of Spain (PID2019-105408GB) and by the founding to research group of the DGA-FEDER (E25_20R).

Published
2022

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