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Your search keyword '"Ottaviani, Alessio"' showing total 9 results
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9 results on '"Ottaviani, Alessio"'

1. GD2-targeting CAR T-cell therapy for patients with GD2+ medulloblastoma

Author

Ciccone, Roselia, primary, Quintarelli, Concetta, additional, Camera, Antonio, additional, Pezzella, Michele, additional, Caruso, Simona, additional, Manni, Simona, additional, Ottaviani, Alessio, additional, Guercio, Marika, additional, Del Bufalo, Francesca, additional, Quadraccia, Maria Cecilia, additional, Orlando, Domenico, additional, Di Cecca, Stefano, additional, Sinibaldi, Matilde, additional, Aurigemma, Mariasole, additional, Iaffaldano, Laura, additional, Sarcinelli, Andrea, additional, D' Amore, Maria Luisa, additional, Ceccarelli, Manuela, additional, Nazio, Francesca, additional, Marabitti, Veronica, additional, Giorda, Ezio, additional, Pezzullo, Marco, additional, De Stefanis, Cristiano, additional, Carai, Andrea, additional, Rossi, Sabrina, additional, Alaggio, Rita, additional, Del Baldo, Giada, additional, Becilli, Marco, additional, Mastronuzzi, Angela, additional, De Angelis, Biagio, additional, and Locatelli, Franco, additional

Published
2024
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2. Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies

Author

Manni, Simona, primary, Del Bufalo, Francesca, additional, Merli, Pietro, additional, Silvestris, Domenico Alessandro, additional, Guercio, Marika, additional, Caruso, Simona, additional, Reddel, Sofia, additional, Iaffaldano, Laura, additional, Pezzella, Michele, additional, Di Cecca, Stefano, additional, Sinibaldi, Matilde, additional, Ottaviani, Alessio, additional, Quadraccia, Maria Cecilia, additional, Aurigemma, Mariasole, additional, Sarcinelli, Andrea, additional, Ciccone, Roselia, additional, Abbaszadeh, Zeinab, additional, Ceccarelli, Manuela, additional, De Vito, Rita, additional, Lodi, Maria Chiara, additional, Cefalo, Maria Giuseppina, additional, Mastronuzzi, Angela, additional, De Angelis, Biagio, additional, Locatelli, Franco, additional, and Quintarelli, Concetta, additional

Published
2023
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3. Neutralization of IFNγ improves the safety profile of CAR T-cells while maintaining unaffected efficacy against B-cell malignancies

Author

Manni, Simona, primary, Bufalo, Francesca Del, additional, Merli, Pietro, additional, Silvestris, Domenico Alessandro, additional, Guercio, Marika, additional, Caruso, Simona, additional, Reddel, Sofia, additional, Iaffaldano, Laura, additional, Pezzella, Michele, additional, Cecca, Stefano Di, additional, Sinibaldi, Matilde, additional, Ottaviani, Alessio, additional, Quadraccia, Maria Cecilia, additional, Aurigemma, Mariasole, additional, Sarcinelli, Andrea, additional, Ciccone, Roselia, additional, Abbaszadeh, Zeinab, additional, Ceccarelli, Manuela, additional, De Vito, Rita, additional, Lodi, Maria Chiara, additional, Cefalo, Maria Giuseppina, additional, Mastronuzzi, Angela, additional, De Angelis, Biagio, additional, Locatelli, Franco, additional, and Quintarelli, Concetta, additional

Published
2023
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5. Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment

Author

Sconocchia, Giuseppe, primary, Lanzilli, Giulia, additional, Cesarini, Valeriana, additional, Silvestris, Domenico A, additional, Rezvani, Katayoun, additional, Arriga, Roberto, additional, Caratelli, Sara, additional, Chen, Ken, additional, Dou, Jinzhuang, additional, Cenciarelli, Carlo, additional, Toietta, Gabriele, additional, Baldari, Silvia, additional, Sconocchia, Tommaso, additional, De Paolis, Francesca, additional, Aureli, Anna, additional, Iezzi, Giandomenica, additional, Irno Consalvo, Maria, additional, Buccisano, Francesco, additional, del Principe, Maria I, additional, Maurillo, Luca, additional, Venditti, Adriano, additional, Ottaviani, Alessio, additional, and Spagnoli, Giulio C, additional

Published
2022
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8. Antibody-Independent Antitumor Effects of Cd32A-Chimeric Receptor T Cells: Implications for Breast Cancer Prognosis and Treatment

Author

Sconocchia, Giuseppe, primary, Lanzilli, Giulia, additional, Cesarini, Valeriana, additional, Silvestris, Domenico Alessandro, additional, Arriga, Roberto, additional, Rezvani, Katayoun, additional, Caratelli, Sara, additional, Chen, Ken, additional, Dou, Jinzhuang, additional, Cenciarelli, Carlo, additional, Toietta, Gabriele, additional, Baldari, Silvia, additional, Sconocchia, Tommaso, additional, Paolis, Francesca De, additional, Aureli, Anna, additional, Iezzi, Giandomenica, additional, del Principe, Maria Ilaria, additional, Venditti, Adriano, additional, Ottaviani, Alessio, additional, and Spagnoli, Giulio Cesare, additional

Published
2021
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9. From Antarctica to cancer research: a novel human DNA topoisomerase IB inhibitor from Antarctic sponge Dendrilla antarctica.

Author

Ottaviani, Alessio, Welsch, Joshua, Agama, Keli, Pommier, Yves, Desideri, Alessandro, Baker, Bill J., and Fiorani, Paola

Subjects
*DNA topoisomerase I, *HUMAN DNA, *DNA topoisomerase inhibitors, *DNA-binding proteins, *CANCER research, *HUMAN experimentation
Abstract

Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the identification of a natural compound, membranoid G, derived from the Antarctic sponge Dendrilla antarctica displaying an in vitro inhibitory activity against human DNA topo-isomerase 1B. The experiments indicate that membranoid G, when pre-incubated with the enzyme, strongly and irreversibly inhibits the relaxation of supercoiled DNA. This compound completely inhibits the cleavage step of the enzyme catalytic mechanism by preventing protein binding to the DNA. Membranoid G displays also a cytotoxic effect on tumour cell lines, suggesting its use as a possible lead compound to develop new anticancer drugs. [ABSTRACT FROM AUTHOR]

Published
2022
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