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Your search keyword '"PARK, S. C."' showing total 6 results
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6 results on '"PARK, S. C."'

1. On Isomonodromic Deformation of Massive Ising Spinors

Author

Park, S. C.

Subjects
Mathematics - Probability, Mathematical Physics
Abstract

In this short note, we give a self-contained derivation of the formula for the $2$-point full-plane Ising spin correlation function under massive scaling limit in terms of a third Painlev\'e transcendant. This formula, first derived in a celebrated work of Wu, McCoy, Tracy, and Barouch, was subsequently reformulated in terms of the theory of isomonodromic deformation by Sato, Miwa, and Jimbo. In view of recent developments in the discrete analysis which have enabled, in particular, a convergence proof of spin correlation functions on isoradial lattice, we give a concise and rigorous account of the continuous theory in the same framework yielding this iconic result., Comment: 15 pages

Published
2022

4. P1022 One-year safety and effectiveness of ustekinumab in patients with Crohn’s disease: The K-STAR study

Author

Lee, C K, primary, Moon, W, additional, Chun, J, additional, Kim, E S, additional, Kim, H W, additional, Yoon, H, additional, Kim, H S, additional, Lee, Y J, additional, Choi, C H, additional, Jung, Y, additional, Park, S C, additional, Song, G A, additional, Lee, J H, additional, Jung, E S, additional, Kim, Y, additional, Jung, S Y, additional, Choi, J M, additional, and Ye, B D, additional

Published
2024
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6. SARS-CoV-2 exploits cellular RAD51 to promote viral propagation: implication of RAD51 inhibitor as a potential drug candidate against COVID-19.

Author

Pham TX, Huynh TTX, Choi J, Lee J-B, Park S-C, Kim B, Lim Y-S, and Hwang SB

Subjects
Humans, Molecular Docking Simulation, Rad51 Recombinase antagonists & inhibitors, Rad51 Recombinase metabolism, RNA, Viral, Host-Pathogen Interactions, COVID-19 metabolism, COVID-19 virology, SARS-CoV-2 physiology
Abstract

Importance: Viruses are constantly evolving to promote propagation in the host. Here, we show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes host RAD51 for replication. Silencing of RAD51 impaired SARS-CoV-2 propagation. Viral RNA colocalized with RAD51 in the cytoplasm of SARS-CoV-2-infected cells, suggesting that both viral RNA and RAD51 may form a replication complex. We, therefore, evaluated RAD51 inhibitors as possible therapeutic agents against SARS-CoV-2. Indeed, RAD51 inhibitors exerted antiviral activities against not only Wuhan but also variants of SARS-CoV-2. Molecular docking model shows that RAD51 inhibitors impede SARS-CoV-2 propagation by interfering with dimerization of RAD51. These data suggest that RAD51 may represent a novel host-based drug target for coronavirus disease 2019 treatment., Competing Interests: The authors declare no conflict of interest.

Published
2023
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