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Your search keyword '"P. Beauparlant"' showing total 19 results
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19 results on '"P. Beauparlant"'

5. Tutoring: To Hire or Not to Hire Pro? What Are the Differences?

Author

Cathia Papi, Caroline Charbonneau, René Beauparlant, and Marie Beigas

Abstract

This study focuses on the practices implemented by tutors, considering education professionals, especially teachers, on the one hand, and on the other, non-education professionals, namely students. Interviews with 24 tutors, inspired by the explicitation interview technique, enabled us to determine that the nine most frequently implemented practices are similar regardless of whether the tutor is an education professional. Nevertheless, eight elements are likely to influence tutoring, most notably being familiar with the tutored students and their difficulties before the session, and knowing how the concepts are addressed in class. In this regard, tutoring provided by education professionals is likely to be even more effective the more they know the tutees. However, it would appear that non-professionals trained in program concepts and who benefit from follow-ups with the students' teachers or parents are also able to provide quality tutoring.

Published
2024
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6. Teaching Single Crystal X-Ray Crystallography In the Undergraduate Classroom with Sugar and Epsom Salt

Author

Alain M. Beauparlant, Cassandra T. Eagle, Reza Mohseni, and Colin D. McMillen

Abstract

We developed a single crystal X-ray crystallography experiment based on the crystal structure of sucrose (table sugar), and a more challenging experiment using Epsom salt. Both crystals are readily available in X-ray quality crystalline form. In these experiments, students mounted a crystal on a MiTeGen loop and analyzed it using a Rigaku XtaLAB Mini diffractometer (built 2011). Students generated models of both compounds using CrysAlis[superscript Pro], Olex2, SHELXT, and SHELXL. All aspects of this experiment use free software programs which have user-friendly interfaces. A step-by-step laboratory protocol for determining the structure of both compounds is included in the Supporting Information. These experiments were used in the Fall of 2019 at the Junior and the Senior level. In the Summer of 2020, a take-home version of the lab was created in response to the Novel 2019 Coronavirus (COVID-19) pandemic and implemented in the General Chemistry laboratory curriculum; this experiment was used for the duration of the 2020-2021 academic year. These experiments are suitable for all undergraduate experience levels.

Published
2023
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7. Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Author

Wilcox, Naomi, Dumont, Martine, González-Neira, Anna, Carvalho, Sara, Joly Beauparlant, Charles, Crotti, Marco, Luccarini, Craig, Soucy, Penny, Dubois, Stéphane, Nuñez-Torres, Rocio, Pita, Guillermo, Gardner, Eugene J., Dennis, Joe, Alonso, M. Rosario, Álvarez, Nuria, Baynes, Caroline, Collin-Deschesnes, Annie Claude, Desjardins, Sylvie, Becher, Heiko, Behrens, Sabine, Bolla, Manjeet K., Castelao, Jose E., Chang-Claude, Jenny, Cornelissen, Sten, Dörk, Thilo, Engel, Christoph, Gago-Dominguez, Manuela, Guénel, Pascal, Hadjisavvas, Andreas, Hahnen, Eric, Hartman, Mikael, Herráez, Belén, Jung, Audrey, Keeman, Renske, Kiechle, Marion, Li, Jingmei, Loizidou, Maria A., Lush, Michael, Michailidou, Kyriaki, Panayiotidis, Mihalis I., Sim, Xueling, Teo, Soo Hwang, Tyrer, Jonathan P., van der Kolk, Lizet E., Wahlström, Cecilia, Wang, Qin, Perry, John R. B., Benitez, Javier, Schmidt, Marjanka K., Schmutzler, Rita K., Pharoah, Paul D. P., Droit, Arnaud, Dunning, Alison M., Kvist, Anders, Devilee, Peter, Easton, Douglas F., and Simard, Jacques

Published
2023
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9. Author Correction: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Author

Wilcox, Naomi, Dumont, Martine, González-Neira, Anna, Carvalho, Sara, Joly Beauparlant, Charles, Crotti, Marco, Luccarini, Craig, Soucy, Penny, Dubois, Stéphane, Nuñez-Torres, Rocio, Pita, Guillermo, Gardner, Eugene J., Dennis, Joe, Alonso, M. Rosario, Álvarez, Nuria, Baynes, Caroline, Collin-Deschesnes, Annie Claude, Desjardins, Sylvie, Becher, Heiko, Behrens, Sabine, Bolla, Manjeet K., Castelao, Jose E., Chang-Claude, Jenny, Cornelissen, Sten, Dörk, Thilo, Engel, Christoph, Gago-Dominguez, Manuela, Guénel, Pascal, Hadjisavvas, Andreas, Hahnen, Eric, Hartman, Mikael, Herráez, Belén, Jung, Audrey, Keeman, Renske, Kiechle, Marion, Li, Jingmei, Loizidou, Maria A., Lush, Michael, Michailidou, Kyriaki, Panayiotidis, Mihalis I., Sim, Xueling, Teo, Soo Hwang, Tyrer, Jonathan P., van der Kolk, Lizet E., Wahlström, Cecilia, Wang, Qin, Perry, John R. B., Benitez, Javier, Schmidt, Marjanka K., Schmutzler, Rita K., Pharoah, Paul D. P., Droit, Arnaud, Dunning, Alison M., Kvist, Anders, Devilee, Peter, Easton, Douglas F., and Simard, Jacques

Published
2023
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13. Hedgehog signaling regulates Wolffian duct development through the primary cilium†

Author

Alves, Maíra Bianchi Rodrigues, Girardet, Laura, Augière, Céline, Moon, Kyeong Hye, Lavoie-Ouellet, Camille, Bernet, Agathe, Soulet, Denis, Calvo, Ezequiel, Teves, Maria E, Beauparlant, Charles Joly, Droit, Arnaud, Bastien, Alexandre, Robert, Claude, Bok, Jinwoong, Hinton, Barry T, and Belleannée, Clémence

Abstract

Primary cilia play pivotal roles in embryonic patterning and organogenesis through transduction of the Hedgehog signaling pathway (Hh). Although mutations in Hh morphogens impair the development of the gonads and trigger male infertility, the contribution of Hh and primary cilia in the development of male reproductive ductules, including the epididymis, remains unknown. From a Pax2Cre; IFT88fl/flknock-out mouse model, we found that primary cilia deletion is associated with imbalanced Hh signaling and morphometric changes in the Wolffian duct (WD), the embryonic precursor of the epididymis. Similar effects were observed following pharmacological blockade of primary cilia formation and Hh modulation on WD organotypic cultures. The expression of genes involved in extracellular matrix, mesenchymal-epithelial transition, canonical Hh and WD development was significantly altered after treatments. Altogether, we identified the primary cilia-dependent Hh signaling as a master regulator of genes involved in WD development. This provides new insights regarding the etiology of sexual differentiation and male infertility issues.Modulation of primary-ciliogenesis and downstream Hedgehog signaling controls Wolffian duct development.

Published
2023
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14. Children with Acute Lymphoblastic Leukemia and Early Thrombosis Have Dysregulated Coagulation-Related Genes and Pathways

Author

Santiago, Raoul, Pelland-Marcotte, Marie-Claude, Droit, Arnaud, George Clement, Jeyani, Herrmann, Lara, Rémy, Meredith Michelle, Ma, Yan, Raufaste-Cazavieille, Virgile, Liu, Jessica, Joly-Beauparlant, Charles, Leclercq, Mickael, Jimenez-Cortes, Camille, Sontag, Thomas, Caron, Maxime, St-Onge, Pascal, Langlois, Sylvie, Koch, Victoria, Sinnett, Daniel, Silverman, Lewis B., and Tran, Thai Hoa

Published
2022
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15. Molecular signatures associated with venous thromboembolism in children with acute lymphoblastic leukemia

Author

Pelland-Marcotte, Marie-Claude, Belaktib, Anas, Droit, Arnaud, Remy, Meredith Michelle, Clement, Jeyani George, Bianco, Stéphanie, Ma, Yan, Liu, Jessica, Herrmann, Lara, Raufaste-Cazavieille, Virgile, Joly-Beauparlant, Charles, Mangnier, Loïc, Leclercq, Mickael, Sontag, Thomas, Caron, Maxime, St-Onge, Pascal, Langlois, Sylvie, Koch, Victoria, Flamand, Yael, Sinnett, Daniel, Silverman, Lewis, Tran, Thai Hoa, and Santiago, Raoul

Abstract

Venous thromboembolism (VTE) is a frequent complication of childhood acute lymphoblastic leukemia (ALL).

Published
2024
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19. MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions

Author

Devoucoux, Maëva, Roques, Céline, Lachance, Catherine, Lashgari, Anahita, Joly-Beauparlant, Charles, Jacquet, Karine, Alerasool, Nader, Prudente, Alexandre, Taipale, Mikko, Droit, Arnaud, Lambert, Jean-Philippe, Hussein, Samer M.I., and Côté, Jacques

Abstract

MRG15/MORF4L1 is a highly conserved protein in eukaryotes that contains a chromodomain (CHD) recognizing methylation of lysine 36 on histone H3 (H3K36me3) in chromatin. Intriguingly, it has been reported in the literature to interact with several different factors involved in chromatin modifications, gene regulation, alternative mRNA splicing, and DNA repair by homologous recombination. To get a complete and reliable picture of associations in physiological conditions, we used genome editing and tandem affinity purification to analyze the stable native interactome of human MRG15, its paralog MRGX/MORF4L2 that lacks the CHD, and MRGBP (MRG-binding protein) in isogenic K562 cells. We found stable interchangeable association of MRG15 and MRGX with the NuA4/TIP60 histone acetyltransferase/chromatin remodeler, Sin3B histone deacetylase/demethylase, ASH1L histone methyltransferase, and PALB2–BRCA2 DNA repair protein complexes. These associations were further confirmed and analyzed by CRISPR tagging of endogenous proteins and comparison of expressed isoforms. Importantly, based on structural information, point mutations could be introduced that specifically disrupt MRG15 association with some complexes but not others. Most interestingly, we also identified a new abundant native complex formed by MRG15/X-MRGBP-BRD8-EP400NL (EP400 N-terminal like) that is functionally similar to the yeast TINTIN (Trimer Independent of NuA4 for Transcription Interactions with Nucleosomes) complex. Our results show that EP400NL, being homologous to the N-terminal region of NuA4/TIP60 subunit EP400, creates TINTIN by competing for BRD8 association. Functional genomics indicate that human TINTIN plays a role in transcription of specific genes. This is most likely linked to the H4ac-binding bromodomain of BRD8 along the H3K36me3–binding CHD of MRG15 on the coding region of transcribed genes. Taken together, our data provide a complete detailed picture of human MRG proteins–associated protein complexes, which are essential to understand and correlate their diverse biological functions in chromatin-based nuclear processes.

Published
2022
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