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Your search keyword '"Pachnis, Vassilis"' showing total 11 results
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11 results on '"Pachnis, Vassilis"'

5. A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Author

Pachnis, Vassilis, primary, Laddach, Anna, additional, Chng, Song Hui, additional, Lasrado, Reena, additional, Progatzky, Franze, additional, Shapiro, Michael, additional, Erickson, Alek, additional, Sampedro-Castaneda, Marisol, additional, Artemov, Artem, additional, Bon-Frauches, Ana Carina, additional, Kleinjung, Jens, additional, Boeing, Stefan, additional, Ultanir, Sila, additional, Adameyko, Igor, additional, and Amaniti, Eleni-Maria, additional

Published
2023
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6. Single-cell analysis of mast cell populations across organs reveals insights into cell origins, anatomical niches and neuron-associated functions.

Author

Gaudenzio, Nicolas, primary, Tauber, Marie, additional, Basso, Lilian, additional, Wemelle, Eve, additional, Martin, Jeremy, additional, Bostan, Luciana, additional, Pinto, Marlene Magalhaes, additional, Thierry, Guilhem, additional, Houmadi, Raissa, additional, Serhan, Nadine, additional, Loste, Alexia, additional, Bleriot, Camille, additional, Samrout, Celine El, additional, Lasrado, Reena, additional, Kamphuis, Jasper, additional, Pachnis, Vassilis, additional, Grujic, Mirjana, additional, Kjellén, Lena, additional, Pejler, Gunnar, additional, Paul, Carle, additional, Dong, Xinzhong, additional, Galli, Stephen, additional, Reber, Laurent, additional, Ginhoux, Florent, additional, Bajenoff, Marc, additional, Gentek, Rebecca, additional, and Knauff, Claude, additional

Published
2022
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8. A branching model of cell fate decisions in the enteric nervous system

Author

Laddach, Anna Christine, primary, Chng, Song Hui, additional, Lasrado, Reena, additional, Progatzky, Fränze, additional, Shapiro, Michael, additional, Artemov, Artem, additional, Castaneda, Marisol Sampedro, additional, Erickson, Alek, additional, Bon-Frauches, Ana Carina, additional, Kleinjung, Jens, additional, Boeing, Stefan, additional, Ultanir, Sila, additional, Adameyko, Igor, additional, and Pachnis, Vassilis, additional

Published
2022
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11. TrajectoryGeometry suggests cell fate decisions can involve branches rather than bifurcations.

Author

Laddach A, Pachnis V, and Shapiro M

Abstract

Differentiation of multipotential progenitor cells is a key process in the development of any multi-cellular organism and often continues throughout its life. It is often assumed that a bi-potential progenitor develops along a (relatively) straight trajectory until it reaches a decision point where the trajectory bifurcates. At this point one of two directions is chosen, each direction representing the unfolding of a new transcriptional programme. However, we have lacked quantitative means for testing this model. Accordingly, we have developed the R package TrajectoryGeometry. Applying this to published data we find several examples where, rather than bifurcate, developmental pathways branch . That is, the bipotential progenitor develops along a relatively straight trajectory leading to one of its potential fates. A second relatively straight trajectory branches off from this towards the other potential fate. In this sense only cells that branch off to follow the second trajectory make a 'decision'. Our methods give precise descriptions of the genes and cellular pathways involved in these trajectories. We speculate that branching may be the more common behaviour and may have advantages from a control-theoretic viewpoint., (© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.)

Published
2024
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