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Background: chronic kidney disease is considered a global public health problem, being asymptomatic in its earliest stages, the population is not aware of it. Objective: to determine the hidden morbidity by chronic renal disease in early stages, in patients with arterial hypertension. Methods: a study was conducted based on a descriptive, longitudinal, retrospective study. The universe was made up of 150 hypertensive patients from the No. 33 Doctors Office, from “Pedro Díaz Coello” Polyclinic, in the municipality of Holguín, during the year 2021. The sample of 41 patients was selected through non-probabilistic sampling taking into account some inclusion and exclusion criteria. Results: the highest number of hypertensive patients was between 59 and 68 years, representing 36 %; males predominated in 19.5 %; the main risk factor was smoking in 12 patients with 29.26 %. According to renal markers (creatinine, microalbuminuria), 16 were altered with 39 %; according to the degree of chronic renal disease, in stage I, there is the greatest predominance for 62.5 % with 10 patients. Conclusions: there was predominance in hypertensive patients with chronic kidney disease between the ages of 59 to 68 years and males, with smoking and obesity associated as risk factors present in most, with a higher number of stage I patients and a close relationship between high blood pressure and the hidden morbidity of chronic kidney disease.

Fundamento: la evaluación de un programa supone la colección sistemática de datos y el análisis e interpretación de los mismos, con el propósito de determinar su validez e impacto. Servirá también para tomar decisiones sobre el programa. Objetivo: evaluar el subprograma de atención comunitaria al adulto mayor en el Policlínico Universitario “Pedro Díaz Coello”, del municipio Holguín, durante el año 2020. Métodos: se realizó una investigación en sistemas y servicios de salud, en el policlínico y periodo de tiempo declarados en el objetivo. El universo estuvo constituido por los 7446 adultos mayores, distribuidos en 38 consultorios médicos de familia. La muestra seleccionada, por muestreo aleatorio simple, fue de 160 historias clínicas pertenecientes a 16 consultorios médicos, para evaluar la dimensión proceso. La evaluación final del subprograma se consideró a partir del resultado de la evaluación de los tres componentes, estructura, proceso y resultado, a nivel de consultorio y policlínico. Resultados: las dimensiones estructura y proceso resultaron evaluadas de no satisfactorias; en los recursos humanos, de los siete criterios a evaluar, el 57,1 % obtuvo calificación de mal y en los institucionales el criterio más desfavorable fue la no existencia de una casa de abuelos; en la dimensión proceso, ocho de los diez criterios fueron evaluados de mal. La dimensión resultado tuvo 11 de los 15 criterios con calificación de bien, lo que representó el 73,3 % del total. Conclusiones: en la evaluación final del subprograma se evidenciaron dificultades tanto en la dimensión estructura como en los procesos.

Introduction: Early‐onset atrial fibrillation (AF) has already been observed in approximately 2% of patients with genetically proven long QT syndrome (LQTS). This frequency is higher than population‐based estimates of early‐onset AF. However, the concomitant expression of AF in LQTS is likely underestimated. The purpose of this study was to examine the clinical presentation, genetic background, and outcomes of a cohort of patients with LQTS and early‐onset AF referred to a single tertiary center. Methods: Twenty‐seven patients diagnosed with congenital LQTS were included in the study based on the documentation of early‐onset (age ≤50 years) clinical or subclinical AF episodes in all available medical records, including standard electrocardiograms, wearable monitor or cardiac implantable electronic devices. Results: Seventeen patients experienced clinical AF during the follow‐up period. Subclinical AF was detected in 10 patients through insertable or wearable cardiac monitors. In our series, the mean heart rate during AF episodes was found to be relatively low despite the patients' young age and the low or minimal effective doses of beta‐blockers used for QTc interval control. All patients exhibiting LQTS and early‐onset AF were genotype positive, carrying mutations in the KCNQ1 (66%), KCNH2, KCNE1, and SCN5A genes. Notably, most of these patients carried the same p.(R231C) mutation in the KCNQ1 gene (59%) and were from the same families, suggesting concurrent expression of familial AF and LQTS. Conclusion: LQTS patients are prone to developing clinical and subclinical AF, even at a younger age. The occurrence of early‐onset AF in the LQTS population could be more frequent than previously assumed. AF should be considered as a potential dysrhythmia related to LQTS. Our study emphasizes the importance of carefully researching clinical and/or subclinical episodes of AF through strict heart rhythm monitoring in the LQTS population. [ABSTRACT FROM AUTHOR]

This study aims to present the time behavior of wastewater flow parameters, organic matter, biogas flow, biogas composition, and its relations, measured through online sensors, in a municipal wastewater treatment plant (WWTP) operating full-scale upflow anaerobic sludge blanket (UASB) reactors, installed in the south of Brazil. WWTP has online measurement devices to evaluate some physicochemical variables of the sewage and the biogas. The COD analyzer (UV– Vis probe), ultrasonic flow meter, biogas flow meter, and biogas composition analyzer were the equipment used. The monitoring occurred for two time periods each of 72 h and one time period for 48 h in the year 2018. Data were checked with descriptive statistics, data independence was checked through the autocorrelation Box– Ljung test, normality behavior was checked with several tests (Shapiro– Wilk, Kolmogorov–Smirnov, Lilliefors, Anderson–Darling, D’Agostino K2, and Chen–Shapiro), and Spearman’s correlation coefficient was used to evaluate the correlations among the parameters. The mean sewage flow was 345 ± 120 L.s-1; removed organic load was, in average, 48%; biogas quality values were 82.32% ± 3.62% v/v (CH4), 2.66% ± 1.19% v/v (CO2), and 3453 ± 1268 ppm (H2S); and the production per capita obtained was 4.51 ± 1.65 NL.hab-1.d-1. It was estimated an electric power generation of 3118.6 kWh.d-1, which is equivalent to an installed power of 130 KW. The behavior of removed organic load and biogas flow (Nm3.h-1), produced in the treatment plant, showed variable, periodic, and nonstationary time behavior.

Solid-state chemiresistive gas sensors have attracted a lot of researchers' attention during the last half-century thanks to their ability to detect different gases with high sensitivity, low power consumption, low cost, and high portability. Among the most promising sensitive materials, carbon nanotubes (CNTs) have attracted a lot of interest due to their large active surface area (in the range of 50–1400 m2/g, depending on their composition) and the fact that they can operate at room temperature. In this study, single-walled carbon nanotube (SWCNT)-based sensing films were prepared and deposited by spray deposition for the fabrication of gas sensors. For the deposition, various SWCNTs were prepared in deionized water with the addition of specific surfactants, i.e., carboxymethyl cellulose (CMC) and sodium dodecyl sulfate (SDS), which act as dispersing agents to create a suitable ink for deposition. This study aims to elucidate the possible differences in the sensing performance of the fabricated devices due to the use of the two different surfactants. To achieve this goal, all the devices were tested versus ethanol (C2H5OH), carbon monoxide (CO), nitrogen dioxide (NO2), and ammonia (NH3). The produced devices demonstrated high selectivity towards NH3 and NO2. The different sensors, prepared with different deposition thicknesses (from 0.51 nm to 18.41 nm), were tested in dry and wet conditions (40% humidity), highlighting an enhanced response as a function of relative humidity. In addition, sensor performance was evaluated at different working temperatures, showing the best performance when heated up to 150 °C. The best sensing conditions we found were against NO2, sensors with 10 layers of deposition and an operating temperature of 150 °C; in this condition, sensors showed high responses compared those found in the literature (62.5%—SDS-based and 78.6%—CMC-based). Finally, cross-sensitivity measurements showed how the produced sensors are good candidates for the practical and selective detection of NO2, even in the presence of the most important interfering gases identified, i.e., NH3. [ABSTRACT FROM AUTHOR]

Molecular catalysts based on coordination complexes for the generation of hydrogen via photochemical water splitting exhibit a large versatility and tunability of the catalytic properties through chemical functionalization. In the present work, we report on light-driven hydrogen production in an aqueous solution using a series of cobalt polypyridine complexes as hydrogen evolving catalysts (HECs) in combination with CuInS2@ZnS quantum dots (QDs) as sensitizers, and ascorbate as the electron donor. A peculiar trend in activity has been observed depending on the substituents present on the polypyridine ligand. This trend markedly differs from that previously recorded using [Ru(bpy)3]2+ (where bpy = 2,2'-bipyridine) as the sensitizer and can be ascribed to different kinetically limiting pathways in the photochemical reaction (viz. protonation kinetics with the ruthenium chromophore, catalyst activation via electron transfer from the QDs in the present system). Hence, this work shows how the electronic effects on light-triggered molecular catalysis are not exclusive features of the catalyst unit but depend on the whole photochemical system. [ABSTRACT FROM AUTHOR]

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Background: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms., Methods: Twenty cancer centers in the International Network for Sharing Practices on Electrochemotherapy (InspECT) prospectively collected data. ECT was performed following ESOPE protocol. Response was evaluated by lesion size development. Pain, symptoms, performance status (ECOG-Index) and health status (EQ-5D questionnaire) were evaluated., Results: 716 patients with ulcerated (n = 302) and non-ulcerated (n = 414) cutaneous tumors and metastases were included (minimum follow-up of 45 days). Non-ulcerated lesions responded to ECT better than ulcerated lesions (complete response 65 % vs. 51 %, p = 0.0061). Only 38 % (115/302) with ulcerated lesions before ECT presented with ulcerated lesions at final follow-up. Patients with ulcerated lesions reported higher pain and more severe symptoms compared to non-ulcerated lesions, which significantly and continuously improved following ECT. In non-ulcerated lesions however, pain spiked during the treatment. No serious adverse events were reported., Conclusions: ECT is a safe and effective local treatment for cutaneous tumors. While ECT improves symptoms especially in patients with ulcerated lesions, data suggest the implementation of a perioperative pain management in non-ulcerated lesions during ECT., (© 2022 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)

Hintergrund: Elektrochemotherapie (ECT) ist eine wirksame lokale Behandlung von Hauttumoren. Ziel dieser Studie war es, die Wirksamkeit der ECT bei ulzerierten gegenüber nichtulzerierten Tumoren zu vergleichen und den Effekt auf tumorassoziierte Symptome zu untersuchen., Methodik: 20 Krebszentren des International Network for Sharing Practices on Electrochemotherapy (InspECT) sammelten prospektiv Daten. Die ECT wurde nach dem ESOPE-Protokoll durchgeführt. Das Therapieansprechen wurde anhand der Entwicklung der Läsionsgröße bewertet. Zusätzlich wurden Schmerzen, Symptome, Leistungsstatus (ECOG-Index) und Gesundheitszustand (EQ-5D-Fragebogen) untersucht., Ergebnisse: 716 Patienten mit ulzerierten (n = 302) und nichtulzerierten (n = 414) Hauttumoren und Metastasen wurden eingeschlossen (Mindest-Nachsorge 45 Tage). Nicht-ulzerierte Läsionen sprachen besser auf die ECT an als ulzerierte Läsionen (vollständiges Ansprechen: 65 % gegenüber 51 %, p = 0,0061). Nur 38 % (115/302) der Patienten mit ulzerierten Läsionen vor der ECT wiesen bei der letzten Nachuntersuchung ulzerierte Läsionen auf. Patienten mit ulzerierten Läsionen berichteten über stärkere Schmerzen und schwerere Symptome im Vergleich zu Patienten mit nichtulzerierten Läsionen, die sich nach der ECT signifikant und kontinuierlich besserten. Bei Patienten mit nichtulzerierten Läsionen hingegen nahmen die Schmerzen während der Behandlung vorübergehend zu. Es wurden keine schwerwiegenden Nebenwirkungen beobachtet., Schlussfolgerungen: Die ECT ist eine sichere und wirksame lokale Behandlung von Hauttumoren. Während die ECT die Symptome insbesondere bei Patienten mit ulzerierten Läsionen verbessert, sollte auf Basis der Daten die Implementation eines perioperativen Schmerzmanagements besonders bei nichtulzerierten Läsionen während der ECT erwogen werden., (© 2022 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)