11 results on '"Overbeek L"'
Search Results
2. Correction: Protocol of the Healthy Brain Study: An Accessible Resource for Understanding the Human Brain and How It Dynamically and Individually Operates in Its Bio-Social Context
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Healthy Brain Study consortium, Aarts, E, Akkerman, A, Altgassen, M, Bartels, R, Beckers, D, Bevelander, K, Bijleveld, E, Davidson, EB, Boleij, A, Bralten, J, Cillessen, T, Claassen, J, Cools, R, Cornelissen, I, Dresler, M, Eijsvogels, T, Faber, M, Fernández, G, Figner, B, Fritsche, M, Füllbrunn, S, Gayet, S, van Gelder, MMHJ, van Gerven, M, Geurts, S, Greven, CU, Groefsema, M, Haak, K, Hagoort, P, Hartman, Y, van der Heijden, B, Hermans, E, Heuvelmans, V, Hintz, F, den Hollander, J, Hulsman, AM, Idesis, S, Jaeger, M, Janse, E, Janzing, J, Kessels, RPC, Karremans, JC, de Kleijn, W, Klein, M, Klumpers, F, Kohn, N, Korzilius, H, Krahmer, B, de Lange, F, van Leeuwen, J, Liu, H, Luijten, M, Manders, P, Manevska, K, Marques, JP, Matthews, J, McQueen, JM, Medendorp, P, Melis, R, Meyer, A, Oosterman, J, Overbeek, L, Peelen, M, Popma, J, Postma, G, Roelofs, K, van Rossenberg, YGT, Schaap, G, Scheepers, P, Selen, L, Starren, M, Swinkels, DW, Tendolkar, I, Thijssen, DHJ, Timmerman, H, Tutunji, R, Tuladhar, A, Veling, H, Verhagen, M, Verkroost, J, Vink, J, Vriezekolk, V, Vrijsen, J, Vyrastekova, J, van der Wal, S, Willems, R, Willemsen, A, and Language, Communication and Cognition
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Questionnaires ,Male ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,COVID-19/diagnosis ,230 Affective Neuroscience ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Social Sciences ,Social Environment ,330 000 Food & Cognition ,Social Development ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Analytical Chemistry ,RC1200 ,Experimental Psychopathology and Treatment ,Study Protocol ,Cognition ,Surveys and Questionnaires ,130 000 Cognitive Neurology & Memory ,Affect/physiology ,Medicine and Health Sciences ,Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] ,Psychology ,Public and Occupational Health ,Cognition/physiology ,Work, Health and Performance ,Intelligence Tests ,Grammar ,Psycholinguistics ,Multidisciplinary ,Non-nativeness in Communication ,Brain ,220 Statistical Imaging Neuroscience ,180 000 Predictive Brain ,Cognitive artificial intelligence ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Semantics ,Research Design ,Medicine ,Female ,Behavioral and Social Aspects of Health ,Institute for Management Research ,Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] ,Personality Tests ,Adult ,110 000 Neurocognition of Language ,Psychometrics ,Science ,Decision Making ,Sensation ,BF ,Neuroimaging ,Research and Analysis Methods ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,Language and Speech, Learning and Therapy ,QH301 ,All institutes and research themes of the Radboud University Medical Center ,Humans ,Speech Production and Comprehension ,Sensation/physiology ,320 000 MR Structural Quantitative Imaging ,Behavior ,Survey Research ,Behaviour Change and Well-being ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Neuro- en revalidatiepsychologie ,Action, intention, and motor control ,Neuropsychology and rehabilitation psychology ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,Cognitive Psychology ,Biology and Life Sciences ,COVID-19 ,Linguistics ,Brain/diagnostic imaging ,QP ,Language & Communication ,Communication and Media ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Affect ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,Narrative, Cognition & Communication ,RC0321 ,Cognitive Science ,Digital Security ,170 000 Motivational & Cognitive Control ,Developmental Psychopathology ,Neuroscience - Abstract
The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30–39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955.
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- 2022
3. Concepts and criteria defining emerging microbiome applications.
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Kostic T, Schloter M, Arruda P, Berg G, Charles TC, Cotter PD, Kiran GS, Lange L, Maguin E, Meisner A, van Overbeek L, Sanz Y, Sarand I, Selvin J, Tsakalidou E, Smidt H, Wagner M, and Sessitsch A
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- Humans, Animals, Microbiota
- Abstract
In recent years, microbiomes and their potential applications for human, animal or plant health, food production and environmental management came into the spotlight of major national and international policies and strategies. This has been accompanied by substantial R&D investments in both public and private sectors, with an increasing number of products entering the market. Despite widespread agreement on the potential of microbiomes and their uses across disciplines, stakeholders and countries, there is no consensus on what defines a microbiome application. This often results in non-comprehensive communication or insufficient documentation making commercialisation and acceptance of the novel products challenging. To showcase the complexity of this issue we discuss two selected, well-established applications and propose criteria defining a microbiome application and their conditions of use for clear communication, facilitating suitable regulatory frameworks and building trust among stakeholders., (© 2024 The Author(s). Microbial Biotechnology published by John Wiley & Sons Ltd.)
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- 2024
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4. Microbiome Interconnectedness throughout Environments with Major Consequences for Healthy People and a Healthy Planet.
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Sessitsch A, Wakelin S, Schloter M, Maguin E, Cernava T, Champomier-Verges MC, Charles TC, Cotter PD, Ferrocino I, Kriaa A, Lebre P, Cowan D, Lange L, Kiran S, Markiewicz L, Meisner A, Olivares M, Sarand I, Schelkle B, Selvin J, Smidt H, van Overbeek L, Berg G, Cocolin L, Sanz Y, Fernandes WL Jr, Liu SJ, Ryan M, Singh B, and Kostic T
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- Animals, Humans, Soil Microbiology, Soil, Water, Planets, Microbiota physiology
- Abstract
Microbiomes have highly important roles for ecosystem functioning and carry out key functions that support planetary health, including nutrient cycling, climate regulation, and water filtration. Microbiomes are also intimately associated with complex multicellular organisms such as humans, other animals, plants, and insects and perform crucial roles for the health of their hosts. Although we are starting to understand that microbiomes in different systems are interconnected, there is still a poor understanding of microbiome transfer and connectivity. In this review we show how microbiomes are connected within and transferred between different habitats and discuss the functional consequences of these connections. Microbiome transfer occurs between and within abiotic (e.g., air, soil, and water) and biotic environments, and can either be mediated through different vectors (e.g., insects or food) or direct interactions. Such transfer processes may also include the transmission of pathogens or antibiotic resistance genes. However, here, we highlight the fact that microbiome transmission can have positive effects on planetary and human health, where transmitted microorganisms potentially providing novel functions may be important for the adaptation of ecosystems., Competing Interests: The authors declare no conflict of interest.
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- 2023
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5. Medically ready for discharge: A multisite "point-in-time" assessment of hospitalized patients.
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Bann M, Meo N, Lopez JP, Ou A, Rosenthal M, Khawaja H, Goodman LA, Barone M, Coleman B, High HJ, Overbeek L, Shelbourn P, VerMaas L, Baughman A, Sekaran A, Cyrus R, O'Dorisio N, Beatty L, Loica-Mersa S, Kubey A, Jaffe R, Vokoun C, Koom-Dadzie K, Graves K, Tuck M, and Helgerson P
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- Humans, Cross-Sectional Studies, Length of Stay, Hospitals, Patient Discharge, Hospitalization
- Abstract
Background: Time spent awaiting discharge after the acute need for hospitalization has resolved is an important potential contributor to hospital length of stay (LOS)., Objective: To measure the prevalence, impact, and context of patients who remain hospitalized for prolonged periods after completion of acute care needs., Design, Setting, and Participants: We conducted a cross-sectional "point-in-time" survey at each of 15 academic US hospitals using a structured data collection tool with on-service acute care medicine attending physicians in fall 2022., Main Outcomes and Measures: Primary outcomes were number and percentage of patients considered "medically ready for discharge" with emphasis on those who had experienced a "major barrier to discharge" (medically ready for discharge for ≥1 week). Estimated LOS attributable to major discharge barriers, contributory discharge needs, and associated hospital characteristics were measured., Results: Of 1928 patients sampled, 35.0% (n = 674) were medically ready for discharge including 9.8% (n = 189) with major discharge barriers. Many patients with major discharge barriers (44.4%; 84/189) had spent a month or longer medically ready for discharge and commonly (84.1%; 159/189) required some form of skilled therapy or daily living support services for discharge. Higher proportions of patients experiencing major discharge barriers were found in public versus private, nonprofit hospitals (12.0% vs. 7.2%; p = .001) and county versus noncounty hospitals (14.5% vs. 8.8%; p = .002)., Conclusions: Patients experience major discharge barriers in many US hospitals and spend prolonged time awaiting discharge, often for support needs that may be outside of clinician control., (© 2023 Society of Hospital Medicine.)
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- 2023
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6. Prevalence, attachment ability and strength of the biological control agent Bacillus thuringiensis on tomato.
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Zhao X, Hendriks M, Deleu E, Spanoghe P, Höfte M, van Overbeek L, and Uyttendaele M
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- Animals, Biological Control Agents, Prevalence, Insecta, Bacillus cereus, Bacterial Proteins, Bacillus thuringiensis, Solanum lycopersicum
- Abstract
Bacillus thuringiensis (Bt) is commonly used as a biological control agent (BCA) to control insect pests in edible plant production and can as such be introduced into the food chain of fresh produce. Using standard food diagnostics Bt will be detected and reported as presumptive B. cereus. Tomato plants are often sprayed with Bt biopesticides for insect control, thus these Bt BCAs can also reach the tomato fruits and persist until consumption. In this study, vine tomatoes from the retail in Belgium (Flanders) were investigated for the occurrence and residual numbers of presumptive B. cereus and Bt. Of 109 tomato samples, 61 (56%) were tested positive for presumptive B. cereus. Of the presumptive B. cereus isolates (n = 213) recovered from these samples, 98% were identified as Bt by the production of parasporal crystals. Further quantitative real-time PCR assays on a subselection of Bt isolates (n = 61) showed that 95% of Bt isolates were indistinguishable from Bt biopesticide strains that are approved to be used on crops in the EU. Furthermore, the attachment strength of tested Bt biopesticide strains showed easier wash-off properties if using the commercial Bt granule formulation than the unformulated lab-cultured Bt or B. cereus spore suspensions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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7. Identification and characterization of Bacillus thuringiensis and other Bacillus cereus group isolates from spinach by whole genome sequencing.
- Author
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Zhao X, Zervas A, Hendriks M, Rajkovic A, van Overbeek L, Hendriksen NB, and Uyttendaele M
- Abstract
Bacillus thuringiensis (Bt), used as a biological control agent (BCA), can persist on plants, and from there can be introduced into the final food product. In routine food safety diagnostics, these Bt residues cannot be distinguished from natural populations of Bacillus cereus present in plants and all are enumerated as "presumptive B. cereus ." In this study, information on eventual use of Bt biopesticides, brand, application times and intervals provided by three food processing companies in Belgium, were integrated with quantitative data on presumptive B. cereus measured from fresh to frozen food products. This information together with data on genomic similarity obtained via whole genome sequencing (WGS) and cry gene profiling using a quantitative real-time PCR (qPCR) assay, confirmed that six out of 11 Bt isolates originated from the applied Bt biocontrol products. These identified Bt strains were shown to carry enterotoxin genes ( nhe, hbl, cytK-2 ) and express Hbl enterotoxin in vitro . It was also noted that these Bt biopesticide strains showed no growth at standard refrigeration temperatures and a low or moderate biofilm-forming ability and cytotoxic activity. Our results also showed that the use of Bt as a BCA on spinach plants in the field led to higher residual counts of Bt in spinach (fresh or frozen) in the food supply chain, but the residual counts exceeding at present commonly assumed safety limit of 10
5 CFU/g was only found in one fresh spinach sample. It is therefore recommended to establish a pre-harvest interval for Bt biopesticide application in the field to lower the likelihood of noncompliance to the generic B. cereus safety limit. Furthermore, WGS was found to be the best way to identify Bt biopesticide isolates at the strain level for foodborne outbreaks and clinical surveillance. The developed qPCR assay for screening on the presence of cry genes in presumptive B. cereus can be applied as a rapid routine test as an amendment to the already existing test on Bt crystal proteins determined via phase-contrast microscopy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Zhao, Zervas, Hendriks, Rajkovic, van Overbeek, Hendriksen and Uyttendaele.)- Published
- 2022
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8. Species Identity, Life History, and Geographic Distance Influence Gut Bacterial Communities in Lab-Reared and European Field-Collected Culicoides Biting midges.
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Möhlmann TWR, Ter Braak CJF, Te Beest DE, Hendriks M, Nijhuis EH, Warris S, Drolet BS, van Overbeek L, and Koenraadt CJM
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- Animals, Insect Vectors microbiology, RNA, Ribosomal, 16S genetics, Ceratopogonidae, Gastrointestinal Microbiome, Wolbachia genetics
- Abstract
Bacteria are part of the insect gut system and influence many physiological traits of their host. Gut bacteria may even reduce or block the transmission of arboviruses in several species of arthropod vectors. Culicoides biting midges are important arboviral vectors of several livestock and wildlife diseases, yet limited information is available on their gut bacterial communities. Addressing this gap will help inform how these communities can be manipulated and ultimately used as novel tools to control pathogens. To assess how bacterial communities change during the life stages of lab-reared C. nubeculosus and C. sonorensis, endosymbiotic bacteria were identified using Illumina sequencing of 16S rRNA and taxonomically characterised. Analyses were conducted to determine how gut bacterial communities in adults are influenced by species identity and geographic distance among biting midge populations. Communities of the two lab-reared Culicoides species significantly changed after pupation and with maturation into 6-day-old adults. Pseudomonas, Burkholderiaceae and Leucobacter bacteria were part of a core community that was trans-stadially transmitted and found throughout their life cycle. Among field-collected biting midges, the bacterial communities were unique for almost each species. Cardinium, Rickettsia and Wolbachia were some of the most abundant bacteria in midges collected from wetlands. Only Pseudomonas was present in high relative abundance in all field-collected species. In this study, species identity, as well as geographic distance, influenced the gut bacterial communities and may partly explain known inter- and intra-species variability in vector competence. Additionally, stably associated bacterial species could be candidates for paratransgenic strategies to control vector-borne pathogens., (© 2021. The Author(s).)
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- 2022
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9. Correction: Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context.
- Author
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Aarts E, Akkerman A, Altgassen M, Bartels R, Beckers D, Bevelander K, Bijleveld E, Davidson EB, Boleij A, Bralten J, Cillessen T, Claassen J, Cools R, Cornelissen I, Dresler M, Eijsvogels T, Faber M, Fernández G, Figner B, Fritsche M, Füllbrunn S, Gayet S, van Gelder MMHJ, Gerven MV, Geurts S, Greven CU, Groefsema M, Haak K, Hagoort P, Hartman Y, van der Heijden B, Hermans E, Heuvelmans V, Hintz F, Hollander JD, Hulsman AM, Idesis S, Jaeger M, Janse E, Janzing J, Kessels RPC, Karremans JC, Kleijn W, Klein M, Klumpers F, Kohn N, Korzilius H, Krahmer B, Lange F, Leeuwen JV, Liu H, Luijten M, Manders P, Manevska K, Marques JP, Matthews J, McQueen JM, Medendorp P, Melis R, Meyer A, Oosterman J, Overbeek L, Peelen M, Popma J, Postma G, Roelofs K, van Rossenberg YGT, Schaap G, Scheepers P, Selen L, Starren M, Swinkels DW, Tendolkar I, Thijssen D, Timmerman H, Tutunji R, Tuladhar A, Veling H, Verhagen M, Verkroost J, Vink J, Vriezekolk V, Vrijsen J, Vyrastekova J, Wal SV, Willems R, and Willemsen A
- Abstract
[This corrects the article DOI: 10.1371/journal.pone.0260952.].
- Published
- 2022
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- View/download PDF
10. Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context.
- Author
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Aarts E, Akkerman A, Altgassen M, Bartels R, Beckers B, Bevelander K, Bijleveld E, Davidson EB, Boleij A, Bralten J, Cillessen T, Claassen J, Cools R, Cornelissen I, Dresler M, Eijsvogels T, Faber M, Fernández G, Figner B, Fritsche M, Füllbrunn S, Gayet S, van Gelder MMHJ, van Gerven M, Geurts S, Greven CU, Groefsema M, Haak K, Hagoort P, Hartman Y, van der Heijden B, Hermans E, Heuvelmans V, Hintz F, den Hollander J, Hulsman AM, Idesis S, Jaeger M, Janse E, Janzing J, Kessels RPC, Karremans JC, de Kleijn W, Klein M, Klumpers F, Kohn N, Korzilius H, Krahmer B, de Lange F, van Leeuwen J, Liu H, Luijten M, Manders P, Manevska K, Marques JP, Matthews J, M. McQueen J, Medendorp P, Melis R, Meyer A, Oosterman J, Overbeek L, Peelen M, Popma J, Postma G, Roelofs K, van Rossenberg YGT, Schaap G, Scheepers P, Selen L, Starren M, Swinkels DW, Tendolkar I, Thijssen D, Timmerman H, Tutunji R, Tuladhar A, Veling H, Verhagen M, Verkroost J, Vink J, Vriezekolk V, Vrijsen J, Vyrastekova J, van der Wal S, Willems R, and Willemsen A
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- Adult, Affect physiology, Behavior, Brain diagnostic imaging, COVID-19 diagnosis, Cognition physiology, Female, Humans, Male, Neuroimaging, Sensation physiology, Surveys and Questionnaires, Brain physiology, Social Environment
- Abstract
The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
- Full Text
- View/download PDF
11. Transmission of Escherichia coli from Manure to Root Zones of Field-Grown Lettuce and Leek Plants.
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van Overbeek L, Duhamel M, Aanstoot S, van der Plas CL, Nijhuis E, Poleij L, Russ L, van der Zouwen P, and Andreo-Jimenez B
- Abstract
Pathogenic Escherichia coli strains are responsible for food-borne disease outbreaks upon consumption of fresh vegetables and fruits. The aim of this study was to establish the transmission route of E. coli strain 0611, as proxy for human pathogenic E. coli , via manure, soil and plant root zones to the above-soil plant compartments. The ecological behavior of the introduced strain was established by making use of a combination of cultivation-based and molecular targeted and untargeted approaches. Strain 0611 CFUs and specific molecular targets were detected in the root zones of lettuce and leek plants, even up to 272 days after planting in the case of leek plants. However, no strain 0611 colonies were detected in leek leaves, and only in one occasion a single colony was found in lettuce leaves. Therefore, it was concluded that transmission of E. coli via manure is not the principal contamination route to the edible parts of both plant species grown under field conditions in this study. Strain 0611 was shown to accumulate in root zones of both species and metagenomic reads of this strain were retrieved from the lettuce rhizosphere soil metagenome library at a level of Log 4.11 CFU per g dry soil.
- Published
- 2021
- Full Text
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